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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi Yang Stroke center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience research center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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IEEE standard pioneered an IT-led interdisciplinary approach to structure low-altitude airspace for uav operations

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Science China(Information Sciences) 2022年第10期65卷 295-296页

作者： Chenchen XU Xiaohan LIAO Fei YANG State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences the research center for uav applications and regulation Chinese Academy of Sciences Office of Air Traffic regulation Civil Aviation Administration of China (CAAC)

Unmanned aerial vehicles(uavs) equiped with state-of-theart information and automation technologies are developing rapidly, especially in low-altitude airspace within 1000 m above ground. Many commercialized uav flights may soon jam this slice of airspace. Thus, the IEEE Communications Society has established a working group to develop a standard for structuring a low-altitude airspace framework for uav operation.

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Iterative construction of low-altitude uav air route network in urban areas:Case planning and assessment

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Journal of Geographical Sciences 2020年第9期30卷 1534-1552页

作者： XU Chenchen LIAO Xiaohan YE Huping YUE Huanyin Institute of Geographic Sciences and Natural Resources research CASState Key Laboratory of Resources and Environmental Information SystemBeijing 100101China University of Chinese Academy of Sciences Beijing 100190China Institute of uav Application research Tianjin and CASTianjin 301800China the research center for uav applications and regulation CASBeijing 100101China

With the rapid increase of Unmanned Aircraft Vehicle(uav) numbers,the contradiction between extensive flight demands and limited low-altitude airspace resources has become increasingly *** ensure the safety and efficiency of low-altitude uav operations,the low-altitude uav public air route creatively proposed by the Chinese Academy of Sciences(CAS) and supported by the Civil Aviation Administration of China(CAAC) has been gradually ***,present planning research on uav low-altitude air route is not enough to explore how to use the ground transportation infrastructure,how to closely combine the surface pattern characteristics,and how to form the mechanism of "network".Based on the solution proposed in the early stage and related researches,this paper further deepens the exploration of the low-altitude public air route network and the implementation of key technologies and steps with an actual case study in Tianjin,***,a path-planning environment consisting of favorable spaces,obstacle spaces,and mobile communication spaces for uav flights was ***,air routes were planned by using the conflict detection and path re-planning *** study also assessed the network by computing the population exposure risk index(PERI) and found that the index value was greatly reduced after the construction of the network,indicating that the network can effectively reduce the operational *** this study,a low-altitude uav air route network in an actual region was constructed using multidisciplinary approaches such as remote sensing,geographic information,aviation,and transportation;it indirectly verified the rationality of the *** can provide practical solutions to low-altitude traffic problems in urban areas.

关键词： uav air route network urban area iterative construction remote sensing geographic information

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A Comprehensive Taxi Assessment Index Using Floating Car Data

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Journal of Harbin Institute of Technology(New Series) 2014年第1期21卷 7-16页

作者： Dao-Zheng Zhang Daniel (Jian) Sun Zhong-Ren Peng center for uav applications and ITS research Shanghai Jiaotong University Department of Urban and Regional Planning University of Florida

With the expansion of urban area and development of taxi system,problems arise,such as low operation efficiency,high taxi idling rate,and long passenger waiting-time. Although various studies have been conducted,only limited overview of the factors towards urban taxi system has been provided. Consequently,a comprehensive evaluation of taxi system is essential for the urban planner to analyze the current situation and take effective measures. This paper,by using Floating Car Data( FCD),proposes a Comprehensive Taxi Assessment Index( CTAI) to quantify the quality of existing urban taxi system with the assistance of Geographic Information System( GIS) technology. The proposed index system extracts and classifies key factors,reflecting the taxi system from the perspectives of operation efficiency,customer and taxi-driver satisfaction. The system contributes to improving the organization and operation of urban taxi system. Based on the data obtained from the city of Shenzhen,Guangdong Province,China,for both weekday and weekends( Dec.,2011),the proposed CTAI was illustrated by using the Principal Component Analysis( PCA) with ArcGIS 10. 0 platform. The results indicate that the system provides a good multi-dimensional view to delve into the existing urban taxi operation, thus to point out the most sensitive indices towards the entire system,which consequently provides guidelines for future improvement and management of urban taxi system.

关键词： taxi evaluation system principle component analysis(PCA) floating car data(FCD) geographic information system(GIS)

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Freight Vehicle Routing Optimization for Sporadic Orders Using Floating Car Data

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Journal of Donghua University(English Edition) 2013年第2期30卷 96-102页

作者：常晶晶彭仲仁孙健 center for ITS and uav applications research Shanghai Jiaotong University Department of Urban and Regional Planning University of Florida

The increasing popularity of e-commerce brings large volumes of sporadic orders from different customers,which have to be handled by freight trucks and distribution centers. To improve the level of service and reduce the total shipping cost as well as traffic congestions in urban area, flexible methods and optimal vehicle routing strategies should be adopted to improve the efficiency of distribution effort. An optimization solution for vehicle routing and scheduling problem with time window for sporadic orders (VRPTW- S) was provided based on time-dependent travel time extracted from floating car data (FCD) with ArcGIS platform. A VRPTW-S model derived from the traditional vehicle routing problem was proposed, in which uncertainty of customer orders and travel time were considered. Based on this model, an advanced vehicle routing algorithm was designed to solve the problem. A case study of Shenzhen, Guangdong province, China, was conducted to demonstrate the vehicle operation flow,in which process of FCD and efficiency of delivery systems under different situations were discussed. The final results demonstrated a good performance of application of time-dependent travel time information using FCD in solving vehicle routing problems.

关键词： freight routing and scheduling time-dependent travel time floating car data (FCD) sporadic order ArcGIS

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Analyzing Spatio-Temporal Distribution Pattern and Correlation for Taxi and Metro Ridership in Shanghai

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Journal of Shanghai Jiaotong university(Science) 2019年第2期24卷 137-147页

作者： YE Yingwei SUN Jian LUO Jing State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University center for ITS and uav applications research Shanghai Jiao Tong University

Taxicab is an important mode in urban transportation system, while the role of taxicabs, especially the relationship with metro system has not been fully studied. This study aims at exploring the factors influencing the role played by taxicabs in Shanghai, China. Firstly, taxi trips are categorized into three types, namely metroreplaceable(MR), metro-extending(ME) and metro-supplement(MS) ones. Then, the tendency of travelers towards taxi or metro at a specific metro station is proposed and calculated on the basis of MR taxi trips and metro trips. Factors influencing the tendency are investigated through semi-parametric regression models, with the results indicating that the most significant factors and the influencing radii during the peak and off-peak hours are different. Some built environment factors, such as the number of hospitals and government agencies, have significant positive relationship with the tendency in the time periods. Furthermore, land use related factors, such as the increase of forestry and commercial land, generally promote taxi-hiring in the off-peak hours, while they have a negative impact during the peak hours. Findings of this study can assist governments and policy makers to understand the impact of built environment and land use on trip patterns, and thus may contribute to more reasonable policies and optimized urban planning, which may promote modal switch from taxi to subway.

关键词： taxi trip global positioning system(GPS) role of taxi industry semi-parametric model

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A PSO-SVM Model for Short-Term Travel Time Prediction Based on Bluetooth Technology

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Journal of Harbin Institute of Technology(New Series) 2015年第3期22卷 7-14页

作者： Qun Wang Zhuyun Liu Zhongren Peng center for ITS and uav applications research Shanghai Jiao Tong University School of Transportation Science and Engineering Harbin Institute of Technology Department of Urban and Regional Planning University of Florida

The accurate prediction of travel time along roadway provides valuable traffic information for travelers and traffic managers. Aiming at short-term travel time forecasting on urban arterials,a prediction model( PSOSVM) combining support vector machine( SVM) and particle swarm optimization( PSO) is developed. Travel time data collected with Bluetooth devices are used to calibrate the proposed model. Field experiments show that the PSO-SVM model 's error indicators are lower than the single SVM model and the BP neural network( BPNN) model. Particularly,the mean-absolute percentage error( MAPE) of PSO-SVM is only 9. 453 4 %which is less than that of the single SVM model( 12. 230 2 %) and the BPNN model( 15. 314 7 %). The results indicate that the proposed PSO-SVM model is feasible and more effective than other models for shortterm travel time prediction on urban arterials.

关键词： urban arterials travel time prediction Bluetooth detection support vector machine(SVM) particle swarm optimization(PSO)

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Investigation of the spatiotemporal variation and influencing factors on fine particulate matter and carbon monoxide concentrations near a road intersection

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Frontiers of Earth Science 2017年第1期11卷 63-75页

作者： Zhanyong WANG Qing-Chang LU Hong-Di HE Dongsheng WANG Ya GAO Zhong-Ren PENG center for ITS and uav applications research State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean & Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China Logistics research center Shanghai Maritime University Shanghai 201306 China Department of Urban and Regional Planning University of Florida Gainesville FL 32611-5706 USA

The minute-scale variations of fine particulate matter （PM2.5） and carbon monoxide （CO） concentrations near a road intersection in Shanghai, China were investigated to identify the influencing factors at three traffic periods. Measurement results demonstrate a synchronous variation of pollutant concentrations at the roadside and setbacks, and the average concentration of PM2.5 at the roadside is 7% （44% for CO） higher than that ofsethacks within 500 m of the intersection. The pollution level at traffic peak periods is found to be higher than that of off-peak periods, and the morning peak period is found to be the most polluted due to a large amount of diesel vehicles and unfavorable dispersion conditions. Partial least square regressions were constructed for influencing factors and setback pollutant concentrations, and results indicate that meteorological factors are the most significant, followed by setback distance from the intersection and traffic factors. CO is found to be sensitive to distance from the traffic source and vehicle type, and highly dependent on local traffic conditions, whereas PM2.5 originates more from other sources and background levels. These findings demonstrate the importance of localized factors in understanding spatiotemporal patterns of air pollution at intersections, and support decision makers in roadside pollution management and control.

关键词： traffic-related pollutants fine-scale variation distance gradient meteorology road intersection

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Improved Model of Start-Wave Velocity at Intersections Based on Unmanned Aerial Vehicle Data

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Journal of Donghua University(English Edition) 2016年第1期33卷 13-19页

作者：王宏伟程珂路庆昌彭仲仁 State Key Laboratory of Ocean Engineering Center for UAV Applications and ITS ResearchShanghai Jiao Tong University School of Transportation Engineering Tongji University Department of Urban and Regional Planning University of Florida

The basic parameters involved in current start-wave theoretical models such as density and velocity are difficult to obtain through traditional traffic detection devices. Thus it is hard to apply these theoretical models to the actual verification and prediction for real situation. Unmanned aerial vehicle( uav),which can shoot aerial video and identify vehicles, roads and other objects, is introduced in this study as a new type of traffic information collection method to gather the real-time data of the necessary parameters. An improved start-wave velocity model is proposed,where the speed and density of traffic flow are converted into vehicle space headway,mean vehicle length and other auxiliary parameters which can be recognized from aerial video or other means. A uav was used for video shooting at intersections in a flight experiment in order to verify the accuracy of the calculated start-wave *** mean absolute error rate between the calculated velocity and the actual velocity is 2. 277%. Moreover, the improved start-wave velocity model showed much better accuracy than the traditional start-wave velocity model. The results indicate that the improved model is accurate enough to be used for model calibration and validation in signal timing optimization.

关键词： unmanned aerial vehicle(uav) traffic wave theory queue length dissipation time start-wave velocity

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Impacts of Bus Lane on Bus Travel Time Reliability:a Case Study in Shenzhen

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Journal of Donghua University(English Edition) 2017年第2期34卷 189-194页

作者：鲁雯卓路庆昌彭仲仁孙健 center for ITS and uav applications research State Key Laboratory of Ocean EngineeringSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong University Department of Urban and Regional Planning University of Florida

The aim of the paper is to evaluate the impacts of bus lane on bus travel time *** data used are the Geographic Positioning System(GPS) data of two bus lines running parallel streets in Shenzhen,China,one of which is a bus lane and the other is a regular *** linear regression models are developed to evaluate the influence of bus lane which has a separated right of *** factors including running direction,day of week,time of day,dwell time,and delay at the start point are also considered in the *** published time tables,coefficient of variance(CV) of travel time is employed to explore the impacts of bus *** results indicate that bus lane can save 22.0% of travel time,reduce 11.5% of the CV of travel time,and decrease the variance of headway by 17.4%.The analysis on bus travel time reliability could help operators and drivers improve the quality of transit *** also sheds light on how to assess the effectiveness of bus lane for transit planners and service operators.

关键词： bus lane travel time travel time reliability Geographic Positioning System(GPS) data

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