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Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis diagnosis treatment Discharge management Traditional Chinese medicine guideline

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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

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Science China Materials 2018年第11期61卷 1367-1386页

作者： Serge Mignani Joao Rodrigues Helena Tomas Anne-Marie Caminade Regis Laurent Xiangyang Shi Jean-Pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance state key laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging

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Application value of biochemical and immunological indicators in Lee's classification of IgA nephropathy

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China Medical Abstracts (Internal Medicine) 2016年第4期 193-193页

作者：南京柱 Dept Clin Biochem State Key Kidney Dis LabChin PLA General Hosp

Objective To analyze the differences of biochemical and immunological indicators in gender or Lee’s classification of Ig A nephropathy(Ig AN)and to provide laboratory evidence for clinical diagnosis and treatment of Ig *** Retrospective cohort study was *** information of biochemical and immunological indicators of 213 in-hospital patients admitted in Chi-

关键词： of Ig that CYS were HCY in Application value of biochemical and immunological indicators in Lee’s classification of IgA nephropathy

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Clinical Intelligent diagnosis Path Based on the Chief Complaint

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Digital Chinese Medicine 2020年第1期3卷 44-49页

作者： ZHOU Xiao-Qing TONG Tian-Hao ZENG Yi-Di ZHONG Lu Hunan University of Chinese Medicine ChangshaHunan 410208China Provincial key laboratory of TCM Diagnostics Hunan University of Chinese MedicineChangshaHunan 410208China Collaborative Center for Research and Innovation of Digital Chinese Medicine Hunan University of Chinese MedicineChangshaHunan 410208China Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine NanningGuangxi 530011China

Goals of traditional Chinese medicine(TCM)include precision,accuracy,and recognition by clinical *** of a diagnosis and treatment system that closely conforms to the principle-method-recipe-medicines system and derivation of an accurate diagnosis and treatment plan should be considerations of *** intelligence research based on computer technology is one of the effective ways to solve this *** the research of intelligent diagnosis path,reflecting the characteristics of the overall view and dialectical treatment of TCM such as"Combination of four diagnostic methods""overall examination""combination of disease and syndrome"and"treatment individualized to patient,season and locality"are key for successful research of artificial intelligence in TCM diagnosis or recognition by clinical practice.

关键词： Chief complaint Intelligent diagnosis TCM diagnosis Correlation analysis Combination of four diagnostic methods Symptom pair Symptom group

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A pairwise radiomics algorithm–lesion pair relation estimation model for distinguishing multiple primary lung cancer from intrapulmonary metastasis

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Precision Clinical Medicine 2023年第4期6卷 239-247页

作者： Ting-Fei Chen Lei Yang Hai-Bin Chen Zhi-Guo Zhou Zhen-Tian Wu Hong-He Luo Qiong Li Ying Zhu Department of Thoracic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China Breax laboratory PCAB Research Center of Breath and MetabolismBeijing 100017China Reliable Intelligence and Medical Innovation laboratory(RIMI Lab) Department of Biostatistics&Data ScienceUniversity of Kansas Medical Centerand University of Kansas Cancer CenterKansas CityKS 66160USA Center for Information Technology&Statistics Statistics SectionThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China Department of Radiology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510000China Department of Radiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China

Background:Distinguishing multiple primary lung cancer(MPLC)from intrapulmonary metastasis(IPM)is critical for their disparate treatment strategy and *** study aimed to establish a non-invasive model to make the differentiation ***:We retrospectively studied 168 patients with multiple lung cancers(307 pairs of lesions)including 118 cases for modeling and internal validation,and 50 cases for independent external *** features on computed tomography(CT)were extracted to calculate the absolute deviation of paired *** were then selected by correlation coefficients and random forest classifier 5-fold cross-validation,based on which the lesion pair relation estimation(PRE)model was developed.A major voting strategy was used to decide diagnosis for cases with multiple pairs of *** from another institute were included as the external validation set for the PRE model to compete with two experienced ***:Seven radiomic features were selected for the PRE model *** major voting strategy,the mean area under receiver operating characteristic curve(AUC),accuracy,sensitivity,and specificity of the training versus internal validation versus external validation cohort to distinguish MPLC were 0.983 versus 0.844 versus 0.793,0.942 versus 0.846 versus 0.760,0.905 versus 0.728 versus 0.727,and 0.962 versus 0.910 versus 0.769,*** of the two clinicians were 0.619 and ***:The CT radiomic feature-based lesion PRE model is potentially an accurate diagnostic tool for the differentiation of MPLC and IPM,which could help with clinical decision making.

关键词： multiple primary lung cancer radiomics intrapulmonary metastasis

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Research gaps for three main tropical diseases in the People’s Republic of China

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infectious diseases of Poverty 2013年第1期2卷 112-125页

作者： Qi Zheng Samantha Vanderslott Bin Jiang Li-Li Xu Cong-Shan Liu Le-Le Huo Li-Ping Duan Ning-Bo Wu Shi-Zhu Li Zhi-Gui Xia Wei-Ping Wu Wei Hu Hao-Bing Zhang National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionWHO Collaborating Centre on MalariaSchisostomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of Health207 Rui Jin Er RdShanghai 200025People’s Republic of China The Department of Science and Technology Studies University College LondonLondon WC1E 6BTUK

This scoping review analyzes the research gaps of three diseases:schistosomiasis japonica,malaria and *** on available data in the ***,we highlight the gaps between control capacity and prevalence levels,and between diagnostic/drug development and population need for treatment at different stages of the national control *** reviewing the literature from 848 original studies and consultations with experts in the field,the gaps were identified as ***,the malaria research gaps include(i)deficiency of active testing in the public community and no appropriate technique to evaluate elimination,(ii)lack of sensitive diagnostic tools for asymptomatic patients,(iii)lack of safe drugs for mass ***,gaps in research of schistosomiasis include(i)incongruent policy in the implementation of integrated control strategy for schistosomiasis,(ii)lack of effective tools for Oncomelania *** control,(iii)lack of a more sensitive and cheaper diagnostic test for large population samples,(iv)lack of new drugs in addition to ***,gaps in research of echinococcosis include(i)low capacity in field epidemiology studies,(ii)lack of sanitation improvement studies in epidemic areas,(iii)lack of a sensitivity test for early diagnosis,(iv)lack of more effective drugs for short-term *** believe these three diseases can eventually be eliminated in China's Mainland if all the research gaps are abridged in a short period of time.

关键词： Schistosomiasis Malaria Echinococcosis Epidemiology diagnosis Chemotherapy Research capacity building

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Cutaneous leishmaniasis in Louisiana-one-year follow-up:A case report

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World Journal of Clinical infectious diseases 2021年第1期11卷 19-26页

作者： Ashaur Azhar Hillary E Connell Christopher Haas Jelena Surla Devin Reed Sanjay Kamboj Gordon L Love Yussef Bennani Department of Medicine Section of Infectious DiseasesLouisiana State University Health Sciences CenterSchool of MedicineNew OrleansLA 70112United States Department of Medicine Louisiana State University Health Sciences CenterSchool of MedicineNew OrleansLA 70112United States Department of Dermatology Louisiana State University Health Sciences CenterSchool of MedicineNew OrleansLA 70112United States Jack Perry Strong Professor and Chair Department of PathologyLouisiana State University Health Sciences CenterSchool of MedicineNew OrleansLA 70112United States

Reports of leishmaniasis are scarce in North *** is considered to be one of the neglected tropical *** is seen in immigrants from endemic areas to United *** are not readily available in the United *** or inadequately treated cutaneous leishmaniasis not only causes localized disfigurement but can advance to more permanent and devastating mucosal disfigurement and perforation,if caused by a species that can also cause mucocutaneous *** SUMMARY A 42-year-old human immunodeficiency virus negative male immigrant from Honduras presented to the emergency department of our facility in Louisiana with a 2-mo history of a left lower extremity *** started as a painless blister that progressed in size and developed into other smaller lesions tracking up the thigh and became tender and *** looked nontoxic and *** was *** tests,except inflammatory markers,were within normal *** cellulitis of the leg was treated with 6 d of vancomycin that also relieved the *** biopsy was obtained,and histopathology was suspicious for *** chain reaction/deoxyribonucleic acid sequencing done by centers for disease control and prevention confirmed the diagnosis as Leishmania *** was no involvement of nasooropharyngeal mucosa,confirmed by *** patient was treated with miltefosine for 28 *** follow-up after approximately 11 mo revealed a healed skin *** Cutaneous leishmaniasis should be in the differential diagnosis of skin ulcers of travelers from endemic *** regarding diagnosis and treatment of leishmaniasis needs to be enhanced.

关键词： Cutaneous leishmaniasis Neglected diseases Leishmania(Viannia)panamensis Miltefosine Leishmania Case report

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Nanotechnology for cardiovascular diseases

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The Innovation 2022年第2期3卷 17-37页

作者： Qinqin Hu Zheyan Fang Junbo Ge Hua Li Department of Cardiology Shanghai Institute of Cardiovascular DiseasesShanghai Xuhui District Central Hospital&Zhongshan-xuhui HospitalZhongshan HospitalFudan UniversityShanghai 200032China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China

Cardiovascular diseases have become the major killers in today’s world,among which coronary artery diseases(CADs)make the greatest contributions to morbidity and *** state-of-the-art technologies have increased our knowledge of the cardiovascular system,the current diagnosis and treatment modalities for CADs still have *** an emerging cross-disciplinary approach.

关键词： diseases cardiovascular diagnosis

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mNGS-based dynamic pathogen monitoring for accurate diagnosis and treatment of severe pneumonia caused by fungal infections

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生物安全与健康(英文) 2023年第3期5卷 138-143页

作者： Zhen Li Changcheng Wu Li-An Tang Yinjie Liang Ruhan A Debin Huang Chuanyi Ning Wenling Wang Wenjie Tan Collaborative Innovation Centre of Regenerative Medicine and Medical BioResourse Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanning 530021China NHC key laboratory of Biosafety National Insttute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBejing 102206China The First Affliated Hospital of Guangxi Medical University Nanning 530021China School of Nursing Guangxi Medical UniversityNanning 530021China

Metagenomic next-generation sequencing(mNGs)has been widely applied to identify pathogens associated with infectious ***,limited studies have explored the use of mNGs-based dynamic pathogen monitoring in intensive care unit patients with severe ***,we present a clinical case of an 86-year-old male patient with severe pneumonia caused by a fungal *** the clinical treatment,four mNGS analyses were performed within two consecutive *** respiratory fungal pathogens,including Candida orthopsilosis,Candida albicans,and Aspergillus fumigatus were detected by mNGS of bronchoalveolar lavage fluid(BALF).Based on conventional pathogen identification and clinical symptoms,the patient was diagnosed with severe pneumonia caused by a fungal *** abundance of fungal species decreased gradually in response to antifungal and empirical therapies,and the fungal infections were effectively *** summary,our results demonstrated that mNGS could effectively identify pathogens in patients with severe ***,dynamic pathogen monitoring based on mNGS could assist in the precise diag-nosis of complex infections and may facilitate rapid induction of the most appropriate therapy.

关键词： Metagenomic next-generation sequencing Severe pneumonia Dynamic detection Precision diagnosis Respiratory pathogens

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diagnosis and Clinical Management of Acute Severe Hepatitis of Unknown Origin: Operational Recommendation of Peking Union Medical College Hospital

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infectious diseases & Immunity 2022年第3期2卷 179-182页

作者： Wei Cao Zhenghong Li Huadong Zhu Xiang Zhou Qiwen Yang Yang Han Jihai Liu Qing Chang Taisheng Li Department of infectious diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Emergency Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Clinical laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Medical Affairs Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Around 450 cases of acute severe hepatitis of unknown origin in children have been reported in 21 countries and region globally since April 2022,which has exceeded the past annual incidences of related regions,and has aroused wide *** patients were predominantly children under 16years of age,presented with symptoms of acute hepatitis with markedly elevated liver enzymes,and had been ruled out of common viral infections such as hepatitis A,B,C,D,and *** cases have not been reported in China ***,considering that the severe acute hepatitis has involved worldwide areas,still with unknown origin,and incidences of severity is relatively high,we formulated this recommendation to standardize diagnosis and treatment of acute severe hepatitis of unknown origin in Peking Union Medical College Hospital,to get fully prepared to the possible public health events.

关键词： Child Acute severe hepatitis of unknown origin diagnosis treatment

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