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Maillard reaction affecting immunobinding activity and digestibility of tropomyosin in Alectryonella plicatula food matrix

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Food Science and Human Wellness 2024年第5期13卷 2959-2969页

作者： Chenchen Yu Xinrong He Nairu Ji Shuai Kang Dongxiao Li Huilin Zhang Yang Yang Dong Lai Qingmei Liu Guangming Liu College of Ocean Food and Biological engineering Xiamen Key Laboratory of Marine Functional FoodFujian Provincial Engineering Technology Research Center of Marine Functional FoodJimei UniversityXiamen 361021China The second Affiliated Hospital of Xiamen Medical College Xiamen 361021China

In recent years,the allergy rate of oysters has surged,and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin(TM).In this study,the Maillard reaction with xylose significantly reduced the IgE binding capacity of Alectryonella plicatula food matrix(AFM),that reduced by(77.81±2.68)%.The study found the Maillard reaction changes the structure of the AFM,in which the content ofα-helix decreased by(24.64±1.46)%.Structural transformation further explains why the Maillard reaction alters the immunobinding activity of *** addition,the Maillard reaction reduces the digestive stability of the AFM and makes TM in the *** food matrix Maillard reaction products(AFM-MRPs)more easily *** on the above research,10 amino acids on the 7 IgE epitopes of TM were *** result indicates that the Maillard reaction reduces the immunobinding activity of the AFM by changing the structure and modifying the amino acids on the epitope.

关键词： Alectryonella plicatula Food matrix Immunobinding activity Maillard reaction Tropomyosin

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Underwater inertial error rectification with limited acoustic observations

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Satellite Navigation 2024年第1期5卷 207-223页

作者： Hongqiong Tang Hongyang He Fangneng Li Jiangning Xu Department of Navigation engineering Naval University of EngineeringWuhan430000China

Underwater inertial navigation is particularly difficult for the long-durance operations as many navigation systems such global satellite navigation systems are *** acoustic signal is a marvelous choice for underwater inertial error rectification due to its underwater penetration ***,the traditional Acoustic Positioning Systems(APS)are expensive and incapable of positioning with limited acoustic *** novel underwater inertial error rectification algorithms with limited acoustic observations are *** first one is the single acoustic-beacon Range-only Matching Aided Navigation(RMAN)method,which is inspired by matching navigation without reference maps and presented for the first *** second is the improved single acoustic-beacon Virtual Long Baseline(VLBL)method,which considers the impact of indicated relative position increments on virtual beacon *** RMAN and improved VLBL are further developed when multi acoustic-beacons are available,named mAB-RMAN and *** comprehensive simulations and field investigations were *** results demonstrated that the proposed methods achieved excellent accuracy and stability compared to the baseline,specifically,the mAB-RMAN and mAB-VLBL can reduce the inertial error by more than 90%and 98%when using single and double acoustic-beacons,*** proposed techniques will provide new perspectives for underwater positioning,navigation,and timing.

关键词： Underwater PNT Range-only matching aided navigation Virtual long baseline Inertial error rectification

Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin

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Acta Oceanologica Sinica 2024年第2期43卷 120-129页

作者： Shihao Yang Zhaocai Wu Yinxia Fang Mingju Xu Jialing Zhang Fanlin Yang College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Submarine Geoscience Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Geomatics and Municipal engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Ocean College Zhejiang UniversityZhoushan 316021China

Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided.

关键词： 3D constrained gravity inversion continent-ocean boundary Mozambique continental margin Moho depth

Exploring non-invasive diagnostics for metabolic dysfunctionassociated fatty liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3447-3451页

作者： Biao Qu Zheng Li Department of Clinical Pharmacology The Second Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Jiangsu engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

The population with metabolic dysfunction-associated fatty liver disease(MAFLD)is increasingly common *** of people at risk of progression to advanced stages is necessary to timely offer interventions and appropriate *** biopsy is currently considered the gold standard for the diagnosis and staging of MAFLD,but it has associated risks and *** has spurred the exploration of non-invasive diagnostics for MAFLD,especially for steatohepatitis and *** non-invasive approaches mostly include biomarkers and algorithms derived from anthropometric measurements,serum tests,imaging or stool metagenome ***,they still need rigorous and widespread clinical validation for the diagnostic performance.

关键词： Metabolic dysfunction-associated fatty liver disease Non-invasive diagnostics Circulating biomarkers Imaging biomarkers Stool microbial biomarkers

Midterm outcome of stapled transanal rectal resection for obstructed defecation syndrome:A single-inst.tution experience in China

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World Journal of Gastroenterology 2013年第38期19卷 6472-6478页

作者： Bin Zhang Jian-Hua Ding Yu-Juan Zhao Meng Zhang Shu-Hui Yin Ying-Ying Feng Ke Zhao Department of Colorectal Surgery the Second Artillery General Hospital Department of Laboratory Medicine the Second Artillery General Hospital

AIM:To assess midterm results of stapled transanal rectal resection(STARR)for obstructed defecation syndrome(ODS)and predictive factors for ***:From May 2007 to May 2009,75 female patients underwent STARR and were included in the present *** and postoperative workup consisted of standardized interview and physical examination including proctoscopy,colonoscopy,anorectal manometry,and *** and functional results were assessed by standardized questionnaires for the assessment of constipation constipation scoring system(CSS),Longo’s ODS score,and symptom severity score(SSS),incontinence Wexner incontinence score(WS),quality of life Patient Assessment of Constipation-Quality of Life Questionnaire(PAC-QOL),and patient satisfaction visual analog scale(VAS).Data were collected prospectively at baseline,12 and 30 ***:The median follow-up was 30 mo(range,30-46 mo).Late postoperative complications occurred in 11(14.7%)*** of these patients required procedure-related reintervention(one diverticulectomy and two excision of staple granuloma).Although the recurrence rate was 10.7%,constipation scores(CSS,ODS score and SSS)significantly improved after STARR(P<0.0001).Significant reduction in ODS symptoms was matched by an improvement in the PAC-QOL and VAS(P<0.0001),and the satisfaction index was excellent in 25(33.3%)patients,good in 23(30.7%),fairly good in 14(18.7%),and poor in 13(17.3%).Nevertheless,the WS increased after STARR(P=0.0169).Incontinence was present or deteriorated in 8(10.7%)patients;6(8%)of whom were new *** analysis revealed that the occurrence of fecal incontinence(preoperative,postoperative or new-onset incontinence;P=0.028,0.000,and 0.007,respectively)was associated with the success of the ***:STARR is an acceptable procedure for the surgical correction of ***,its impact on symptomatic recurrence and postoperative incontinence may be problematic.

关键词： Colorectal surgery Constipation Stapled transanal rectal resection

Ultraclean transfer of graphene by mechanically exfoliating polymer with modified crosslink density

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Nano Research 2024年第8期17卷 6795-6802页

作者： Qi Lu Jiawei Yang Chaofan Zhou Zhaoning Hu Saiyu Bu Bingbing Guo Yixuan Zhao Junhao Liao Mingpeng Shang Ge Chen Kaicheng Jia Jianbo Yin Qiang Zeng Li Lin Zhongfan Liu College of Science China University of Petroleum(Beijing)Beijing 102249China School of Materials Science and engineering Peking UniversityBeijing 100871China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene inst.tute Beijing 100095China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Electronics Peking UniversityBeijing 100871China second Clinical Division National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing 100081China

The transfer of graphene from metallic substrates onto application-specific substrates is usually inevitable for the applications of high-quality graphene films derived from chemical vapour deposition(CVD)*** used to support the graphene films during the transfer,the coating of the polymer would produce the surface contaminations and hinder the industrially compatible *** this work,through the thermal imidization of polyamide acid(PAA)to polyimide(PI)and tuning of the concentration of dangling chains,we achieved the ultraclean and crack-free transfer of graphene wafers with high electronic *** resulting contamination-free and hydrophilic surface also enabled the observed improved cell viability in a biomedical *** avoiding aqueous etching or the usage of strong bases,our proposed transfer method is industrially compatible for batch transfer of graphene films towards the real applications.

关键词： chemical vapour deposition(CVD)graphene films graphene transfer ultraclean transfer transfer medium crosslink density cell viability assay

Modified attitude pursuit guidance law for low-cost missiles using strap-down seekers

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Journal of Beijing inst.tute of Technology 2014年第2期23卷 158-164页

作者：宋韬林德福李川 School of Aerospace engineering Beijing Institute of Technology Equipment inst.tute of second artillery

Attitude pursuit guidance law is suitable for low cost missiles.A strap-down seeker is used to achieve this guidance *** additional angles of attack or sideslip caused by wind and by control system are considered as two disturbing factors which make attitude pursuit law ***,general attitude pursuit guidance law did not account for this two disturbing factors,because with those disturbing factors,it is difficult to *** solve the problem,the principle of strap-down seeker detecting target is investigated,the mathematical control model is established,then a modified attitude pursuit guidance law which employs the angular correction for those two disturbing factors is *** is proved that the modified attitude pursuit guidance law is appropriated to both in the presence of the additional angle of attack or sideslip via the simulations with the mathematical control model and Monte-Carlo method.

关键词： modified attitude pursuit guidance law strap-down seeker angle of attack additional angel of attack or sideslip Monte-Carlo method

DYNAMIC ANALYSIS OF UNDERGROUND COMPOSITE STRUCTURES UNDER EXPLOSION LOADING

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Applied Mathematics and Mechanics(English Edition) 2004年第3期25卷 272-278页

作者：赵晓兵薛大为赵玉祥 The Command inst.tute of the second artillery of PLA University of Macao Luoyang Hydraulic engineering Technology inst.tute

In selecting rational types of underground structures resisting explosion,in order to improve stress states of the structural section and make full use of material strength of each part of the section,the research method of composite structures is presented. Adopting the analysis method of micro-section free body,equilibrium equations,constraint equations and deformation coordination equations are given. Making use of the concept of generalized work and directly introducing Lagrange multiplier specific in physical meaning,the validity of the constructed generalized functional is proved by using variation method. The rational rigidity matching relationship of composite structure section is presented through example calculations.

关键词： composite structure dynamic analysis rational rigidity matching generalized variation principle

Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies

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Regenerative Biomaterials 2024年第2期3卷 1-16页

作者： Xiaoqian Hong Geer Tian Yang Zhu Tanchen Ren Department of Cardiology of the second Affliated Hospital and State Key Laboratory of Transvascular Implantation Devices Cardiovascular Key Laboratory of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310o09China Binjiang inst.tute of Zhejiang University Hangzhou 310053China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Metal ions participate in many metabolic processes in the human body,and their homeostasis is crucial for *** cardiovascular diseases(CVDs),the equilibriums of metal ions are frequently interrupted,which are related to a variety of disturbances of physiological processes leading to abnormal cardiac *** supplement of metal ions has the potential to work as therapeutic strategies for the treatment of *** with other therapeutic drugs,metal ions possess broad availability,good stability and safety and diverse drug delivery *** delivery strategies of metal ions are important to exert their ther-apeutic effects and reduce the potential toxic side effects for cardiovascular applications,which are also receiving increasing *** local delivery strategies for metal ions based on various biomaterials are constantly being *** this review,we comprehensively summarized the positive roles of metal ions in the treatment of cVDs from three aspects:protecting cells from oxidative stress,inducing angiogenesis,and adjusting the functions of ion *** addition,we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair,as well as the currently available engineered strategies for the precise delivery of metal ions,such as integrated with nanoparticles,hydrogels and scaffolds.

关键词： metal ions cardiovascular disease tissue engineering oxidative stress angiogenesis ion channel