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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research 2024年第4期11卷 543-566页

作者： Ying Chen Xing Wang Sheng Tao Qi Wang Pan-Qin Ma Zi-Biao Li Yun-Long Wu Da-Wei Li Fujian Provincial Key Laboratory of Innovative Drug Target Research and state Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen 361102FujianChina Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100090China University of Chinese Academy of Sciences Beijing 100049China Senior Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijing 100091China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore 138634Singapore

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical *** reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity,good drug-loading ability and sustained drug release *** a typical example,hyaluronic acid dressing(Healoderm)has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ***,the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound *** to the intricacy of diabetic wounds,antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice,although these medications are easily hindered by the hostile *** this case,scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds(such as high glucose and low pH)or combined with external stimuli(such as light or magnetic field)to achieve controllable drug release,gel degradation,and microenvironment improvements in order to overcome these clinical *** responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound ***,we review recent advances on responsive-hydrogel dressings towards diabetic wound healing,with focus on hydrogel structure design,the principle of responsiveness,and the behavior of *** but not least,the advantages and limitations of these responsive-hydrogels in clinical applications will also be *** hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.

关键词： Responsive-hydrogel Diabetic wound Anti-inflammation Tissue remodeling

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J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals

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General Psychiatry 2024年第1期37卷 44-52页

作者： Chengzhang Liu Qiguo Meng Yuanxiu Wei Xinyue Su Yuanyuan Zhang Panpan He Chun Zhou Mengyi Liu Ziliang Ye Xianhui Qin Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhuiChina institute of Biomedicine Anhui Medical UniversityHefeiAnhuiChina Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhouGuangdongChina

Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains *** To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese *** The study included a total of 3106 participants capable of completing repeated cognitive function *** nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment *** decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive *** The median follow-up duration was 5.9 *** was a J-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine *** the inflection point,thiamine intake was not significantly associated with cognitive *** the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all p<0.05).Conclusions This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

关键词： intake shaped cognitive

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Biomass valorization via electrocatalytic carbon–carbon bond cleavage

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Journal of Energy Chemistry 2024年第4期91卷 542-578页

作者： Keping Wang Zhenyan Guo Min Zhou Ying Yang Lanyun Li Hu Li Rafael Luque Shunmugavel Saravanamurugan National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025GuizhouChina Departamento de Quimica Organica Universidad de CordobaCampus de RabanalesEdificio Marie Curie(C-3)Ctra Nnal IVKm.396E-14014 CordobaSpain Laboratory of Bioproduct Chemistry Centre of Innovative and Applied Bioprocessing(CIAB)Mohali 140306PunjabIndia

Renewable electrocatalytic upgrading of biomass feedstocks into valuable chemicals is one of the promising strategies to relieve the pressure of traditional energy-based *** electrocatalytic carbon–carbon bond cleavage of high selectivity,various functionalized molecules,such as organic acids,amides,esters,and nitriles,have great potential to be accessed from ***,it has merely received finite concerns and interests in the *** review first showcases the research progress on the electrocatalytic conversion of lipid/sugar-and lignin-derived molecules(e.g.,glycerol,mesoerythritol,xylose,glucose,1-phenylethanol,and cyclohexanol)into organic acids via specific carbon–carbon bond scission processes,with focus on disclosing reaction mechanisms,recognizing actual active species,and collecting feasible modification *** the guidance of further extensive studies on biomass valorization,organic transformations via a variety of reactions,including decarboxylation,ring-opening,rearrangement,reductive hydrogenation,and carboxylation,are also disclosed for the construction of similar carbon skeletons/*** remaining challenges,prospective applications,and future objectives in terms of biomass conversion are also *** review is expected to provide references to develop renewed electrocatalytic carbon–carbon bond cleavage transformation paths/strategies for biomass upgrading.

关键词： Electrocatalysis Biomass conversion Carbon-carbon bond cleavage Organic acids

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KLF4 facilitates chromatin accessibility remodeling in porcine early embryos

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Science China(Life Sciences) 2024年第1期67卷 96-112页

作者： Wei Zhu Guowei Bu Ruifeng Hu Jixiang Zhang Lianyong Qiao Kai Zhou Tingting Wang Qiao Li Jingjing Zhang Linhui Wu Yali Xie Taotao Hu Shichun Yang Jiaqi Guan Xiaoyu Chu Juanjuan Shi Xia Zhang Falong Lu Xin Liu Yi-Liang Miao Institute of Stem Cell and Regenerative Biology College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Key Laboratory of Agricultural Animal Genetics Breeding and Reproduction(Huazhong Agricultural University)Ministry of EducationWuhan 430070China state Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Frontiers Science center for Animal Breeding and Sustainable Production Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China

Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early *** studies have illustrated several pioneer factors as being important for agricultural animals,but what are the pioneer factors and how the pioneer factors remodel the chromatin accessibility in porcine early embryos is not *** employing low-input DNase-seq(liDNase-seq),we profiled the landscapes of chromatin accessibility in porcine early embryos and uncovered a unique chromatin accessibility reprogramming pattern during porcine preimplantation *** data revealed that KLF4 played critical roles in remodeling chromatin accessibility in porcine early *** down of KLF4 led to the reduction of chromatin accessibility in early embryos,whereas KLF4 overexpression promoted the chromatin openness in porcine ***,KLF4 deficiency resulted in mitochondrial dysfunction and developmental failure of porcine *** addition,we found that overexpression of KLF4 in blastocysts promoted lipid droplet accumulation,whereas knockdown of KLF4 disrupted this *** together,our study revealed the chromatin accessibility dynamics and identified KLF4 as a key regulator in chromatin accessibility and cellular metabolism during porcine preimplantation embryo development.

关键词： porcine embryos liDNase-seq chromatin accessibility KLF4 mitochondrion lipid droplets

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Insights into the Impact of Bifidobacterium bifidum， B. breve， and B. longum on the Immune Response Against Salmonella Infection in Neonatal Rats

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Food Science and Human Wellness 2024年

作者： Chunxiu Lin Yugui Lin Min Guo Rui Xiao Shunhe Wang Yonghua Zhou Jianxin Zhao Hao Zhang Wei Chen Gang Wang state Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Microbiology Laboratory， Zhongshan Bo'ai Hospital， Southern Medical University Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention， Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology， Jiangsu Institute of Parasitic Diseases National Engineering Research center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University Wuxi Translational Medicine Research center and Jiangsu Translational Medicine Research Institute Wuxi Branch

Infants exhibit diminished susceptibility to external infections， a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract. Nonetheless， a significant knowledge gap remains concerning the distinct species of bifidobacteria initiating anti-infection immune responses during the early developmental stages. In this study， the impact of early intervention with Bifidobacterium bifidum (B. bifidum)， B. breve， and B. longum on neonatal rats infected with Salmonella enterica serovar Typhimurium (S. typhimurium) SL1344 were compared. The study encompasses various immunity levels， including gut immunity， central immunity (thymus)， peripheral immunity (spleen)， and brain immunity. Following Salmonella infection， significant alterations in neonatal rats were observed in growth and developmental levels， immune markers， cytokine levels， balance of T lymphocyte subpopulations， intestinal barrier function， and blood-brain barrier integrity. Compared with B. breve and B. longum， B. bifidum demonstrated more pronounced efficacy in regulating these physiological processes. By conducting multi-level analyses of gut microbiota， bifidobacterial community， colonic content metabolomics， and serum metabolomics， the significance of B. bifidum's role is underscored， and the immune-enhancing function of messenger metabolites is unveiled. Among these metabolites， γ-L-Glutamyl-L-glutamic acid and Orotic acid were found to be shared by all three species， while Hippuric acid and 1a，1b-dihomo Prostaglandin F2α were unique to B. bifidum， and DL-Arginine was specific to B. longum. Overall， this study has provided novel insights into the intervention and immunomodulation by Bifidobacterium in early-life infections， emphasizing the significant role of B. bifidum.

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Effectiveness of urban distributed runoff model for discharge and water depth calculation in urban drainage pipe networks

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Journal of Hydrodynamics 2024年第3期36卷 582-591页

作者： Yang Zhou Yi-ling Leng Peng-yu Wang Shang-hong Zhang Yu-long Zhu Yu-jun Yi School of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing102206China state Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing100875China

Effective urban land-use re-planning and the strategic arrangement of drainage pipe networks can significantly enhance urban flood defense *** at reducing the potential risks of urban flooding,this paper presents a straightforward and efficient approach to an urban distributed runoff model(UDRM).The model is developed to quantify the discharge and water depth within urban drainage pipe networks under varying rainfall intensities and land-use *** Nash efficiency coefficient of UDRM exceeds 0.9,which indicates its high computational efficiency and potential benefit in predicting urban *** prediction of drainage conditions under both current and re-planned land-use types is achieved by adopting different flood recurrence *** findings reveal that the re-planned land-use strategies could effectively diminish flood risk upstream of the drainage pipe network across 20-year and 50-year flood recurrence ***,in the case of extreme rainfall events(a 100-year flood recurrence),the re-planned land-use approach fell short of fulfilling the requirements necessary for flood disaster *** these instances,the adoption of larger-diameter drainage pipes becomes an essential requisite to satisfy drainage ***,the proposed UDRM effectively combines land-use information with pipeline data to give practical suggestions for pipeline modification and land-use optimization to combat urban ***,this methodology warrants further promotion in the field of urban re-planning.

关键词： Stormwater runoff water depth urban distributed runoff model urban drainage pipe networks urban land-use re-planning

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Quantifying structural distortion manipulation for desired perovskite phase:PartⅠ.Paradigm demonstration in tungsten oxides

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Journal of Materiomics 2024年第2期10卷 293-303页

作者： Cheng Fang Hong Wang Siqi Shi state Key Laboratory of Green Building Materials China Building Materials AcademyBeijing100024China Beijing Key Laboratory of Solar Energy and Building Energy-saving Glass Materials Processing Technology China Building Materials AcademyBeijing100024China Materials Genome Initiative center Shanghai Jiao Tong UniversityShanghai200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China School of Materials Science and Engineering Shanghai UniversityShanghai200444China Materials Genome Institute Shanghai UniversityShanghai200444China

Slight distortions can cause dramatic changes in the properties of crystalline perovskite materials and their *** to the numerous types of distortions and unclarified distortion-structure relations,a quantitative distortion manipulation for the desired crystalline phase of perovskite materials suitable for various application remains ***,by establishing parameter sets to systematically describe the types,magnitudes and positional relations involved in distortions,we are able to interpret the structural regulations and manipulation strategies in 7 reported crystal *** the con-struction of distortion-phase-property functional curves,we further propose a paradigm to quantify the structural distortion manipulation for desired perovskite *** the example of perovskite-like tungsten oxides,we successfully quantify their volume shrinkage and symmetry increase during *** work verifies that the complicated research and development of perovskite materials can be simplified into a mathematical problem solving process,which will inspire researchers with different backgrounds to participate,especially mathematicians and computer scientists.

关键词： Distortion manipulation Distortion-phase-property function Coordination polyhedron Tungsten oxide Perovskite

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Anchoring mechanical characteristics of Ductile-Expansion bolt

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International Journal of Mining Science and Technology 2024年第8期34卷 1115-1134页

作者： Yu Chen Wang Liu Linchong Huang Hang Lin Yixian Wang Yanlin Zhao Cungang Lin state Key Laboratory for Tunnel Engineering Guangzhou 510275China Guangdong Research center for Underground Space Exploitation Technology Guangdong Key Laboratory of Marine Civil EngineeringSchool of Civil EngineeringSun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China School of Resources and Safety Engineering Central South UniversityChangsha 410083China School of Civil Engineering Hefei University of TechnologyHefei 230009China School of Energy and Safety Engineering Hunan University of Science and TechnologyXiangtan 411201China

The application of ductile rock bolts has been a crucial method for solving the problems of large deformations,energy absorption and stability control issues in deep rock *** study the anchoring mechanism of the key expansive structure,this paper proposes a novel type of bolt—the Ductile-Expansion bolt,and conducts research on anchoring mechanics,energy absorption characteristics,and failure modes of the *** addition,this paper defines the concept of load-volume ratio of metal rock bolts and proves the Ductile-Expansion bolt is capable of better improving the unit volume bearing capacity of the bolt ***,laboratory and field tests verify the Ductile-Expansion bolt had better anchoring effect than the traditional rebar bolt,with the expansion structure favorably enhancing the ductility and energy absorption performance of the ***,this paper microscopically analyzes the crack propagation and distribution morphology of the bolts by establishing a 3D coupled numerical model based on *** results illustrate the interface at the variable diameter of the Ductile-Expansion bolt serves as the transition zone between high and low stress *** expansion structure can impose radial compression on the medium around the bolt,which can improve the bolt anchorage performance.

关键词： Ductile-Expansion bolt Pull-out test Peak load Anchoring mechanical characteristics

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Soil type and wetting intensity control the enhancement extent of N_(2)O efflux in soil with drought and rewetting cycles

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International Soil and Water Conservation Research 2024年第1期12卷 137-144页

作者： Panpan Jiao Lei Yang Zhongwu Li Peng Zheng Xiaodong Nie School of Geographical Sciences Hunan Normal UniversityChangsha 410081China state Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau The Research Center of Soil and Water Conservation and Ecological EnvironmentChinese Academy of Sciences and Ministry of EducationYangling 712100China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

Climate change alters the intensity and frequency of drought and rewetting(D/W)events;however,the influence patterns of D/W on soil N_(2)O efflux in the water-limited area were not fully ***,the impacts of D/W cycles varying in different extent of rewetting and frequency to N_(2)O efflux in two kinds of soil on the Loess Plateau were *** incubation conditions consisted of 1)D/W treatments with four 7-day cycles from 10%water holding capacity(WHC)to 60%WHC or 90%WHC,2)constant moisture of 60%WHC and 90%*** pulse of N_(2)O efflux rate under 10-60%WHC treatment was higher than that under 10-90%WHC treatment in calcic cambisols,while opposite trend was observed in earth-cumuli-orthic ***,the pulse of N_(2)O efflux rate decreased as cycle number increased for different wetting intensities and soil *** direct N_(2)O efflux under 10-60%WHC and 10-90%WHC treatments were 5.49 and 1.89μg N_(2)O-N g^(-1)soil in calcic cambisols,with those being 1.92 and 10.85μg N_(2)O-N g^(-1)soil in earth-cumuli-orthic anthrosols,*** N loss in earth-cumuli-orthic anthrosols was approximately 5.74 times greater than that in calcic cambisols under 10-90%WHC treatment,whereas the N loss under 10-60%WHC treatment was about 2.86 times greater in calcic cambisols than that in earth-cumuli-orthic *** study suggested that extreme rainfall events can enhance the N_(2)O efflux and N loss in agricultural soils on the Loess Plateau in terms of soil type and wetting intensity,which should not be ignored in the N fertilizer management.

关键词： Drought/rewetting cycles N_(2)O efflux Wetting intensity Microbial biomass N Dissolved organic N Loess plateau

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A review of data-driven whole-life state of health prediction for lithium-ion batteries:Data preprocessing,aging characteristics,algorithms,and future challenges

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Journal of Energy Chemistry 2024年第10期97卷 630-649,I0013页

作者： Yanxin Xie Shunli Wang Gexiang Zhang Paul Takyi-Aninakwa Carlos Fernandez Frede Blaabjerg School of information Engineering Southwest University of Science and TechnologyMianyang 621010SichuanChina College of Electric Power Inner Mongolia University of TechnologyHohhot 010080Inner MongoliaChina School of Pharmacy and Life Sciences Robert Gordon UniversityAberdeen AB10-7GJUK Department of Energy Technology Aalborg UniversityPontoppidanstraede 1119220 Aalborg EastDenmark

Lithium-ion batteries are the preferred green energy storage method and are equipped with intelligent battery management systems(BMSs)that efficiently manage the *** not only ensures the safety performance of the batteries but also significantly improves their efficiency and reduces their damage *** their whole life cycle,lithium-ion batteries undergo aging and performance degradation due to diverse external environments and irregular degradation of internal *** degradation is reflected in the state of health(SOH)***,this review offers the first comprehensive analysis of battery SOH estimation strategies across the entire lifecycle over the past five years,highlighting common research focuses rooted in data-driven *** delves into various dimensions such as dataset integration and preprocessing,health feature parameter extraction,and the construction of SOH estimation *** approaches unearth hidden insights within data,addressing the inherent tension between computational complexity and estimation *** enha nce support for in-vehicle implementation,cloud computing,and the echelon technologies of battery recycling,remanufacturing,and reuse,as well as to offer insights into these technologies,a segmented management approach will be introduced in the *** will encompass source domain data processing,multi-feature factor reconfiguration,hybrid drive modeling,parameter correction mechanisms,and fulltime health *** on the best SOH estimation outcomes,health strategies tailored to different stages can be devised in the future,leading to the establishment of a comprehensive SOH assessment *** will mitigate cross-domain distribution disparities and facilitate adaptation to a broader array of dynamic operation *** article reviews the current research landscape from four perspectives and discusses the challenges that lie *** and practitioners can gain

关键词： Lithium-ion batteries Whole life cycle Aging mechanism Data-driven approach state of health Battery management system

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