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Repeatability and reproducibility of corneal higher-order aberrations measurements after small incision lenticule extraction using the Scheimpfug-Placido topographer

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Eye and Vision 2024年第1期10卷 1-9页

作者： Rui Ning Rongrong Gao David PPiñero Jun Zhang Qingyi Gao Yili Jin Yiran Wang Chenxiao Wang Jinhai Huang Eye Hospital and school of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina Eye Institute and Department of Ophthalmology Eye and ENT HospitalFudan UniversityShanghaiChina Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicanteSpain NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina

Background:To evaluate the precision of corneal higher-order aberrations measurements after small incision lenticule extraction(SMILE)using the Sirius Scheimpfug-Placido topographer(CSO,Italy).Methods:Seventy-fve eyes from 75 postoperative subjects were included in this prospective *** consecutive corneal aberrometric measurements were obtained with the Scheimpfug-Placido topographer by two experienced operators to assess intra-and inter-observer *** within-subject standard deviation(Sw),test-retest repeatability(TRT)and the intraclass correlation coefcient(ICC)were ***:For intraobserver repeatability of anterior and total corneal aberrations,all ICCs were more than 0.922,except for trefoil(0.722 to 0.768).The ICCs of total root mean square(RMS),coma Z(3,±1),and spherical aberration Z(4,0)were over 0.810 while higher-order RMS,trefoil Z(3,±3),and astigmatism II Z(4,±2)were below 0.634 for posterior corneal surface *** Sw values for all types of aberrations were equal to or below 0.07μ*** interobserver reproducibility,all TRT values were no more than 0.12μm,0.05μm,and 0.11μm for anterior,posterior,and total corneal aberrations,*** ICC values ranged from 0.875 to 0.989,from 0.686 to 0.976 and over 0.834 for anterior,posterior,and total corneal aberrations,***:The repeatability of measurements of anterior and total corneal aberrations with the Sirius system in corneas after SMILE surgery was high,except for *** was some variability in posterior corneal aberrometric *** reproducibility of corneal aberrometric measurements was observed between measurements of both examiners,except for trefoil,with poor to moderate reproducibility.

关键词： Sirius Higher-order aberrations Repeatability Reproducibility Small incision lenticule extraction

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Traditional craniotomy versus current minimally invasive surgery for spontaneous supratentorial intracerebral haemorrhage:A propensity-matched analysis

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World Journal of Radiology 2024年第8期16卷 317-328页

作者： Zhen-Kun Xiao Yong-Hong Duan Xin-Yu Mao Ri-Chu Liang Min Zhou Yong-Mei Yang Hengyang Key Laboratory of Hemorrhagic Cerebrovascular Disease Department of NeurosurgeryHengyang Medical SchoolUniversity of South ChinaHengyang 421000Hunan ProvinceChina Department of anatomy Hengyang Medical SchoolUniversity of South ChinaHengyang 421000Hunan ProvinceChina

BACKGROUND Minimally invasive surgery(MIS)and craniotomy(CI)are the current treatments for spontaneous supratentorial cerebral haemorrhage(SSTICH).AIM To compare the efficacy and safety of MIS and CI for the treatment of *** Clinical and imaging data of 557 consecutive patients with SSTICH who underwent MIS or CI between January 2017 and December 2022 were retrospectively *** patients were divided into two subgroups:The MIS group and CI *** score matching was performed to minimise case selection *** primary outcome was a dichotomous prognostic(favourable or unfavourable)outcome based on the modified Rankin Scale(mRS)score at 3 months;an mRS score of 0–2 was considered *** In both conventional statistical and binary logistic regression analyses,the MIS group had a better *** outcome of propensity score matching was unexpected(odds ratio:0.582;95%CI:0.281–1.204;P=0.144),which indicated that,after excluding the interference of each confounder,different surgical modalities were more effective,and there was no significant difference in their *** Deciding between MIS and CI should be made based on the individual patient,considering the hematoma size,degree of midline shift,cerebral swelling,and preoperative Glasgow Coma Scale score.

关键词： Cerebral haemorrhage Intracerebral haemorrhage Minimally invasive surgery Craniotomy Propensity-matched analysis

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Increased alcohol consumption during the COVID-19 pandemic:A cross-sectional study

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World Journal of Clinical Cases 2024年第18期12卷 3410-3416页

作者： Rajni Rathore Shahid Bakhsh Rangrej Victoria Carvalho Department of Pharmacology and Therapeutics Saint James School of MedicineArnos Vale VC0280Saint Vincent and the Grenadines Department of anatomy and Research Saint James School of MedicineArnos Vale VC0280Saint Vincent and the Grenadines Medical school Basic Sciences Saint James School of MedicineArnos Vale VC0280Saint Vincent and the Grenadines

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has significantly impacted health,mental well-being,and societal functioning,particularly for individuals with psychiatric conditions and substance use *** evidence highlights a concerning increase in alcohol consumption during the pandemic,with a study spanning 2015-2020 indicating heightened usage,especially among young and middle-aged adults,for relaxation and tension ***,addressing challenges exacerbated by the pandemic,another study underscored persistent barriers to healthcare access,resulting in increased alcohol and tobacco use rates and limited healthcare *** findings shed light on the unique vulnerabilities exposed by the pandemic,emphasizing the need to investigate further its impact on alcohol consumption in diverse non-urban American *** To investigate the impact of the COVID-19 pandemic on alcohol abuse using socioeconomic and medical parameters in diverse non-urban community in *** Based on a cross-sectional analysis of 416 participants the United States in 2021,the study utilized The Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria to categorize alcohol consumption *** aged 21 years and above were surveyed through an online platform due to COVID-19 *** survey was conducted from January 14 to January 31,2022,recruiting participants via social media and ensuring *** consent was secured,emphasizing the voluntary nature of participation,and participants could only take the survey *** Out of 416 survey respondents,396 met eligibility criteria,with 62.9%reporting increased alcohol consumption during ***(68.8%)and ages 21-29 years(34.6%)*** alcohol consumption decreased by 2.8%(P=0.237),moderate by 21.4%(P<0.001),and heavy increased by 14.9%(P<0.001).Alcohol abuse rose by 6.5%(P=0.0439),with a 7%increase in self-identified alcohol abuser

关键词： Alcoholism 2019 Novel coronavirus SARS-CoV-2 COVID-19 Mental health issue

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Developmental Patterns and Gender Differences of Vocal Production in Marmoset Monkeys

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Neuroscience Bulletin 2024年第1期40卷 133-138页

作者： Ruixin An Chaocheng Lu Chen Wang Liangtang Chang Junfeng Huang Fan Jiang Tian-Le Xu Neng Gong Center for Brain Science Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine Huashan HospitalFudan University12 Middle Wulumuqi RoadShanghai 200040China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Lingang Laboratory Shanghai 200031China Shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 201210China

Dear Editor,The common marmoset(Callithrix jacchus),a small New World monkey species,is considered an ideal non-human primate model for studying the evolution and neural mechanism of vocal behavior due to their rich call repertoire and vocal communication[1-3].Especially,the early vocal development of marmoset monkeys has attracted much attention,because newborn marmosets have been shown to exhibit a vocal development *** two months after birth,marmosets'vocalizations undergo dramatic changes from cries to adult-like mature calls,a process that is influenced not only by inner physical maturation but also by parental care and feedback[4].

关键词： parental birth Pattern

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Genetic pathways in cerebral palsy:a review of the implications for precision diagnosis and understanding disease mechanisms

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Neural Regeneration Research 2024年第7期19卷 1499-1508页

作者： Yiran Xu Yifei Li Seidu A.Richard Yanyan Sun Changlian Zhu Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina National Health Council(NHC)Key Laboratory of Birth Defects Prevention Henan Key Laboratory of Population Defects PreventionZhengzhouHenan ProvinceChina Department of Human anatomy School of Basic Medicine and Institute of NeuroscienceZhengzhou UniversityZhengzhouHenan ProvinceChina Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologyUniversity of GothenburgGothenburgSweden

Ce rebral palsy is a diagnostic term utilized to describe a group of permanent disorders affecting movement and *** with cerebral palsy are often only capable of limited activity,resulting from non-progressive disturbances in the fetal or neonatal *** disturbances severely impact the child’s daily life and impose a substantial economic burden on the *** cerebral palsy encompasses various brain injuries leading to similar clinical outcomes,the unde rstanding of its etiological pathways remains incomplete owing to its complexity and *** review aims to summarize the current knowledge on the genetic factors influencing cerebral palsy *** is now widely acknowledged that genetic mutations and alterations play a pivotal role in cerebral palsy development,which can be further influenced by environmental fa *** pite continuous research endeavors,the underlying fa ctors contributing to cerebral palsy remain are still ***,significant progress has been made in genetic research that has markedly enhanced our comprehension of the genetic factors underlying cerebral palsy *** r,these genetic factors have been categorized based on the identified gene mutations in patients through clinical genotyping,including thrombosis,angiogenesis,mitochondrial and oxidative phosphorylation function,neuronal migration,and cellular ***,exploring targeted genotypes holds potential for precision *** conclusion,advancements in genetic research have substantially improved our understanding of the genetic causes underlying cerebral *** breakthroughs have the potential to pave the way for new treatments and therapies,consequently shaping the future of cerebral palsy research and its clinical *** investigation of cerebral palsy genetics holds the potential to significantly advance treatments and management *** elucidating the underlying cellular mechanisms,w

关键词： cerebral palsy environmental factors etiology genetic factors genetic mutation movement disorder spastic diplegia

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A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid

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Science China(Life Sciences) 2024年第10期67卷 2213-2223页

作者： Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor Serrano Lopes Fangxiao Cheng Junhao Yan Yu Fu Wanyi Fu Zhaoheng Xie Jianfei Sun Jicong Zhang Zhiqian Tong Yajuan Gao Hongbin Han Department of Radiology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Department of Informatics Technical University of MunichGarching 80539Germany Department of anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Neurology Peking University Third HospitalBeijing 100191China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China school of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Key Laboratory of Alzheimer’s Disease of Zhejiang Province Institute of AgingSchool of Mental HealthWenzhou Medical UniversityWenzhou 325035China NMPA Key Laboratory for Evaluation of Medical Imaging Equipment and Technique Beijing 100191China

Ischemic stroke is a leading cause of death and disability *** response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial implantation(EAI),for accelerating interstitial fluid(ISF)drainage,which provides a promising strategy to clear pro-inflammatory cytokines in the brain extracellular space(ECS).In this study,the method of EAI was modified(m-EAI)to control its function of accelerating the ISF drainage at different time points following ischemic *** neuroprotective effect of m-EAI on ischemic stroke was evaluated with the transient middle cerebral artery occlusion(tMCAO)rat *** results demonstrated the accumulation of IL-1β,IL-6,and TNF-αwas significantly decreased by activating m-EAI at 7 d before and immediately after ischemic attack in tMCAO rats,accompanied with decreased infarct volume and improved neurological *** study consolidates the hypothesis of exacerbated ischemic damage by inflammatory response and provides a new perspective to treat encephalopathy via brain *** research is essential to investigate whether m-EAI combined with neuroprotective drugs could enhance the therapeutic effect on ischemic stroke.

关键词： ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation

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Infanticide in golden snub-nosed monkeys with multilevel society

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Current Zoology 2024年第2期70卷 273-275页

作者： Wei Li Shixuan Dong Fei Niu Nianlong Li Ziyi Su Chengliang Wang Kang Huang Haitao Zhao Ruliang Pan Pei Zhang Baoguo Li Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi'an 710069China Shaanxi Key Laboratory for Animal Conservation Shaanxi Institute of ZoologyXi'an 710032China school of anatomy Physiology and Human BiologyThe University of Western AustraliaWestern Australia 6907Australia International Centre of Biodiversity and Primate Conservation Dali UniversityDali 671003China Division of ExpressiveTherapies.Lesley University.Cambridae.MA02138.USA

Infanticide,killing unweaned offspring in conspecifics,occurs widely among mammals,such as rodents,ungulates,and carnivores,especially in primates(Lukas and Huchard 2014).Such scenarios are often triggered by intruders that have replaced the former dominant males in nonhuman primates(Borries 1997).It has widely been viewed that infanticide is one of the solutions of sexually driven evolutionary selection:males kill infants to end lactational amenorrhea of the victim's mothers,forcing them to return to estrus and providing infanticidal males with the opportunities to sire their new offspring(Hrdy 1979).There is a broad spectrum regarding the patterns and mechanisms causing such events,referring to alternative breeding behaviors and mating systems-monogamy,polyandry,polygyny,and promiscuity(Qi et al.2020).

关键词： primates breeding mother

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： Xiao-xia BAN Hao WAN Xin-xing WAN Ya-ting TAN Xi-min HU Hong-xia BAN Xin-yu CHEN Kun HUANG Qi ZHANG Kun XIONG Department of Human anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China Hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

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Mitochondrial targeting sequence of magnetoreceptor MagR:More than just targeting

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Zoological Research 2024年第3期45卷 468-477页

作者： Yanqi Zhang Peng Zhang Junjun Wang Jing Zhang Tianyang Tong Xiujuan Zhou Yajie Zhou Mengke Wei Chuanlin Feng Jinqian Li Xin Zhang Can Xie Tiantian Cai High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China University of Science and Technology of China HefeiAnhui 230026China Department of anatomy School of Basic MedicineAnhui Medical UniversityHefeiAnhui 230032China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China Key Laboratory of Tropical Translational Medicine of Ministry of Education NHC Key Laboratory of Tropical Disease ControlSchool of Tropical Medicine and The Second Affiliated HospitalHainan Medical UniversityHaikouHainan 571199China International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Iron-sulfur clusters(ISC)are essential cofactors for proteins involved in various biological processes,such as electron transport,biosynthetic reactions,DNA repair,and gene expression *** assembly protein IscA1(or MagR)is found within the mitochondria of most ***(MagR)is a highly conserved A-type iron and iron-sulfur cluster-binding protein,characterized by two distinct types of iron-sulfur clusters,[2Fe-2S]and[3Fe-4S],each conferring unique magnetic *** forms a rod-like polymer structure in complex with photoreceptive cryptochrome(Cry)and serves as a putative magnetoreceptor for retrieving geomagnetic information in animal *** the N-terminal sequences of MagR vary among species,their specific function remains *** the present study,we found that the N-terminal sequences of pigeon MagR,previously thought to serve as a mitochondrial targeting signal(MTS),were not cleaved following mitochondrial entry but instead modulated the efficiency with which iron-sulfur clusters and irons are ***,the N-terminal region of MagR was required for the formation of a stable MagR/Cry ***,the N-terminal sequences in pigeon MagR fulfil more important functional roles than just mitochondrial *** results further extend our understanding of the function of MagR and provide new insights into the origin of magnetoreception from an evolutionary perspective.

关键词： Magnetoreceptor(MagR) N-terminal sequence Mitochondrial targeting signal Iron-sulfur cluster

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