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Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance

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Chinese Journal of Natural Medicines 2024年第4期22卷 341-355页

作者： WANG Hao GENG Xiaolong AI Fangbin YU Zhilun ZHANG Yan ZHANG Beibei LV Cheng GAO Ruiyang YUE Bei DOU Wei The MOE key laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaSchool of Traditional Chinese Materia MedicaShanghai University of Traditional Chinese Medicine(SHUTCM)Shanghai 201203China

Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective ***,an alkaloid found in lotus leaf,has shown promising anti-inflammatory and anti-tumor effects,yet its efficacy in RA treatment remains *** study investigated the antiproliferative effects of nuciferine on the MH7A cell line,a human RA-derived fibroblast-like synoviocyte,revealing its ability to inhibit cell proliferation,promote apoptosis,induce apoptosis,and cause G1/S phase ***,nuciferine significantly reduced the migration and invasion capabilities of MH7A *** therapeutic potential of nuciferine was further evaluated in a collagen-induced arthritis(CIA)rat model,where it markedly alleviated joint swelling,synovial hyperplasia,cartilage injury,and inflammatory *** also improved collagen-induced bone erosion,decreased pro-inflammatory cytokines and serum immunoglobulins(IgG,IgG1,IgG2a),and restored the balance between T helper(Th)17 and regulatory T cells in the spleen of CIA *** results indicate that nuciferine may offer therapeutic advantages for RA by decreasing the proliferation and invasiveness of FLS cells and correcting the Th17/Treg cell imbalance in CIA rats.

关键词： Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte Immune imbalance Nuciferine

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Design of hadronic calorimeter for DarkSHINE experiment

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Nuclear Science and Techniques 2024年第9期35卷 155-167页

作者： Zhen Wang Rui Yuan Han-Qing Liu Jing Chen Xiang Chen Kim Siang Khaw Liang Li Shu Li Kun Liu Qi-Bin Liu Si-Yuan Song Tong Sun Xiao-Long Wang Yu-Feng Wang Hai-Jun Yang Jun-Hua Zhang Yu-Lei Zhang Zhi-Yu Zhao Chun-Xiang Zhu Xu-Liang Zhu Yi-Fan Zhu Tsung-Dao Lee Institute Shanghai Jiao Tong University1 Lisuo RoadShanghai 201210China Institute of Nuclear and Particle Physics School of Physics and Astronomy800 Dongchuan RoadShanghai 200240China key laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China key laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200443China Institute of Modern Physics Fudan UniversityShanghai 200443China

The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector *** paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation *** geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV *** overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.

关键词： Hadronic calorimeter GEANT4 simulation Neutron background Scintillation detector Dark photon

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Experimental Investigation on Heat Transfer and Combustion of a Stirling Engine Combustor Fueled by Reformed Gas and Diesel Fuel

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Journal of Thermal Science 2024年第5期33卷 1907-1919页

作者： LAN Jian ZHAO Yanchun LIN Guangtao LI Yelin REN Zhe LYU Tian SHEN Mengmeng GU Genxiang HAN Dong key laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China shanghai Marine Diesel Engine Research Institute Shanghai 201108China

Thermochemical recuperation heat recovery is an advanced waste heat utilization technology that can effectively recover exhaust waste heat from oxy-fuel Stirling *** novel combustor of a Stirling engine with thermochemical recuperation heat recovery system is expected to utilize both reformed gas and diesel fuels as sources of *** this research,the effects of various factors,including the H_(2)O addition,fuel distribution ratio(FDR),excess oxygen coefficient,and cyclone structure on the temperature distribution in the combustor,combustion emissions,and external combustion system efficiency of the Stirling engine were experimentally *** the increase of steam-to-carbon ratio(S/C),the temperature difference between the upper and lower heating tubes reduces and the circumferential temperature fluctuation decreases,and the combustion of diesel and reformed gas remains close to complete *** S/C=2,the external combustion efficiency is 80.6%,indicating a 1.6%decrease compared to conventional *** the increase of FDR,the temperature uniformity of the heater tube is improved,and the CO and HC emissions ***,the impact of the FDR on the maximum temperature difference and temperature fluctuation across the heater is *** the FDR rises from 21%to 38%,the external combustion efficiency increases from 87.4%to92.3%.The excess oxygen coefficient plays a secondary role in influencing temperature uniformity and temperature difference,and the reformed gas and diesel fuel can be burned efficiently at a low excess oxygen coefficient of *** an increase in the cyclone angle,the heater tube temperature increases,while the maximum temperature difference at the lower part decreases,and the temperature fluctuation ***,the CO and HC emissions increase,and the external combustion efficiency experiences a decrease.A cyclone angle of 30°is found to be an appropriate value for achieving optimal

关键词： Stirling engine fuel reforming synthetic gas oxy-combustion external combustion efficiency

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Divergence angle consideration in energy spread measurement for high-quality relativistic electron beam in laser wakefield acceleration

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Chinese Physics B 2024年第6期33卷 363-368页

作者：卢光伟李曜均胡曦辰陈思宇徐豪祝铭阳闫文超陈黎明 key laboratory for Laser Plasmas of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China

The thorough exploration of the transverse quality represented by divergence angle has been lacking yet in the energy spread measurement of the relativistic electron beam for laser wakefield acceleration(LWFA). In this work, we fill this gap by numerical simulations based on the experimental data, which indicate that in a C-shape magnet, magnetic field possesses the beam focusing effect, considering that the divergence angle will result in an increase in the full width at half maxima(FWHM) of the electron density distribution in a uniformly isotropic manner, while the length-to-width ratio decreases. This indicates that the energy spread obtained from the electron deflection distance is smaller than the actual value, regardless of the divergence angle. A promising and efficient way to accurately correct the value is presented by considering the divergence angle(for instance, for an electron beam with a length-to-width ratio of 1.12, the energy spread correct from 1.2% to 1.5%), providing a reference for developing the high-quality electron beam source.

关键词： relativistic electron beams acceleration by laser–plasma interactions finite element analysis

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Three‐dimensional(3D)‐printed MXene high‐voltage aqueous micro‐supercapacitors with ultrahigh areal energy density and low‐temperature tolerance

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Carbon Energy 2024年第8期6卷 36-48页

作者： Yuanyuan Zhu Qingxiao Zhang Jiaxin Ma Pratteek Das Liangzhu Zhang Hanqing Liu Sen Wang Hui Li Zhong‐Shuai Wu State key laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina key laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhouChina shanghai key laboratory of Rare Earth Functional Materials and Education Ministry key laboratory of Resource Chemistry Shanghai Normal UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina Dalian National laboratory for Clean Energy Chinese Academy of SciencesDalianChina

The rapid advancement in the miniaturization,integration,and intelligence of electronic devices has escalated the demand for customizable microsupercapacitors(MSCs)with high energy ***,efficient microfabrication of safe and high‐energy MXene MSCs for integrating microelectronics remains a significant challenge due to the low voltage window in aqueous electrolytes(typically≤0.6 V)and limited areal mass loading of MXene ***,we tackle these challenges by developing a highconcentration(18mol kg^(−1))“water‐in‐LiBr”(WiB)gel electrolyte for MXene symmetric MSCs(M‐SMSCs),demonstrating a record high voltage window of 1.8 ***,additive‐free aqueous MXene ink with excellent rheological behavior is developed for three‐dimensional(3D)printing customizable all‐MXene microelectrodes on various *** the synergy of a highvoltage WiB gel electrolyte and 3D‐printed microelectrodes,quasi‐solid‐state MSMSCs operating stably at 1.8 V are constructed,and achieve an ultrahigh areal energy density of 1772μWhcm^(−2)and excellent low‐temperature tolerance,with a long‐term operation at−40℃.Finally,by extending the 3D printing protocol,M‐SMSCs are integrated with humidity sensors on a single planar substrate,demonstrating their reliability in miniaturized integrated microsystems.

关键词： 3D printing aqueous electrolyte high voltage micro‐supercapacitors MXene

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Mitochondria at the Crossroads of Cholestatic Liver Injury:Targeting Novel Therapeutic Avenues

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 792-801页

作者： Xutao Li Tianyin Ruan Siyuan Wang Xin Sun Chenghai Liu Yuan Peng Yanyan Tao Institute of Liver Diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina shanghai key laboratory of Traditional Chinese Clinical Medicine ShanghaiChina key laboratory of Liver and Kidney Diseases Ministry of EducationShanghaiChina

Bile acids are byproducts of cholesterol metabolism in the liver and constitute the primary components of *** of bile flow leads to cholestasis,characterized by the accumulation of hydrophobic bile acids in the liver and *** accumulation can exacerbate liver *** review discussed recent developments in understanding how bile acids contribute to liver damage,including disturbances in mitochondrial function,endoplasmic reticulum stress,inflammation,and autophagy *** play a pivotal role in cholestatic liver injury by influencing hepatocyte apoptosis and *** findings linking bile acids to liver damage highlight new potential treatment targets for cholestatic liver injury.

关键词： Bile acids Mitochondria Endoplasmic reticulum Inflammatory Cholestatic liver injury Review

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Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第1期14卷 140-148页

作者： Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru Shi Men Yu Qingxia Huang Huiru Tang State key laboratory of Genetic Engineering School of Life SciencesHuman Phenome InstituteZhangjiang Fudan International Innovation CenterMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsZhongshan HospitalFudan UniversityShanghai200032China Wuhan laboratory for shanghai Metabolome Institute(SMI)Ltd. Wuhan430000China

Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection 0.992), accuracy (relative error 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices.

关键词： Acylcarnitine UPLC-MS/MS Quantitative structure-retention relationship Molecular phenotype

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Solid-state NMR study on sodium intercalation at low voltage window for Na_(3)V_(2)(PO_(4))_(3) as an anode

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Magnetic Resonance Letters 2024年第2期4卷 40-45页

作者： Yuxin Liao Fushan Geng Ming Shen Bingwen Hu shanghai key laboratory of Magnetic Resonance State Key Laboratory of Precision SpectroscopySchool of Physics and Electronic ScienceEast China Normal UniversityShanghai200241China

In-situ XRD,^(31)P NMR and ^(23)Na NMR were used to analyze the interaction behavior of Na_(3)V_(2)(PO_(4))_(3) at low voltage,and then a new intercalation model was *** the transition from Na_(3)V_(2)(PO_(4))_(3) to Na_(4)V_(2)(PO_(4))_(3),Na ions insert into M1,M2 and M3 sites ***,during the transition of Na_(4)V_(2)(PO_(4))_(3)to Na_(5)V_(2)(PO_(4))_(3),Na ions mainly insert into M3 site.

关键词： Na_(3)V_(2)(PO_(4))_(3) Anode Low voltage NMR Sodium ion battery

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Honeycomb-like MoCo alloy on 3D nitrogen-doped porous graphene for efficient hydrogen evolution reaction

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Rare Metals 2024年第3期43卷 1072-1082页

作者： Lin-Ping Wang Kuang Li Hua-Long Ding Le Xu Chen Huang Jiao-Jiao Zhou Cong-TaoWen Pei-Lin Zhang Wei-Wei Wang Lu-Yang Chen key laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China State key laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai200050China State key laboratory of Chemical Engineering and School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai200237China

An efficient electrocatalyst is indispensable to significantly reduce energy consumption and accelerate the conversion efficiency of water *** this work,the honeycomb-like porous MoCo alloy on nitrogen-doped three-dimensional(3D)porous graphene substrate(Mo_(0.3)Co_(0.7)@NPG)has been synthesized from the annealing of layered double hydroxide(MoCo-LDH@NPG).Especially,the Mo_(0.3)Co_(0.7)@NPG exhibits low hydrogen evolution overpotential of 75 mV(10 mA·cm^(-2))and a Tafel slope of 69.9 mV·dec^(-1),which can be attributed to highly conductive NPG substrate,the unique nanostructure and the synergistic effect of Mo and ***,the Mo_(0.3)Co_(0.7)@NPG can maintain the original morphology and high catalytic activity after 50-h stability *** work proposes a general strategy to synthesize a multi-element alloy on conductive substrates with high porosity for electrocatalytic reaction.

关键词： MoCo alloy Three-dimensional nitrogen-doped porous graphene Hydrogen evolution reaction(HER)

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The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(H)

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： Huan WANG Qin WANG Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China key laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(H) Coarse geometry K-Theory

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