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chinese Journal of Integrative medicine 2025年第2期31卷 183-192页

作者： YE Hai-min LI Zhuo-yan ZHANG Peng KANG Zhen ZHOU De-sheng School of Integrated chinese and Western medicine Hunan University of Chinese MedicineChangsha(410208)China Neurology Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Acupuncture and Moxibustion Massage Rehabilitation Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Neurology Department The First Hospital of Hunan University of Chinese MedicineChangsha(410011)China

Neuroinflammatory responses play an important role in the pathogenesis of various diseases,particularly those affecting the central nervous *** of neuroinflammation is a crucial therapeutic strategy for the management of central nervous system *** intestinal microbial-gut-brain axis serves as a key regulatory pathway that modulates neuroinflammatory *** flora metabolites such as short-chain fatty acids,indoles and their derivatives,lipopolysaccharides,trimethylamine oxide,and secondary bile acids exert direct or indirect effects on *** have shown that electroacupuncture(EA)modulates the composition of the intestinal microbiota and its metabolites,while also suppressing neuroinflammation by targeting the TLR4/NF-κB,NLRP3/caspase-1,and microglial cell M2-type transformation *** review discusses the mechanisms by which EA regulates neuroinflammation via intestinal microbiota and its metabolites,providing information and a foundation for further investigation of the precise therapeutic mechanisms of EA in neurological disorders.

关键词： electroacupuncture intestinal flora metabolites of intestinal flora neuroinflammation nervous system disease review

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Study on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy based on expert consensus

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Journal of Traditional chinese medicine 2025年第1期45卷 167-175页

作者： WANG Dan HUANG Xiaoyan LI Ping HONG Xiaofan ZHANG Yumin WANG Rongrong BAO Kun LIANG Xing Nephrology Department Qianxinan Autonomous Prefecture Hospital of Traditional Chinese Medicine Nephrology Department Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Key Laboratory of chinese medicine for Prevention and Treatment of Refractory Chronic Disease the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of chinese medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of chinese medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangdong-Hong Kong-Macau Joint Lab on chinese medicine and Immune Disease Research

OBJECTIVE: To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN) patients by literature research and expert investigation(interviews and a Delphi method). METHODS: Our study was consistent with T/CACM 1336-2020. We searched the monographs and references published in the past 40 years(1983-2022), and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional chinese medicine(TCM) based on literature by using frequency statistics and correlation analysis. Expert investigation(interview method and two rounds of Delphi method) was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy. Clinical diagnostic test research was carried out, and compared with “Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023) to evaluate the authenticity, reliability and clinical application value of the standard. RESULTS: A total of 122 relevant guides, standards, monographs and documents were included through searching books and chinese databases. Four experts were interviewed and two rounds of delphi method(75 experts nationwide) were carried out. The experts' opinions are relatively concentrated and the differences are small. Based on the weight of each index, the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected. After discussion by the core group members, the diagnostic model of "necessary symptoms and optional symptoms" was established, and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established. One hundred and ninety-one inpatients and outpatients of Guangdong Provincial hospital of chinese medicine from January 2021 to February 2023 were included in Diagnostic test study. There was no statistical difference in gender, age and course of disease(P > 0.05). The sensitivity and s

关键词： combination of disease and syndrome diagnostic tests, routine glomerulonephritis, membranous syndrome diagnostic criteria syndrome of dampness obstruction

Gut microbial characteristics of the damp-heat constitution:a population-based multicenter cross-sectional study

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Journal of Traditional chinese medicine 2025年第1期45卷 140-151页

作者： LI Tianxing ZHU Linghui WANG Xueke TANG Jun YANG Lingling PANG Guoming LI Huang WANG Liying DONG Yang ZHAO Shipeng LI Yingshuai LI Lingru Institute of Basic Theory for chinese medicine China Academy of Chinese Medical Sciences National Institute of TCM Constitution and Preventive medicine Beijing University of Chinese Medicine the second Clinical Medical College Henan University of Chinese Medicine Department of Hepatobiliary Spleen and Stomach the First Affiliated Hospital of Zhejiang Chinese Medical University Henna Province hospital of Traditional chinese medicine Department of Endocrinology Kaifeng Hospital of traditional Chinese Medicine State Key Laboratory of Dampness Syndrome of chinese medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine College of chinese medicine Beijing University of Chinese Medicine Graduate School of China Academy of chinese Medical Sciences

OBJECTIVE: To investigate the difference in gut microbiota between population with damp-heat constitution(DHC) and balanced constitution(BC). METHODS: A multi-centered cross-sectional casecontrol study was conducted, which included 249 participants with damp-heat constitution or balanced constitution. Baseline information of participants was collected, and stool samples were collected for gut microbiota analysis. Principal coordinate analysis, linear discriminant analysis effect size analysis, receiver operating characteristic, random forest model, and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution. RESULTS: Compared to those in the BC group, the richness and diversity of the microbiota, specifically those of several short-chain fatty acid producing genera such as Barnesiella, Coprobacter, and Butyricimonas, were significantly decreased in the DHC group. Regarding biological functions, flavonoid biosynthesis, propanoate metabolism, and nucleotide sugar metabolism were suppressed, while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group. Finally, a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations. CONCLUSION: The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation, metabolic disorders, and liver steatosis, which is consistent with clinical observations, thus serving as a potential diagnostic tool for traditional chinese medicine constitution discrimination.

关键词： PICRUSt Traditional chinese medicine constitution balanced constitution cross-sectional studies damp-heat constitution inflammatory microbiota multicenter study

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older chinese population

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Journal of Environmental Sciences 2025年第1期147卷 332-341页

作者： Haiyan Jiang Simei Zhang Yaoyao Lin Lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang Kun Chen Department of Public Health Fourth Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health National Clinical Research Center for Child Health of Children’s HospitalZhejiang University School of MedicineHangzhou 310058China

Growing evidences showed that heavy metals exposure may be associated with metabolic ***,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully *** we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was *** determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly *** events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident *** investigate the role of SUA in the association between As andMetS,amediation analysiswas *** the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased *** with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS *** mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the chinese older adults *** analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关键词： Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults

Electroacupuncture enhances the mitophagy of granulosa cells in premature ovarian insufficiency model mice by inactivating the hippo-yes-associated protein/transcriptional co-activator with postsynaptic density protein,drosophila disc large tumor suppresso

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Journal of Traditional chinese medicine 2025年第1期45卷 13-21页

作者： WU Jiaman TANG Meng LUO Yu ZHU Haimin ZHAO Tianqi MA Fei NING Yan Department of chinese medicine Affiliated Shenzhen Maternity and Child Healthcare HospitalSouthern Medical University Guangzhou university of chinese medicine Southern Medical university

OBJECTIVE: To investigate the potential mechanism of electroacupuncture（EA） in alleviating premature ovarian insufficiency（POI） and to provide a theoretical basis for EA treatment of POI. METHODS: For this purpose, a POI mice model was developed by injecting 12 mg/kg busulfan and 120 mg/kg cyclophosphamide intraperitoneally to induce POI. It was then proceeded by EA intervention at Guanyuan（CV4） acupoint on the second day following modeling. Similarly, apoptosis in ovarian granulosa cells was detected by terminal deoxynucleotidyl transferase d UTP nick end labeling staining, while enzyme-linked immunosorbent assay was employed for measuring serum folliclestimulating hormone（FSH）, luteinizing hormone（LH）, estrogen（E2）, and anti-müllerian hormone（AMH） levels. Moreover, transmission electron microscopy（TEM） was employed for examining mitochondrial morphology, while autophagy and hippo-yes-associated protein/transcriptional co-activator with postsynaptic density protein, drosophila disc large tumor suppressor, and zonula occludens-1 protein binding motif（YAP/TAZ） pathway related protein levels in ovarian tissue were detected via Western blotting. RESULTS: Analysis of serum levels of various hormones indicated that serum FSH and LH were reduced in EA compared to the POI group, while E2and AMH levels were found to be elevated in EA compared to the POI group. The EA was found to inhibit apoptosis in granulosa cells in POI model mice, in addition to improved mitochondrial damage and significantly improved mitophagy. Pathway analysis revealed that EA was involved in activating the hippo-YAP/TAZ pathway, followed by reversing EA effects on granulosa cell apoptosis and mitophagy with the use of verteporfin, an autophagy and YAP-T-cell factor/enhancer of split and activator of transcription domain family member interaction inhibitor. CONCLUSIONS: EA at the Guanyuan（CV4） acupoint protected the granulosa cell by inhibiting cell apoptosis and promoting mitophagy, which was mediate

关键词： acupuncture hippo signaling pathway mitophagy point CV4 (Guanyuan) primary ovarian insufficiency

Effect of negative mood,serum inflammatory factors,miR-155,and brain-derived neurotrophic factor

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World Journal of Psychiatry 2025年第2期15卷 85-91页

作者： Qi Zhang Yue Zhao Guang-Yu Cheng Prevention and Treatment Center First Affiliated Hospital Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina Department of Medical First Affiliated Hospital Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina Traditional chinese medicine Translational medicine Research Center First Affiliated Hospital Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their *** has shown potential to relieve this *** To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal *** Abdominal postoperative patients with depression between January 2015 and December 2023 at the First affiliated hospital of heilongjiang university of chinese medicine were *** were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were *** Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(Pchinese medicine syndrome differentiation and ensures the pertinence and effectiveness of *** addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.

关键词： Syndrome differentiation acupuncture Abdominal surgery Depression Negative mood Serum inflammatory factor Tiny RNA-155

NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University Department of Critical Care medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University Department of Emergency The First Affiliated Hospital of Guangxi Medical University College & hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxelmirrored homotopic connectivity:a resting state fMRI study

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 297-307页

作者： Xue-Lin Wang Yu Chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-Min Ge Xu Chen Yi Shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeShangrao Center HospitalEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Department of Traditional chinese medicine the Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht university Maastricht 6200MSLimburg Provinciethe Netherlands Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To analyze whether alterations of voxel mirror homology connectivity(VMHC)values,as determined by resting-state functional magnetic resonance imaging(rsfMRI),occur in cerebral regions of patients with hypertensive retinopathy(HR)and to determine the relationship between VMHC values and clinical characteristics in patients with ***:Twenty-one patients with HR and 21 agematched healthy controls(HCs)were assessed by rsfMRI *** functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC,with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic(ROC)curve *** in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample *** relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation ***:Mean VMHC values of the bilateral cuneus gyrus(BA19),bilateral middle orbitofrontal gyrus(BA47),bilateral middle temporal gyrus(BA39)and bilateral superior medial frontal gyrus(BA9)were lower in the HR than in the HC ***:VMHC values can predict the development of early HR,prevent the transformation of hypertensive microangiopathy,and provide useful information explaining the changes in neural mechanism associated with HR.

关键词： hypertensive retinopathy voxel-mirrored homotopic connectivity neuroimaging functional MRI resting state

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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