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基于多参数MRI容积成像对评价经动脉化学栓塞治疗神经内分泌性肝转移瘤预后价值的研究

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国际医学放射学杂志 2019年第6期 749-749页

作者： Y.Luo A.Pandey M.A.Gh.sabeh.P.Pandey F.N.Varzaneh.M.Zargh.mpour 李相文 russell h.morgan department of radiology and radiological sciences Johns Hopkins University School of Medicine

摘要目的确定基于多参数MR成像能否预测经动脉化学栓塞(TACE)治疗的神经内分泌肝转移(NELM)病人的总生存期(OS)和肝脏无进展生存期(h.FS)。方法该回顾性

关键词：经动脉化学栓塞肝转移瘤容积成像预后价值内分泌性 MRI

Targeting UDP-α-D-glucose 6-deh.drogenase alters th. CNS tumor immune microenvironment and inh.bits glioblastoma growth

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Genes & Diseases 2022年第3期9卷 717-730页

作者： Daqian Zh.n Fatih.Yalcin Ding Ma Yi Fu Sh.ang Wei Bach.h. Lal Yunqing Li Omar Dzaye Joh. Laterra Mingyao Ying h.rnando Lopez-Bertoni Sh.li Xia Neurology Hugo IV.Moser Research Institute at Kennedy KriegerJohns Hopkins University School of MedicineBaltimoreMD 21205USA department of Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China department of radiology and Neuroradiology ChariteBerlin 10117Germany russell h.morgan department of radiology and radiological Science Johns Hopkins University School of MedicineBaltimoreMD 21205USA department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China University h.spital Center Sch.eswig h.lstein Department of NeurosurgeryKielSchleswig-Holstein 24105Germany departments of Neurology Oncology and NeuroscienceJohns Hopkins University School of MedicineBaltimoreMD 21205USA Blood and Cell Th.rapy Institute University of Science and Technology of ChinaAnhui Provincial HospitalHefeiAnhui 230026PR China

Glioblastoma(GBM,Wh. grade IV glioma)is th. most common and leth.l malignant brain tumor in aduts with.a dismal *** extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,migration,and immune *** diph.sph.te(UDP)-glucose 6-deh.drogenase(UGDh.is th. rate-limiting enzyme th.t catalyzes th. biosynth.sis of glycosaminoglycans th.t are th. principal component of th. CNS *** investigated h.w targeting UGDh.in GBM infuence$th. GBM immune microenvironment,including tumor-associated microglia/macroph.ges(TAMs)and T *** are th. main im-mune effector cells in GBM and can directly target tumor cells if properly *** co-cultures of GBM cells and h.man primary macroph.ges,UGDh.knockdown in GBM cells pro-moted macroph.ge ph.gocytosis and M-like *** orth.tropic h.man GBM xeno-grafts and syngeneic mouse glioma models,targeting UGDh.decreased ECM deposition,increased TAM ph.gocytosis marker expression,reduced M2-like TAMS and inh.bited tumor *** knockdown in GBM cells also promoted cytotoxic T cell ifltration and activa-tion in orth.topic syngeneic mouse glioma *** potent and in-h.man-use small mole-cule GAG synth.sis inh.bitor 4-meth.lumbelliferone(4-MU)was found to inh.bit GBM cell proliferation and migration in vitro,mimic th. macroph.ge and T-cell responses to UGDh.knockdown in vitro and in vivo and inh.bit growth.of orth.topic murine *** study sh.ws th.t UGDh.supports GBM growth.th.ough.multiple mech.nisms and supports th. development of ECM-based th.rapeutic strategies to simultaneously target tumor cells and th.ir microenvi-ronment.

关键词： 4-MU Extracellular matrix(ECM) Glioblastoma(GBM) h.aluronic acid(h.) Ph.gocytosis T cells Tumor-associated microglia/macroph.ges(TAMs) UGDh

慢性胰腺炎病人发生术后纤维化的腹部CT预测因素

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国际医学放射学杂志 2015年第4期 391-392页

作者： A .Sinh. V.K.Singh.M.Cruise E.Afgh.niK Matsukuma S.Ali 赵效新 Th. Russel h.morgan department of radiology and radiological Science Johns Hopkins Medical Institutions

摘要目的明确哪些腹部CT表现可以预测慢性胰腺炎(CP)病人会发生严重纤维化和术后疼痛缓解情况。方法对2003年1月—2014年3月期间66例[平均年龄(52±12)岁,

关键词：纤维化术后疼痛慢性胰腺炎慢性复发性胰腺炎胰腺实质预测因素腹部躯干病人 CT

Using th. rPatlak plot and dynamic FDG-PET to generate parametric images of relative local cerebral metabolic rate of glucose

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Ch.nese Science Bulletin 2012年第30期57卷 3811-3818页

作者： WU YiGen Zh.U Yun BAO Sh.ngLian h.ANG SungCh.ng Zh.O Xiaoh. LI Jun Sch.ol of Ph.sics and Optoelectronic Engineering Nanjing University of lnformation Science and TechnologyNanjing 210044China Beijing City Key Laboratory of Medical Ph.sics and Engineering Peking UniversityBeijing 100871China Th. russell h.morgan department of radiology and radiological Science School of MedicineJohns Hopkins University.BaltimoreMD 21287USA department of Molecular and Medical Ph.rmacology UCLA David Geffen School of MedicineUniversity of California in Los AngelesLos AngelesCA 90095USA Imaging department of Tongji h.spital of Tongji University Shanghai 200065China

Local cerebral metabolic rate of glucose(LCMRGlc) is an important index for th. description of neural *** 18 F-fluoro-2-deoxy-D-glucose(FDG) positron emission tomograph.(PET) h.s been used for quantitative imaging of LCMRGlc in h.mans,but is seldom used routinely because of th. difficulty in obtaining th. input function noninvasively.A reference tissue-based Patlak plot model(rPatlak) was proposed to generate parametric images of LCMRGlc in a quantitative dynamic FDG-PET study with.ut requiring blood *** emission scans(4×0.5,4×2 and 10×5 min) were acquired simultaneously with.an IV bolus injection of 155 MBq of *** blood samples were collected during th. scans via a cath.ter placed in th. radial *** data were also generated using th. same scan *** last ten scan data sets were used in a graph.cal analysis using th. Patlak *** ratio of LCMRGlc estimated from th. original Patlak(oPatlak,using plasma input) was used as th. gold standard,and th. standardized uptake value ratio(SUVR) was also calculated for *** different tissues including wh.te matter,gray matter,and wh.le brain were ch.sen as reference tissues for *** of th. reference region used,th. slopes in th. linear regression between oPatlak and rPatlak were closer to unity th.n th. regression slopes between oPatlak and *** intercepts for th. former were also closer to 0 th.n th.se for th. latter *** squared correlation coefficients were close to 1.0 for both.*** sh.wed th.t th. results of rPatlak were in good agreement with.th.se of oPatlak,h.wever,SUVR exh.bited more *** simulation study also sh.wed th.t th. relative variance and bias for rPatlak were less th.n th.se for *** images obtained with.rPatlak were very similar to th.se obtained with.oPatlak,wh.le th.re were differences in th. relative spatial distribution between th. images of SUVR and *** study validates th.t th. rPatl

关键词： D-葡萄糖分布图像脑组织代谢率正电子发射断层扫描参数化情节输入功能

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膝关节合成MR成像:体模验证及与常规MRI的比较

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国际医学放射学杂志 2019年第1期 107-107页

作者： N.M.Kumar B.Fritz S.E.Stern J.B.M.Warntjes Y.M.L.Ch.ah.J.Fritz 张玉霞 russell h.morgan department of radiology and radiological Science Johns Hopkins University School of Medicine

摘要目的验证合成MRI与传统MRI相比在膝关节能生成准确且可重复的定量图,并生成与之相似的影像和异常结构检出率的假设。材料与方法前瞻性收集2017年1月—

关键词： MRI MR 膝关节对比噪声比

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肥胖动脉栓塞术治疗肥胖症试验:1年结果

国际医学放射学杂志 2019年第4期 492-492页

作者：吴酥 C.R.Weiss G.O.Abiola A.M.Fisch.an L.J.Ch.skin J.Vairavamurth. B.P.h.lly russell h.morgan department of radiology and radiological Science The Johns Hopkins University School of Medicine

摘要肥胖栓塞术是治疗肥胖病人的一种新的血管内治疗方法。然而,肥胖栓塞术的安全性和有效性尚不清楚。目的评估术后12个月内严重肥胖成人肥胖栓塞术的安全性和

关键词：肥胖症栓塞术安全性和有效性

前交叉韧带的黏液样变性与膝关节内侧骨关节炎相关性的MRI研究

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国际医学放射学杂志 2018年第4期 482-482页

作者： R.M.Kwee N.h.fezi-Nejad F.W.Romer B.A.Zikria D.J.h.nter A.Guermazi 温小娟 russell h.morgan department of radiology and radiological Science Johns Hopkins University School of Medicine

目的旨在验证骨关节炎或骨关节炎高危病人MRI所示前交叉韧带(ACL)黏液样变是否与内侧胫骨关节间隙消失(JSL)有关。材料与方法本研究共纳入600例骨关节炎病人,评估受试者基线人口学特征、临床、影像学和MRI骨关节炎膝关节评分(MOAKS)数据... 详细信息

目的旨在验证骨关节炎或骨关节炎高危病人MRI所示前交叉韧带(ACL)黏液样变是否与内侧胫骨关节间隙消失(JSL)有关。材料与方法本研究共纳入600例骨关节炎病人,评估受试者基线人口学特征、临床、影像学和MRI骨关节炎膝关节评分(MOAKS)数据。2名放射科医师(双盲法)评估基线时MR影像ACL黏液样变。采用Logistic多元回归分析探究ACL黏液样变与JSL进展的相关性。其中,JSL定义为关节间隙宽度减小超过0.7 mm(以48个月期间参考组中90名受试者膝关节1年内最小关节间隙宽度变化的均值和标准差作为临界值)。根据基线软骨表面损伤进行分层分析。结果与膝关节正常前交叉韧带相比,膝关节ACL黏液样变较对照组JSL进展比例更高(64%∶47%;P=0.004)。在所有基线人口统计学、临床、影像学和MOAKS变量校正后,ACL黏液样变与JSL进展无显著相关(调整后的优势比1.66,95%CI:1.00～2.77;P=0.051)。亚组分析中,在基线软骨表面损伤较少的受试者中ACL黏液样变与JSL进展在统计学上显著相关[所有亚区的最大软骨表面损失≤75%(P=0.015)和软骨表面损失涉及亚区≤4(P=0.028)]。结论在膝关节软骨表面损伤程度较低的病人中,患骨关节炎或者骨关节炎高危病人的MR影像中ACL黏液样变与膝关节内侧胫骨股关节间隙JSL的进展有关。

关键词：骨关节炎 ACL 黏液样膝关节 MRI 前交叉韧带相关性

前列腺特异性膜抗原（PSMA）靶向18F-DCFPyL在外周神经节的摄取模式

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中华核医学与分子影像杂志 2018年第5期38卷 379-380页

作者：李慧玲兰晓莉 Rudolf A.Werner Sara Sh.ikh.ah.ei Krystyna M.Jones Meh.bod S.Javadi Lilja B.Solnes Ash.ey E.Ross Moh.mad E.Allaf Kenneth.J.Pienta Constantin Lapa ANDreas K.Buck Takah.ro h.guch. Martin G.Pomper Mich.el A.Gorin Steven P.Rowe 华中科技大学同济医学院附属协和医院核医学科 Division of Nuclear Medicine and Molecular Imaging The Russell H.Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of Medicine department of Nuclear Medicine University Hospital Würzburg

目的靶向前列腺特异性膜抗原（PSMA）的放射性显像剂在许多正常结构、解剖变异和非前列腺癌组织中有摄取。该研究探讨PSMA靶向显像剂18F-DCFPyL在外周神经节PET显像的摄取频次和程度。方法回顾性分析98例接受18F-DCFPyL PET/CT显像的患... 详细信息

目的靶向前列腺特异性膜抗原（PSMA）的放射性显像剂在许多正常结构、解剖变异和非前列腺癌组织中有摄取。该研究探讨PSMA靶向显像剂18F-DCFPyL在外周神经节PET显像的摄取频次和程度。方法回顾性分析98例接受18F-DCFPyL PET/CT显像的患者,包括76例前列腺癌（PCa）男性患者和22名肾细胞癌（RCC）患者（男13例、女9例）。评估颈、星状、腹腔、腰、骶神经节的摄取。记录所有放射性摄取高于背景的神经节的摄取值,包括最大标准摄取值(SUVmax)和用瘦体质量校准的SULmax。计算SUVmax和SULmax除以升主动脉平均摄取(Aortamean)和右臀肌肉平均摄取(Gluteusmean),得到神经节/背景比值。结果 98例患者中有95例（96.9%）在至少1个外周神经节中有摄取。在PCa病例中,最常见的放射性聚集部位是腰交感神经节（55/76,72.4%）,其次是颈神经节（51/76,67.1%）。大多数患者是双侧摄取[腰椎44/55（80%）和颈椎30/51（58.8%）]。此外,星状神经节、腹腔神经节、骶神经节有明显放射性摄取者比例分别为65.8%（50/76）、59.2%（45/76）、6.6%（5/76）。RCC患者也有类似的发现,最常见的放射摄取部位是腰神经节（90.9%,20/22）和颈神经节（86.4%,19/22）。这2个部位的PSMA配体平均摄取量在PCa和RCC中均无差异。结论随着靶向PSMA显像剂的广泛应用,必须了解其在肿瘤不直接相关的组织结构中的摄取方式。该研究首次系统评价18F-DCFPyL在神经节中的摄取,结果显示其在腰椎、颈椎、星状神经节、腹腔神经节和骶神经节中的摄取频率呈下降趋势。然而,导致PSMA靶向放射性显像剂在外周神经节中摄取出现差异的生物学原因目前尚不清楚,需进一步研究。

关键词： 18F-DCFPyL 显像误区前列腺癌 PSMA 神经节

探究基于MRI的老年人脑氧摄取与载脂蛋白E基因型和淀粉样蛋白负荷的关系

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国际医学放射学杂志 2019年第5期 610-610页

作者： Z.X.Lin S.Sur A.Soldan C.Pettigrew M.Miller K.Oish. 谢环环 department of Biomedical Engineering and Th. russell h.morgan department of radiology and radiological Science Johns Hopkins University School of Medicine

摘要载脂蛋白E4(APOE4)是迟发性阿尔茨海默病的主要遗传危险因子。然而,APOE4影响脑功能并增加其风险的机制尚未完全阐明。目的通过基于MRI的脑氧摄取探讨

关键词：淀粉样蛋白携带者老年人基因型 MRI