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Mapping Network-Coordinated Stacked Gated Recurrent Units for Turbulence Prediction

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1331-1341页

作者： Zhiming Zhang Shangce Gao MengChu Zhou Mengtao Yan Shuyang Cao Faculty of Engineering University of ToyamaToyama 930-8555Japan Helen and john C.Hartmann Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewark NJ 07102 USA Gaoling school of Artificial Intelligence Renmin University of ChinaBeijing 100872China College of Civil Engineering Tongji UniversityShanghai 200092China IEEE

Accurately predicting fluid forces acting on the sur-face of a structure is crucial in engineering ***,this task becomes particularly challenging in turbulent flow,due to the complex and irregular changes in the flow *** this study,we propose a novel deep learning method,named mapping net-work-coordinated stacked gated recurrent units(MSU),for pre-dicting pressure on a circular cylinder from velocity ***-cally,our coordinated learning strategy is designed to extract the most critical velocity point for prediction,a process that has not been explored *** our experiments,MSU extracts one point from a velocity field containing 121 points and utilizes this point to accurately predict 100 pressure points on the *** method significantly reduces the workload of data measure-ment in practical engineering *** experimental results demonstrate that MSU predictions are highly similar to the real turbulent data in both spatio-temporal and individual ***,the comparison results show that MSU predicts more precise results,even outperforming models that use all velocity field *** with state-of-the-art methods,MSU has an average improvement of more than 45%in various indicators such as root mean square error(RMSE).Through comprehensive and authoritative physical verification,we estab-lished that MSU’s prediction results closely align with pressure field data obtained in real turbulence *** confirmation underscores the considerable potential of MSU for practical applications in real engineering *** code is available at https://***/zhangzm0128/MSU.

关键词： Convolutional neural network deep learning recurrent neural network turbulence prediction wind load predic-tion.

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Evolution and Role of Optimizers in Training Deep Learning Models

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2039-2042页

作者： XiaoHao Wen MengChu Zhou Guangxi Normal University Guilin 541004China school of Information and Electronic Engineering Zhejiang Gongshang UniversityHangzhou 310018China the Helen and john C. Hartmann Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102 USA IEEE

TO perform well,deep learning(DL)models have to be trained *** optimizer should be adopted?We answer this question by discussing how optimizers have evolved from traditional methods like gradient descent to more advanced techniques to address challenges posed by highdimensional and non-convex problem *** challenges include their hyperparameter sensitivity,balancing between convergence and generalization performance,and improving interpretability of optimization *** continue to seek robust,efficient,and universally applicable optimizers to advance the field of DL across various domains.

关键词： Which Deep continue

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Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

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Journal of Diabetes Mellitus 2024年第2期14卷 133-152页

作者： Abdoulaye Diawara Djibril Mamadou Coulibaly Drissa Kone Mama A. Traore Drissa Konaté Dicko S. Bazi Oumar Kassogue Djeneba Sylla Fatoumata Gniné Fofana Oudou Diabaté Mariam Traore Ibrahim Antoine Nieantao Kaly Keїta Mamadou Diarra Olivia Smith Jian Li Cheickna Cisse Talib Yusuf Abbas Crystal Zheng Segun Fatumo Kassim Traore Mamadou Wele Mahamadou Diakité Seydou O. Doumbia Jeffrey G. Shaffer University of Sciences Techniques and Technologies of Bamako Bamako Mali National Federation of Community Health Associations Bamako Mali Department of Tropical Medicine Medical Microbiology & Pharmacology John A. Burns School of Medicine University of Hawaii Manoa Honolulu USA Department Biostatistics and Data Science School of Public Health and Tropical Medicine Tulane University New Orleans USA Department of Biotechnology and Computer Science Burhani College Mazgaon Mumbai India school of Medicine Tulane University New Orleans USA medical research Council Uganda Virus Research Institute Entebbe Uganda London school of Hygiene and Tropical Medicine London UK Departement of Biochemistry and Genetics Duquesne University College of Medicine Pittsburgh USA

Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (P = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (P = .013 and.036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (P = .029 and .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

关键词： Cholesterol Cross-Sectional Study Dyslipidemia Lipids Mali Type 2 Diabetes

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Better engineering layered vanadium oxides for aqueous zinc‐ion batteries: Going beyond widening the interlayer spacing

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SmartMat 2024年第1期5卷 83-109页

作者： Yue Guo Hanmei Jiang Binbin Liu Xingyang Wang Yifu Zhang Jianguo Sun john Wang Department of Materials Science and Engineering National University of SingaporeSingaporeSingapore State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalianChina Institute of Materials research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

Aqueous zinc‐ion batteries(ZIBs)are regarded as among the most promising candidates for large‐scale grid energy storage,owing to their high safety,low costs,and environmental *** the past decade,vanadium oxides,which are exemplified by V2O5,have been widely developed as a class of cathode materials for ZIBs,where the relatively high theoretical capacity and structural stability are among the main ***,there are considerable challenges in the construction of vanadium‐based ZIBs with high capacity,long lifespan,and excellent rate *** widenings of the interlayer spacing in the layered vanadium oxides by pre‐intercalations appear to have reached their limitations in improving the energy density and other key performance parameters of ZIBs,although various metal ions(Na+,Ca2+,and Al3+)and even organic cations/groups have been ***,we discuss the advances made more recently,and also the challenges faced by the high‐performance vanadium oxides(V2O5‐based)cathodes,where there are several strategies to improve their electrochemical performance ranging from the new structural designs down to sub‐nano‐scopic/molecular/atomic levels,including cation pre‐intercalation,structural water optimization,and defect engineering,to macroscopic structural *** key principles for an optimal structural design of the V2O5‐based cathode materials for high energy density and fast‐charging aqueous ZIBs are examined,aiming at paving the way for developing energy storage designed for those large scales,high safety,and low‐cost systems.

关键词： aqueous zinc‐ion batteries cations pre‐intercalation defect engineering structural water vanadium oxides

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Late Cambrian Magmatic Events in SW Yunnan and Implications for the Tectonic Reconstruction of Northern Gondwana

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Journal of Earth Science 2024年第5期35卷 1407-1425页

作者： Guichun Liu Jianwei Zi Xiaomei Nie M.Santosh Cai Zhu Wei Wang Tianyu Zhao Guangyan Chen Qinglai Feng Yunnan Institute of Geological Sciences Kunming 650216China school of Earth Sciences China University of GeosciencesWuhan 430074China State Key Lab of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China john de Laeter Centre State Key Curtin UniversityBentley 6102Australia school of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA5005Australia Yunnan Geotechnical Engineering Survey and Design Institute Kunming 650214China Yunnan Exploration Institute of Geology and Mineral Resources Kunming 650051China

In this study,we investigated Early Paleozoic magmatic rocks of the Manlai Formation exposed along the eastern margin of the Lancang terrane to better understand the tectonic history of the *** present petrological,geochemical and whole-rock Sr-Nd and zircon Hf isotopic data for basalts and gabbros sampled from the Qianmai mé*** grains from six basaltic and gabbroic samples yielded U-Pb ages of 495-482 *** rocks are characterized by tholeiitic and Nbenriched compositions,with Nb/La ratios in the range of 0.38-1.38,similar to the typical Nb-enriched *** the mafic rocks show slightly negative to positiveε_(Nd)(t)(-1.67 to+4.32)and zirconε_(Hf)(t)values(-7.3 to+3.8).Elemental and isotopic data suggest that the Qianmai Nb-enriched mafic rocks were mainly derived from the mixing of an OIB-like source with a subduction-modified mantle wedge *** with magmatic and sedimentary records of similar ages in the Lancang terrane and the Baoshan Block,our results reveal Early Paleozoic magmatic and sedimentary sequences along an active margin of the *** into account the recently identified Early Paleozoic ophiolitic mélange in the Yunxian-Menghai belt,we consider the Qianmai magmatic rocks to represent the products of early-stage subduction-related magmatism within a primitive island arc or fore-arc setting associated with the southward subduction of the *** infer that prolonged south-dipping subduction on the northern margin of Gondwana persisted from the Cambrian to the Late Ordovician.

关键词： Qianmai melange Nb-enriched basalts island arc Proto-Tethys northern margin of Gondwana SW Yunnan tectonics geochemistry

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Harnessing CRISPR-Cas system diversity for gene editing technologies

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The Journal of Biomedical research 2021年第2期35卷 91-106页

作者： Alexander McKay Gaetan Burgio Department of Immunology and Infectious Diseases John Curtin School of Medical ResearchAustralian National UniversityCanberraACT 2601Australia

The discovery and utilization of RNA-guided surveillance complexes,such as CRISPR-Cas9,for sequencespecific DNA or RNA cleavage,has revolutionised the process of gene modification or *** optimise the use of this technology,an exploratory race has ensued to discover or develop new RNA-guided endonucleases with the most flexible sequence targeting requirements,coupled with high cleavage efficacy and *** we review the constraints of existing gene editing and assess the merits of exploiting the diversity of CRISPR-Cas effectors as a methodology for surmounting these limitations.

关键词： CRISPR-Cas systems gene editing biological evolution DNA repair classification DNA transposable elements

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Storylines of family medicine Ⅺ:professional identity formation—nurturing one’s own story

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Family Medicine and Community Health 2024年第S3期12卷 99-108页

作者： William B Ventres Leslie A Stone Hamish J Wilson Sumi M Sexton David J Doukas Jessica P Cerdena David M Kelley Michael D Fetters Jeffrey J Haney john J Frey III Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA General Practice and Rural Health University of Otago Dunedin School of MedicineDunedinNew Zealand Family Medicine Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA Family and Community Medicine Tulane University School of MedicineNew OrleansLouisianaUSA Family Medicine Residency Program Middlesex HealthMiddletownConnecticutUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA medical Education and Clinical Sciences Washington State UniversitySpokaneWashingtonUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅺ:professional identity formation—nurturing one’s own story’,authors address the following themes:‘The social construction of professional identity’,‘On becoming a family physician’,‘What’s on the test?—professionalism for family physicians’,‘The ugly doc-ling’,‘Teachers—the essence of who we are’,‘Family medicine research—it starts in the clinic’,‘Socially accountability in medical education’,‘Personal philosophy and how to find it’and‘Teaching and learning with Storylines of Family Medicine’.May these essays encourage readers to find their own creative spark in medicine.

关键词： own becoming professional

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Targeting pancreatic ductal adenocarcinoma:New therapeutic options for the ongoing battle

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 4-6页

作者： Pratibha Malhotra Ranjith Palanisamy Marco Falasca Metabolic Signalling Group Curtin Medical SchoolCurtin Health Innovation Research InstituteCurtin UniversityPerthWA6102Australia

Pancreatic ductal adenocarcinoma(PDAC),the most commonly reported form of pancreatic cancer,is a lethal malignancy that con-tributes to the global cancer burden with high morbidity and mor-tality[1].It has a poor 5-year survival mainly because PDAC poses a significant diagnostic challenge,has a high metastatic rate at di-agnosis and is stubbornly resistant to therapy[2].

关键词： adenocarcinoma ductal cancer

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Mutations of voltage-gated sodium channel contribute to pyrethroid resistance in Panonychus citri

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Insect Science 2024年第3期31卷 803-816页

作者： Deng Pan Qiu-Juan Luo Andrias O.O'Reilly Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina school of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resistance in Panonychus citri is a major obstacle to mite control in citrus *** insecticides are continually used to control mites in China,although resistance to pyrethroids has evolved in some ***,the resistance to the pyrethroid fenpropathrin was investigated and 7 out of 8 field-collected populations of P citri exhibited a high level of resistance,ranging from 171-fold to 15391-fold higher than the susceptible(SS)comparison *** voltage-gated sodium channel(VGSC)mutations were identified in the tested populations:L1031V,F1747L,and *** sequencing was used to evaluate the frequency of these mutations in the 19 field populations.L1031V and F1751I were present in all populations at frequencies of 11.6%-82.1%and 0.5%-31.8%,respectively,whereas the F1747L mutation was only present in 12 populations from Chongqing,Sichuan,Guangxi,and Yunnan *** of these mutations singly or in combination into transgenic flies significantly increased their resistance to fenpropathrin and these flies also exhibited reduced mortality after exposure to the pyrethroids permethrin andβ-*** citri VGSC homology modeling and ligand docking indicate that F1747 and F1751 form direct binding contacts with pyrethroids,which are lost with mutation,whereas L1031 mutation may diminish pyrethroid effects through an allosteric ***,the results provide molecular markers for monitoring pest resistance to pyrethroids and offer new insights into the basis of pyrethroid actions on sodium channels.

关键词： amplicon sequencing kdr mutation molecular docking Panonychus citri pyrethroid resistance transgenic flies

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Delineation of a novel dendritic-like subset in human spleen

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Cellular & Molecular Immunology 2016年第4期13卷 443-450页

作者： Sawang Petvises Dipti Talaulikar Helen C O'Neill research school of Biology The Australian National University Canberra Australia john curtin school of medical research The Australian National University Canberra Australia ANU medical school College of Medicine Biology and Environment The Australian National University Canberra Australia Department of Haematology Canberra Hospital Canberra Australia

Dendritic cells （DCs） and monocyte subpopulations present in the human spleen were analyzed by flow cytometry in an attempt to identify the presence of a novel dendritic-like cell subset described previously in mice and named L-DCs. In this study, an equivalent of this novel murine subset was characterized in the human spleen, thus increasing our knowledge of the antigen-presenting cell types present in the human spleen. Human L-DCs were identified as a hCD11c^hCD11b＋HLA-DR-hCD86＋ subset in the spleen, along with the previously described subsets of hCDlc＋ DCs, hCD123＋ plasmacytoid DCs （pDCs）, hCD16＋ DCs and hCD141＋ DCs. Three subsets of monocytes were also characterized. DC and monocyte subsets in human spleen had phenotypes similar to those of subsets in human blood. In line with murine studies, the presence of L-DC progenitors within the spleen was also investigated. When human splenocytes depleted of T and B cells were cocultured with the murine stromal line 5G3, hematopoiesis ensued and hCD11c＋HLA-DR＋ and hCD11c＋HLA-DR- cells were produced. The latter resemble L-DCs, which are also produced in murine spleen cocultures. Both subsets expressed hCDSO and hCD86, which identifies them as antigen-presenting cells, particularly DCs, and were highly endocytic. It is noteworthy that murine splenic stroma can serve as a support matrix for human hematopoiesis and DC production. These results support the hypothesis that 5G3 must express both cell-associated and soluble factors that can signal hematopoiesis in human and murine progenitors.

关键词： dendritic cells myelopoiesis spleen stroma

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