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The National Immunization Advisory Committee in China:Roles of National Experts in Making Evidence-Based Recommendations for Immunization

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China CDC weekly 2019年第2期1卷 28-30页

作者： Chao Ma Lance Rodewald Zhijie An Zundong Yin Zijian Feng National Immunization program Chinese Center for Disease Control and PreventionBeijingChina

In 2017,the State Council requested the National Health and Family Planning Commission(NHFPC),known as the Ministry of Health(MoH)before 2013 and as the National Health Commission(NHC)after 2018,to establish China’s National Immunization Advisory Committee(NIAC)(1).The NIAC acts as China’s National Immunization Technical Advisory Group(NITAG)—a deliberative body of national experts who advise national authorities and policy makers with evidence-based recommendations on immunization policy and program(2-3).

关键词： policy Recommendations authorities

Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第1期 303-305页

作者： Ziqian Xu Lianpan Dai Jun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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The Impact of COVID-19 Epidemic on Tuberculosis Reports Among Students — Guizhou Province, China, 2020

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China CDC weekly 2022年第11期4卷 216-219页

作者： Yuying He Tao Li Lijie Zhang Renzhong Li Zaiping Chen Yunzhou Ruan Wei Su Jinlan Li Institute for Tuberculosis Control Guizhou Center for Disease Control and PreventionGuiyangGuizhouChina National Center for Tuberculosis Control and prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training program Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?In 2020,the implementation of non-medical interventions during the coronavirus disease 2019(COVID-19)epidemic has created a negative impact on tuberculosis(TB)*** is unclear if the prevalence of TB among students in Guizhou Province was also *** is added by this report?Among TB cases,the proportion of student TB patients was 19.91%in the back-to-school period in 2020,which was higher than the 13.37%registered in 2017–2019,but this decreased in the COVID-19 pandemic *** time interval between symptom onset and care-seeking of the student TB patients was the shortest in the back-to-school and physical checkup *** are the implications for public health practice?TB active screening was effective for timely detection and diagnosis of TB among students,which could prevent TB outbreaks in schools.

关键词： Guizhou seeking Impact

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City,China,2010-2022

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Biomedical and Environmental Sciences 2024年第9期37卷 1015-1029页

作者： Ying Li Runze Lu Liyan Dong Litao Sun Zongyi Zhang Yating Zhao Qing Duan Lijie Zhang Fachun Jiang Jing Jia Huilai Ma Chinese Field Epidemiology Training program Chinese Center for Disease Control and PreventionBeijing 100050China National Institute for Viral Disease Control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China Qingdao Municipal Center for Disease Control and prevention Qingdao 266024ShandongChina Jiaozhou Center for Disease Control and prevention Qingdao 266399ShandongChina Institute for Infectious Disease Control and prevention Shandong Center for Disease Control and PreventionJinan 250013ShandongChina Office of Epidemiology(Technical Guidance Office for Patriotic Health Work) Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,*** Information was collected on HFRS cases in Qingdao City from 2010 to *** epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were *** A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”*** HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring *** HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and *** spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter *** The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering *** typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.

关键词： Hemorrhagic fever with renal syndrome Epidemic characteristics Spatio-temporal distribution

Huaqing Wang,China CDC’s Chief Expert in National Immunization program

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China CDC weekly 2020年第30期2卷 577-578页

作者： Peter Hao Ying Zhang Zhenjun Li Jingjing Xi Feng Tan Chinese Center for Disease Control and prevention BeijingChina

Huaqing Wang has had a long and distinguished career in developing and implementing immunization programs to protect China’s *** graduating from Harbin Medical University in 1986 with a major in preventive medicine,Huaqing Wang was assigned to Heilongjiang Provincial CDC and has dedicated his career to infectious disease control and immunization.

关键词： immunization. Expert career

Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021

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China CDC weekly 2022年第4期4卷 57-65页

作者： Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin Chinese Center for Disease Control and prevention BeijingChina Henan Provincial Disease Control and prevention ZhengzhouHenanChina Akesu Prefectural Center for Disease Control and prevention AkesuXinjiang Uygur Autonomous RegionChina China Field Epidemiology Training program Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe ***,separate or combined VE estimates for the two inactivated vaccines against Delta are not *** is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was *** are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta *** of the completed primary vaccination with two doses is necessary for protection from Delta.

关键词： vaccination doses vaccine

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

“If the world doesn’t share the vaccine,the virus will take on the world”

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China CDC weekly 2021年第13期3卷 265-266页

作者： Zundong Yin Lance Rodewald Dan Wu National Immunization program Chinese Center for Disease Control and PreventionBeijingChina.

What did George Gao mean by the title quote?The statement certainly feels like a warning,but it is a warning that comes with a prescription that carries optimism and *** warning that the virus will“take on the world”has indeed been the world’s experience during the first year of *** the warning is more ominous with the continual emergence of variants of the coronavirus that have differing characteristics-transmission speed,pathogenicity,evasion of immunity to prior infection or immunization(1).

关键词： immunity prescription statement

Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

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China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu Sichuan Center for Disease Control and prevention Chengdu CitySichuan ProvinceChina National Immunization program Chinese Center for Disease Control and PreventionBeijingChina Suqian Center for Disease Control and prevention Suqian CityJiangsu ProvinceChina Jiangsu Center for Disease Control and prevention Nanjing CityJiangsu ProvinceChina Zhejiang Center for Disease Control and prevention Hangzhou CityZhejiang ProvinceChina Shandong Center for Disease Control and prevention Jinan CityShandong ProvinceChina Anhui Center for Disease Control and prevention Hefei CityAnhui ProvinceChina Hubei Center for Disease Control and prevention Wuhan CityHubei ProvinceChina Hunan Center for Disease Control and prevention Changsha CityHunan ProvinceChina Guizhou Center for Disease Control and prevention Guiyang CityGuizhou ProvinceChina Gansu Center for Disease Control and prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder