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Current state of the art imaging approaches for colorectal liver metastasis

hepatobiliary Surgery and Nutrition 2020年第1期9卷 35-48页

作者： Bita hazhirkarzar Pegah Khoshpouri Mohammadreza Shaghaghi Mounes Aliyari Ghasabeh Timothy M.Pawlik Ihab R.Kamel russell h.morgan department of radiology and radiological sciences Johns Hopkins University School of MedicineBaltimoreMDUSA department of Surgery The Ohio State UniversityWexner Medical CenterColumbusOHUSA

One of the most common cancers worldwide, colorectal cancer (CRC) has been associated with significant morbidity and mortality and therefore represents an enormous burden to the health care system. Recent advances in CRC treatments have provided patients with primary and metastatic CRC a better long-term prognosis. The presence of synchronous or metachronous metastasis has been associated, however, with worse survival. The most common site of metastatic disease is the liver. A variety of treatment modalities aimed at targeting colorectal liver metastases (CRLM) has been demonstrated to improve the prognosis of these patients. Loco-regional approaches such as surgical resection and tumor ablation (operative and percutaneous) can provide patients with a chance at long-term disease control and even cure in select populations. Patient selection is important in defining the most suitable treatment option for CRLM in order to provide the best possible survival benefit while avoiding unnecessary interventions and adverse events. Medical imaging plays a crucial role in evaluating the characteristics of CRLMs and disease resectability. Size of tumors, proximity to adjacent anatomical structures, and volume of the unaffected liver are among the most important imaging parameters to determine the suitability of patients for surgical management or other appropriate treatment approaches. We herein provide a comprehensive overview of current-state-of-the-art imaging in the management of CRLM, including staging, treatment planning, response and survival assessment, and post-treatment surveillance. Computed tomography (CT) scan and magnetic resonance imaging (MRI) are two most commonly used techniques, which can be used solely or in combination with functional imaging modalities such as positron emission tomography (PET) and diffusion weighted imaging (DWI). Providing up-to-date evidence on advantages and disadvantages of imaging modalities and tumor assessment criteria, the current

关键词： Colorectal metastasis liver imaging tumor response

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Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth

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Genes & Diseases 2022年第3期9卷 717-730页

作者： Daqian Zhan Fatih Yalcin Ding Ma Yi Fu Shuang Wei Bachchu Lal Yunqing Li Omar Dzaye John Laterra Mingyao Ying hernando Lopez-Bertoni Shuli Xia Neurology Hugo IV.Moser Research Institute at Kennedy KriegerJohns Hopkins University School of MedicineBaltimoreMD 21205USA department of Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China department of radiology and Neuroradiology ChariteBerlin 10117Germany russell h.morgan department of radiology and radiological science Johns Hopkins University School of MedicineBaltimoreMD 21205USA department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China University hospital Center Schleswig holstein Department of NeurosurgeryKielSchleswig-Holstein 24105Germany departments of Neurology Oncology and NeuroscienceJohns Hopkins University School of MedicineBaltimoreMD 21205USA Blood and Cell Therapy Institute University of Science and Technology of ChinaAnhui Provincial HospitalHefeiAnhui 230026PR China

Glioblastoma(GBM,WhO grade IV glioma)is the most common and lethal malignant brain tumor in aduts with a dismal *** extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,migration,and immune *** diphosphate(UDP)-glucose 6-dehydrogenase(UGDh)is the rate-limiting enzyme that catalyzes the biosynthesis of glycosaminoglycans that are the principal component of the CNS *** investigated how targeting UGDh in GBM infuence$the GBM immune microenvironment,including tumor-associated microglia/macrophages(TAMs)and T *** are the main im-mune effector cells in GBM and can directly target tumor cells if properly *** co-cultures of GBM cells and human primary macrophages,UGDh knockdown in GBM cells pro-moted macrophage phagocytosis and M-like *** orthotropic human GBM xeno-grafts and syngeneic mouse glioma models,targeting UGDh decreased ECM deposition,increased TAM phagocytosis marker expression,reduced M2-like TAMS and inhibited tumor *** knockdown in GBM cells also promoted cytotoxic T cell ifltration and activa-tion in orthotopic syngeneic mouse glioma *** potent and in-human-use small mole-cule GAG synthesis inhibitor 4-methylumbelliferone(4-MU)was found to inhibit GBM cell proliferation and migration in vitro,mimic the macrophage and T-cell responses to UGDh knockdown in vitro and in vivo and inhibit growth of orthotopic murine *** study shows that UGDh supports GBM growth through multiple mechanisms and supports the development of ECM-based therapeutic strategies to simultaneously target tumor cells and their microenvi-ronment.

关键词： 4-MU Extracellular matrix(ECM) Glioblastoma(GBM) hyaluronic acid(hA) Phagocytosis T cells Tumor-associated microglia/macrophages(TAMs) UGDh

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Role of transcatheter arterial embolization for massive bleeding from gastroduodenal ulcers

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World Journal of Gastroenterology 2009年第47期15卷 5889-5897页

作者： Romaric Loffroy Boris Guiu the russell h morgan department of radiology and radiological science Division of Cardiovascular and Interventional Radiology The Johns Hopkins Hospital 600 North Wolfe Street Blalock 545 BaltimoreMD 21287 United States Division of Vascular and Interventional radiology University of Dijon School of Medicine Bocage Teaching Hospital 2 bd du Maréchal de Lattre de Tassigny BP 77908 21079 Dijon Cedex France

Intractable bleeding from gastric and duodenal ulcers is associated with significant morbidity and mortality. Aggressive treatment with early endoscopic hemostasis is essential for a favourable outcome. In as many as 12%-17% of patients,endoscopy is either not available or unsuccessful. Endovascular therapy with selective catheterization of the culprit vessel and injection of embolic material has emerged as an alternative to emergent operative intervention in high-risk patients. There has not been a systematic literature review to assess the role for embolotherapy in the treatment of acute upper gastrointestinal bleeding from gastroduo-denal ulcers after failed endoscopic hemostasis. here,we present an overview of indications,techniques,and clinical outcomes after endovascular embolization of acute peptic-ulcer bleeding. Topics of particular relevance to technical and clinical success are also discussed. Our review shows that transcatheter arterial embolization is a safe alternative to surgery for massive gastroduodenal bleeding that is refractory to endoscopic treatment,can be performed with high technical and clinical success rates,and should be considered the salvage treatment of choice in patients at high surgical risk.

关键词：十二指肠溃疡胃镜检查大出血肝动脉治疗栓塞导管上消化道出血

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高级影像检查在老年人X线隐匿性髋部骨折中的应用:系统综述及荟萃分析

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国际医学放射学杂志 2020年第6期 731-732页

作者：董力宁 A.haj-Mirzaian J.Eng R.Khorasani A.S.Raja A.S.Levin S.E.Smith The russell h.morgan department of radiology and radiological science Johns Hopkins University School of Medicine

摘要临床上怀疑有髋部骨折的老年病人中,X线摄影未发现但需行手术治疗的髋部骨折(即外科髋部骨折)的总发生率仍不清楚。此外,对这些病人进一步行高级影像检查的

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他汀类药物与表现为heberden结节的膝关节骨性关节炎的关系：来自于OAI的研究结果

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国际医学放射学杂志 2020年第1期 107-108页

作者： A. haj-Mirzaian B. Mohajer A. Guermazi P.G. Conagham J.A.C. Lima M.J. Blaha 邹明珠 department of Musculoskeletal radiology Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine

他汀类药物对于膝关节骨性关节炎(OA)影像学表现的确切影响,以及OA病人对他汀类药物的疗效反应特征尚不明确。目的探讨他汀类药物的应用对于依据heber-

关键词：他汀类药物 heberden 研究结果骨性关节炎 OAI

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Using the rPatlak plot and dynamic FDG-PET to generate parametric images of relative local cerebral metabolic rate of glucose

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Chinese science Bulletin 2012年第30期57卷 3811-3818页

作者： WU YiGen ZhOU Yun BAO ShangLian hUANG SungCheng ZhAO Xiaohu LI Jun School of Physics and Optoelectronic Engineering Nanjing University of lnformation Science and TechnologyNanjing 210044China Beijing City Key Laboratory of Medical Physics and Engineering Peking UniversityBeijing 100871China The russell h.morgan department of radiology and radiological science School of MedicineJohns Hopkins University.BaltimoreMD 21287USA department of Molecular and Medical Pharmacology UCLA David Geffen School of MedicineUniversity of California in Los AngelesLos AngelesCA 90095USA Imaging department of Tongji hospital of Tongji University Shanghai 200065China

Local cerebral metabolic rate of glucose(LCMRGlc) is an important index for the description of neural *** 18 F-fluoro-2-deoxy-D-glucose(FDG) positron emission tomography(PET) has been used for quantitative imaging of LCMRGlc in humans,but is seldom used routinely because of the difficulty in obtaining the input function noninvasively.A reference tissue-based Patlak plot model(rPatlak) was proposed to generate parametric images of LCMRGlc in a quantitative dynamic FDG-PET study without requiring blood *** emission scans(4×0.5,4×2 and 10×5 min) were acquired simultaneously with an IV bolus injection of 155 MBq of *** blood samples were collected during the scans via a catheter placed in the radial *** data were also generated using the same scan *** last ten scan data sets were used in a graphical analysis using the Patlak *** ratio of LCMRGlc estimated from the original Patlak(oPatlak,using plasma input) was used as the gold standard,and the standardized uptake value ratio(SUVR) was also calculated for *** different tissues including white matter,gray matter,and whole brain were chosen as reference tissues for *** of the reference region used,the slopes in the linear regression between oPatlak and rPatlak were closer to unity than the regression slopes between oPatlak and *** intercepts for the former were also closer to 0 than those for the latter *** squared correlation coefficients were close to 1.0 for both *** showed that the results of rPatlak were in good agreement with those of oPatlak,however,SUVR exhibited more *** simulation study also showed that the relative variance and bias for rPatlak were less than those for *** images obtained with rPatlak were very similar to those obtained with oPatlak,while there were differences in the relative spatial distribution between the images of SUVR and *** study validates that the rPatl

关键词： D-葡萄糖分布图像脑组织代谢率正电子发射断层扫描参数化情节输入功能

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表观扩散系数鉴别浆液性和黏液性胰腺囊性肿瘤的价值

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国际医学放射学杂志 2019年第6期 742-743页

作者： P.Pandey A.Pandey N.Shao F.N.Varzaneh M.A.Ghasabeh M.Zharghampour 杨琳 russell h.morgan department of radiology and radiological sciences Central Radiology Johns Hopkins University School of Medicine

摘要目的评估MR扩散加权成像(DWI)用于鉴别浆液性与黏液性胰腺囊性肿瘤(PCN)的价值。方法纳入117例PCN≥10 mm的病人。3名阅片者在是否使用表观扩散系

关键词：胰腺囊性肿瘤黏液性浆液性扩散系数

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偶然发现的胰腺囊性肿瘤的随访：基线MRI和CT的特征能预测囊肿的生长吗？

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国际医学放射学杂志 2019年第6期 728-729页

作者： P.Pandey A.Pandey Y.Luo M.A.Ghasabeh P.Khoshpouri S.Ameli 张瀚 russell h.morgan department of radiology and radiological sciences Johns Hopkins University School of Medicine

摘要目的使用修订的美国放射学会(ACR)建议评估偶然检测到的胰腺囊性肿瘤(PCN)在长期影像学随访中的增长情况,并评估基线成像的影像特征与生长之间的关联。

关键词：胰腺囊性肿瘤 CT MRI

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心脏CT评估致心律失常性右心室型心肌病的心外脂肪分布

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国际医学放射学杂志 2019年第1期 110-111页

作者： M.A.Ghasabeh A.S.J.M.Te Riele C.A.James h.S.Vincent Chen C.Tichnell B.Murray 刘会娜 The russell h. morgan department of radiology and radiological sciences Johns Hopkins University School of Medicine

摘要目的比较致心律失常性右心室型心肌病(ARVD/C)病人和健康对照组的心外膜脂肪差异。材料与方法回顾性对比研究2008年1月—2015年7月期间行心脏CT检查

关键词：心肌病心律失常右心室 CT

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Value of FDG PET/CT in the Management of Mesothelioma

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Journal of Pharmacy and Pharmacology 2016年第11期4卷 631-638页

作者： Mohamad Faizul Abu hanifa Mehdi Taghipour Fard Ardekani Rathan Subramaniam Perdana University Graduate School of Medicine Kuala Lumpur 50000 Malaysia The russell h. morgan department of radiology and radiological science Johns Hopkins Medicine Baltimore 21231 USA

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