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Nanoparticle–Cartilage Interaction: pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Nano-Micro Letters 2021年第10期13卷 29-76页

作者： Xu Li Bingyang Dai Jiaxin Guo Lizhen Zheng Quanyi Guo Jiang Peng Jiankun Xu Ling Qin Musculoskeletal Research laboratory Department of Orthopedics and TraumatologyThe Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China Joint laboratory of Chinese Academic of Science and Hong Kong for Biomaterials The Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China Beijing key lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLAInstitute of OrthopedicsChinese PLA General HospitalBeijingPeople’s Republic of China Innovative Orthopedic Biomaterial and Drug Translational Research laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongSha TinHong KongSARPeople’s Republic of China

Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic ***-articular administration of agents is clinically used for pain ***,the effectiveness is inapparent caused by the rapid clearance of *** overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic *** the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of *** this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug ***,we review the interactions of nanoparticles with cartilage microenvironment and the rational ***,we highlight advances in the therapeutic schemes according to the pathology ***,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological *** anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation.

关键词： Nanoparticle Drug delivery Osteoarthritis Articular cartilage Nanomedicine

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Fungal diversity notes 1277-1386:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2020年第5期104卷 1-266页

作者： Hai-Sheng Yuan Xu Lu Yu-Cheng Dai Kevin D.Hyde Yu-He Kan Ivana Kušan Shuang-Hui He Ning-Guo Liu V.Venkateswara Sarma Chang-Lin Zhao Bao-Kai Cui Nousheen Yousaf Guangyu Sun Shu-Yan Liu Fang Wu Chuan-Gen Lin Monika C.Dayarathne Tatiana Baptista Gibertoni Lucas B.Conceição Roberto Garibay-Orijel Margarita Villegas-Ríos Rodolfo Salas-Lizana Tie-Zheng Wei Jun-Zhi Qiu Ze-Fen Yu Rungtiwa Phookamsak Ming Zeng Soumitra Paloi Dan-Feng Bao Pranami DAbeywickrama De-Ping Wei Jing Yang Ishara S.Manawasinghe Dulanjalee Harishchandra Rashika S.Brahmanage Nimali Ide Silva Danushka S.Tennakoon Anuruddha Karunarathna Yusufjon Gafforov Dhandevi Pem Sheng-Nan Zhang AndréL.C.Mde Azevedo Santiago Jadson Diogo Pereira Bezerra Bálint Dima Krishnendu Acharya Julieta Alvarez-Manjarrez Ali H.Bahkali Vinod K.Bhatt Tor Erik Brandrud Timur S.Bulgakov E.Camporesi Ting Cao Yu-Xi Chen Yuan-Yuan Chen Bandarupalli Devadatha Abdallah M.Elgorban Long-Fei Fan Xing Du Liu Gao Camila Melo Gonçalves Luis F.P.Gusmão Naruemon Huanraluek Margita Jadan Ruvishika S.Jayawardena Abdul Nasir Khalid Ewald Langer Diogo X.Lima Nelson Correia de Lima-Júnior Carla Rejane Sousa de Lira Jian-Kui(Jack)Liu Shun Liu Saisamorn Lumyong Zong-Long Luo Neven Matočec M.Niranjan JoséRibamar Costa Oliveira-Filho Viktor Papp Eduardo Pérez-Pazos Alan J.L.Phillips Peng-Lei Qiu Yihua Ren Rafael F.Castañeda Ruiz Kamal C.Semwal Karl Soop Carlos A.Fde Souza Cristina Maria Souza-Motta Li-Hua Sun Meng-Le Xie Yi-Jian Yao Qi Zhao Li-Wei Zhou CAS key laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China School of Ecology and Nature Conservation Beijing Advanced Innovation Center for Tree Breeding By Molecular DesignBeijing Forestry UniversityBeijing 100083People’s Republic of China CAS key laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Ruđer BoškovićInstitute Bijenička cesta 5410000 ZagrebCroatia Faculty of Agriculture Natural Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Department of Biotechnology School of Life SciencesPondicherry UniversityR.V.NagarKalapetPondicherry 605014India College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China Department of Botany Govt.College UniversityKatchery RoadLahorePakistan State key laboratory of Crop Stress Biology in Arid Areas and College of plant Protection Northwest A&F UniversityYanglingShaanxiPeople’s Republic of China laboratory of plant pathology College of Plant ProtectionJilin Agricultural UniversityChangchun 130118Jilin ProvincePeople’s Republic of China Centro de Biociências Departamento de MicologiaUniversidade Federal de PernambucoCidade UniversitáriaAvenida da Engenharia s/nRecifePernambuco 50740-600Brazil Departamento de Ciências Biológicas Universidade Estadual de Feira de SantanaAv.Transnordestina s/nNovo HorizonteFeira de SantanaBA 44036-900Brazil L

This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and strain culture,combined with DNA sequence analyses.110 taxa are described and illustrated,including five new genera,92 new species,eight new combinations and other taxonomic contributions(one new sequenced species,one new host and three new records)which are accommodated in 40 families and 1 incertae sedis in *** new genera are Amyloceraceomyces,Catenuliconidia,Hansenopezia,Ionopezia and *** new species are Amyloceraceomyces angustisporus,Amylocorticium ellipsosporum,Arthrinium sorghi,Catenuliconidia uniseptata,Clavulina sphaeropedunculata,Colletotrichum parthenocissicola,Coniothyrium triseptatum,Cortinarius indorusseus,***,***,***,***,Diaporthe pimpinel-lae,Dictyosporella guizhouensis,Diplodia torilicola,Fuscoporia marquesiana,***,Hansenopezia decora,Helicoarcta-tus thailandicus,Hirsutella hongheensis,Humidicutis brunneovinacea,Lentaria gossypina,***,Lycoperdon lahorense,***,Magnopulchromyces scorpiophorus,Moelleriella gracilispora,Neodevriesia manglicola,Neodidymelliopsis salvia,***,Neoroussoella magnoliae,Neottiella gigaspora,Ophiosphaerella chiangraiensis,Phaeotremella yunnanensis,Podosphaera yulii,Rigidoporus juniperinus,Rhodofomitopsis pseudofeei,Russula benghalensis,Scleroramularia vermispora,Scytinopogon minisporus,Sporormurispora paulsenii,Thaxteriellopsis obliqus,Tomentella asiae-orientalis,***,***,***,***,***,***,***,***,***-nocystidiata,***,***,***,***,***,***,***,***,***,***,***,***,***,***,***,

关键词： 110 taxa Agaricomycetes Ascomycota Basidiomycota Mucoromycota New combinations New genera New species Phylogeny Taxonomy

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Genomic Diversity Comparison among Multi-Strains of the Sinorhizobium meliloti by CGH Microarray

Genomic Diversity Comparison among Multi-Strains of the Sino...

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全国寄生虫学与热带医学学术研讨会

作者：郭虹孙晟徐建平 key laboratory Hainan Medical CollegeHaikouHainan ProvinceP.R.China 571101 Center for Environmental Genomics Department of BiologyMcMaster UniversityHamiltonOntarioCanada L8S 4K1

Microarray based comparative genomic hybridization(CGH) have been used to study genomic diversity in ten Sinorhizobium meliloti strains by comparing with a sequenced lab model strain Rm1021(reference strain).The strains used in this study(tester strains) originated from different ET types,different plant host and various geographic *** genome-wide *** Rm1021 Sm6k-oligonucleotide chips were used for the two colors CGH *** of *** showed considerable diversity in gene content(variable present ORFs,VAP-absent or VAP-duplicate):In VAP-absent group,total 2154 ORFs were considered absent in at least one of the natural strains tested compared to *** ratio of absent ORFs to all ORFs annotated on pSymA was significantly higher than that of on pSymB and chromosome. The percentage of absent divergent genes in the tester strains varied from 1.51%to 6.35;58.34%of all absent ORFs was considered as highly diversity for absent in more than two natural *** the VAP-duplicate group,total 1904 ORFs were considered duplicate in at least one of the natural strains *** number of duplicate genes varied greatly in the individual strains, from 0.27%up to 8.56%.52.86%of all duplicate ORFs were considered as highly diversity. The relationships among genome size,the number of absent ORF,and the number of duplicated ORF were analyzed and *** potential ecological significance was also discussed by comparing the mummer of absent/duplicated ORFs with the host species,geographic origin,ET types of tester *** variation was found in functional categories corresponding to each replicon genome.

关键词： CGH Microarray genome diversity Sinorhizobium meliloti

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Additions to Pseudocamarosporium;two new species from Italy

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Studies in Fungi 2016年第1期1卷 1-10页

作者： Wijayawardene NN Tibpromma S Hyde KD An YL Camporesi E Wang Y Department of plant pathology Agriculture CollegeGuizhou University550025 Center of Excellence in Fungal Research and School of ScienceMae Fah Luang UniversityChiang Rai57100Thailand key laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650201P.R.China World Agroforestry Centre East Asia OfficeKunming 650201YunnanP.R.China P.R.China The key laboratory of Karst Environment and Geohazard Prevention Ministry of EducationGuizhou University A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani” Via Roma 18ForlìItaly/A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly/Societàper gli Studi Naturalistici della RomagnaC.P.144Bagnacavallo(RA)Italy

Two coelomycetous taxa with muriform conidia were collected from Italy,and subjected to morpho-molecular taxonomic analyses.A mega blast search showed that the new taxa had a close relationship with ***-likelihood and Bayesian analyses of combined LSU,SSU and ITS sequence data also showed that these strains reside in Didymosphaeriaceae and cluster with Pseudocamarosporium sensu *** detailed morphological and molecular analyses,these are introduced as new species in *** new taxa are illustrated and compared with other known species in the genus.

关键词： Camarosporium Coelomycetous fungi Muriform Phylogeny

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通过机器学习开发基于作物基因型的抗病表型精准预测方法（英文）

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Engineering 2024年第9期 100-110页

作者：刘琪左世敏彭沙莎张昊彭烨李魏熊叶辉林润茂冯志明李慧慧杨俊王国梁康厚祥 State key laboratory for Biology of plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Zhongshan Biological Breeding laboratory & Jiangsu key laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou University Hunan Provincial key laboratory of Crop Germplasm Innovation and Utilization and College of Agronomy Hunan Agricultural University State key laboratory of Crop Gene Resources and Breeding Institute of Crop Sciences Chinese Academy of Agricultural Sciences College of plant Protection Hunan Agricultural University key laboratory of Green Prevention and Control of Tropical plant Diseases and Pests Ministry of Education College of Plant Protection Hainan University MARA key laboratory of Surveillance and Management for plant Quarantine Pests Department of Plant Biosecurity College of Plant Protection China Agricultural University Department of plant pathology Ohio State University

The traditional method of screening plants for disease resistance phenotype is both time-consuming and costly. Genomic selection offers a potential solution to improve efficiency, but accurately predicting plant disease resistance remains a challenge. In this study, we evaluated eight different machine learning(ML)methods, including random forest classification(RFC), support vector classifier(SVC), light gradient boosting machine(light GBM), random forest classification plus kinship(RFC＿K), support vector classification plus kinship(SVC＿K), light gradient boosting machine plus kinship(light GBM＿K), deep neural network genomic prediction(DNNGP), and densely connected convolutional networks(Dense Net), for predicting plant disease resistance. Our results demonstrate that the three plus kinship(K) methods developed in this study achieved high prediction accuracy. Specifically, these methods achieved accuracies of up to 95% for rice blast(RB), 85% for rice black-streaked dwarf virus(RBSDV), and 85% for rice sheath blight(RSB) when trained and applied to the rice diversity panel I(RDPI). Furthermore, the plus K models performed well in predicting wheat blast(WB) and wheat stripe rust(WSR) diseases, with mean accuracies of up to 90% and 93%, respectively. To assess the generalizability of our models, we applied the trained plus K methods to predict RB disease resistance in an independent population, rice diversity panel Ⅱ(RDPⅡ). Concurrently, we evaluated the RB resistance of RDPⅡ cultivars using spray inoculation. Comparing the predictions with the spray inoculation results, we found that the accuracy of the plus K methods reached 91%. These findings highlight the effectiveness of the plus K methods(RFC＿K, SVC＿K, and light GBM＿K) in accurately predicting plant disease resistance for RB, RBSDV, RSB,WB, and WSR. The methods developed in this study not only provide valuable strategies for predicting disease resistance, but also pave the way for using machine learning to str

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The record of cultivated rice from archaeobiological evidence in northwestern China 5000 years ago

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Chinese Science Bulletin 2007年第10期52卷 1372-1378页

作者： LI XiaoQiang ZHOU XinYing ZHANG HongBin ZHOU Jie SHANG Xue DODSON John State key lab of Loess & Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Institute of Environmental Research Australian Nuclear Science and Technology Organisation Sydney NSW 2234 Australia Institute for the Environment Brunel University Uxbridge Middlesex UB8 3PH UK

Pollen, plant seeds and phytoliths from an AMS dated sediment profile at the Xishanping site indicate that the cultivation of rice might start no later than 5070 cal. a BP in the region of Tianshui, Gansu province. It continued from 5070 to 4300 cal. a BP. This is so far the oldest and the most northwestern record of cultivated rice in Neolithic China, which extends the known region of prehistoric rice cultivation at least 2° longitude to the west. This finding provides important evidence for reconstructing the cultivation region of rice at 5000 a BP (an important time period), and its spreading history in East Asia, during the Neolithic.

关键词：中国西北地区 5000年前栽培稻古生物学证据遗址记录

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Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri Ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana Mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui Lin Zhao Erio Camporesi Guizhou key laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina key laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–J Azad Housing SocietyCurcaGoa VelhaIndia Muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of Microbiology&Beijing key laboratory for Forest Pest Control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The key laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083China Mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,***,***,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,***,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

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Prediction of medium-to-coal ratio effect in a dense medium cyclone by using both traditional and coarse-grained CFD-DEM models

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Particuology 2022年第9期20卷 44-56页

作者： Zhaoyang Li Kaiwei Chu Zongqing Zhou Yixiong Feng Aimin Wang School of Mechanical Engineering Zhejiang UniversityHangzhou 310027China School of Qilu Transportation Shandong UniversityJinan 250002China Shandong Iron and Steel Group Co. Ltd.Jinan 250101China State key lab Fluid Power&Mechatron Syst Zhejiang UniversityHangzhou 310027China4.Hengda Fuji Elevator Co.Ltd.Huzhou 313009China JITRI Institute for Process Modelling and Optimization Suzhou 215123China

Dense medium cyclone(DMC)is the working horse in coal *** practice,it is usually operated under constant pressure and the operational conditions(mainly medium-to-coal(M:C)ratio and oper-ational pressure)need to be adjusted according to coal washability data(mainly coal particle size and density distributions).Nonetheless,until now it is still not well understood how the M:C ratio would affect the performance of DMCs especially under the practical *** this work,the effect of M:C ratio is for the first time numerically studied under conditions similar to plant operation by using both tra-ditional and coarse-grained(CG)combined approach of computational fluid dynamics(CFD)and discrete element method(DEM),called as traditional CFD-DEM and CG CFD-DEM,in which the flow of coal par-ticles is modelled by DEM or CG DEM which applies Newton's laws of motion to individual particles and that of medium flow by the conventional CFD which solves the local-averaged Navier-Stokes equations,allowing consideration of particle-fluid mutual interaction and particle-particle ***,impulse and momentum connection law is used to achieve energy conservation between traditional CFD-DEM and CG *** is found that under constant pressure,the M:C ratio affects DMC perfor-mance *** specific effect depends on coal washability or coal *** extremely low M:C ratio,the phenomenon that high-quality coal product is misplaced to reject is successfully repro-duced,which has been observed in plants in Australian coal industry and called as"low-density tail".Moreover,strategies are proposed to mitigate the"low-density tail"phenomenon based on the model.

关键词： Dense medium cyclone Medium-to-coal ratio Discrete element method Computational fluid dynamics Low-density coal tail

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Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

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Food Science and Human Wellness 2024年第4期13卷 2116-2131页

作者： Yu Peng Xiaoao Xiao Tingting Ji Xinyuan Wang Yixuan Xu Jianbo Xiao Hui Cao Zhiyong Chen Huifan Liu Yuanqing Gao Hongxun Tao key laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Department of Analytical Chemistry and Food Science Faculty of ScienceUniversity of VigoVigo 36310Spain CISPAC Fontan BuildingCity of CultureSantiago de Compostela 15707Spain Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003China Guangdong key laboratory of Science and Technology of Lingnan Specialty Food Zhongkai University of Agriculture and EngineeringGuangzhou 510550China State key laboratory of Southwestern Chinese Medicine Resources Chengdu 610075China

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in ***,our previous work has found that *** extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced ***,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against *** chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were ***,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable *** decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of *** metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid ***,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

关键词： Rhodiola crenulate Colitis Chemical characterization Plasma pharmacochemistry Metabolomics

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Freshwater Dothideomycetes

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Fungal Diversity 2020年第6期105卷 319-575页

作者： Wei Dong Bin Wang Kevin D.Hyde Eric H.C.McKenzie Huzefa A.Raja Kazuaki Tanaka Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Mingkwan Doilom Rungtiwa Phookamsak Sinang Hongsanan Dhanushka N.Wanasinghe Xian-Dong Yu Gen-Nuo Wang Hao Yang Jing Yang Kasun M.Thambugala Qing Tian Zong-Long Luo Jian-Bo Yang Andrew N.Miller Jacques Fournier Saranyaphat Boonmee Dian-Ming Hu Sarunya Nalumpang Huang Zhang Faculty of Agriculture and Food Kunming University of Science and TechnologyKunming 650500China Department of Entomology and plant pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Innovative Agriculture Research Center Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Mai 57100Thailand Innovative Institute of plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225China School of Environment and Resource Southwest University of Science and TechnologySichuan 621010China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Research Center of Microbial Diversity and Sustainable Utilization Faculty of SciencesChiang Mai UniversityChiang Mai 50200Thailand Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Department of Chemistry and Biochemistry University of North CarolinaGreensboro 27413USA Faculty of Agriculture and Life Science Hirosaki UniversityBunkyo-cho3HirosakiAomori 035-8561Japan Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt CAS key laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanChina East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Shenzhen key laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731China Faculty of Environmental Science and Engineering Kunming University of Science&TechnologyKunming 650500China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Genetics and Molecular Biology Unit

Freshwater Dothideomycetes are a highly diverse group of fungi,which are mostly saprobic in freshwater habitats *** are important decomposers of submerged woody debris and leaves in *** this paper,we outline the genera of freshwater Dothideomycetes with notes and keys to *** on multigene analyses and morphology,we introduce nine new genera,***,Aquatospora,Aquihelicascus,Fusiformiseptata,Neohelicascus,Neojahnula,Pseudojahnula,Purpureofaciens,Submersispora;33 new species,*** bipolare,Aquimassariosphaeria kun-mingensis,Aquatospora cylindrica,Aquihelicascus songkhlaensis,***,Ascagilis submersa,***,Bambusicola aquatica,Caryospora submersa,Dictyocheirospora thailandica,Fusiformiseptata crocea,Helicosporium thai-landense,Hongkongmyces aquaticus,Lentistoma aquaticum,Lentithecium kunmingense,Lindgomyces aquaticus,Longipedi-cellata aquatica,Neohelicascus submersus,Neohelicomyces dehongensis,***,Neohelicosporium submersum,Nigrograna aquatica,Occultibambusa kunmingensis,Parabambusicola aquatica,Pseudoasteromassaria aquatica,Pseu-doastrosphaeriella aquatica,Pseudoxylomyces aquaticus,Purpureofaciens aquatica,Roussoella aquatica,Shrungabeeja aquatica,Submersispora variabilis,Tetraploa puzheheiensis,***;16 new combinations,***-eria typhicola,Aquihelicascus thalassioideus,Ascagilis guttulaspora,***,***,***,Ernakulamia xishuangbannaensis,Neohelicascus aquaticus,***,***,***,***,***,***,Neojahnula australiensis,Pseudojahnula potamophila;17 new geographical and habitat records,*** khaoyaiensis,Aquastroma magniostiolata,Caryospora aquatica,***,Dendryphiella vinosa,Ernakulamia cochinensis,Fissuroma neoaggregatum,Helicotruncatum palmigenum,Jahnula rostrata,Neorous-soella bambusae,***,Occultibambusa pustula,Paramonodictys solitarius,Pleopunctum pseud

关键词： 42 new taxa Freshwater distribution Phylogeny Submerged wood Taxonomy

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