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Direct in vivo injection of ^(131)I-GMS and its distribution and excretion in rabbit

World Journal of Gastroenterology 2010年第17期16卷 2120-2128页

作者： Yu Ma,Yi Wan,Li-Geng Duan,Xiao-Li Chen,the research unit of hepato-bilio-pancreatology and department of hepatic surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China Dong-Hui Luo,Chuan-Qin Xia,College of Chemistry,Sichuan University,Chengdu 610041,Sichuan Province,China Lin Li,department of Nuclear Medicine and The National Key Discipline of Medical Imaging and Nuclear Medicine,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China the research unit of hepato-bilio-pancreatology and department of hepatic surgery West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China.

AIM: To explore the distribution and metabolism of 131 I-gelatin microspheres ( 131 I-GMSs) in rabbits after direct injection into rabbits’ ***: Twenty-eight healthy New Zealand rabbits were divided into seven groups,with four rabbits per *** rabbit’s hepatic lobes were directly injected with 41.336 ± 5.106 MBq 131 *** day after 131 I-GMSs administration,4 rabbits were randomly selected,and 250 μL of serum was collected for γ *** and thyroid functions were tested on days 1,4,8,16,24,32,48 and 64 after 131 I-GMSs ***-photon emission computed tomography (SPECT) was taken for each group on days 0,1,4,8,16,24,32,48,64 after 131 I-GMSs administration.A group of rabbits were sacrificed respectively on days 1,4,16,24,32,48,64 after 131 I-GMSs *** livers were taken out for histological ***: After 131 I-GMSs administration,the nuclide was collected in the hepatic area with *** radiation could be detected on day 48 after 131 IGMSs administration,and radiography could be seen in thyroid areas in SPECT on days 4,8,16 and *** day after 131 I-GMSs administration,the liver function was damaged but recovered 4 d *** days after 131 I-GMSs administration,the levels of free triiodothyronine and free thyroxin were reduced,which restored to normal levels on day *** examination showed that the microspheres were degraded to different degrees at 24,32 and 48 d after 131 I-GMSs *** surrounding parts of injection points were in fibrous *** microspheres were detected in histological examination on day 64 after 131 I-GMSs ***: Direct in vivo injection of 131 I-GMSs is safe in *** may be a promising method for treatment of malignant tumors.

关键词： 131 I Label Gelatin microspheres Animal Rabbit hepatic Direct injection

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Long-term sustained clinical remission of peritoneal metastatic pancreatic ductal adenocarcinoma after sequential chemoradiation therapy: a case report

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胰腺病学杂志(英文) 2024年第3期07卷 233-236页

作者： Yang Sen Hua Yuze Liu Qiaofei Liao Quan department of General surgery Key Laboratory of Research in Pancreatic Tumor State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China

Patients with peritoneal metastatic pancreatic ductal adenocarcinoma (pmPDAC) with high-level serum carbohydrate antigens (CAs) always suffer extremely dismal prognosis, with a median survival of several months. Herein, we reported a case of pmPDAC with high serum CAs who had long-term clinical remission with normalization of CAs after chemoradiation. In November 2019, a 64-year-old male patient was admitted to our center with a solid mass measuring 2.8 × 2.5 × 2.0 cm in the body of the pancreas near the celiac trunk. Positron emission tomography-computed tomography (PET-CT) revealed an standardized uptake value max (SUVmax) of 4.2. The serum CA 242 level exceeded 150.0 U/mL (normal range: 0–20 U/mL), and CA 19-9 was elevated at 975.2 U/mL (normal range: 0–34 U/mL). During laparotomy, the tumor was found to encircle the celiac trunk over 180°, with several small peritoneal nodules in the lesser omental cavity. Pathological examination confirmed the diagnosis of pmPDAC. Next-generation sequencing revealedRAS G12V, EGFR mutation (-), low tumor mutation burden (TMB), and microsatellite stability (MSS). The patient underwent 6 cycles of the AG regimen (gemcitabine plus nab-paclitaxel), resulting in significant tumor shrinkage and a sharp decline in CAs. Partial remission was achieved. However, due to intolerant neurotoxicity, the AG regimen was discontinued. Subsequently, synchronous oral fluorouracil (S1) and radiation therapy were administered. Five months after radiation treatment, all CAs normalized. Oral S1 was continued for an additional 3 months. Eventually, all anti-cancer drugs were stopped. Computed tomography scans indicated that the tumor still surrounded the celiac trunk and common hepatic artery. After a thorough discussion, a wait-and-see strategy was adopted. Remarkably, 32 months after stopping anti-cancer medication, the patient remains in good health, with sustained normalization of CAs. At the last follow-up, he had lived for 50 months, and the norma

关键词： Chemoradiation Clinical remission Peritoneal metastatic pancreatic cancer

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Metastatic well-differentiated pancreatic neuroendocrine tumors to the liver: a narrative review of systemic and surgical management

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Journal of pancreatology 2021年第2期4卷 82-89页

作者： Tanaz Vaghaiwalla Kelvin Memeh Chih-Yi Liao Xavier M.Keutgen department of surgery Division of General SurgeryUniversity of Tennessee Graduate School of MedicineKnoxvilleTN b department of surgery Division of Surgical OncologyEndocrine Surgery Research ProgramUniversity of Chicago Medicine department of Medicine Section of Hematology and OncologyUniversity of Chicago MedicineChicagoILUSA

Pancreatic neuroendocrine tumors(PNETs)are a rare group of neoplasms originating from the endocrine *** are classified as functional or non-functional *** are more often diagnosed at a higher stage with distant metastases or advanced locoregional *** majority of individuals with hepatic metastases will ultimately die of liver failure;therefore,the treatment of liver tumor burden is critical to providing a survival *** surgical resection remains the only chance of cure for disease confined to the pancreas or for locoregional disease,the treatment of advanced or metastatic PNETs is more complex and often requires a multimodal *** review focuses on treatment options for well and moderately differentiated PNETs with metastatic disease to the *** include surgery,liver-directed therapies including ablative and intra-arterial therapies,and systemic therapies such as somatostatin analogues,targeted therapies,chemotherapy,and peptide receptor radionuclide *** an individualized treatment strategy requires careful assessment of liver tumor burden and predicted biological *** surgical resection of hepatic metastases secondary to PNET primary tumors is associated with improved survival in multiple retrospective *** goals of treatment for metastatic disease include prolonging overall survival and progression free survival,improving quality of life,and control of symptoms.

关键词： hepatic cytoreduction Metastatic disease Pancreatic neuroendocrine tumor Peptide receptor radionuclide therapy Review

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Biliary obstruction following transjugular intrahepatic portosystemic shunt placement in a patient after liver transplantation:A case report

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World Journal of hepatology 2022年第5期14卷 1038-1046页

作者： Peter Macinga Darina Gogova Jan Raupach Jana Jarosova Libor Janousek Eva Honsova Pavel Taimr Julius Spicak Jiri Novotny Jan Peregrin Tomas Hucl department of Gastroenterology and hepatology Institute for Clinical and Experimental MedicinePrague 14021Czech Republic department of Radiology University HospitalHradec Kralove 50005Czech Republic department of Transplant surgery Institute for Clinical and Experimental MedicinePrague 14021Czech Republic department of Pathology Institute for Clinical and Experimental MedicinePrague 14021Czech Republic department of Diagnostic and Interventional Radiology Institute for Clinical and Experimental MedicinePrague 14021Czech Republic

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a method used to decrease portal *** stricture is the rarest of the complications associated with this procedure with only 12 cases previously reported in the *** of these cases have documented the resolution of biliary stenosis induced by a stent *** only curative solutions reported are liver transplantation or bypassing the stenosis with an artificial biliary tract using advanced endoscopic *** SUMMARY This is the first reported case of biliary obstruction secondary to TIPS placement in a transplanted *** our patient,a portosystemic shunt was created to treat severe veno-occlusive liver graft disease manifesting itself primarily by fluid retention.A cholestatic liver lesion and cholangitis with abscesses developed due to a stent graft-induced stricture in the dorsal segment of the right hepatic duct and the stricture diminished following percutaneous *** drainage was performed after unsuccessful removal of the percutaneous catheter resulting in a bilio-cutaneous *** the liver graft now functions well,the stricture remains refractory even after 44 mo of *** Biliary strictures caused by TIPS in both transplanted and native livers seem refractory to endoscopic treatment.

关键词： Biliary stricture Transjugular intrahepatic portosystemic shunt Liver trans-plantation Sinusoidal obstruction syndrome Literature review Case report

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The Chinese guidelines for the diagnosis and treatment of pancreatic neuroendocrine neoplasms(2020)

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Journal of pancreatology 2021年第1期4卷 1-17页

作者： Wenming Wu Jie Chen Chunmei Bai Yihebali Chi Yiqi Du Shiting Feng Li Huo Yuxin Jiang Jingnan Li Wenhui Lou Jie Luo Chenghao Shao Lin Shen Feng Wang Liwei Wang Ou Wang Yu Wang Huanwen Wu Xiaoping Xing Jianming Xu Huadan Xue Ling Xue Yang Yang Xianjun Yu Chunhui Yuan Hong Zhao Xiongzeng Zhu Yupei Zhao on behalf of the Chinese Pancreatic surgery Association department of General surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing department of Gastroenterology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong Province department of Medical Oncology Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing department of Medical Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing department of Gastroenterology Changhai Hospital Affiliated to Navy Medical UniversityShanghai department of Radiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong Province department of Nuclear Medicine Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing department of Ultrasound Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing department of General surgery Zhongshan Hospital of Fudan University department of Pathology China-Japan Friendship HospitalBeijing department of Pancreatic-biliary surgery Changzheng HospitalNavy Medical UniversityShanghai department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijing department of Nuclear Medicine Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu Province department of Oncology Renji HospitalShanghai JiaoTong University School of MedicineShanghai department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sc

Pancreatic neuroendocrine neoplasms(pNENs)are highly heterogeneous,and the management of pNENs patients can be *** address this challenge,an expert committee was established on behalf of the Chinese Pancreatic surgery Association,which consisted of surgical oncologists,gastroenterologists,medical oncologists,endocrinologists,radiologists,pathologists,and nuclear medicine *** reviewing the important issues regarding the diagnosis and treatment of pNENs,the committee concluded evidence-based statements and recommendations in this article,in order to further improve the management of pNENs patients in China.

关键词： Diagnosis Guidelines Pancreatic Neuroendocrine Neoplasm Treatment

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