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the institute of urology, Peking University prostatectomy score： a simple preoperative classification of prostate cancer for predicting surgical difficulty and risk

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Asian Journal of Andrology 2018年第6期20卷 581-586页

作者： Bing-Lei Ma Lin Yao Wei Yu Yu Wang Hai-Feng Song Zhe-Nan Zhang Si-Meng Lu Qian Zhang Zhi-Song He lie Jin Li-Qun Zhou Department of urology Peking University First Hospital and Institute of UrologyPeking UniversityBeijing 100034China.

Traditional laparoscopic radical prostatectomy is a treatment choice in many developing countries and regions for most patients with localized prostate cancer; however, no system for predicting surgical difficulty and risk has been established. This study aimed to propose a simple and standard preoperative classification system of prostate cancer using preoperative data to predict surgical difficulty and risk and to evaluate the relationship between the data and postoperative complications. We collected data from 236 patients and divided them into three groups to evaluate and validate the relationships among preoperative, operative, and postoperative data. This new scoring system is based on the body mass index, ultrasonic prostate volume, preoperative prostate-specific antigen level, middle lobe protrusion, and clinical stage. In the scoring group, we classified 89 patients into two groups： the low-risk group （score of 〈4） and high-risk group （score of ~4）, and then compared the postoperative data between the two groups. The positive surgical margin rate was higher in the high-risk group than low-risk group. The results in validation Groups A and B were similar to those in the scoring group. The focus of our scoring system is to allow for preliminary assessment of surgical difficulty by collecting the patients＇ basic information. Urologists can easily use the scoring system to evaluate the surgical difficulty and predict the risks of a positive surgical margin and urinary incontinence in patients undergoing laparoscopic radical prostatectomy.

关键词： laparoscopic radical prostatectomy prostate cancer scoring system surgical difficulty and risk

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Robotic assisted laparoscopic simple suprapubic prostatectomy--The Smith institute for urology experience with an evolving technique

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Asian Journal of urology 2014年第1期1卷 55-59页

作者： Sammy E.Elsamra Nikhil Gupta Haris Ahmed David Leavitt Jessica Kreshover Louis Kavoussi Lee Richstone The Smith institute for urology New Hyde ParkNYUSA

Objective:Despite a multitude of minimally invasive surgical options available for benign prostatic enlargement,open simple prostatectomy(OSP)remains the standard for large prostates(typically greater than 100 g).OSP,however,is associated with significant ***,a few reports touting robotic application to simple prostatectomy have been ***,we reviewed our series of robotic assisted laparoscopic simple suprapubic prostatectomy(RALSSP)and detailed modifications in our technique as our experience ***:All RALSSP cases performed between January 2013 and January 2014 were reviewed for demographics,pre-operative features,and perioperative *** parameters were tabulated and mean values were ***’s t-test was utilized with p<0.05 deemed *** regarding surgical technique were reviewed and ***:Fifteen patients underwent RALSSP during this *** age of these men was 68.7 *** body mass index(BMI)was 28.5 kg/m^*** Society of Anesthesiologists(ASA)score was on average *** International Prostate Symptom Score(IPSS)was 16.2 with the majority of men experiencing some adverse clinical sequela of such benign prostatic hyperplasia(BPH).For those patients not in retention,preoperative post-void residual(PVR)was 428 *** patients underwent successful RALSSP without need for conversion or need for blood *** estimated blood loss(EBL)was 290 *** patients underwent other concurrent procedures(e.g.,cystolithotomy).Mean length of hospital stay(LOS)was 2.4 days and only five patients required continuous bladder irrigation(CBI)*** PVR improved to a mean of 33 mL and IPSS improved to 4.5(p<0.001).No major complications were *** of low transverse cystotomy,utilization of a robotic tenaculum in the#3 arm with its control by a surgeon on a second console,and the utilization of mucosal advancement have all subjectively a

关键词： Robotic assisted laparoscopic simple suprapubic prostatectomy Benign prostatic hyperplasia Blood loss Hospital stay

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Predictors of renal angioembolization outcome:A retrospective analysis with 148 patients at a tertiary urology institute

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Asian Journal of urology 2022年第2期9卷 103-108页

作者： Hashim Mohamed Farg Mohamed Mohamed Elawdy Karim Ali Soliman Mohamed Ali Badawy Ali Elsorougy Abdalla Abdelhamid Tarek Mohsen Tarek El-Diasty Department of Radiology Urology and Nephrology CentreMansoura UniversityMansouraEgypt Department of urology Urology and Nephrology CentreMansoura UniversityMansouraEgypt

Objective:The aim of this study was to evaluate the predictor of unsuccessful outcome of renal angioembolization(RAE).Knowing those predictors may help in avoiding unnecessary RAE procedures and their associated side effects,while helping to prepare for an alternate procedure and improving patient's overall ***:A retrospective analysis between January 2006 and December 2018 was performed,and the indications for RAE were classified into post-traumatic,iatrogenic,renal tumors,and *** who underwent RAE prior to nephrectomy were *** tomography angiography was performed in patients with normal renal function and those who had no contrast allergy,otherwise magnetic resonance angiography was *** the purpose of statistical analysis,we stratified patients into two main categories based on the final outcome—successful or ***:Of 180 patients,32 with negative angiography were eliminated,leaving 148 patients;136(91%)had successful outcomes after one or more trials and 12 had unsuccessful *** mean age was 45±15 years,and 105(71%)were *** gender,side of the lesion,presence of hematuria,indication for RAE,nor the type of lesion affected the *** the other hand,renal anatomy with presence of accessory artery was the only predictor to failed RAE(p=0.001).Failed RAE trial was a predictor for nephrectomy as a secondary procedure(p=0.03).Conclusion:No pre-procedural predictors could anticipate the RAE outcome,and different indications can be scheduled to RAE,which is equally *** presence of accessory renal artery on diagnostic angiography is the only factor that may predict the failure of the procedure.

关键词： Angioembolization Renal angioembolization Embolization Renal trauma Outcome

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Expanding role of antibodies in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 57-71页

作者： Khawar Abbas Muhammed Mubarak Department of Transplant Immunology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan Javed I.Kazi Department of Histopathology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan

The role of antibodies in kidney transplant(KT)has evolved significantly over the past few *** role of antibodies in KT is multifaceted,encompassing both the challenges they pose in terms of antibody-mediated rejection(AMR)and the opportunities for improving transplant outcomes through better detection,prevention,and treatment *** our understanding of the immunological mechanisms continues to evolve,so too will the approaches to managing and harnessing the power of antibodies in KT,ultimately leading to improved patient and graft *** narrative review explores the multifaceted roles of antibodies in KT,including their involvement in rejection mechanisms,advancements in desensitization protocols,AMR treatments,and their potential role in monitoring and improving graft survival.

关键词： Antibodies Humoral theory Kidney transplantation Rejection

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De novo patients with high-volume metastatic hormone-sensitive prostate cancer can benefit from the addition of docetaxel to triplet therapy: Network-analysis and systematic review

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中华医学杂志(英文版) 2025年第2期138卷 2024 Sep 27页

作者： Guo Hanxu Jin Chengqi Ding Li Xie Jun Xu Jing Wang Ruiliang Wang Hong Guo Changcheng Zhang Jiansheng Peng Bo Yao Xudong Yuan Jing Yang Bin Department of urology Shanghai Tenth People’s Hospital Tongji University School of Medicine Shanghai China Department of urology Urologic Cancer Institute Tongji University School of Medicine Shanghai China Department of urology School of Medicine Anhui University of Science and Technology Huainan Anhui China Department of urology Shanghai Clinical College Anhui Medical University Shanghai China Department of urology Shanghai Tenth People’s Hospital Nanjing Medical University Nanjing Jiangsu China

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Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer

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Chinese Chemical Letters 2025年第2期36卷 289-296页

作者： Ze Wang Hao Liang Annan Liu Xingchen Li Lin Guan Lei Li Liang He Andrew K.Whittaker Bai Yang Quan Lin State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Department of Endocrinology Lequn Branch the First Hospital of Jilin University Department of urology the First Hospital of Jilin University Australian institute for Bioengineering and Nanotechnology the University of Queensland

Prostate cancer(PCa) is characterized by high incidence and propensity for easy metastasis, presenting significant challenges in clinical diagnosis and treatment. Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy. Considering that tumor-derived alkaline phosphatase(ALP) is over-expressed in metastatic PCa, it makes a great chance to develop a theranostics system with ALP responsive in the TME. Herein, an ALP-responsive aggregationinduced emission luminogens(AIEgens) nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa. The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence, and enhanced accumulation and prolonged retention period at the tumor site. In terms of detection, the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR) multi-mode imaging effect of nanoprobe was significantly improved post-aggregation, enabling precise diagnosis through the amalgamation of multiple imaging modes. Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis, and enhanced FL imaging technology can achieve “intraoperative visual navigation”, showing its potential application value in clinical tumor detection and surgical guidance. In terms of treatment, AMNF showed strong absorption in the near infrared region after aggregation, which improved the photothermal treatment effect. Overall, our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.

关键词： AIE ALP responsive Enhanced multi-mode imaging Enhanced photothermal therapy Prostate cancer

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Advancements in implantable temperature sensors:Materials,mechanisms,and biological applications

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Journal of Semiconductors 2025年第1期46卷 166-177页

作者： Zhuofan Yang Hongcheng Song He Ding Beijing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China Department of urology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China

Implantable temperature sensors are revolutionizing physiological monitoring and playing a crucial role in diagnostics,therapeutics,and life sciences *** review classifies the materials used in these sensors into three categories:metal-based,inorganic semiconductor,and organic semiconductor ***-based materials are widely used in medical and industrial applications due to their linearity,stability,and *** semiconductors provide rapid response times and high miniaturization potential,making them promising for biomedical and environmental *** semiconductors offer high sensitivity and ease of processing,enabling the development of flexible and stretchable *** review analyzes recent studies for each material type,covering design principles,performance characteristics,and applications,highlighting key advantages and challenges regarding miniaturization,sensitivity,response time,and ***,critical performance parameters of implantable temperature sensors based on different material types are summarized,providing valuable references for future sensor design and *** future development of implantable temperature sensors is discussed,focusing on improving biocompatibility,long-term stability,and multifunctional *** advancements are expected to expand the application potential of implantable sensors in telemedicine and dynamic physiological monitoring.

关键词： implantable temperature sensors biological applications flexible electronics

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A smart finger patch with coupled magnetoelastic and resistive bending sensors

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Journal of Semiconductors 2025年第1期46卷 194-203页

作者： Ziyi Dai Mingrui Wang Yu Wang Zechuan Yu Yan Li Weidong Qin Kai Qian School of Integrated Circuits Shandong UniversityJinan 250100China Department of Mechanical Engineering University of AucklandAuckland 1010New Zealand Department of urology Qilu Hospital of Shandong UniversityJinan 250100China Shenzhen Research institute of Shandong University Shenzhen 518000China Department of Critical Care Medicine Qilu hospital of Shandong universityJinan 250100China

In the era of Metaverse and virtual reality(VR)/augmented reality(AR),capturing finger motion and force interactions is crucial for immersive human-machine *** study introduces a flexible electronic skin for the index finger,addressing coupled perception of both state and process in dynamic tactile *** device integrates resistive and giant magnetoelastic sensors,enabling detection of surface pressure and finger joint *** e-skin identifies three phases of finger action:bending state,dynamic normal force and tangential force(sweeping).The system comprises resistive carbon nanotubes(CNT)/polydimethylsiloxane(PDMS)films for bending sensing and magnetoelastic sensors(NdFeB particles,EcoFlex,and flexible coils)for pressure *** inward bending resistive sensor,based on self-assembled microstructures,exhibits directional specificity with a response time under 120 ms and bending sensitivity from 0°to 120°.The magnetoelastic sensors demonstrate specific responses to frequency and deformation magnitude,as well as sensitivity to surface roughness during sliding and material *** system’s capability is demonstrated through tactile-based bread type and condition recognition,achieving 92%*** intelligent patch shows broad potential in enhancing interactions across various fields,from VR/AR interfaces and medical diagnostics to smart manufacturing and industrial automation.

关键词： human machine interface flexible sensor wearable sensor giant magnetoelastic effect inward bending sensor

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Endothelial dysfunction in the kidney transplant population:Current evidence and management strategies

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World Journal of Transplantation 2025年第1期15卷 24-43页

作者： Arun Prabhahar Akshey Batta Juniali Hatwal Vivek Kumar Raja Ramachandran Akash Batta Department of Telemedicine(Internal Medicine and Nephrology) Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of urology and Renal Transplant Neelam HospitalRajpura 140401PunjabIndia Department of Internal Medicine Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Nephrology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Cardiology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and *** dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future cardiovascular(CV)*** kidney disease,a state of chronic inflammation caused by oxidative stress,metabolic abnormalities,infection,and uremic toxins damages the *** is also associated with a decline in estimated glomerular filtration *** kidney transplantation,endothelial functions undergo immediate but partial restoration,promising graft longevity and enhanced CV ***,the anticipated CV outcomes do not happen due to various transplant-related and unrelated risk factors for ED,culminating in poor CV health and graft *** in kidney transplant recipients is an underrecognized and poorly studied *** diseases are the leading cause of death among kidney transplant candidates with functioning *** contributes to the pathogenesis of many of the CV *** biomarkers and vasoreactivity tests are available to study endothelial *** an increasing number of transplants happening every year,and improved graft rejection rates due to the availability of effective immunosuppressants,the focus has now shifted to endothelial protection for the prevention,early recognition,and treatment of CV diseases.

关键词： Endothelial dysfunction Endothelium Cardiovascular disease Kidney transplantation Chronic kidney disease Nitric oxide Flow-mediated dilatation Nitro-glycerine-mediated dilatation Biomarkers

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Effect of kidney transplantation on sexual dysfunction in patients with end stage renal disease:A systematic review

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World Journal of Nephrology 2025年第1期14卷 127-137页

作者： Jaydeep Jain Mahendra Singh Shashank Kumar Om Kumar Yadav Ankit Shettar Shiv Charan Navriya Deepak Prakash Bhirud Gautam Ram Choudhary Arjun Singh Sandhu Department of urology All India Institute of Medical SciencesJodhpur 342008RājasthānIndia

BACKGROUND End-stage renal disease(ESRD)is associated with a multitude of physical,psychological,and social health challenges,including a profound impact on sexual and reproductive *** males with ESRD,erectile dysfunction(ED)is highly prevalent due to factors such as underlying comorbidities,including diabetes and hypertension,and the physiological effects of long-term *** transplantation(KTx)has been proposed as a potential intervention to mitigate the effects of ED by restoring renal function and improving hormonal ***,the evidence surrounding the effectiveness of KTx in improving sexual function,specifically erectile function(EF),remains *** systematic review and meta-analysis aim to evaluate the effects of KTx on sexual dysfunction(SexDys),particularly ED,in male ESRD *** To evaluate the benefits and potential harms of KTx compared to other forms of renal replacement therapy in improving EF in adult males with ESRD,assessed using the international index of EF(IIEF),to survey the prevalence of SexDys in this population,and to assess the correlation between various factors and SexDys through regression *** A systematic search of PubMed,EMBASE,Cochrane Library,Scopus,***,and Google Scholar was conducted,following the PRISMA 2020 *** and retrospective cohort studies,as well as cross-sectional studies assessing EF pre-and post-transplantation,were *** studies used validated tools such as the IIEF to measure ***-analyses were performed using a random-effects model to estimate standardized mean differences(SMD)and hazard ratios(HR)with 95%confidence intervals(CI).Heterogeneity was assessed using the I²statistic,and publication bias was evaluated with a funnel plot and the Egger’s *** A total of 2419 studies were identified,with 362 abstracts screened and 193 full-text articles ***,11 studies were included for qualitative analys

关键词： Kidney transplantation Sexual dysfunction Erectile dysfunction International index of erectile function Syste-matic review Meta analyses

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