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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Weighted and Resonance Quasilinear Elliptic Problems with Jumping Nonlinearities

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Acta Mathematicae Applicatae Sinica 2018年第2期34卷 438-450页

作者： Gao JIA Chun-yan DAI Jie CHEN College of Science University of Shanghai for Science and Technology Shanghai 200093 China Shanghai Tianshan second middle school Shanghai 200336 China Xiang Yifu Rong second middle school Changsha 410000 China

In this paper, the existence of a nontrivial solution for a class of quasilinear elliptic equations with a disturbance term in a weighted Sobolev space is proved. The proofs rely on Galerkin method, Brouwer＇s theorem... 详细信息

关键词： weighted Sobolev space quasilinear elliptic equation Oalerkin method

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Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology

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Chinese Journal of Natural Medicines 2021年第1期19卷 28-35页

作者： ZHOU Hao-Nan LI Hao-Yu XU Wen-Hua WEI Yan-Yi YU Rui-Xin WANG Wei CHEN Yuan-Ming Graduate school Guangxi University of Chinese MedicineNanning 530000China Graduate school Guangxi Medical UniversityNanning 530000China Department of Orthopedics the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China

Osteoporosis is a health problem to cause global concern.A lot of methods have been used to prevent and treat osteoporosis,but there is still a lack of effective treatment for osteoporosis owing to limited understanding of its ***,the aim of this present study is to explore the underlying mechanism of Wuling Powder,a traditional Chinese medicine on treating *** this study,we firstly screened and identified the common targets between Wuling Powder and osteoporosis through the related databases,and then explored the relationships among these targets,Wuling Powder and osteoporosis by using Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)and network ***,the molecular docking was performed by using systemsDock to evaluate the potential binding relationships between the active components of Wuling Powder and their related *** results showed that in total of 14 common targets including CREBBP,ADAM17,GOT1,GAPDH,USP8,ERBB2,EEF1 A1,MTOR,RAC1,ETS1,DDX58,GCK,EGF and S100 A8 were ***,ERBB2,MTOR and HIF-1 were the potential therapeutic targets for osteoporosis,and they were also the related targets for predicting active components in Wuling *** together,we concluded that Wuling Powder might be used to treat osteoporosis through above these targets.

关键词： Wuling Powder Osteoporosis Network Pharmacology

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A Critical Review of the Effects of Stock Returns and Market Timing on Capital Structure

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Management Studies 2023年第6期11卷 312-321页

作者： YE Hongru JI Jie ZOU Yuanyuan Keystone Academy BeijingChina Shanghai Lingke Bilingual school ShanghaiChina the second middle school of nanning NanningChina

Capital structure is regarded as the combination of debt and equity firms used to finance operations and *** choice of capital structure significantly impacts a company’s cost of capital,profitability,and risk *** a series of factors that affect capital structure,this paper focuses on stock returns and market *** this review,an array of papers is analyzed to summarize what current research claims regarding the influence of stock returns and market timing on capital *** paper centers on the stock return and market timing theories and also discusses other theories like the trade-off theory,the pecking order theory,and the signaling theory.

关键词： capital structure stock returns market timing

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New lower bounds of classical Ramsey numbers R(6,12), R(6,14) and R(6,15)

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Chinese Science Bulletin 1998年第10期43卷 817-818页

作者： LUO Haipeng 1, SU Wenlong 2 and LI Qiao 3 1. Guangxi Academy of Sciences, nanning 530031, China 2. Wuzhou First middle school, Wuzhou 543002, China 3. Shanghai Jiaotong University, Shanghai 200030, China Guangxi Academy of Sciences Nanning China Wuzhou First middle school Wuzhou China Shanghai Jiaotong University Shanghai China

Three new cyclic graphs are constructed by using a computer, and the lower bounds of three Ramsey numbers obtained: R(6,12)≥224, R(6,14)≥258,R(6,15)≥338, which fill in three blanks in the table of bounds of Ram... 详细信息

关键词： Ramsey number lower bound cyclic graph.

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An Extended Dielectric Crack Model for Fracture Analysis of a Thermopiezoelectric Strip

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Acta Mechanica Solida Sinica 2020年第4期33卷 521-545页

作者： Xianci Zhong Yuanbo Wu Keshi Zhang school of Civil Engineering and Architecture Guangxi UniversityNanning 530004China school of Mathematics and Information Science Guangxi UniversityNanning 530004China

An extended dielectric crack model is proposed to capture the effects of the physical properties of crack interior on crack-tip thermoelectroelastic *** typical crack-face boundary conditions can be retrieved by considering the limiting cases of electrical permeability and thermal conductivity inside a *** use of the Fourier transform technique,the problem of a thermopiezoelectric strip weakened by a Griffith crack is investigated and transformed to solve the system of the second kind Fredholm integral equations with Cauchy *** Lobatto-Chebyshev collocation method is used to form a nonlinear system of algebraic equations,which is solved by elaborating on an *** crack-tip thermoelectroelastic fields are determined by using the approximate *** simulations are carried out to show the variations of the fracture parameters of concern under applied thermoelectromechanical loads,the physical properties of the dielectric medium inside the crack and the geometry of the cracked thermopiezoelectric *** comparisons with the experimental results are reported to reveal the effectiveness of the extended dielectric crack model.

关键词： Extended dielectric crack model Thermopiezoelectric strip Fourier transform technique Crack-tip field.Experimental comparison

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Epidemiological and Clinical Characteristics of Non-neonatal Tetanus Patients in Guangxi,China:An 11-year Retrospective Study(2011–2021)

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Biomedical and Environmental Sciences 2023年第9期36卷 880-885页

作者： KANG Yi Wen MAI Guo Feng ZHU Xiao Ling DENG Shang Qin YANG Shi Xiong TENG Hong Li YUAN Zong Xiang MO Chu Ye LIN Jian Yan YE Li TANG Hua Min Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Department of Emergency the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007GuangxiChina The Fourth People's Hospital of nanning Nanning 530023GuangxiChina Department of Emergency Guangxi International Zhuang Medicine HospitalNanning 530000GuangxiChina

Tetanus is the only non-communicable disease among vaccine-preventable infectious *** is caused by an infection with Clostridium tetanus bacterium and is characterized by continuous tonic contraction and paroxysmal sp... 详细信息

关键词： Tetanus vaccine neonatal

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Dual-functional pyrene implemented mesoporous silicon material used for the detection and adsorption of metal ions

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Chinese Journal of Chemical Engineering 2023年第8期60卷 108-117页

作者： Jing Huang Honghui Cai Qian Zhao Yunpeng Zhou Haibo Liu Jing Wang school of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China

A fluorescent active organic–inorganic hybrid material Py N-SBA-15 was synthesized by implementing pyrene derivatives into mesoporous SBA-15 *** N-SBA-15 had detection and removal functionalities toward Al^(3+),Cu^(2+),and Hg^(2+).On the one hand,Py N-SBA-15 was used as a fluorescence sensor and displayed high sensitivity toward Al^(3+),Cu^(2+),and Hg^(2+)cations (limit of detection:8.0×10^(-7),1.1×10^(-7),and 2.9×10^(-6)mol·L^(–1),respectively) among various analytes with“turn-off”*** the other hand,the adsorption studies for these toxic analytes (Cu^(2+),Hg^(2+),and Al^(3+)) showed that the ion removal capacity could reach up to 45,581,and 85 mg·g^(-1),***,the Langmuir isotherm models were better fitted with the adsorption data,indicating that the adsorption was mono-layer *** analysis revealed that the adsorption process was well described by the pseudo-second-order kinetic model for Cu^(2+)and Hg^(2+)and pseudo-first-order kinetic model for Al^(3+).The prepared silica material could be reused in four recycles without significantly decreasing its adsorption ***,the Py N-SBA-15 material can serve as a promising candidate for the simultaneous rapid detection and efficient adsorption of metal ions.

关键词： Dual function Nanomaterials Mesoporous silica Metal ions Detection and adsorption

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NUMERICAL ANALYSIS OF A NONLINEAR SINGULARLY PERTURBED DELAY VOLTERRA INTEGRO-DIFFERENTIAL EQUATION ON AN ADAPTIVE GRID

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Journal of Computational Mathematics 2022年第2期40卷 258-274页

作者： Libin Liu Yanping Chen Ying Liang school of Mathematics and Statistics Nanning Normal UniversityNanning 530023China school of Mathematical Sciences South China Normal UniversityGuangzhou 510631China

In this paper,we study a nonlinear first-order singularly perturbed Volterra integro-differential equation with *** equation is discretized by the backward Euler for differential part and the composite numerical quadrature formula for integral part for which both an a priori and an a posteriori error analysis in the maximum norm are *** on the a priori error bound and mesh equidistribution principle,we prove that there exists a mesh gives optimal first order convergence which is robust with respect to the perturbation *** a posteriori error bound is used to choose a suitable monitor function and design a corresponding adaptive grid generation ***,we extend our presented adaptive grid algorithm to a class of second-order nonlinear singularly perturbed delay differential *** results are provided to demonstrate the effectiveness of our presented monitor ***,it is shown that the standard arc-length monitor function is unsuitable for this type of singularly perturbed delay differential equations with a turning point.

关键词： Delay Volterra integro-differential equation Singularly perturbed Error analysis Monitor function

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NETWORK CROWN ETHER POLYMERS WITH CENTRIC FUNCTIONAL GROUP (Ⅳ) SYNTHESIS OF NETWORK CROWN ETHER POLYMER WITH PENDANT DIETHYLAMINO THIAALKYL GROUP AND ITS PLATINUM COMPLEX

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Chinese Journal of Polymer Science 1994年第4期12卷 316-322页

作者：陈远荫孟令芝殷以华耿成爱 Department of Chemistry Wuhan University Wuhan 430072 The second middle school in Caidian Wuhan 430100

The title polymer was prepared from 5-diethylamino-3-thia-pentyl glycidyl ether anddiethylene glycol bisglycidyl ether via ring-opening copolymerization. It was found that thisreaction could be catalyzed by sodium, but not Lewis acid. The obtained polymer can coordinatewith platinum compound, and the platinum complex is a new kind of catalyst for thehydrosilylation of olefins with triethoxysilane.

关键词： Crown ether Crown ether polymer Platinum complex Hydrosilylation catalyst

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