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Multifunctional polyeugenol-based nanoparticles with antioxidant and antibacterial properties

Particuology 2024年第4期87卷 194-204页

作者： Qiaoqiao Lan Xuying Zhang Jiaming Liang Wei Wang Leili Lv Jiamin He Zefeng Wang Chunsheng Qu The people's hospital of lishui Lishui323000China College of Ecology Lishui UniversityLishui32300China R&D Center of Green Manufacturing New Materials and Technology of synthetic Leather sichuan University-lishui University Lishui323000China

Over the past few decades,extensive scientific has been dedicated to polymer synthesis employing renewable *** this study,we devised and synthesized multifunctional polyeugenol-based nanoparticles,exhibiting remarkable antioxidant and antibacterial *** grafting of eugenol onto the nanoparticle surface was achieved via a thiol-ene chemical reaction with a grafting rate of 3.5%.To comprehend the properties of the synthesized nanoparticles,we employed Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and pyrolysis-gas chromatography mass *** scanning electron microscopic and transmission electron microscopic analyses revealed the presence of a crosslinked structure within the polyeugenol-based nanoparticles,as well as a heteroge-neous microsphere structure on the *** to the inherent crosslinking structure,the polyeugenol-based nanoparticles demonstrated robust the resistance to solvents,as ascertained through thermog-ravimetric analysis and solvent resistance ***,nitrogen adsorption/desorption studies confirmed the adsorption capacity of the polyeugenol-based nanoparticles,rendering them potentially suitable for drug transport ***,the assays for assessing cytocompatibility and reactive oxygen species scavenging activities demonstrated better performance of the eugenol-based nano-particles compared to ***,the polyeugenol-based nanoparticles exhibited certain bactericidal activities against Escherichia coli,staphylococcus aureus,and Fusobacterium ***,these observations indicated the nontoxic nature and expansive application prospects of the polyeugenol-based nanoparticles in the domains of medicine and food *** work presented a pioneering concept for the development of antioxidant and antibacterial multifunctional polymer materials derived from eugenol.

关键词： Polyeugenol-based nanoparticles Bactericidal activities Cytocompatibility

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Amitriptyline inhibits NLRP3 inflammasome activation via the AsM/CE pathway in a cell model of NAFLD

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BIOCELL 2024年第5期48卷 759-769页

作者： QIN LIU CHUNYAN NIU QIANG ZHANG sHIQIN sUN YUE CHEN YONGQIANG sHI shengli Clinical Medical College Fujian Medical UniversityFuzhou350001China Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing211200China Department of Gastroenterology Yancheng Third People’s Hospital(The Yancheng School of Clinical Medicine of Nanjing Medical University)Yancheng224000China Administrative Department of Teaching and scientific Research Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing211200China

Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(AsM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome identified as pivotal players in lipid disorders and *** study explores the interaction mechanism between the AsM/CE pathway and NLRP3 in NAFLD cell models,aiming to understand the impact of amitriptyline(Ami),an AsM inhibitor,on lipid deposition and hepatocyte injury by regulating the AsM/CE-NLRP3 ***:HepG2 and HL-7702 cells were exposed to free fatty acids(FFAs)to establish the NAFLD *** cells were divided into 5 groups:control group,model group,Ami group,tumor necrosis factoralpha(TNF-α)group,and Ami+TNF-α*** lipid droplets were visualized using Oil Red O staining,and Western blot analysis quantified AsM,NLRP3,and caspase 1 protein *** linked immunosorbent assay(ELIsA)was measured CE and AsM levels,while qRT-PCR assessed mRNA *** apoptotic rate was evaluated by flow cytometry(FCM).Results:Following FFAs incubation,significant increases in AsM and CE levels were observed in HepG2 and HL-7702 cells,accompanied by elevated expression of NLRP3,and caspase 1,and IL-1β.TNF-αtreatment further amplified these *** demonstrated a reduction in lipid deposition,suppressed AsM/CE pathway activation,downregulated NLRP3 and caspase 1 expression,and improved ***,MCC950,a selective inhibitor of the NLRP3,mitigated NLRP3,caspase 1,and IL-1βexpression,alleviating lipid deposition and apoptosis in the NAFLD cell ***:The AsM/CE-NLRP3 pathway in NAFLD cells promotes hepatocyte steatosis,inflammation,and cell *** emerges as a promising therapeutic agent by inhibiting the AsM/CE-NLRP3 pathway,underscoring its potential as a key target for NAFLD treatment.

关键词： Nonalcoholic fatty liver disease Hepatocyte Amitriptyline AsM/CE pathway NLRP3 Nonalcoholic steatohepatitis

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Lung ultrasound score evaluation of the effect of pressure-controlled ventilation volume-guaranteed on patients undergoing laparoscopicassisted radical gastrectomy

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1717-1725页

作者： Jian Tan Cheng-Ming Bao Xiao-Yuan Chen Department of Critical Care Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina Department of Ultrasound Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina

BACKGROUND Laparoscopic-assisted radical gastrectomy(LARG)is the standard treatment for early-stage gastric carcinoma(GC).However,the negative impact of this proce-dure on respiratory function requires the optimized intraoperative management of patients in terms of *** To investigate the influence of pressure-controlled ventilation volume-guaranteed(PCV-VG)and volume-controlled ventilation(VCV)on blood gas analysis and pulmonary ventilation in patients undergoing LARG for GC based on the lung ultrasound score(LUs).METHODs The study included 103 patients with GC undergoing LARG from May 2020 to May 2023,with 52 cases undergoing PCV-VG(research group)and 51 cases undergoing VCV(control group).LUs were recorded at the time of entering the operating room(T0),20 minutes after anesthesia with endotracheal intubation(T1),30 minutes after artificial pneumoperitoneum(PP)establishment(T2),and 15 minutes after endotracheal tube removal(T5).For blood gas analysis,arterial partial pressure of oxygen(PaO_(2))and partial pressure of carbon dioxide(PaCO_(2))were *** airway pressure(P_(peak)),plateau pressure(Pplat),mean airway pressure(P_(mean)),and dynamic pulmonary compliance(C_(dyn))were recorded at T1 and T2,1 hour after PP establishment(T3),and at the end of the operation(T4).Postoperative pulmonary complications(PPCs)were ***-and postoperative serum interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)were measured by enzyme-linked immunosorbent *** Compared with those at T0,the whole,anterior,lateral,posterior,upper,lower,left,and right lung LUs of the research group were significantly reduced at T1,T2,and T5;in the control group,the LUs of the whole and partial lung regions(posterior,lower,and right lung)decreased significantly at T2,while at T5,the LUs of the whole and some regions(lateral,lower,and left lung)increased *** comparison with the control group,the whole and regional LUs of the research group were reduc

关键词： Lung ultrasound score Pressure-controlled ventilation volume-guaranteed Laparoscopic-assisted radical gastrectomy Blood gas analysis indexes Pulmonary ventilation

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site-directed mutagenesis of bifunctional riboflavin kinase/FMN adenylyltransferase via CRIsPR/Cas9 to enhance riboflavin production

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synthetic and systems Biotechnology 2024年第3期9卷 503-512页

作者： Bing Fu Meng Chen Xianfeng Bao Jiajie Lu Zhiwen Zhu Fuyao Guan Chuyang Yan Peize Wang Linglin Fu Ping Yu College of Food science and Biotechnology Zhejiang Gongshang University149 Jiaogong RoadHangzhouZhejiang Province310035People’s Republic of China College of Forestry science and Technology Lishui Vocational and Technical College357 Zhongshan Street NorthLishuiZhejiang Province323000People’s Republic of China lishui Institute for Quality Inspection and Testing 395 Zhongshan StreetLishuiZhejiang Province323000People’s Republic of China

Vitamin B_(2)is an essential water-soluble *** most prokaryotes,a bifunctional enzyme called FAD synthase catalyzes the successive conversion of riboflavin to FMN and *** this study,the plasmid pNEW-AZ containing six key genes for the riboflavin synthesis was transformed into strain R2 with the deleted FMN riboswitch,yielding strain *** R5 strain could produce 540.23±5.40 mg/L riboflavin,which was 10.61%higher than the R4 strain containing plasmids pET-AE and pAC-Z harboring six key *** further enhance the production of riboflavin,homology matching and molecular docking were performed to identify key amino acid residues of FAD *** point mutation sites were *** comparing riboflavin kinase activity,mutations of T203D and N210D,which respectively decreased by 29.90%and 89.32%compared to wild-type FAD synthase,were selected for CRIsPR/Cas9 gene editing of the genome,generating engineered strains R203 and ***-AZ was transformed into R203,generating R6.R6 produced 657.38±47.48 mg/L riboflavin,a 21.69%increase compared to *** study contributes to the high production of riboflavin in recombinant *** BL21.

关键词： Vitamin B_(2) FAD synthase Escherichia coli BL21 Riboflavin kinase CRIsPR/Cas9

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Evaluation of the effects of health education interventions for hypertensive patients based on the health belief model

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World Journal of Clinical Cases 2024年第15期12卷 2578-2585页

作者： Hong-Mei Wang Ying Chen Yan-Hua shen Xiao-Mei Wang Department of Emergency Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Pancreatic and Biliary surgery The First Affiliated Hospital of China Medical UniversityShenyang 110002Liaoning ProvinceChina

BACKGROUND Hypertension is a major risk factor for cardiovascular disease and stroke,and its prevalence is increasing *** education interventions based on the health belief model(HBM)can improve the knowledge,attitudes,and behaviors of patients with hypertension and help them control their blood *** To evaluate the effects of health education interventions based on the HBM in patients with hypertension in *** Between 2021 and 2023,140 patients with hypertension were randomly assigned to either the intervention or control *** intervention group received health education based on the HBM,including lectures,brochures,videos,and counseling sessions,whereas the control group received routine *** were measured at baseline,three months,and six months after the intervention and included blood pressure,medication adherence,self-efficacy,and perceived benefits,barriers,susceptibility,and *** The intervention group had significantly lower systolic blood pressure[mean difference(MD):-8.2 mmHg,Pstolic blood pressure(MD:-5.1 mmHg,P=0.002)compared to the control group at six *** intervention group also had higher medication adherence(MD:1.8,Pself-efficacy(MD:12.4,Ps(MD:3.2,Ps(MD:-2.6,P=0.001),higher perceived susceptibility(MD:2.8,P=0.002),and higher perceived severity(MD:3.1,Psix *** Health education interventions based on the HBM effectively improve blood pressure control and health beliefs in patients with hypertension and should be implemented in clinical practice and community settings.

关键词： Hypertension Health education Health belief model Blood pressure control Randomized controlled trial

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Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1045-1055页

作者： LIU Gui-hong YAO Ze-qin CHEN Guo-qiang LI Ya-lang LIANG Bing Department of Urology Sanya Central Hospital (The Third People's Hospital of Hainan Province) Department of Urology Yuzhou People's Hospital

Prostate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment strategies. Green tea, a well-known beverage derived from the Camellia sinensis plant, contains bioactive compounds with potential health benefits, including catechins and polyphenols. This comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing literature. Green tea possesses antioxidant, anti-inflammatory, and anti-carcinogenic properties attributed to its catechins, particularly epigallocatechin gallate. Epidemiological studies have reported an inverse association between green tea consumption and prostate cancer risk, with potential protection against aggressive forms of the disease. Laboratory studies demonstrate that green tea components inhibit tumor growth, induce apoptosis, and modulate signaling pathways critical to prostate cancer development and progression. Clinical trials and human studies further support the potential benefits of green tea. Green tea consumption has been found to be associated with a reduction in prostate-specific antigen levels, tumor markers, and played a potential role in slowing disease progression. However, challenges remain, including optimal dosage determination, formulation standardization, and conducting large-scale, long-term clinical trials. The review suggests future research should focus on combinatorial approaches with conventional therapies and personalized medicine strategies to identify patient subgroups most likely to benefit from green tea interventions.

关键词： epigallocatechin gallate green tea prevention prostate cancer review treatment

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Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： Chang-sheng MA shu-Lin WU shao-Wen LIU Ya-Ling HAN Chinese society of Cardiology Chinese Medical Association Heart Rhythm Committee of Chinese society of Biomedical Engineering Beijing Anzhen hospital Capital Medical University Guandong Provincial people’s hospital shanghai First people’s hospital General hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese society of Cardiology of the Chinese Medical Association and the Heart Rhythm Committee of the Chinese society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2Ds2-VAsc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis

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superhydrophobic surface-Assisted Preparation of Microspheres and supraparticles and Their Applications

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Nano-Micro Letters 2024年第4期16卷 110-138页

作者： Mengyao Pan Huijuan shao Yue Fan Jinlong Yang Jiaxin Liu Zhongqian Deng Zhenda Liu Zhidi Chen Jun Zhang Kangfeng Yi Yucai su Dehui Wang Xu Deng Fei Deng Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China school of Materials science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China shenzhen Institute for Advanced study University of Electronic Science and Technology of ChinaShenzhen 518110People’s Republic of China Pharmaceutical Glass Co.Ltd Zibo 256100People’s Republic of China Department of Nephropathy School of MedicineSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China Department of Nephrology Sichuan Provincial People’s Hospital Jinniu HospitalChengdu Jinniu District People’s HospitalChengduPeople’s Republic of China

superhydrophobic surface(sHs) has been well developed, as sHs renders the property of minimizing the water/solid contact interface. Water droplets deposited onto sHs with contact angles exceeding 150°, allow them to retain spherical shapes, and the low adhesion of sHs facilitates easy droplet collection when tilting the substrate. These characteristics make sHs suitable for a wide range of applications. One particularly promising application is the fabrication of microsphere and supraparticle materials. sHs offers a distinct advantage as a universal platform capable of providing customized services for a variety of microspheres and supraparticles. In this review, an overview of the strategies for fabricating microspheres and supraparticles with the aid of sHs, including cross-linking process, polymer melting,and droplet template evaporation methods, is first presented. Then, the applications of microspheres and supraparticles formed onto sHs are discussed in detail, for example, fabricating photonic devices with controllable structures and tunable structural colors, acting as catalysts with emerging or synergetic properties, being integrated into the biomedical field to construct the devices with different medicinal purposes, being utilized for inducing protein crystallization and detecting trace amounts of analytes. Finally,the perspective on future developments involved with this research field is given, along with some obstacles and opportunities.

关键词： superhydrophobic surface Microspheres and supraparticles Photonic devices Catalysts Biomedical and trace detections

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Preparation of Laser Cladding Coating Undercooling Cu-based Alloy and Co on Non-equilibrium solidification structure

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Journal of Wuhan University of Technology(Materials science) 2024年第2期39卷 463-472页

作者：田徐铭 CAO shichao HOU Kai HOU Xiaopeng WANG Hongfu 张煜 Department of Outpatient Xinzhou People’s HospitalXinzhou 034099China school of Mechanical Engineering North University of ChinaTaiyuan 030051China Department of Neurosurgery Xinzhou People’s HospitalXinzhou 034099China Department of Orthopedics Xinzhou People’s HospitalXinzhou 034099China

The effect of the gradient content of Co element on the solidification process of Cu-based alloy under deep under cooling conditions was *** non-equilibrium solidification structure of the under cooled alloy samples were *** is found that the rapidly solidified alloy has undergone twice grain refinement during the undercooling *** and significance of the maximum undercooling refinement structure of Cu60Ni35Co5 at T=253 K were ***-density defects were observed,such as dislocations,stacking faults networks,and twinning *** standard FCC diffraction pattern represents that it is still a single-phase *** on the metallographic diagram,EBsD and TEM data analysis,it is illustrated that the occurrence of grain refinement under high undercooling is due to stress induced *** addition,the laser cladding technology is used to coat Co-based alloy(stellite12) coating on 304 stainless steel substrate;the microstructure of the coating cross-section was *** was found that the microstructure of the cross-section is presented as columnar crystals,planar crystals,and disordered growth direction,so that the coating has better hardness and wear *** electrochemical corrosion of the substrate and coating,it can be seen that the Co and Cr elements present in the coating are more likely to form a dense passivation film,which improved the corrosion resistance of the coating.

关键词： non-equilibrium solidification structure undercooling recrystallization laser cladding coating

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Dapagliflozin and sacubitril on myocardial microperfusion in patients with post-acute myocardial infarction heart failure and type 2 diabetes

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World Journal of Clinical Cases 2024年第22期12卷 5008-5015页

作者： Yuan Lv Wei-Jun Luo Department of Cardiology Lishui People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Coronary heart disease and type 2 diabetes mellitus(T2DM)frequently coexist,creating a complex and challenging clinical scenario,particularly when complicated with acute myocardial infarction(AMI).AIM To examine the effects of dapagliflozin combined with sakubactrovalsartan sodium tablets on myocardial *** In total,98 patients were categorized into control(n=47)and observation(n=51)*** control group received noxital,while the observation group was treated with dapagliflozin combined with noxital for 6 *** in myocardial microperfusion,blood glucose level,cardiac function,N-terminal prohormone of brain natriuretic peptide(NT-proBNP)level,growth differentiation factor-15(GDF-15)level,and other related factors were compared between the two ***,the incidence of major adverse cardiovascular events(MACE)and adverse reactions were *** After treatment,in the observation and control groups,the corrected thrombolysis in myocardial infarction frame counts were 37.12±5.02 and 48.23±4.66,*** NT-proBNP levels were 1502.65±255.87 and 2015.23±286.31 pg/mL,the N-terminal pro-atrial natriuretic peptide(NT-proANP)levels were 1415.69±213.05 and 1875.52±241.02 ng/mL,the GDF-15 levels were 0.87±0.43 and 1.21±0.56 g/L,and the high-sensitivity C-reactive protein(hs-CRP)levels were 6.54±1.56 and 8.77±1.94 mg/L,respectively,with statistically significant differences(Ps in the observation group was significantly lower than that in the control group(Pse reactions was 13.73%(7/51)in the observation group and 10.64%(5/47)in the control group,with no statistically significant difference(P>0.05).CONCLUsION Dapagliflozin combined with nocinto can improve myocardial microperfusion and left ventricular remodeling and reduce MACE incidence in patients with post-AMI heart failure and *** underlying mechanism may be related to the reduction i

关键词： Dagelin Nocinto Acute myocardial infarction Type 2 diabetes Heart failure Myocardial microperfusion

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