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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province key laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China state key laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

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人工神经网络与遗传算法预测液体晃荡参数的比较

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 292-301页

作者： Hassan Saghi Mohammad Reza Sarani Nezhad Reza Saghi Sepehr Partovi Sahneh Department of Civil engineering Hakim Sabzevari UniversitySabzevarIran Department of Electrical and Computer engineering University of BirjandBirjandIran state key laboratory of coastal and offshore engineering Dalian University of TechnologyDalian116024China Department of Marine engineering Amirkabir University of TechnologyTehranIran

This paper develops a numerical code for modelling liquid *** coupled boundary element-finite element method was used to solve the Laplace equation for inviscid fluid and nonlinear free surface boundary *** Nakayama and Washizu’s results,the code performance was *** the developed numerical mode,we proposed artificial neural network(ANN)and genetic algorithm(GA)methods for evaluating sloshing loads and comparing *** compare the efficiency of the suggested methods,the maximum free surface displacement and the maximum horizontal force exerted on a rectangular tank’s perimeter are *** can be seen from the results that both ANNs and GAs can accurately predict η_(max) and F_(max).

关键词： Sloshing loads Fluid structure interactions Potential flow analysis Artificial neural network Genetic algorithm

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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China state key laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China key laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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Physical and mechanical properties and microstructures of submarine soils in the Yellow Sea

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Deep Underground Science and engineering 2024年第2期3卷 197-206页

作者： Zhuangcai Tian Yihua Chang Sichao Chen Gengchen Wang Yanhong Hu Chuan Guo Lei Jia Lei Song Jianhua Yue state key laboratory for Geomechanics and Deep Underground engineering China University of Mining and TechnologyXuzhouChina School of Mechanics and Civil engineering China University of Mining and TechnologyXuzhouChina Research Center for Deep Ocean Science and Underwater engineering China University of Mining and TechnologyXuzhouChina School of Resources and Geosciences China University of Mining and TechnologyXuzhouChina

In recent years,the exploration of seabed has been intensified,but the submarine soils of silt and sand in the Yellow Sea area have not been well investigated so *** this study,the physical and mechanical properties of silt and sand from the Yellow Sea were measured using a direct shear apparatus and their microstructures were observed using a scanning electron *** test results suggest that the shear strength of silt and sand increases linearly with the increase of normal *** on the direct shear test,the scanning electron microscope was used to observe the section surface of *** is observed that the section surface becomes rough,with many“V”‐shaped *** particles appear on the surface of the silt structure and tend to be *** X‐ray diffraction experiment reveals that the sand and silt have different *** shear strength of sand is slightly greater than that of silt under high stress,which is related to the shape of soil particles and the mineral *** results can be a reference for further study of other soils in the Yellow Sea;meanwhile,they can serve as soil parameters for the stability and durability analyses of offshore infrastructure construction.

关键词： direct shear test microscope physical properties submarine soil Yellow Sea

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Hollow Multishelled Structure: Synthesis Chemistry and Application

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Chemical Research in Chinese Universities 2024年第3期40卷 346-393页

作者： MAO Dan WANG Chao LI Wei ZHOU Liang LIU Jian ZHENG Zjian ZHAO Yong CAO An-min WANG Shutao HUANG Jiaxing HUO Fengwei CHEN Hongyu MAI Liqiang YU Ranbo WANG Lianzhou LU Yunfeng YU Chengzhong YANG Qihua YANG Zhenzhong ZENG Hua Chun ZHAO Hujun TANG Zhiyong ZHAO Dongyuan WANG Dan state key laboratory of Biochemical engineering Institute of Process EngineeringChineseAcademy of SciencesBeijing 100190P.R.China key laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBejing 100190P.R.China School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong SARP.R.China Department of Chemistry Fudan UniversityShanghai 200433P.R.China state key laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070P.R.China state key laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China School of Chemistry Beihang UniversityBejing 100191P.R.China CAS key laboratory of Molecular Nanostructure and Nanotechnology and Beijing National laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China CAS key laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of engineering Westlake UniversityHangzhou 310024P.R.China School of Flexible Electronics(Future Technologies) Nanjing Tech UniversityNanjing 211816P.R.China School of Science Westlake UniversityHangzhou 310024P.R.China School of Materials Science and engineering Wuhan University of TechnologyWuhan 430070P.R.China School of Metallurgical and Ecological engineering University of Science and Technology BeijingBeijing 100083P.R.China School of Chemical engineering and Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072Australia College of Life Science and Technology Bejing University of Chemical TechnologyBejing 100029P.R.China School of Chemistry and Molecular engineering East China Normal UniversityShanghai 200241P.R.China College of Life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China Department of Chemical engineering Tsinghua UniversityBeijing 100

Hollow multishelled structure(HoMS),a promising and complex multifunctional structural system,features at least two shells that are separated by internal *** unique structure endows it with numerous advantages including low density,high loading capacity,large specific surface area,facilitated mass transport,and multiple spatial confinement *** the past twenty years,benefiting from the booming development of synthesis methods,various HoMS materials have been prepared and show promising applications in diverse areas.

关键词： Hollow multishelled structure Synthesis chemistry Energy storage Catalysis Electromagnetic wave absorption Drug delivery Sensor

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砂土中长径比对三筒基础水平承载特性的影响

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 406-416页

作者：张浦阳冯嘉成石延杰乐丛欢丁红岩 state key laboratory of Hydraulic engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China

The tripod foundation(TF)is a prevalent foundation configuration in contemporary engineering *** comparison to a single pile,TF comprised interconnected individual piles,resulting in enhanced bearing capacity and stability.A physical model test was conducted within a sandy soil foundation,systematically varying the length-to-diameter ratio of the *** investigation aimed to comprehend the impact of altering the height of the central bucket on the historical horizontal bearing capacity of the foundation in saturated ***,the study scrutinized the historical consequences of soil pressure and pore water pressure surrounding the bucket throughout the loading *** historical findings revealed a significant enhancement in the horizontal bearing capacity of the TF under undrained *** subjected to a historical horizontal loading angle of 0°for a single pile,the multi-bucket foundation exhibited superior historical bearing capacity compared to a single-pile foundation experiencing a historical loading angle of 180°under pulling *** each historical increment in bucket height from 150 mm to 350 mm in 100 mm intervals,the historical horizontal bearing capacity of the TF exhibited an approximately 75%increase relative to the 150 mm bucket height,indicating a proportional ***,the historical internal pore water pressure within the bucket foundation remained unaffected by drainage conditions during ***,undrained conditions led to a historical elevation in pore water pressure at the lower side of the pressure ***,in practical engineering applications,the optimization of the historical bearing efficacy of the TF necessitated the historical closure of the valve atop the foundation to sustain internal negative pressure within the *** historical measure served to augment the historical horizontal bearing ***,historical external loads,such as wind,waves,a

关键词： offshore wind Suction bucket jacket foundation Horizontal bearing capacity Vertical load Soil pressure Finite element model

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Geographical features and development models of estuarine cities

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Journal of Geographical Sciences 2024年第1期34卷 25-40页

作者： CHEN Mingxing XIAN Yue HUANG Yaohuan SUN Zhigang WU Chengbin key laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resource and Environment University of Chinese Academy of SciencesBejing 100049China state key laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China key laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China Zhongke Shandong Dongying Institute of Geography Dongying 257509ShandongChina CAs engineering laboratory for Yellow River Delta Modern Agriculture Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China

Cities are the key areas for human beings to achieve sustainable development goals in the *** cities are a special type of coastal city in urgent need of a clear *** paper proposed that estuarine cities are cities developed on the coast where rivers and oceans meet and defined four connotations,including the intersection of rivers and marine water systems,the coordinated development of land and oceans,the location advantages of connecting rivers and seas,and the important fragility of the ecological *** used Hydro SHEDS,OSM,GPW,and urban socioeconomic statistics and selected 50 estuarine cities with large rivers as representatives to summarize the main geographical basis and socioeconomic *** are primarily found in low-altitude,flat regions with average annual temperatures that mainly vary from 10℃to 25℃,relatively abundant precipitation,and extensive biological *** are substantial variations in the socioeconomic features of estuarine *** proposed eight development patterns,including open and inclusive city spirit,high-quality livable cities,high-quality development driven by innovation,integration of internal and external communication with ports and cities,construction of an international financial center,ecological environment protection and restoration,active promotion of cultural tourism,and positive international exchanges.

关键词： estuarine cities great rivers development models sustainability physical geography socioeconomy

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Anomaly-Resistant Decentralized state Estimation Under Minimum Error Entropy With Fiducial Points for Wide-Area Power Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 74-87页

作者： Bogang Qu Zidong Wang Bo Shen Hongli Dong Hongjian Liu the College of Automation engineering Shanghai University of Electric PowerShanghai 200090China IEEE the Department of Computer Science Brunel University LondonUxbridgeMiddiesex UB83PHUK the College of Information Science and Technology Donghua UniversityShanghai 200051 the engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China the Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318 the Heilongjiang Provincial key laboratory of Networking and Intelligent Control Northeast PetroleumDaqing 163318 the Sanya offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572024China the key laboratory of Advanced Perception and Intelligent Control of High-End Equipment Ministry of EducationAnhui Polytechnic UniversityWuhu 2410000 the School of Mathematics and Physics Anhui Polytechnic UniversityWuhu 241000China

This paper investigates the anomaly-resistant decentralized state estimation(SE) problem for a class of wide-area power systems which are divided into several non-overlapping areas connected through transmission lines. Two classes of measurements(i.e., local measurements and edge measurements) are obtained, respectively, from the individual area and the transmission lines. A decentralized state estimator, whose performance is resistant against measurement with anomalies, is designed based on the minimum error entropy with fiducial points(MEEF) criterion. Specifically, 1) An augmented model, which incorporates the local prediction and local measurement, is developed by resorting to the unscented transformation approach and the statistical linearization approach;2) Using the augmented model, an MEEF-based cost function is designed that reflects the local prediction errors of the state and the measurement;and 3) The local estimate is first obtained by minimizing the MEEF-based cost function through a fixed-point iteration and then updated by using the edge measuring information. Finally, simulation experiments with three scenarios are carried out on the IEEE 14-bus system to illustrate the validity of the proposed anomaly-resistant decentralized SE scheme.

关键词： Decentralized state estimation(SE) measurements with anomalies minimum error entropy unscented Kalman filter wide-area power systems

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A nonlinear wake model of a wind turbine considering the yaw wake steering

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Journal of Oceanology and Limnology 2024年第3期42卷 715-727页

作者： Yunzhou LI Zhiteng GAO Shoutu LI Suiping QI Xiaoyu TANG College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Multi-function Towing Tank School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Energy and Power engineering Lanzhou University of TechnologyLanzhou 730050China Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266061China state key laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang UniversityHangzhou 310027China Laoshan laboratory Qingdao 266237China

Duo to fluctuations in atmospheric turbulence and yaw control strategies,wind turbines are often in a yaw *** predict the far wake velocity field of wind turbines quickly and accurately,a wake velocity model was derived based on the method of momentum conservation considering the wake steering of the wind turbine under yaw *** consider the shear effect of the vertical incoming wind direction,a two-dimensional Gaussian distribution function was introduced to model the velocity loss at different axial positions in the far wake region based on the assumption of nonlinear wake *** work also developed a“prediction-correction”method to solve the wake velocity field,and the accuracy of the model results was verified in wake experiments on the Garrad Hassan wind ***,a 33-kW two-blade horizontal axis wind turbine was simulated using this method,and the results were compared with the classical wake model under the same parameters and the computational fluid dynamics(CFD)simulation *** results show that the nonlinear wake model well reflected the influence of incoming flow shear and yaw wake steering in the wake velocity ***,computation of the wake flow for the Horns Rev offshore wind farm with 80 wind turbines showed an error within 8%compared to the experimental *** established wake model is less computationally intensive than other methods,has a faster calculation speed,and can be used for engineering calculations of the wake velocity in the far wakefield of wind turbines.

关键词： far wake wake model wake steering wind shear wind farm

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Application of GNSS-PPP on Dynamic Deformation Monitoring of offshore Platforms

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China Ocean engineering 2024年第2期38卷 352-361页

作者： YU Li-na XIONG Kuan GAO Xi-feng LI Zhi FAN Li-long ZHANG Kai Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China China Railway Construction Bridge engineering Bureau Group Co.LTD Tianjin 300300China School of Civil engineering Tianjin UniversityTianjin 300072China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina state key laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

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