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Research progress in immunotherapy of pancreatic cancer

TMR Integrative Medicine 2017年第1期1卷 2-8页

作者： Yong Tang Hong-Yin Zhang Xiao-Li Zhou Department of Pancreatic Oncology Tianjin Medical University Cancer Institute and Hospital National ClinicalCenter for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China the thirddepartment of general surgery Tianjin Xi-Qing Hospital Department of Toxicology Tianjin Center for DiseaseControl and Prevention

胰腺癌是恶性程度最高的肿瘤,并且对常规治疗无效.近年来,更多研究关注于基因工程修饰T细胞、T细胞检测点抑制剂、树突状细胞和细胞因子诱导的杀伤细胞对胰腺癌的治疗作用;胰腺原位和瘤外肿瘤冷冻免疫治疗,免疫治疗联合化疗也可增强抗... 详细信息

胰腺癌是恶性程度最高的肿瘤,并且对常规治疗无效.近年来,更多研究关注于基因工程修饰T细胞、T细胞检测点抑制剂、树突状细胞和细胞因子诱导的杀伤细胞对胰腺癌的治疗作用;胰腺原位和瘤外肿瘤冷冻免疫治疗,免疫治疗联合化疗也可增强抗肿瘤的作用;胰腺癌疫苗研究也取得一定进展.现代药理学研究也发现中草药的免疫增效作用,比如人参皂苷Rg3能够增强胰腺癌化疗病人T细胞亚群和NK细胞活性.

关键词：胰腺癌,改良T细胞,检查点抑制剂,杀伤细胞,免疫治疗加冷冻治疗,免疫治疗联合化疗,中药

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Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site

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Cancer Biology & Medicine 2019年第3期16卷 587-594页

作者： Xi Wei Meng Wang Xiaoqing Wang Xiangqian Zheng Ying Li Yi Pan Yueguo Li Jiali Mu Yang Yu Dapeng Li Ming Gao Sheng Zhang Department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China Department of Thyroid and Cervical Tumor Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China The thirddepartment of Breast Cancer Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China Department of Pathology Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China Department of Clinical Laboratory Tianjin Medical UniversityCancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention andTherapyTianjinTianjin's Clinical Research Center for CancerTianjin300060China

Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis.Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed.We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models.The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status.Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement.In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node metastases.The cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients.

关键词： Ultrasonography thyroid lymph nodes metastasis evaluation

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