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Research progress in immunotherapy of pancreatic cancer

TMR Integrative Medicine 2017年第1期1卷 2-8页

作者： Yong Tang Hong-Yin Zhang Xiao-Li Zhou Department of Pancreatic Oncology Tianjin Medical University Cancer Institute and Hospital National ClinicalCenter for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China the thirddepartment of general surgery Tianjin Xi-Qing Hospital Department of Toxicology Tianjin Center for DiseaseControl and Prevention

Pancreatic cancer is among the most lethal malignancies resistant to conventional therapies. The urgent need fornew therapies has turned the spotlights on immunotherapy. In recent years, a growing body of evidence has alreadybeen gathered regarding the efficacy of genetic engineering modified T-cells, checkpoint inhibitors of T-cells, killercells induced by dendritic cells and cytokine in patients with pancreatic cancer. Cryoimmunotherapy in situ andextra-tumor and immunotherapy combined with chemotherapy could also increase the effectiveness. Research ofpancreatic cancer vaccine has made some progress. The immunity enhancing function of some traditional herbshave been reported, such as Ginsenoside Rg3, which could enhance T-cell subsets and NK cell activity inpancreatic cancer patients with chemotherapy.

关键词： Pancreatic cancer Modified T-cells Checkpoint inhibitors Killer cells Immunotherapy plus cryotherapy Immunotherapy combined with chemotherapy Traditional herbal medicine

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Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site

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Cancer Biology & Medicine 2019年第3期16卷 587-594页

作者： Xi Wei Meng Wang Xiaoqing Wang Xiangqian Zheng Ying Li Yi Pan Yueguo Li Jiali Mu Yang Yu Dapeng Li Ming Gao Sheng Zhang Department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China Department of Thyroid and Cervical Tumor Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China The thirddepartment of Breast Cancer Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China Department of Pathology Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China Department of Clinical Laboratory Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China

Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative ***: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were *** analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate *** ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node ***: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node *** the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node *** cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients.

关键词： Ultrasonography thyroid lymph nodes metastasis evaluation

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