检索结果-南通市图书馆

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and replication.RRM2 performs a critical role in the malignant biological behaviors of cancers.The structure,regulation,and function of RRM2 and its inhibitors were discussed.RRM2 gene can produce two transcripts encoding the same ORF.RRM2 expression is regulated at multiple levels during the processes from transcription to translation.Moreover,this gene is associated with resistance,regulated cell death,and tumor immunity.In order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different mechanisms.Thus,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor microenvironment.Moreover,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integration of advanced biotechnology for green carbon

引用

Green Carbon 2024年第2期2卷 164-175页

作者： Miao Wang Yixiang Wang Jingyuan Liu Hua Yu Peng Liu Yujing Yang Dan Sun Heng Kang Yanting Wang Jingfeng Tang Chunxiang Fu Liangcai Peng key laboratory of fermentation engineering(Ministry of Education) National"111"Center for Cellular Regulation&Molecular PharmaceuticsCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)Hubei Key Laboratory of Industrial MicrobiologyBiomass&Bioenergy Research CenterHubei University of TechnologyWuhan 430068China College of Plant Science&Technology Huazhong Agricultural UniversityWuhan 430070China Shandong provincial key laboratory of Energy Genetics CAS Key Laboratory of BiofuelsQingdao Institute of Bioenergy&Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China

Carbon neutralization has been introduced as a long-term policy to control global warming and climate change.As plant photosynthesis produces the most abundant lignocellulosic biomass on Earth,its conversion to biofuels and bioproducts is considered a promising solution for reducing the net carbon release.However,natural lignocellulose recalcitrance crucially results in a costly biomass process along with secondary waste liberation.By updating recent advances in plant biotechnology,biomass engineering,and carbon nanotechnology,this study proposes a novel strategy that integrates the genetic engineering of bioenergy crops with green-like biomass processing for cost-effective biofuel conversion and high-value bioproduction.By selecting key genes and appropriate genetic manipulation approaches for precise lignocellulose modification,this study highlights the desirable genetic site mutants and transgenic lines that are raised in amorphous regions and inner broken chains account for high-density/length-reduced cellulose nanofiber assembly in situ.Since the amorphous regions and inner-broken chains of lignocellulose substrates are defined as the initial breakpoints for enhancing biochemical,chemical,and thermochemical conversions,desirable cellulose nanofibers can be employed to achieve nearcomplete biomass enzymatic saccharification for maximizing biofuels or high-quality biomaterials,even under cost-effective and green-like biomass processes in vitro.This study emphasizes the optimal thermal conversion for generating high-performance nanocarbons by combining appropriate nanomaterials generated from diverse lignocellulose resources.Therefore,this study provides a perspective on the potential of green carbon productivity as a part of the fourth industrial revolution.

关键词： Lignocellulose biofuels Nanomaterials Nanocarbon Genetic engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis and Characterization of Carboxyl-terminated Polyethylene Glycol Functionalized Mesoporous Silica Nanoparticles

引用

Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1540-1545页

作者：王瑜 WANG Youyun WANG Wanxia ZHU Hongda 刘明星 key laboratory of fermentation engineering (Ministry of Education) Hubei Provincial Cooperative Innovation Center of Industrial Fermentation National "111" Center for Cellular Regulation and Molecular Pharmaceutics Hubei Key Laboratory of Industrial MicrobiologyHubei University of Technology

Colloidal mesoporous silica nanoparticles functionalized with carboxy-terminated polyethylene glycol(CMS-PEG-COOH) were successfully synthesized by covalently grafting dicarboxy-terminated polyethylene glycol(HOOC-PEG-COOH) on the surface of the amino functionalized CMS nanoparticles with amide bond as a cross linker. Moreover, the structural and particle properties of CMS-PEG-COOH were characterized by nuclear magnetic resonance spectroscopy(1 H-NMR), transmission electron microscopy(TEM), dynamic light scattering(DLS), nitrogen adsorption-desorption measurements, X-ray diffraction(XRD), and Fourier transform infrared spectroscopy(FT-IR). The nanomaterials presented a relatively uniform spherical shape morphology with diameters of about 120 nm,and favorable dispersibility in weak acid solution. The CMSPEG-COOH exhibited no changes in the state of amorphous, while the mesopores sizes of 5.25 nm might provide the nanomaterials with large capacity for the loading and releasing of drugs. So the results indicated that CMSPEG-COOH might be a critical nanomaterial for drug delivery system in the future.

关键词： mesoporous silica nanoparticles polyethylene glycol functionalization carboxy-terminated synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in the study of hepatitis B virus covalently closed circular DNA

引用

Virologica Sinica 2017年第6期32卷 454-464页

作者： Mengying Ji Kanghong Hu Sino-German biomedical Center Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Provincial Cooperative Innovation Center of Industrial FermentationNational"111"Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan 430068China

Chronic hepatitis B infection is caused by hepatitis B virus(HBV) and a total cure is yet to be achieved. The viral covalently closed circular DNA(ccc DNA) is the key to establish a persistent infection within hepatocytes. Current antiviral strategies have no effect on the pre-existing ccc DNA reservoir. Therefore, the study of the molecular mechanism of ccc DNA formation is becoming a major focus of HBV research. This review summarizes the current advances in ccc DNA molecular biology and the latest studies on the elimination or inactivation of ccc DNA, including three major areas:(1) epigenetic regulation of ccc DNA by HBV X protein,(2) immune-mediated degradation,and(3) genome-editing nucleases. All these aspects provide clues on how to finally attain a cure for chronic hepatitis B infection.

关键词： hepatitis B virus(HBV) covalently closed circular DNA(cccDNA) HBx immunemediated genome-editing nucleases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-parallelism between the effect of microbial flocculants on sewerage disposal and the flocculation rate

引用

Chinese Journal Of Geochemistry 2006年第2期25卷 139-142页

作者：李静连宾郝建朝赵金朱立军 the provincial key laboratory of fermentation engineering and bio-pharmaceutics Guizhou University Guiyang 550003 China State key laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences key laboratory of Karst Environment and Geological Hazard Prevention (Guizhou University) Ministry of Education

This paper dealt with non-parallelism between the effect of microbial flocculant (MBF) on sewerage disposal and the flocculation rate, the high flocculation rate doesn’t mean the fine disposal effectiveness, and revealed the problem encountered when the exclusive parameter―flocculation rate is used to evaluate the effect of MBF on sewerage disposal. The results showed that MBF made from different carbon sources have some influence on the effectiveness of sewerage disposal; flocculation rate cannot authentically reflect the status of sewerage disposal. When the exclusive parameter―flocculation rate is used to evaluate the effect of MBF on sewerage disposal, it would be exaggerated, especially in disposing COD-low sewerage. The authors considered that when flocculation rate is used to evaluate the effect of MBF on sewerage disposal, it is better to take COD-removal rate into account.

关键词：絮凝率 COD 去除率微生物凝聚剂污水处理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbonaceous Nanofibers-titanium Dioxide Nanocomposites: Synthesis and Use as a Platform for Removal of Dye Pollutants

引用

Journal of Wuhan University of Technology(Materials Science) 2019年第2期34卷 303-307页

作者：郭洪影 JIANG Shan WANG Chaoyuan LI Shenwan FENG Jianjian 孙红梅 ZHU Hongda GUO Huiling LIU Mingxing SUN Honghao School of bioengineering and Food Key Laboratory of Fermentation Engineering (Ministry of Education) Key Laboratory of Industrial Microbiology in Hubei National ‘‘111'' Center for Cellular Regulation and Molecular Pharmaceutics Hubei Provincial Cooperative Innovation Center of Industrial Fermentation Hubei University of Technology

A mild chemistry route was developed to prepare carbonaceous nanofibers-titanium dioxide(CNF-TiO_2) nanocomposites for removal of dye pollutants. In the process of the template-directed hydrothermal carbonization(HTC), ultrathin Te nanowires were adopted as templates and glucose as the carbon source, and TiO_2 was decorated on CNF via the hydrolysis of tetrabutyltitanate in the presence of CNF in ethanol. The as-prepared materials were characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM), energy-dispersive X-ray(EDX) and X-ray diffraction(XRD). SEM and TEM observations displayed that TiO_2 nanoparticles were anchored on the CNF. EDX and XRD data confirmed that the assynthesized samples were CNF-TiO_2, and TiO_2 belonged to anatase titania. Taking advantage of combined benefits of carbonaceous nanofibers and titanium dioxide, these CNF-TiO_2 nanocomposites exhibited higher removal efficiency in a short time and showed good reusability. It was showed that over 97% of Rhodamine B could be removed in 15 min without generating the solid and liquid wastes. The removal efficiency of dyes was still over 80% after reuse in five cycles. All the results demonstrate that the as-prepared CNF-TiO_2 composites are effective materials for fast and effective removal of dye pollutants and thus can provide a new platform for dye decontamination.

关键词： carbon materials nanocomposites dye pollutants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy

引用

Acta Pharmaceutica Sinica B 2022年第1期12卷 92-106页

作者： Shuwen Fu Guanting Li Wenli Zang Xinyu Zhou Kexin Shi Yinglei Zhai School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Department of pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of Periodontology School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseaseShenyang 110016China bio-system Pharmacology Graduate School of MedicineFaculty of MedicineOsaka UniversityOsaka 565-0871Japan Department of biomedical engineering School of Medical DeviceShenyang Pharmaceutical UniversityShenyang 110016China

Nanoparticulate drug delivery systems(Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature drug leakage and carrier-related toxicity.Recently, pure drug nano-assemblies(PDNAs), fabricated by the self-assembly or co-assembly of pure drug molecules, have attracted considerable attention. Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control, scale-up production and clinical translation. Acting as both carriers and cargos, the carrier-free PDNAs have an ultra-high or even100% drug loading. In addition, combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment, such as tumor metastasis and drug resistance. In the present review, the latest development of PDNAs for cancer treatment is overviewed. First, PDNAs are classified according to the composition of drug molecules, and the assembly mechanisms are discussed. Furthermore, the co-delivery of PDNAs for combination therapies is summarized, with special focus on the improvement of therapeutic outcomes. Finally, future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted.

关键词： Nanotechnology Carrier-free Self-assembly Combination therapy Cancer treatment Pure drug Nanomedicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy

引用

Nano Research 2023年第8期16卷 11125-11138页

作者： Dao Shi Nan Wang Jie Zhang Xi Hu Qiyue Wang Ruixue Xiao Baoyue Ding Fangyuan Li Daishun Ling Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong UniversityShanghai 200240China Institute of pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of pharmaceutics Jiaxing Key Laboratory for Photonanomedicine and Experimental TherapeuticsCollege of MedicineJiaxing UniversityJiaxing 314001China World Laureates Association(WLA)Laboratories Shanghai 201203China School of Pharmacy Anhui University of Chinese MedicineHefei 230012China key laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Photoimmunotherapy(PIT)is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation,while simultaneously preventing tumor metastasis and recurrence by activating the host antitumor immune response.Tumor-responsive dynamic nanoassemblies(TDNs)have evolved from being a mere curiosity to a promising platform for high-performance PIT.However,the dynamic nano-bio interaction between TDNs and tumor microenvironment remains poorly understood,which shall be critical for precise control of TDNs assembling/disassembling behavior and superior PIT efficacy.To deepen the understanding of the structure–function relationship of TDNs,this review introduces the rational design,nano-bio interactions,and controllable functionalities of cutting-edge TDNs for enhanced PIT.Moreover,the synergetic mechanism between TDNs-based PIT and immunomodulatory agents-mediated immunomodulation is particularly emphasized.Finally,the challenges and future perspectives in this emerging field are assessed.

关键词： photoimmunotherapy tumor-responsive dynamic nanoassemblies immunosuppressive tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Selection and characterisation of lactic acid bacteria isolated from different origins for ensiling Robinia pseudoacacia and Morus alba L.leaves

引用

Journal of Integrative Agriculture 2016年第10期15卷 2353-2362页

作者： NI Kui-kui YANG Hui-xiao HUA Wei WANG Yan-ping PANG Hui-li Henan provincial key laboratory of Ion Beam bio-engineering Zhengzhou University Zhengzhou 450051 P.R. China Henan Sanoterre bio-Tec Company Zhengzhou 450000 P.R.China

The objective of this study was to isolate lactic acid bacteria（LAB） strains from different origins and to select the best strains for ensiling Robinia pseudoacacia（RB） and Morus alba L.（MB）leaves. The LAB strains were inoculated into the extracted liquid obtained from RB and MB leaves to evaluate the fermentation products. 11 LAB strains were selected for further experiments based on the highest products of lactic or acetic acid, including 1 strain of Weissella confusa, 2 of Lactobacillus reuteri and 8 of Lactobacillus plantarum.The API 50 CH fermentation experiment indicated that all of the selected 11 LAB strains utilised most of the carbohydrates. All the strains grew at temperatures between 10 and 45℃ and at a p H of 3.5 to 4.5; however, L. reuteri F7 and F8 tolerated a p H as low as 3.0. All 11 LAB strains showed antibacterial activity against Listeria monocytogens, Escherichia coil, Salmonella sp. and Acetobacter pasteurianus; however, after excluding the effect of organic acids, only F7 and F8 still exhibited antibacterial activity. The present study indicated that the selected 11 LAB strains could be used to prepare silages of RB and MB leaves, especially L. reuteri F7 and F8.

关键词： lactic acid bacteria Morus alba L Robinia pseudoacacia silage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new iron(Ⅲ) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059

引用

Chinese Journal of Natural Medicines 2020年第4期18卷 243-249页

作者： HUANG Zhong-Hui LIANG Xiao QI Shu-Hua CAS key laboratory of Tropical Marine bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaInstitution of South China Sea Ecology and Environmental EngineeringSouth China Sea Institute of OceanologyChinese A cademy of SciencesGuangzhou 510301China Southern Marine Science and engineering Guangdong laboratory Guangzhou 511458China

Mycosphazine A(1), a new iron(Ⅲ) chelator of coprogen-type siderophore, and mycosphamide A(2), a new cyclic amide benzoate, together with six known aryl amides(3-8), were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059. Alkaline hydrolysis of 1 afforded a new epimer of dimerum acid, mycosphazine B(1 a), and a new bi-fusarinine-type siderophore, mycosphazine C(1 b). The planar structures of the new compounds were elucidated by extensive spectroscopic data analysis. The absolute configurations of amino acid residues in 1 a and 1 b were determined by acid hydrolysis. And the absolute configuration of 2 was established by quantum chemical calculations of the electronic circular dichroism(ECD) spectra. Compound 1 is the first siderophore-Fe(Ⅲ) chelator incorporating both L-ornithine and D-ornithine unites. Compounds 3-8 were reported as natural products for the first time, and the 1 H and 13 C NMR data of 6 and 8 were assigned for the first time. Compounds 1 and 1 a could greatly promote the biofilm formation of bacterium Bacillus amyloliquefaciens with the rate of about 249% and 524% at concentration of 100 μg·mL-1, respectively.

关键词： Deep-sea-derived fungus Mycosphaerella sp Iron(Ⅲ)chelator Coprogen-type siderophore Cyclic amide biofilm formation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：