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Economic Evaluation of the Comprehensive AIDS prevention and Control program—Tianjin Municipality,China,2011-2022

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China CDC weekly 2023年第48期5卷 1067-1072页

作者： Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun Bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng Jinyu Hou Zhuang Cui STD&AIDS Control and prevention Section Tianjin Centers for Disease Control and PreventionTianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjinChina

What is already known about this topic?Acquired immunodeficiency syndrome(AIDS)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on *** is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(HIV)prevention strategies in *** 2011 and 2022,it is estimated that effective measures could prevent 2,965 new HIV infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese *** are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized HIV prevention and control strategies,as well as to guide public health policymaking.

关键词： prevention globally Tianjin

Progress Towards Hepatitis A Control and prevention Through 2019:the National Immunization program of China

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China CDC weekly 2020年第31期2卷 591-595页

作者： Xiaojin Sun Fuzhen Wang Guomin Zhang Hui Zheng Ning Miao Zundong Yin Zhijie An National Immunization program Chinese Center for Disease Control and PreventionBeijingChina

Hepatitis A is an infectious liver disease caused by hepatitis A virus(HAV)that results in mild to severe *** is spread to immunologically naïve persons who ingest food or water contaminated with feces from HAV-infected individuals(1).Hepatitis A is often seen in sporadic cases,but is also seen in large outbreaks,such as the 1988 outbreak in Shanghai that caused over 300,000 cases and huge economic losses(2).

关键词： cases infected illness

Senior Research Scholars in China CDC’s National Immunization program

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China CDC weekly 2021年第43期3卷 911-913页

作者： Miao Wang Yanmin Liu Tingting Yan Lance Rodewald Zhijie An Zundong Yin National Immunization program Chinese Center for Disease Control and PreventionBeijingChina.

China CDC’s National Immunization program’s Senior Research Scholars program(NIP-SRSP)is a program created to foster the professional development of early-to-mid-career immunization experts,strengthen knowledge exchange and cooperation between national and provincial/prefectural-level CDCs,and deepen scientific and programmatic capacity of the National Immunization program and provincial/prefectural immunization *** in September 2019.

关键词： program CDC provincial

Developing an evaluation model to support evidence-based decision-making on provincial vaccination program of Zhejiang province

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 527-532页

作者： Fuxing Chen Linlin Ding Hui Liang Ying Wang Yu Hu Institute of Immunization and prevention Zhejiang Center for Disease Control and PreventionHangzhouChina

Vaccines are considered as one of the most cost-effective interventions to improve the global public health by reducing mortality and morbidity[1].At an ever-increasing pace,new vaccines are being developed and licensed in China,driven by initiatives from both domestic and international vaccine *** vaccines are evaluated by Chinese Advisory Committee on Immunization,which makes decisions regarding the use of vaccines based on the epidemiological context in China.

关键词： companies China provincial

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

The COVID-19 Vaccines Evaluation program:Implementation,Management,and Experiences,2021-2023

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China CDC weekly 2024年第26期6卷 642-648页

作者： Tingting Yan Hui Zheng Mingshuang Li Chao Ma Xuanyi Wang Xiaoqi Wang Zhenjun Li Yuansheng Chen Wenshang Hu Lance Rodewald Zhijie An Zundong Yin Zijian Feng National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID).National Immunization program Chinese Center for Disease Control and PreventionBeijingChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Office of International Cooperation Chinese Center for Disease Control and PreventionBeijingChina Office of Science and Technology Chinese Center for Disease Control and PreventionBeijingChina Office of Finance Chinese Center for Disease Control and PreventionBeijingChina Chinese Preventive Medicine Association BeijingChina

In 2021,China’s domestically produced coronavirus disease 2019(COVID-19)vaccines received approval from regulatory bodies and were administered *** to a low number of infections within China during that period,it became imperative to evaluate the vaccines’real-world effectiveness through international *** facilitate this,China CDC launched the COVID-19 Vaccines Evaluation program(COVEP).This program formed research collaboration agreements with health institutes across five World Health Organization regions,addressing key questions about vaccine performance through ten cooperative *** findings from COVEP projects reinforced confidence,both domestically and globally,in the effectiveness of the vaccines produced in ***,the outcomes observed internationally were frequently mirrored by later studies conducted within *** thus pioneered a novel approach for fostering cross-national research collaborations,addressing significant public health issues and exemplifying a framework for international *** approach is in line with the strategic objectives and other development efforts of China CDC’s national disease control and prevention initiatives.

关键词： approval COV prevention

Association of cancer prevention awareness with esophageal cancer screening participation rates: Results from a population-based cancer screening program in rural China

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Chinese Journal of Cancer Research 2019年第4期31卷 601-608页

作者： Shangchun Jia He Li Hongmei Zeng Rongshou Zheng Jiang Li Jufang Shi Zhixun Yang Maomao Cao Wanqing Chen Anhui Provincial Center for Disease Control and prevention Hefei 230601China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: : China have implemented population-based esophageal cancer(EC) screening programs, however,the participant rates were relatively low. This study was conducted to examine the association between cancer prevention knowledge and EC screening participation rates(PRs).Methods: : Data in the analyses were obtained from a population-based cancer screening program in four provinces in China since 2007. In the course of 2007-2016, participants who were evaluated as high risk for EC and subsequently recommended for endoscopy examination were included in the final analysis. One-way analysis of variance test, Chi-square test and logistic regression analysis were ***: : A total of 28,543 individuals assessed as high-risk population for EC were included in this study, with13,036 males(45.67%) and 15,507 females(54.33%). The prevalence rates of current smoking and alcohol drinking were higher in males(58.25% and 44.22%, respectively) than in females(5.35% and 4.05%, respectively).Participants of females, and those who had older age, lower income, as well as higher education level and cancer prevention knowledge level were more likely to undergo endoscopy. Multivariable analysis showed that higher cancer prevention knowledge was associated with higher PR for endoscopic screening [adjusted odd ratio(aORQ4/Q1) =1.511, 95% confidence interval(95% CI): 1.398-1.632] among our study subjects. This association between cancer prevention knowledge and compliance with endoscopic screening also tends to be strong within subgroups of males, females, aged below 60 years, aged 60 years and above, and lower level of education(illiterate individuals and those with junior high education or less).Conclusions: : Our results displayed a positive relationship between cancer prevention knowledge and PRs for endoscopic screening, implying cancer prevention awareness being an independent influence factor for compliance with EC screening. Promoting public campaigns about comprehensi

关键词： Cancer prevention knowledge esophageal cancer screening participation rate compliance

Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

Effects of Three Major Immunization Interventions on Measles Control—China,1952–2021

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China CDC weekly 2023年第17期5卷 385-390页

作者： Quanwei Song Chao Ma Lixin Hao Fuzhen Wang Zhijie An Zundong Yin Huaqing Wang National Immunization program Chinese Center for Disease Control and PreventionBeijingChina

Measles,an acute respiratory infectious disease caused by the measles virus,was responsible for millions of deaths annually before the introduction of the measles vaccine(MV)(1).Widespread availability of measles vaccines and the initiation of the Expanded program on Immunization,approved at the 27th World Health Assembly in 1974(2),have significantly improved global measles *** China,measles has been a statutorily notifiable disease since the establishment of the National Notifiable Diseases Reporting System(NNDRS)in 1950(3).

关键词： annually Measles Major