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Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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science China Chemistry 2025年第1期68卷 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen Liu State Key laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China State Key laboratory of Microbial technology Shandong UniversityQingdao 266237China National Health Commission(NHC)Key laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100050China

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM)proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual *** of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding *** the biosynthetic pathway of chuangxinmycin(CXM),a unique indole alkaloid antibiotic with potent anti-infective activity,functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process,which,however,remained to be reconstituted *** here report the dissection of this enzymatic process,which requires the incorporation of Cxm8,a Cbl-dependent radical SAM protein,with Cxm9,a DUF5825family protein that shares no homology to any proteins of known ***8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner,achieving CXM and a recently identified,C3-dimethylated *** biochemical characterization,isotope labeling,structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase *** is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

关键词： cbl-dependent radical SAM protein biosynthesis chuangxinmycin stereoselective methylation

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New self-calibration schemes for accelerometers in platform INS

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Journal of systems Engineering and electronics 2015年第5期26卷 1032-1042页

作者： Hong Cai Anliang Li Yuan Cao College of Aerospace science and Engineering National University of Defence Technology science and technology on complex Land systems simulation laboratory

To ensure success of precise navigation, it is necessary to carry out in-field calibration for the accelerometers in platform inertial navigation system(PINS) before a mission is *** continuous self-calibration methods are not fit for fast calibration of accelerometers because the platform misalignments have to be estimated precisely and the nonlinear coupling terms will affect accuracy. The multi-position methods with a "shape of motion" algorithm also have some existing disadvantages: High precision calibration results cannot be obtained when the accelerometer’s output data are used directly and it is difficult to optimize the calibration scheme. Focusing on this field, this paper proposes new fast self-calibration methods for the accelerometers of PINS. A data compression filter is employed to improve the accuracy of parameter estimation because it is impossible to obtain non-biased estimation for accelerometer parameters when using the "shape of motion" algorithm. Besides, continuous calibration schemes are designed and optimized by the genetic algorithm(GA) to improve the observability of parameters. simulations prove that the proposed methods can estimate the accelerometer parameter more precisely than traditional continuous methods and multi-position methods, and they are more practical to deal with urgent situations than multi-position methods.

关键词： self-calibration accelerometers data compression genetic algorithm

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Study on the off situ reconstruction of the core neutron field based on dual-task hybrid network architecture

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Nuclear science and Techniques 2025年第1期36卷 175-191页

作者： Pei Cao Hui Ding Cheng-Long Cao Zi-Hui Yang Guo-Min Sun School of Artificial Intelligence and Big Data Hefei UniversityHefei 230001China College of electronic Engineering National University of Defense TechnologyHefei 230001China Institute of Nuclear Energy Safety technology HFIPSChinese Academy of SciencesHefei 230027China

The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor *** existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the ***,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field ***,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex ***,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of *** experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed *** results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed ***,the reconstructed ARD was within 2%,RD_(max)was maintained within 17.5%,and the number of RD≥10%was maintained within ***,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RD_(max)was within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.

关键词： Real-time reactor monitoring Core neutron field reconstruction Dual-task hybrid network architecture Global-local feature upsampling module

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A coevolutionary framework of business-IT alignment via the lens of enterprise architecture

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Journal of systems Engineering and electronics 2020年第5期31卷 983-995页

作者： LIN Menglong YI Shuanghui ZHANG Mengmeng CHEN Tao CHEN Honghui ZHANG Xiaoxue science and technology on Information systems Engineering laboratory National University of Defense TechnologyChangsha 410072China National Key laboratory for complex system simulation Academy of Military SciencesBeijing 100000China

Due to the turbulent external business environment, the complexity of internal relations of the organization and the emergence of subversive IT roles, the business-IT alignment(BITA)has become increasingly difficult. The unsuccessful realization of BITA will lead to the waste of organizational resources, the reduction of return on investment and eventually the loss of competitive advantage. In recent years, coevolution has received widespread attention due to its ability to describe the dynamic relationship between IT and business. Multiple principles such as quickening learning action loops and adopt suitable organizing principles for achieving business and IT coevolution(BITC) are obtained. However, the continuous BITC is still hard to be achieved because of the lack of complete BITC management. This paper focuses on the management process of the BITC and how to perform it gradually. A coevolution framework combines the enterprise architecture(EA) approach with the coevolution analysis is proposed, which contains the design of EA, the sensing and governance of the misalignment and the procedure of the EA misalignment *** steps for the governance and prevention of misalignment are discussed in particular. Through comparison with the principles,characteristics and methods of coevolution in the literature, the proposed framework is evaluated. The results show that the proposed framework is effective for BITC implementation.

关键词： business-IT alignment(BITA) coevolution misalignment governance misalignment prevention enterprise architecture

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Modeling the dynamic alignment of business and information systems via the lens of human-centered architecture evolution

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Journal of systems Engineering and electronics 2021年第4期32卷 881-888页

作者： ZHANG Mengmeng YI Shuanghui CHEN Honghui LUO Aimin LIU Junxian ZHANG Xiaoxue science and technology on Information systems Engineering laboratory National University of Defense TechnologyChangsha 410072China National Key laboratory for complex system simulation Military Academy of SciencesBeijing 100080China

The complexity of business and information systems(IS)alignment is a growing concern for researchers and practitioners *** extant research on alignment architecture fails to consider the human viewpoint,which makes it difficult to embrace emergent *** paper contributes to the extant literature in the following ***,we combine an enterprise architecture(EA)framework with a human viewpoint to address alignment issues in the architecture design phase;second,we describe a dynamic alignment model by developing a humancentered meta-model that explains first-and second-order changes and their effects on alignment *** paper provides better support for the theoretical research and the practical application of dynamic alignment.

关键词： business and information systems(IS)alignment human viewpoint enterprise architecture(EA) meta-model dynamic alignment

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Advancing depth perception in spatial computing with binocular metalenses

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Opto-electronic Advances 2025年第1期8卷 1-3页

作者： Junkyeong Park Gyeongtae Kim Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea

Spatial computing and augmented reality are advancing rapidly,with the goal of seamlessly blending virtual and physical ***,traditional depth-sensing systems are bulky and energy-intensive,limiting their use in wearable *** overcome this,recent research by *** et *** a compact binocular metalens-based depth perception system that integrates efficient edge detection through an advanced neural *** system enables accurate,realtime depth mapping even in complex environments,enhancing potential applications in augmented reality,robotics,and autonomous systems.

关键词： metasurface metalens deep learning depth perception edge detection

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Novel polarimetric detector for target detection in heterogeneous clutter

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Journal of systems Engineering and electronics 2016年第6期27卷 1135-1141页

作者： Xu Cheng Longfei Shi Yuliang Chang Yongzhen Li Xuesong Wang State Key laboratory of complex Electromagnetic Environment Effects on electronics and Information system College of Electronic Science and Engineering National University of Defense Technology

A detection of static or slowly moving targets in the inhomogeneous clutter of polarimetric radar is researched and a new detector without exploiting the training set is developed, which has a good performance against the inhomogeneous clutter. The decision rule ensures the constant false alarm rate (CFAR) with respect to the disturbance covariance matrix. Numerical results show the robustness of the proposed method against the inhomogeneous clutter. © 2016 Beijing Institute of Aerospace Information.

关键词： Clutter (information theory) Covariance matrix Numerical methods Polarimeters Radar Radar clutter Radar signal processing Signal processing

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Low Latency Soft Fiberoptic Choledochoscope Robot Control system

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Journal of Shanghai Jiaotong university(science) 2025年第1期30卷 43-52页

作者： ZHOU Hanwei ZHU Xinping MA Youwei WANG Kundong School of electronic Information and Electrical Engineering Shanghai Jiao Tong University200240ShanghaiChina Shanghai Aerospace Control technology Institute Shanghai 201109China

Soft fiberoptic choledochoscope is an important tool for the diagnose and surgical treatment of biliary ***,the traditional soft fiberoptic choledochoscope is hard to operate,due to the low position *** on the conventional soft fiberoptic choledochoscope,an electrical soft fiberoptic choledochoscope robot with a low latency was *** order to improve the controllability of the conventional choledochoscope,the wire traction mechanism and the rotation mechanism are used to bend and rotate the scope,so as to control its movement *** dead band compensation model and control algorithm of the wire traction mechanism are developed to improve the accuracy of the orientation *** human-computer interaction system and complex motion control system are developed based on ARM embedded system and *** to the high-speed synchronization channel between FPGA and peripheral,the design of low latency whole-procedure surgical mode was established and *** with a micro image sensor,real-time video back transmission was *** performance of the robot prototype was verified by animal experiment in vivo on a *** robot has an extremely low operating latency of no more than 0.402 ms,and a high bending positioning accuracy of±1.43°error margin within 99.7%confidence interval,which guarantees the safety of biliary surgery.

关键词： soft fiberoptic choledochoscope electrical control low latency in vivo animal experiment

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SwordDTA： A Dynamic Taint Analysis Tool for Software Vulnerability Detection

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Wuhan University Journal of Natural sciences 2016年第1期21卷 10-20页

作者： CAI Jun ZOU Peng MA Jinxin HE Jun science and technology on complex electronic system simulation laboratory Academy of Equipment Beijing 101416China China Information technology Security Evaluation Center Beijing 100085 China

Software vulnerabilities are the root cause of various information security incidents while dynamic taint analysis is an emerging program analysis technique. In this paper, to maximize the use of the technique to detect software vulnerabilities, we present SwordDTA, a tool that can perform dynamic taint analysis for binaries. This tool is flexible and extensible that it can work with commodity software and hardware. It can be used to detect software vulnerabilities with vulnerability modeling and taint check. We evaluate it with a number of commonly used real-world applications. The experimental results show that SwordDTA is capable of detecting at least four kinds of softavare vulnerabilities including buffer overflow, integer overflow, division by zero and use-after-free, and is applicable for a wide range of software.

关键词： information security software vulnerability detection dynamic taint analysis use-after-free

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An efficient adaptive space partitioning algorithm for electromagnetic scattering calculation of complex 3D models

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Journal of systems Engineering and electronics 2021年第5期32卷 1071-1082页

作者： HUANG Minjie ZHOU Yaoming WANG Yongchao LIU Zhongtie School of Aeronautic science and Engineering Beihang UniversityBeijing 100191China Key laboratory of complex Aviation system simulation Beijing 100076China

The space partitioning algorithm based on the rounding and addressing operations has been proved to be an efficient space partitioning algorithm with the potential for real-time *** improvement on this kind of space partitioning algorithms for solving complex 3D models is *** examples show that the efficiency of the improved algorithm is better than that of the original *** the size of most target elements is smaller than the size of spatial grids,the efficiency of the improved method can be more than four times of that of the original *** adaptive method of space partitioning based on the improved algorithm is developed by taking the surface element density or the curvature as the threshold for deep partitioning and conducting the deep partitioning using the octree method.A computer program implementation for applying the method in some typical applications is discussed,and the performance in terms of the efficiency,reliability,and resource use is *** testing shows that the results of the adaptive spacing partitioning are more convenient for the follow-up use than that of the basic uniform space ***,when it is used to calculate the electromagnetic scattering of complex targets by the ray tracing(RT)method,the adaptive space partitioning algorithm can reduce the calculation time of the RT process by more than 40%compared with the uniform space segmentation algorithm.

关键词： adaptive space partitioning computer graphics binary space partitioning ray tracing(RT)method stealth technology

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