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China CDC weekly 2021年第24期3卷 523-525页

作者： Si Chen Juana Du Fangmin Gong Hongwei Han Jianwen Li Jinjun Liang Patrick Wall Yongning Wu Zhenyi Li National Center for Food Safety Risk Assessment BeijingChina.National Health Commission Key Laboratory of Food Safety Risk AssessmentFood Safety Research Unit(2019RU014)of Chinese Academy of Medical ScienceBeijingChina royal Roads University VictoriaCanada Jishou University JishouHunanChina Hunan Disease Prevention and Control Center ChangshaChina University college Dublin DublinIreland.

Food safety is vital to the development of human *** December 20,2018,the United Nations General Assembly adopted resolution 73/250 proclaiming a World Food Safety *** of 2019,every June 7 is a time to increase social awareness of food safety and to encourage actions for good health *** Third World Food Safety Day on June 7,2021 aims to draw attention and inspire action to help prevent,detect,and manage foodborne risks,contributing to food security,human health,economic prosperity,agriculture,market access,tourism,and sustainable development(1).Food safety risk communication shifts from the traditional approach of one-way sender-oriented to a two-way audience-oriented communication approach.

关键词： promotion safety grading

Amplified optical transduction of proteins derived from Mo6S9-xIx nanowires

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Progress in Natural Science:Materials International 2013年第3期23卷 326-330页

作者： Nijuan Sun Martin McMullan Pagona Papakonstantinou Dragan Mihailovic Meixian Li college of Chemistry and Molecular Engineering Peking University School of Engineering University of UlsterNewtownabbeyCo.Antrim BT37 0QBNorthern IrelandUK Jozef Stefan Institute Jamova 39SI-1000 LjubljanaSlovenia

We demonstrate that Mo6S9-xIx nanowires(MoSI NWs) enable the detection of proteins with cytochrome c as a model protein using UV-vis *** association of cytochrome c with the nanowires was verified by scanning electroctron microscopy,X-ray photoelectron,light scattering and micro-FTIR *** results show that MoSI NWs is a promising nanostructure material for the development of ultrasensitive sensors for detecting *** new MoSI NW derived amplification bioassay is expected to provide a straightforward and effective strategy for protein analysis and biosensor construction.

关键词： Mo6S9-xIx nanowires Cytochrome c UV-vis spectrometry Amplification

Intraocular lens power calculation following laser refractive surgery

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Eye and Vision 2015年第1期2卷 63-70页

作者： Christopher Hodge Colm McAlinden Michael Lawless Colin Chan Gerard Sutton Aifric Martin Vision Eye Institute Level 3270 Avenue ChatwoodVictoriaNSWAustralia Save Sight Institute University of SydneySydneyNSWAustralia Flinders University Bedford ParkAdelaideSouth AustraliaAustralia Wenzhou Medical college WenzhouZhejiangChina School of Optometry and Vision Science University of New South WalesSydneyAustralia University college Dublin MontroseDublinIreland

Refractive outcomes following cataract surgery in patients that have previously undergone laser refractive surgery have traditionally been *** is related to several key issues including the preoperative assessment(keratometry)and intraocular lens power ***-reviewed literature is overwhelmed by the influx of methodology to manipulate the corneal or intraocular lens(IOL)powers following refractive *** would suggest that the optimal derivative formula has yet been *** review discusses the problems facing surgeons approaching IOL calculations in these post-refractive laser patients,the existing formulae and programs to address these *** published outcomes will be reviewed.

关键词： Cataract Laser refractive surgery Intraocular lens calculations

Osteogenic and antibacterial ability of micro-nano structures coated with ZnO on Ti-6Al-4V implant fabricated by two-step laser processing

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Journal of Materials Science & Technology 2022年第36期131卷 240-252页

作者： Yi Wan Zihe Zhao Mingzhi Yu Zhenbing Ji Teng Wang Yukui Cai Chao Liu Zhanqiang Liu Key Laboratory of High Efficiency and Clean Manufacturing School of Mechanical EngineeringShandong UniversityJinan 250061China Department of Oral and Maxilofacial Surgery Qilu Hospital of Shandong UniversityJinan 250012China Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) School of Mechanical and Materials EngineeringUniversity College DublinDublin D04 KW52Ireland School of Engineering Sciences in Chemistry Biotechnology and HealthKTH RoyalInstitute of TechnologyStockholmStockholm S-10044Sweden Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai 200011China

The biological performance of Ti-6Al-4V implant is primarily determined by their surface ***,traditional surface modification methods,such as acid etching,hardly make improvement in their osseointegration ability and antibacterial *** this study,we prepared a multi-scale composite structure coated with zinc oxide(ZnO)on Ti-6Al-4V implant by an innovative technology of two-step laser processing combined with *** with the acid etching method,the physicochemical properties of surface significantly *** in vitro results showed that the particular dimension of micro-nano structure and the multifaceted nature of ZnO synergistically affected MC3T3-E1 osteogenesis and bacterial activities:(1)The surface morphology showed a‘contact guidance'effect on cell arrangement,which was conducive to the adhesion of filopodia and cell spreading,and the osteogenesis level of MC3T3-E1 was enhanced due to the release of zinc ions(Zn^(2+));(2)the characterization of bacterial response revealed that periodic nanostructures and Zn^(2+)released could cause damage to the cell wall of *** and reduce the adhesion and aggregation of *** conclusion,the modified surface showed a synergistic effect of physical topography and chemical composition,making this a promising method and providing new insight into bone defect repairment.

关键词： Ti-6Al-4V implant Laser processing Micro-nano structure Zinc oxide Osseointegration ability Antibacterial capacity

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Renal calcification in children with renal tubular acidosis:What a paediatrician should know

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World Journal of Clinical Pediatrics 2023年第5期12卷 295-309页

作者： Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Samir Hasan Mohamed Basiony Hamza Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityDr.Sulaiman Al Habib Medical GroupManamaBahrainManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBahrainBusaiteen 15503MuharraqBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Chest Disease University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManamaManama 26671ManamaBahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain Department of Pediatrics Faculty of MedicineTanta University HospitalTanta 31511AlgharbiaEgypt Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt

Renal tubular acidosis(RTA)can lead to renal calcification in children,which can cause various complications and impair renal *** review provides pediatricians with a comprehensive understanding of the relationship between RTA and renal calcification,highlighting essential aspects for clinical *** article analyzed relevant studies to explore the prevalence,risk factors,underlying mechanisms,and clinical implications of renal calcification in children with *** show that distal RTA(type 1)is particularly associated with nephrocalcinosis,which presents a higher risk of renal ***,there are limitations to the existing literature,including a small number of studies,heterogeneity in methodologies,and potential publication *** data and control groups are also lacking,which limits our understanding of longterm outcomes and optimal management strategies for children with RTA and renal *** play a crucial role in the early diagnosis and management of RTA to mitigate the risk of renal calcification and associated *** addition,alkaline therapy remains a cornerstone in the treatment of RTA,aimed at correcting the acid-base imbalance and reducing the formation of kidney ***,early diagnosis and appropriate therapeutic interventions are paramount in preventing and managing renal calcification to preserve renal function and improve long-term outcomes for affected *** research with larger sample sizes and rigorous methodologies is needed to optimize the clinical approach to renal calcification in the context of RTA in the pediatric population.

关键词： Renal tubular acidosis Nephrocalcinosis Renal calcification Hypercalciuria Kidney stones Metabolic acidosis Children

Use of three-dimensional printing in preoperative planning in orthopaedic trauma surgery: A systematic review and meta-analysis

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World Journal of Orthopedics 2020年第1期11卷 57-67页

作者： Catrin Morgan Chetan Khatri Sammy A Hanna Hutan Ashrafian Khaled M Sarraf Trauma and Orthopaedics Imperial College NHS TrustLondon W21NYUnited Kingdom The royal London Hospital Barts Health NHS TrustLondon E11BBUnited Kingdom Department of Surgery and Cancer Imperial College LondonLondon W21NYUnited Kingdom

BACKGROUND With the increasing complexity of surgical interventions performed in orthopaedic trauma surgery and the improving technologies used in threedimensional(3D)printing,there has been an increased interest in the *** has been shown that 3D models allow surgeons to better visualise anatomy,aid in planning and performing complex *** is however not clear how best to utilise the technique and whether this results in better *** To evaluate the effect of 3D printing used in pre-operative planning in orthopaedic trauma surgery on clinical *** We performed a comprehensive systematic review of the literature and a ***,Ovid and Embase were searched from inception to February 8,*** controlled trials,case-control studies,cohort studies and case series of five patients or more were included across any area of orthopaedic *** primary outcomes were operation time,intra-operative blood loss and fluoroscopy *** Seventeen studies(922 patients)met our inclusion criteria and were *** use of 3D printing across all specialties in orthopaedic trauma surgery demonstrated an overall reduction in operation time of 19.85%[95%confidence intervals(CI):(-22.99,-16.71)],intra-operative blood loss of 25.73%[95%CI:(-31.07,-20.40)],and number of times fluoroscopy was used by 23.80%[95%CI:(-38.49,-9.10)].CONCLUSION Our results suggest that the use of 3D printing in pre-operative planning in orthopaedic trauma reduces operative time,intraoperative blood loss and the number of times fluoroscopy is used.

关键词： Orthopaedic surgery Trauma Three-dimensional printing

Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery

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World Journal of Gastroenterology 2015年第14期21卷 4150-4158页

作者： Susan Lapthorne Julie E Bines Fiona Fouhy Nicole L Dellios Guineva Wilson Sarah L Thomas Michelle Scurr Catherine Stanton Paul D Cotter Prue M Pereira-Fantini Intestinal Failure and Clinical Nutrition group Murdoch Childrens Research InstituteRoyal Children’s Hospital Intestinal Failure and Clinical Nutrition group Murdoch Childrens Research Institute Department of Paediatrics the University of Melbourne Department of Gastroenterology and Clinical Nutrition Royal Children’s Hospital Teagasc Food Research Centre MooreparkFermoyCorkIreland Department of Microbiology University College Cork Department of Surgery Monash Medical Centre Alimentary Pharmabiotic Centre University College Cork

AIM: To investigate the impact of minor abdominal surgery on the caecal microbial population and on markers of gut ***: Four week old piglets were randomly allocated to a no-surgery "control" group(n = 6) or a "transection surgery" group(n = 5).During the transection surgery procedure, a conventional midline incision of the lower abdominal wall was made and the small intestine was transected at a site 225 cm proximal to the ileocaecal valve, a 2 cm segment was removed and the intestine was *** received a polymeric infant formula diet throughout the study period and were sacrificed at two weeks *** outcomes including weight, stool consistency and presence of stool fat globules were *** throughput DNA sequencing of colonic content was used to detect surgery-relateddisturbances in microbial composition at phylum, family and genus *** and richness estimates were calculated for the control and minor surgery *** disturbances in the gut microbial community are linked to inflammation we compared the gene expression of key inflammatory cytokines(TNF, IL1 B, IL18, IL12, IL8, IL6 and IL10) in ileum, terminal ileum and colon mucosal extracts obtained from control and abdominal surgery groups at two weeks ***: Changes in the relative abundance of bacterial species at family and genus level were confined to bacterial members of the Proteobacteria and Bacteroidetes *** level compositional shifts included a reduction in the relative abundance of Enterobacteriaceae(22.95 ± 5.27 vs 2.07 ± 0.72, P < 0.01), Bacteroidaceae(2.54 ± 0.56 vs 0.86 ± 0.43, P < 0.05) and Rhodospirillaceae(0.40 ± 0.14 vs 0.00 ± 0.00, P < 0.05) following transection ***, at the genus level, changes associated with transection surgery were restricted to members of the Proteobacteria and Bacteroidetes phyla and included decreased relative abundance of Enterobacteriaceae(29.20 ± 6.74 vs 2.88 ±

关键词： Surgery Intestinal Microbiota Dysbiosis Inflammati

NICE指南成年人便失禁的处理:英国国家卫生和临床医疗优选研究所指南概要

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英国医学杂志中文版 2007年第6期10卷 375-377页

作者： Christine Norton Louise Thomas Jennifer Hill 陶梅梅 Florence Nightingale School of Nursing and Midwifery King'S College LondonLondon Buraett projessor of gastrointestinal nursing National Collaborating Centre for Acute Care Royal College of Surgeons of EnglandLondon WC2A 3PE project lead National Collaborating Centre for Acute Care Royal College of Surgeons of EnglandLondon WC2A 3PE Director for the Guideline Development Group

为什么阅读本概要？便失禁在社区中成年人中的发病率是1％～10％，这与采用的便失禁定义不同相关。便失禁是一个容易被忽视的问题，在医学界很少受到关注；尽管其存在巨大的不良影响，但大多数患者在就医时很少和医生提及。实际上，简... 详细信息

为什么阅读本概要？便失禁在社区中成年人中的发病率是1％～10％，这与采用的便失禁定义不同相关。便失禁是一个容易被忽视的问题，在医学界很少受到关注；尽管其存在巨大的不良影响，但大多数患者在就医时很少和医生提及。实际上，简单、经济的干预措施就可以改善甚至将其治愈。尽管已有详尽的二线调研和治疗方法，但是有关的参考资料仍然很少。

关键词：便失禁成年人 NICE 临床医疗研究所指南优选卫生

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Identification and mapping of Rpi-blb4 in diploid wild potato species Solanum bulbocastanum

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The Crop Journal 2023年第6期11卷 1828-1835页

作者： Jie Li Amanpreet Kaur Brian Harrower Miles Armstrong Daolong Dou Xiaodan Wang Ingo Hein Department of Plant Pathology and MOA Key Lab of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193China The James Hutton Institute InvergowrieDundee DD25DAUK University of Dundee Dundee DD14HNUK Crop Research Centre TeagascOakParkCarlow R93 XE12Ireland college of Plant Protection Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095JiangsuChina

More than 170 years after causing the potato famine in ireland,late blight is still considered one of the most devastating crop *** potato breeding efforts depend on natural sources of resistance to protect crops from the rapidly evolving late blight pathogen,Phytophthora *** have identified and mapped a novel broad-spectrum disease resistance gene effective against *** from the wild,diploid potato species Solanum *** resistance gene enrichment sequencing(dRenSeq)was used to confirm the uniqueness of the identified *** and GenSeq-based mapping of the resistance,referred to as Rpi-blb4,alongside recombinant screening,positioned the locus responsible for the resistance to potato chromosome *** interval spans approximately 2.3 Mb and corresponds to the DM reference genome positions of 11.25 and 13.56 Mb.

关键词： Renseq Disease resistance Late blight Solanum bulbocastanum

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Time spent in hospital after liver transplantation:Effects of primary liver disease and comorbidity

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World Journal of Transplantation 2016年第4期6卷 743-750页

作者： Chutwichai Tovikkai Susan C Charman Raaj K Praseedom Alexander E Gimson Jan van der Meulen Hepatopancreatobiliary and Transplant Surgery Unit Division of General Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Mahidol University Clinical Effectiveness Unit the Royal College of Surgeons of England Department of Surgery University of Cambridge Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine Liver Transplant Unit Addenbrooke’s Hospital Cambridge University Hospital NHS Foundation Trust

AIM To explore the effect of primary liver disease and comorbidities on transplant length of stay(TLOS) and LOS in later admissions in the first two years after liver transplantation(LLOS). METHODS A linked United Kingdom Liver Transplant Audit- Hospital Episode Statistics database of patients who received a first adult liver transplant between 1997 and 2010 in Englandwas analysed. Patients who died within the first two years were excluded from the primary analysis, but a sensitivity analysis was also performed including all patients. Multivariable linear regression was used to evaluate the impact of primary liver disease and comorbidities on TLOS and LLOS. RESULTS In 3772 patients, the mean(95%CI) TLOS was 24.8(24.2 to 25.5) d, and the mean LLOS was 24.2(22.9 to 25.5) d. Compared to patients with cancer, we found that the largest difference in TLOS was seen for acute hepatic failure group(6.1 d; 2.8 to 9.4) and the largest increase in LLOS was seen for other liver disease group(14.8 d; 8.1 to 21.5). Patients with cardiovascular disease had 8.5 d(5.7 to 11.3) longer TLOS and 6.0 d(0.2 to 11.9) longer LLOS, compare to those without. Patients with congestive cardiac failure had 7.6 d longer TLOS than those without. Other comorbidities did not significantly increase TLOS nor *** The time patients spent in hospital varied according to their primary liver disease and some comorbidities. Time spent in hospital of patients with cancer was relatively short compared to most other indications. Cardiovascular disease and congestive cardiac failure were the comorbidities with a strong impact on increased LOS.

关键词： Length of stay Hospital stay Comorbidity Liver transplantation