检索结果-南通市图书馆

Vascular Calcification： Current Genetics Underlying This Complex Phenomenon

Chinese Medical Journal 2017年第9期130卷 1113-1121页

作者： Nonanzit Perez-Hernandez Gad Aptilon-Duque Ruben Blachman-Braun Gilberto Vargas-Alarcon Adrian Asael Rodriguez-Cortes Shely Azrad-Daniez Rosalinda Posadas-Sanchez Jose Manuel Rodriguez-Perez Department of molecular biology National Institute of Cardiology "lgnacio Chavez" Mexico Mexico City 14080 Mexico 2Department of Endocrinology National Institute of Cardiology "Ignacio Chavez" Mexico Mexico City 14080 Mexico

Objective： Vascular calcification is the consequence of the complex interaction between genetic, environmental, and vascular factors, which ultimately lead to the deposition of calcium in the tunica intima （atherosclerotic calcification） or tunica media （M6nckenberg＇s sclerosis）. Vascular calcification is also closely related to other pathologies, such as diabetes mellitus, dyslipidemia, and chronic kidney disease. It has been concluded that the degree of vascular calcification may vary from person to person, even if the associated pathologies and environmental factors are the same. Therefore, this suggests an important genetic contribution to the development of vascular calcification. This review aimed to find the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. Data Sources： We conducted an exhaustive search in Scopus, EBSCO, and PubMed with the keywords ＂genetics and vascular calcification＂, ＂molecular pathways, genetic and vascular calcification＂ and included the main articles from January 1995 up to August 2016. We focused on the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. Study Selection： The most valuable published original and review articles related to our objective were selected. Results： Vascular calcification is a multifactorial disease; thus, its pathophysiology cannot be explained by a single specific factor, rather than by the result of the association of several genetic variants, molecular pathway interactions, and environmental factors that promote its development. Conclusion： Although several molecular aspects of this mechanism have been elucidated, there is still a need for a better understanding of the factors that predispose to this disease.

关键词： Atherosclerosis Cardiovascular Risk Genetics Polymorphisms Vascular Calcification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Taxonomic revision of Gelidium tsengii and Gelidium honghaiwanense sp. nov. (Gelidiales, Rhodophyta) from China based upon molecular and morphological data analyses

引用

Chinese Journal of Oceanology and Limnology 2017年第6期35卷 1442-1453页

作者：王旭雷夏邦美 Antonella BOTTALICO 王广策 Key Laboratory of Experimental Marine biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Laboratory for Marine biology and Bioteehnology Qingdao National Laboratory for Marine Science and Technology Qingdao 266071 China University of Chinese Academy of Sciences Beijing 100049 China Department of Marine Organism Taxonomy and Phylogeny Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Department of biology University of Bari A. Moro Bari 70125 Italy

The taxonomic relationship of Chinese GeBdium tsengii and Gelidium johnstonii was ambiguous. For almost 20 years they have been regarded as distinct taxa and until 2002 *** was considered as a misapplied name of G. tsengii. In this study, herbarium specimens that initially attributed to G. tsengii and fresh G. tsengii specimens were used to address the taxonomic issues. In phylogenetic studies, G. tsengii from Dayawan, China, near the type locality of G. tsengii and *** from Sonora, Mexico, the type locality of G. johnstonii, formed a monophyletic group with maximum support in rbcL and COl genes analyses, indicating that they were genetically identical. In morphological studies, G. tsengii was similar to G. johnstonii in branching pattern, inner structures and fructiferous organs. Consequently, we considered that semi-circular outline of G. tsengii could no longer be treated as a discrimating fea^re. *** had priority of publication and according to the International Code of Botanical Nomenclature, G. tsengii was proposed as a synonym of G. johnstonii. Gelidium honghaiwanense sp. nov. was described from Guangdong, China on the basis of morphological and molecular data. For vegetative structures, it was characterized by flattened upright frond, regular two-three times branches pinnate or alternate and clavate ultimate branchlets. For reproductive structures, the tetrasporangial sori were in the apical part of branches and the tetrasporangial branchlets were distichously distributed along second order branches. The present study clarified the relationship between G. tsengii and G. johnstonii from Guangdong and added a new Gelidium species to the Chinese algal flora.

关键词： COI Gelidiumjohnstonii phylogeny rbcL taxonomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel lysosome‐localized fluorescent probe with aggregation‐induced emission without alkalinizing effect

引用

SmartMat 2021年第4期2卷 554-566页

作者： Jingran Zhang Yan Jia Xinyi Xing Mengmei Qin Zibo Wu Yingqian Zhong Lele Liu Shuqing Sun Peng Li Haiyuan Wang Guangjiu Zhao Tianjin Key Laboratory of molecular Optoelectronic Sciences National Demonstration Center for Experimental Chemistry&Chemical Engineering EducationNational Virtual Simulation Experimental Teaching Center for Chemistry&Chemical Engineering EducationDepartment of ChemistrySchool of ScienceTianjin UniversityTianjinChina State Key Laboratory of molecular Reaction Dynamics Dalian Institute of Chemical Physics(DICP)Chinese Academy of Sciences(CAS)DalianChina institute of Frontier and Interdisciplinary Science Institute of Molecular Sciences and EngineeringShandong UniversityQingdaoChina

Herein,a novel small molecule probe,tetraphenylethylene‐cystein(TPE‐Cys),was rationally designed and developed for the intracellular lysosome *** combination of tetraphenylethylene and cysteine serve as a novel strategy for lysosome‐targeting,with significant aggregation‐induced emission increases with the proportion of water by as high as 25‐*** imaging experiments show that the probe TPE‐Cys has a good colocalization effect with the commercially available lysotracker red,with a Pearson correlation coefficient of *** addition,we also demonstrate that TPE‐Cys has good light ***‐Cys,as a neutral compound,is free of alkalinizing effect when applied in lysosome ***,molecular dynamics simulations and density function theories are employed to explore the detailed aggregation process and the mechanism of TPE‐Cys aggregation in water *** mechanism of lysosome localization of probe TPE‐Cys was explained by cellular endocytosis process and the formation of larger particle in the more acidic environment of *** work not only demonstrates an efficient strategy for the construction of fluorescent probes for lysosome localization,but also indicates that they are promising as live cell imaging tools.

关键词： acid‐base neutralization AIEgen cysteine fluorescent probe lysosome localization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flexible electrochemical fiber sensor for intracranial nitric oxide monitoring

引用

Science China Chemistry 2024年第8期67卷 2431-2433页

作者： Ziwei Liu Huisheng Peng State Key Laboratory of molecular Engineering of Polymers Department of Macromolecular ScienceInstitute of Fiber Materials and Devicesand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China

Real-time and accurate monitoring of vital biomarkers in vivo forms a crucial foundation for health assessment,early intervention,and disease ***,continuous monitoring of intracranial nitric oxide(NO)levels plays a pivotal role in promptly assessing immune responses,neurovirulence,and cerebrovascular diseases[1].Differing from non-real-time monitoring methods like chemiluminescence[2]and fluorescent probes[3],implantable electrochemical sensors excel in simultaneously high temporal resolution,sensitivity,and cost-effectiveness[4].

关键词： prompt electrochemical monitoring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epigenetic regulation in Wnt signaling

Epigenetic regulation in Wnt signaling

引用

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Yingying Jia Zhenfei Li Fen Nie Lin Li State Key Laboratory of molecular biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

The canonical Wnt signaling pathway controls and regulates many developmental processes through a complex of P-catenin and the HMG-box transcription factors of the LEF1/TCFs *** co-activators including histone modification enzymes are recruited into P-catenin·LEF1/ TCFs transcription complex at target gene promoters to facilitate gene *** we show that two novel

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans

引用

Natural Products and Bioprospecting 2012年第1期2卷 35-40页

作者： Katharina DEEG Tolga EICHHORN Gladys ALEXIE Nadine KRETSCHMER Kai ANDERSCH Rudolf BAUER Thomas EFFERTH institute of Pharmacy and molecular Biotechnology University of HeidelbergHeidelbergGermany Department of Pharmaceutical biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityMainzGermany Fort McPerson Northwest TerritoriesCanada institute of Pharmaceutical Sciences Department PharmacognosyKarl-Franzens UniversityGrazAustria Wilderness International Dresden(Germany)and Stony Plain(AlbertaCanada)

The Gwich’in,which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and *** analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia(T-ALL)*** anti-leukemic activity of these plants has not been investigated as *** the poor cure rates of some ALL forms,there might be a great potential for medicinal plants as resource for natural products to treat *** found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM *** 50%inhibition concentrations(IC50)were 6.63±0.03μg/ml for Cladina mitis,8.65±0.38μg/ml for Picea mariana(needles),and 9.67±1.36μg/ml for Artemisia *** investigations are required to isolate the active constituents of these plants.

关键词： cytotoxicity herbs leukemia medicinal plants pharmacognosy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High electro-catalytic graphite felt/Mn O2composite electrodes for vanadium redox flow batteries

引用

Science China Chemistry 2018年第6期61卷 732-738页

作者： Qiang Ma Qi Deng Hang Sheng Wei Ling Hong-Rui Wang Hai-Wen Jiao Xiong-Wei Wu Wen-Xin Zhou Xian-Xiang Zeng Ya-Xia Yin Yu-Guo Guo College of Science Hunan Agricultural University Changsha 410128 China Laboratory of molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences (CAS) Beijing 100190 China Hunan Province Yin Feng New Energy Co. LTD Changsha 410000 China

A mild and simple synthesis process for large-scale vanadium redox flow batteries(VRFBs)energy storage systems is desirable.A graphite felt/Mn O_2(GF-MNO)composite electrode with excellent electrocatalytic activity towards VO^(2+)/VO_2^+redox couples in a VRFB was synthesized by a one-step hydrothermal *** resulting GF-MNO electrodes possess improved electrochemical kinetic reversibility of the vanadium redox reactions compared to pristine GF electrodes,and the corresponding energy efficiency and discharge capacity at 150 m A cm^(-2)are increased by 12.5%and 40%,*** discharge capacity is maintained at 4.8 A h L^(-1)at the ultrahigh current density of 250 m A cm^(-2).Above all,80%of the energy efficiency of the GF-MNO composite electrodes is retained after 120 charge-discharge cycles at 150 m A cm^(-2).Furthermore,these electrodes demonstrated that more evenly distributed catalytic active sites were obtained from the Mn O_2particles under acidic *** proposed synthetic route is facile,and the raw materials are low cost and environmentally ***,these novel GF-MNO electrodes hold great promise in large-scale vanadium redox flow battery energy storage systems.

关键词： VRFB one-step hydrothermal graphite felt manganese dioxide composite electrode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interfacial Polymer Engineered Field Effect Transistor Biosensors for Rapid and Efficient Identification of SARS-CoV-2 N Antigen

引用

Chinese Journal of Chemistry 2023年第18期41卷 2253-2260页

作者： Qiumin Peng Wanting Huang Duo Chen Zhipeng Gao Yanbing Yang Quan Yuan College of Chemistry and molecular Sciences Key Laboratory of Biomedical Polymers of Ministry of EducationInstitute of Molecular MedicineRenmin Hospital of Wuhan UniversitySchool of MicroelectronicsWuhan UniversityWuhanHubei 430072China molecular Science and Biomedicine Laboratory(MBL) State Key Laboratoryof Chemo/Biosensing and ChemometricsCollege of Chemistryand Chemical EngineeringHunan UniversityChangshaHunan 410082China

With the advantages of high sensitivity,rapid response,label-free,and simple operation,field effect transistor biosensors have shown promising application prospects in large-scale pathogen ***,in practical biological fluids with relatively high ionic strength,such as saliva and serum,the Debye screening effect will weaken the interaction between FET biosensors and target bio-molecules,thereby affecting the sensing sensitivity and accuracy.

关键词： Field effect transistor Debye screening effect Biosensing Interfacial engineering Epidemic screening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanistic study of Saccharomyces cerevisie Est1 on telomerase activity

Mechanistic study of Saccharomyces cerevisie Est1 on telomer...

引用

第二届全国“跨学科蛋白质研究”学术讨论会

作者：童夏静周金秋 State Key Lab of molecular biology Institute of Biochemistny and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

Telomerase is a specialized reverse transcriptase that extends one strand of the telomere templated by a short element embedded in its RNA *** Saccharomyces cerevisie,Est2p (telomerase catalytic subunit) and Tlc1 (telomerase RNA template subunit) constitute the enzymatic core ***1p and Est3p are essential for telomerase activity in vivo,and believed to be the subunits of telomerase holoenzyme,which contribute to telomerase *** has been proposed previously that Est1p,in spite of the recruitment function,could act as a cell-cycle dependent telomerase activator aithough the precise mechanism is still *** we report that co-overexpression of Est1 witheither Est2 or Tlc1 induces longer telomeres than overexpression of Est1 alone,while,co-overexpression of Est1 with both Est2p and Tlc1 leads to even longer *** have purified recombinant Est1p and tested its biochemical ***1p could bind oligo with yeast telomeric sequence specifically,and further promote the oligo to form a high order DNA ***-of-function mutants of Est1p leads to senescence phenotype,indicating the in cisregulatJon of Est1p on telomerase would be essential in *** study of recombinant Est1p on telomerase activity/processivity is in progress.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Single X-Ray Attosecond Pulse Generation by Using Combined Pulses Irradiating on a United Two-Atom System

引用

Chinese Physics Letters 2007年第1期24卷 86-89页

作者：陈基根李琛池方萍杨玉军 Department of Physics Taizhou University Linhai 317000 College of Physics and Electronic Engineering Ludong University Yantai 264003 institute of Atomic and molecular Physics Jilin University Changchun 130012 institute of Theoretical Chemistry Jilin University Changchun 130012

A scheme of a single x-ray attosecond pulse generation from a two-atom system exposed to the combined laser pulses is proposed. Our numerical results show that a single x-ray attosecond pulse rather than a train one can be produced by modulation of ionization. Furthermore, when we change the peak intensity Ih of the high-frequency pulse and keep the intensity of the low-frequency pulse constant, we can find that a range of Ih where the intensity of the attosecond pulse is optimal is available, and a explanation by the stimulated property of the recombination is also presented.

关键词： Single X-Ray Attosecond Pulse Generation Using Combined Pulses Irradiating United Two-Atom System

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：