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Multilocular thymic cysts-a diagnostic challenge on computed tomography

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World Journal of Clinical Cases 2025年第3期13卷 61-65页

作者： Nirmal Kumar Reddy Onteddu Naga Sai Rasagna Mareddy Sai Swarupa R Vulasala Jayabharath Onteddu Mayur Virarkar Department of Internal Medicine University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic Radiology University of AlabamaBirminghamAL 35294United States Department of Diagnostic Radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Public Health Sciences University of FloridaGainesvilleFL 32611United States

A recent case report provided a patient scenario,wherein,a 39-year-old male patient presented with occasional palpitations,headache,and *** of tumor markers did not show any abnormal ***,a computed tomography(CT)scan was undertaken,and its findings were affirmative of thymic ***,the postoperative histopathological assessment of the mass,after its resection,confirmed it as an anterior mediastinal multilocular thymic cyst(MTC),with concurrent acute upper respiratory tract infection and acute ***,this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.

关键词： Imaging findings Multilocular thymic cyst Histopathology Thymic cancer Mediastinal mass

Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction

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Bone Research 2013年第3期1卷 267-281页

作者： Sen Yang Liang Hao Matthew McConnell Xuedong Zhou Min Wang Yan Zhang John D Mountz Michael Reddy Paul D. Eleazer Yi-Ping Li Wei Chen Department of Pathology University of Alabama at BirminghamBirmingham Alabama USA The State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Department of Medicine University of Alabama at BirminghamBirmingham Alabama USA Department of Periodontology University of Alabama at Birmingham School of DentistryBirmingham Alabama USA Department of Endodontics University of Alabama at BirminghamBirmingham Alabama USA

Regulator of G-protein Signaling 10 （Rgsl0） plays an important function in osteoclast differentiation. However, the role of Rgsl0 in immune cells and inflammatory responses, which activate osteoclasts in inflam- matory lesions, such as bacteria-induced periodontal disease lesions, remains largely unknown. In this study, we used an adeno-associated virus （AAV-） mediated RNAi （AAV-shRNA-Rgs10） knockdown approach to study Rgsl0＇s function in immune cells and osteoclasts in bacteria-induced inflammatory lesions in a mouse model of periodontal disease. We found that AAV-shRNA-Rgs10 mediated Rgs10 knockdown impaired osteoclastogenesis and osteoclast-mediated bone resorption, in vitro and in vivo. Interestingly, local injection of AAV-shRNA-Rgs10 into the periodontal tissues in the bacteria-induced inflammatory lesion greatly decreased the number of dendritic cells, T-cells and osteoclasts, and protected the periodontal tissues from local inflammatory damage and bone destruction. Importantly, AAV-mediated Rgs10 knockdown also reduced local expression of osteoclast markers and pro-inflammatory cytokines. Our results demonstrate that AAV- shRNA-Rgs10 knockdown in periodontal disease tissues can prevent bone resorption and inflammation simultaneously. Our data indicate that Rgsl0 may regulate dendritic cell proliferation and maturation, as well as the subsequent stimulation of T-cell proliferation and maturation, and osteoclast differentiation and acti- vation. Our study suggests that AAV-shRNA-Rgs10 can be useful as a therapeutic treatment of periodontal disease.

关键词： Rgs10 immune cell AAV-mediated RNAi knockdown gene therapy periodontal disease gingivalinflammation bone resorption

Subclinical Indication of Linkage Between Markers of Skeletal and Cardiovascular Properties

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Bone Research 2013年第3期1卷 291-297页

作者： Lynae J.Hanks Ambika P.Ashraf Barbara A.Gower Jessica A.Alvarez Krista Casazza Department of Nutrition Sciences University of Alabama at BirminghamAlabama USA Children's of alabama University of Alabama at BirminghamAlabama USA Division of Endocrinology Diabetes & Lipids Emory University School of MedicineGeorgia USA

Little is known about early coincidental changes in bone and vascular properties, particularly in the context of skeletal anabolism （puberty） versus relative equilibrium （young adulthood）. We aimed to determine if subclinical markers of vascular function were associated with bone mineral content （BMC） and to evaluate the contribution of systemic factors in healthy females ages 14-42 years. Endothelial function was assessed by flow mediated dilatation （FMD）, arterial stiffness by pulse wave velocity （PWV） and augmentation index （AIx）, blood pressure （BP） by sphygmomanometer, BMC by DXA, and systemic factors by fasting blood draw. General linear models controlled for age, race and height indicated a positive association between systolic BP （SBP） and BMC independent of systemic factors. When stratified by age using 19 years as a cut-point, there was an inverse relationship between AIx75 in adolescents with insulin （P〈0.10） or inflammatory markers （P〈0.10） in statistical models. Conversely, there was a positive relationship between BMC and both PWV and AIx75 in young adults （P〈0.05）. The link between bone and the vasculature may be life stage-dependent. In the context of a less dynamic microenvironment in young adult females, metabolic factors appear to moderate less of an effect of hemodynamic properties on the skeleton relative to adolescents.

关键词： bone mineral content endothelial function arterial stiffness systolic blood pressure

Volterra operator, area integral and Carleson measures

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Science China Mathematics 2011年第11期54卷 2487-2500页

作者： WU ZhiJian Department of Mathematics University of Alabama Tuscaloosa Alabama 35487 USA

We characterize the boundedness of Volterra operators from Bergman spaces to Hardy spaces. Area integral operators and Carleson measures are heavily involved.

关键词： Bergman and Hardy spaces Volterra operator area integral Carleson measures

Machine learning and evolutionary prediction of superhard BC-N compounds

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npj Computational Materials 2021年第1期7卷 1034-1041页

作者： Wei-Chih Chen Joanna N.Schmidt Da Yan Yogesh K.Vohra Cheng-Chien Chen Department of Physics University of Alabama at BirminghamBirminghamALUSA Department of Computer Science University of Alabama at BirminghamBirminghamALUSA

We build random forests models to predict elastic properties and mechanical hardness of a compound,using only its chemical formula as *** model training uses over 10,000 target compounds and 60 features based on stoichiometric attributes,elemental properties,orbital occupations,and ionic bonding *** the models,we construct triangular graphs for B-C-N compounds to map out their bulk and shear moduli,as well as hardness *** graphs indicate that a 1:1 B-N ratio can lead to various superhard *** also validate the machine learning results by evolutionary structure prediction and density functional *** study shows that BC_(10)N,B_(4)C_(5)N_(3),and B_(2)C_(3)N exhibit dynamically stable phases with hardness values>40 GPa,which are superhard materials that potentially could be synthesized by low-temperature plasma methods.

关键词： prediction moduli occupation

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Safety and success of precut biliary sphincterotomy: Is it linked to experience or expertise?

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World Journal of Gastroenterology 2007年第15期13卷 2183-2186页

作者： Lindsay S Robison Shyam Varadarajulu C Mel Wilcox Division of Gastroenterology and Hepatology Pancreaticobiliary Center University of Alabama at BirminghamBirminghamAlabama

AIM： To determine the rates of success and complications of precut biliary sphincterotomy （PBS） based on prior experience and to compare the complication rates between PBS and standard endoscopic sphincterotomy （ES）. METHODS： A retrospective evaluation of prospectively collected non-randomized data at an academic tertiary referral center, The study included all patients in an eight-year period who underwent PBS and ES by a single endoscopist who had no formal training in PBS. The main outcorne measures of the study were success and complications of PBS with a comparison to complications of ES.RESULTS： A total of 2939 endoscopic retrograde chola ngiopancreatographies （ERCPs） were performed during the study period, including 818 （28%） ES and 150 （5%） PBS procedures. Selective biliary cannulation via PBS was successful at the first attempt in 75% of the patients. Cannulation was achieved in an additional 13% of the patients at a subsequent attempt （total 87%）. Complication rate from PBS was 45% higher than ES, but did not differ significantly [7% （10/50） vs 5% （38/818）, P = 0.29]. None of the complications from PBS was severe. A significant trend towards increasing success existed with regard to the endoscopist＇s first attempt at precut （P = 0.0393, Cochran-Armitage exact test for trend, Z = -1.7588）. CONCLUSION： Despite the lack of specific training in this technique, PBS was performed with a high success rate and a complication rate similar to or less than reports from other experienced centers. These results suggest that endoscopic experience and perhaps innate endoscopic skill may play an important role in the outcome of this procedure.

关键词： Biliary sphincterotomy Precut sphincterotomy Complication rate Endoscopic skill

Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin

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Chinese Journal of Natural Medicines 2015年第8期13卷 561-577页

作者： NIJAMPATNAM Bhavitavya DUTTA Shilpa VELU Sadanandan E. Department of Chemistry University of Alabama at Birmingham

The ocean continues to provide a plethora of unique scaffolds capable of remarkable biological applications. A large number of pyrroloiminoquinone alkaloids, including discorhabdins, epinardins, batzellines, makaluvamines, and veiutamine, have been isolated from various marine organisms. A class of pyrroloiminoquinone-related alkaloids, known as bispyrroloquinones, is the focus of this review article. This family of marine alkaloids, which contain an aryl substituted bispyrroloquinone ring system, includes three subclasses of alkaloids namely, wakayin, tsitsikammamines A-B, and zyzzyanones A-D. Both wakayin and the tsitsikammamines contain a tetracyclic fused bispyrroloiminoquinone ring system, while zyzzyanones contain a fused tricyclic bispyrroloquinone ring system. The unique chemical structures of these marine natural products and their diverse biological properties, including antifungal and antimicrobial activity, as well as the potent, albeit generally nonspecific and universal cytotoxicities, have attracted great interest of synthetic chemists over the past three decades. Tsitsikammamines, wakayin, and several of their analogs show inhibition of topoisomerases. One additional possible mechanism of anticancer activity of tsitsikammamines analogs that has been discovered recently is through the inhibition of indoleamine 2, 3-dioxygenase, an enzyme involved in tumoral immune resistance. This review discusses the isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids and their analogs.

关键词： Bispyrroloquinones Tsitsikammamines Wakayin Zyzzyanones Topoisomerase Anticancer Antimicrobial

The Grad-Shafranov reconstruction in twenty years: 1996–2016

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Science China Earth Sciences 2017年第8期60卷 1466-1494页

作者： HU Qiang Department of Space Science and CSPAR University of Alabama in Huntsville

We review and summarize the applications of the Grad-Shafranov(GS) reconstruction technique to space plasma structures in the Earth's magnetosphere and in the interplanetary space. We organize our presentations following the branches of the "academic family tree" rooted on Prof. Bengt U. ? Sonnerup, the inventor of the GS method. Special attentions are paid to validations of the GS reconstruction results via(1) the direct validation by co-spatial in-situ measurements among multiple spacecraft, and(2) indirect validation by implications and interpretations of the physical connection between the structures reconstructed and other related processes. For the latter, the inter-comparison and interconnection between the large-scale magnetic flux ropes(i.e., Magnetic Clouds) in the solar wind and their solar source properties are presented. In addition, we also summarize various GS-type(or-like) reconstruction and an extension of the GS technique to toroidal geometry. In particular,we point to a possible advancement with added complexity of "helical symmetry" and mixed helicity, in the hope of stimulating interest in future development. We close by offering some thoughts on appreciating the scientific merit of GS reconstruction in general.

关键词： Grad-Shafranov equation Magnetohydrodynamics Magnetic clouds Magnetic flux ropes Magnetopause Current sheets Flux transfer events Plasmoids Solar flare Coronal mass ejections