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Community structure of aerobic anoxygenic phototrophic bacteria in algae-and macrophyte-dominated areas in Taihu Lake,China

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Journal of Oceanology and Limnology 2022年第5期40卷 1855-1867页

作者： Limei SHI Yuanfeng CAI Xiaoli SHI Min ZHANG Qingfei ZENG Fanxiang KONG Ping XU State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China the philips institute of oral and craniofacial molecular biology Virginia Commonwealth UniversityRichmondVA 23298-0566United States of America

Aerobic anoxygenic phototrophic bacteria(AAPB)repre sent a major group of bacterioplankton assemblages in many water systems and some are assumed to be closely associated with ***,studies on relationships between AAPB and cyanobacterial blooms are in *** dynamics of the abundance and diversity of AAPB was compared based on pufM gene in Meiliang Bay(featured by cyanobacterial blooms)and East Bay(featured by macrophyte)of Taihu Lake,a shallow subtropical lake in the East China *** abundance was not significantly different between the two sites,and they were positively correlated with dissolved organic carbon(DOC)*** ratios of AAPB to total bacteria varied from 3.4%to 11.5%and peaked in winter in both site *** significant differences of AAPB community compositions were detected between the two sites,but there was a separation between warm seasons(June,August,and October)and cold seasons(December,February,and April).Rhizobiales and Limnohabitans-like pufM sequences were significantly contributors for the difference between two seasons,and specially enriched in cold *** a(Ch1 a)and DOC were the most significant variables influencing the AAPB community ***,Porphyrobacter and Rhodospirillales-like pufM sequences were positively correlated with Ch1 a,indicating potential influence of cyanobacterial blooms on these AAPB *** results suggested that diverse AAPB ecotypes coexisted in Taihu Lake,and their ecological role in carbon cycling in the lake may not be ignored.

关键词： aerobic anoxygenic phototrophic bacteria cyanobacterial blooms dissolved organic carbon Alphaproteobacteria chlorophyll a

Mitigating osteonecrosis of the jaw(ONJ) through preventive dental care and understanding of risk factors

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Bone Research 2020年第1期8卷 14-25页

作者： Jason TWan Douglas MSheeley Martha JSomerman Janice SLee National institute of Dental and craniofacial Research National Institutes of HealthBethesdaMDUSA Laboratory for oral Connective Tissue biology National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaMDUSA

It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw(ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860. The subsequent removal of yellow phosphorus from matches in the early 20 th century saw a parallel decline in "phossy jaw" until the early 2000 s, when similar reports of unusual jaw bone necrosis began to appear in the literature describing jaw necrosis in patients undergoing chemotherapy and concomitant steroid and bisphosphonate treatment. Today, the potential side effect of ONJ associated with medications that block osteoclast activity(antiresorptive) is well known, though the mechanism remains unclear and the management and outcomes are often unsatisfactory. Much of the existing literature has focused on the continuing concerns of appropriate use of bisphosphonates and other antiresorptive medications, the incomplete or underdeveloped research on ONJ, and the use of drugs with anabolic potential for treatment of osteoporosis. While recognizing that ONJ is a rare occurrence and ONJ-associated medications play an important role in fracture risk reduction in osteoporotic patients, evidence to date suggests that health care providers can lower the risk further by dental evaluations and care prior to initiating antiresorptive therapies and by monitoring dental health during and after treatment. This review describes the current clinical management guidelines for ONJ, the critical role of dental-medical management in mitigating risks, and the current understanding of the effects of predominantly osteoclast-modulating drugs on bone homeostasis.

关键词： drugs metabolism alterations

BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair

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Bone Research 2018年第4期6卷 355-367页

作者： Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai Center for craniofacial molecular biology University of Southern California Department of oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology In Vitro Cell Research LLC State Key Laboratory of oral Diseases West China Hospital of Stomatology Sichuan University Division of Endodontology Kyushu University Hospital Kyushu University

Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair.

关键词： BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair RANKL

FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development

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Bone Research 2024年第3期12卷 582-594页

作者： Fei Pei Tingwei Guo Mingyi Zhang Li Ma Junjun Jing Jifan Feng Thach-Vu Ho Quan Wen Yang Chai Center for craniofacial molecular biology University of Southern California2250 Alcazar StreetCSA 103Los AngelesCA 90033USA State Key Laboratory of oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhan 430079China

Stem/progenitor cells differentiate into different cell lineages during organ development and *** pathway networks and mechanotransduction are important factors to guide the lineage commitment of stem/progenitor cells... 详细信息

关键词： progenitor mec facial

oral stem cells,decoding and mapping the resident cells populations

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Biomaterials Translational 2022年第1期3卷 24-30页

作者： Xuechen Zhang Ana Justo Caetano Paul T.Sharpe Ana Angelova Volponi Centre for craniofacial and Regenerative biology Faculty of DentistryOral&Craniofacial SciencesKing’s College University of LondonLondonUK Laboratory of Odontogenesis and Osteogenesis Institute of Animal Physiology and GeneticsCASv.v.i.BrnoCzech Republic

The teeth and their supporting tissues provide an easily accessible source of oral stem *** different stem cell populations have been extensively studied for their properties,such as high plasticity and clonogenicity,expressing stem cell markers and potency for multilineage differentiation in *** cells with stem cell properties have been derived and characterised from the dental pulp tissue,the apical papilla region of roots in development,as well as the supporting tissue of periodontal ligament that anchors the tooth within the alveolar socket and the soft gingival *** the dental pulp stem cell populations in a continuously growing mouse incisor model,as a traceable in vivo model,enables the researchers to study the properties,origin and behaviour of mesenchymal stem *** the other side,the oral mucosa with its remarkable scarless wound healing phenotype,offers a model to study a well-coordinated system of healing because of coordinated actions between epithelial,mesenchymal and immune cells *** described as homogeneous cell populations following their in vitro expansion,the increasing application of approaches that allow tracing of individual cells over time,along with single-cell RNA-sequencing,reveal that different oral stem cells are indeed diverse populations and there is a highly organised map of cell populations according to their location in resident tissues,elucidating diverse stem cell niches within the oral *** review covers the current knowledge of diverse oral stem cells,focusing on the new approaches in studying these *** approaches“decode”and“map”the resident cells populations of diverse oral tissues and contribute to a better understanding of the“stem cells niche architecture and *** the high accessibility and simplicity in obtaining these diverse stem cells,the new findings offer potential in development of translational tissue engineering approaches and innovativ

关键词： dental pulp stem cells dental stem cells gingival stem cells periodontal ligament stem cells stem cells from apical papilla

Meeting report:a hard look at the state of enamel research

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International Journal of oral Science 2017年第4期9卷 193-199页

作者： ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer program in craniofacial biology and department of orofacial sciences university of californiasan franciscoSan FranciscoUSA department of pediatrics and institute for human genetics university of californiasan franciscoSan FranciscoUSA laboratory of skin biology national institute of arthritis and muscular and skin diseasesnational institutes of healthBethesdaUSA physical science division pacific northwest national laboratoriesRichlandUSA department of basic science and craniofacial biology new york university college of dentistryNewYorkUSA department of materials science and engineering northwestern universityevanstonusaEvanstonUSA center for craniofacial molecular biology herman ostrow school of dentistryuniversity of southern californiaLos AngelesUSA the forsyth institute CambridgeUSA department of developmental biology harvard school of dental medicineBostonUSA department of pediatric dentistry university of north caroline school of dentistryChapel HillUSA departments of dermatology and cel&developmental biology perelman school of medicineand department of anatomy&cell biologyschool of dental medicineuniversity of pennsylvaniaPhiladelphiaUSA functional genomics section national institute of dental and craniofacial researchBethesdaUSA division of biosciences ohio state universitycollege of dentistryColumbusUSA department of periodontics and center for craniofacial research and diagnosis texas a&m university college of dentistryDallasUSA center for children’s oral health research and department of orofacial sciences university of californiasan franciscoSan FranciscoUSA biologic and materials sciences and division of prosthodontics university of michiganAnn ArborUSA

The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines （ENAMEL） Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National institute of Dental and craniofacial Research （NIDCR）. Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids. Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field.

关键词： enamel mineralized tissue mineralization ameloblast stem cell

3D printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration

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Bio-Design and Manufacturing 2020年第1期3卷 15-29页

作者： Xiangjia Li Yuan Yuan Luyang Liu Yuen‑Shan Leung Yiyu Chen Yuxing Guo Yang Chai Yong Chen Epstein Department of Industrial and Systems Engineering University of Southern CaliforniaLos AngelesUSA Center for craniofacial molecular biology University of Southern CaliforniaLos AngelesUSA Department of Chemical Engineering and Material Science University of Southern CaliforniaLos AngelesUSA Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesUSA Department of oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijingChina

Three-dimensional(3D)-printed scaffolds have attracted considerable attention in recent years as they provide a suitable environment for bone cell tissue regeneration and can be customized in *** many other challenges,the material composition and geometric structure have major impacts on the performance of *** and tricalcium phosphate(HA/TCP),as the major constituents of natural bone and teeth,possess attractive biological properties and are widely used in bone scaffold *** fabrication methods have been investigated in attempts to achieve HA/TCP scaffolds with microporous structure enabling cell growth and nutrient ***,current 3D printing methods can only achieve the fabrication of HA/TCP scaffolds with certain range of microporous *** overcome this challenge,we developed a slurry-based microscale mask image projection stereolithography,allowing us to form a HA/TCP-based photocurable suspension with complex geometry including biomimetic features and hierarchical ***,the curing performance and physical properties of the HA/TCP suspension were investigated,and a circular movement process for the fabrication of highly viscous HA/TCP suspension was *** on these investigations,the scaffold composition was *** determined that a 30 wt%HA/TCP scaffold with biomimetic hierarchical structure exhibited superior mechanical properties and *** proliferation was investigated in vitro,and the surgery was conducted in a nude mouse in vivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem *** results showed our 3D-printed HA/TCP scaffold with biomimetic hierarchical structure is biocompatible and has sufficient mechanical strength for surgery.

关键词： 3D printing Slurry stereolithography Scaffold HA/TCP Hierarchical porosity

FACEts of mechanical regulation in the morphogenesis of craniofacial structures

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International Journal of oral Science 2021年第1期13卷 1-16页

作者： Wei Du Arshia Bhojwani Jimmy K.Hu State Key Laboratory of oral Diseases&National Clinical Research Center for oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina School of Dentistry University of California Los AngelesLos AngelesCAUSA molecular biology institute University of California Los AngelesLos AngelesCAUSA

During embryonic development,organs undergo distinct and programmed morphological changes as they develop into their functional *** genetics and biochemical signals are well recognized regulators of morphogenesis,mechanical forces and the physical properties of tissues are now emerging as integral parts of this process as *** physical factors drive coordinated cell movements and reorganizations,shape and size changes,proliferation and differentiation,as well as gene expression changes,and ultimately sculpt any developing structure by guiding correct cellular architectures and *** this review we focus on several craniofacial structures,including the tooth,the mandible,the palate,and the *** discuss the spatiotemporal regulation of different mechanical cues at both the cellular and tissue scales during craniofacial development and examine how tissue mechanics control various aspects of cell biology and signaling to shape a developing craniofacial organ.

关键词： architectures organs morphogenesis

Salivary Gland Branching Morphogenesis——Recent Progress and Future Opportunities

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International Journal of oral Science 2010年第3期2卷 117-126页

作者： Jeff Chi-feng Hsu Kenneth M.Yamada Laboratory of Cell and Developmental biology National Institute of Dental and Craniofacial ResearchNational Institutes of Health

Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branchingmorphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.

关键词： salivary gland epithelium branching morpho-genesis fibronectin E-cadherin growth factor