检索结果-南通市图书馆

Neutron powder diffraction and high-pressure synchrotron x-ray diffraction study of tantalum nitrides

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Physics B 2018年第2期27卷 210-214页

作者：冯雷豪胡启威雷力房雷鸣戚磊张雷雷蒲梅芳寇自力彭放陈喜平夏元华小岛洋平大藤宏明贺端威陈波入舩徹男 institute of Atomic and molecular Physics Sichuan University Chengdu 610065 China institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Mianyang 621900 China Geodynamics Research Center Ehilne University Matsuyama 790-8577 Japan

Tantalum nitride （TAN） compact with a Vickers hardness of 26 GPa is prepared by a high-pressure and high- temperature （HPHT） method. The crystal structure and atom occupations of WC-type TaN have been investigated by neutron powder diffraction, and the compressibility of WC-type TaN has been investigated by using in-situ high-pressure synchrotron x-ray diffraction. The third-order Birch-Murnaghan equation of state fitted to the x-ray diffraction pressure- volume （P-V） sets of data, collected up to 41 GPa, yields ambient pressure isothermal bulk moduli of B0 = 369（2） GPa with pressure derivatives of B~ = 4 for the WC-type TaN. The bulk modulus of WC-type TaN is not in good agreement with the previous result （Bo = 351 GPa）, which is close to the recent theoretical calculation result （Bo = 378 GPa）. An analysis of the experiment results shows that crystal structure of WC-type TaN can be viewed as alternate stacking of Ta and N layers along the c direction, and the covalent Ta-N bonds between Ta and N layers along the c axis in the crystal structure play an important role in the incompressibility and hardness of WC-type TaN.

关键词： neutron powder diffraction synchrotron x-ray diffraction TaN high pressure

Structural basis of AN2690-resistance by leucyl-tRNA synthetase from Giardia lamblia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural basis of AN2690-resistance by leucyl-tRNA synthet...

第十届全国酶学学术讨论会

作者：刘如娟 En-Duo Wang State Key Laboratory of molecular biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesThe Chinese Academy of Sciences

A large insertion domain called connective peptide 1(CP1) present in class Ia aminoacyl-tRNA synthetases is responsible for post-transfer *** editing domain of leucyl-tRNA synthetase(LeuRS) has been shown to be the target of the antifungal 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole(AN2690). The drug forms a covalent bond with the 2’- and 3’ooxygen atoms of tRNA adenosine 76 which traps tRNA in the editing site of ***2690 has a dominant inhibitory effect on a wide range of LeuRSs from

关键词：

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-lnduced Internalization of NPC1L1

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Block...

第二届全国“跨学科蛋白质研究”学术讨论会

作者：王婧宋保亮 State Key Laboratory of molecular biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

Niemann-Pick C1-like 1 (NPC 1 L1) is a polytopic transmembrane protein that plays a critical role in cholesterol absorption. Ezetimibe,a hypocholesterolemic drug,has been reposed to bind NPC 1L1 and block cholesterol ***, the molecular mechanism of NPC 1L1-mediated cholesterol uptake and how ezetimibe inhibits this process are poorly *** we find that cholesterol specifically promotes the internalization of NPC 1 L1 and that this process requires

关键词：

Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans

在线全文

cnki会议

学校读者我要写书评

暂无评论

Crystal structure of the WOPR-DNA complex and implications f...

2014年第七届中国模式真菌研讨会

作者： Shicheng Zhang Tianlong Zhang Minghui Yan Jianping Ding 陈江野 State Key Laboratory of molecular biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

Worl is a master regulator of the white-opaque switching in Candida albicans,an opportunistic human fungal pathogen,and is associated with its pathogenicity and *** contains a conserved DNA-binding region at the N-terminus consisting of two conserved segments(WOPRa and WORPb)connected by a non-conserved linker that can bind to specific DNA sequences of the promoter regions and then regulates the ***,we report the crystal structure of the *** Worl WOPR segments in complex with a double-stranded DNA corresponding to one promoter region of *** sequentially separated WOPRa and WOPRb are structurally interwound together to form a compact globular domain we term the WOPR

关键词：

Liver tissue microbiota in nonalcoholic liver disease:a change in the paradigm of host-bacterial interactions

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第3期10卷 337-349页

作者： Silvia Sookoian Carlos J.Pirola School of Medicine Institute of Medical Research A LanariUniversity of Buenos AiresCiudad Autónoma de Buenos AiresArgentina Department of Clinical and molecular Hepatology Institute of Medical Research(IDIM)National Scientific and Technical Research Council(CONICET)University of Buenos AiresCiudad Autónoma de Buenos AiresArgentina Department of molecular Genetics and biology of Complex Diseases Institute of Medical Research(IDIM)National Scientific and Technical Research Council(CONICET)University of Buenos AiresCiudad Autónoma de Buenos AiresArgentina

Nonalcoholic fatty liver disease(NAFLD)pathogenesis is explained by the complex relationship among diet and lifestyle-predisposing factors,the genetic variance of the nuclear and mitochondrial genome,associated phenotypic traits,and the yet not fully explored interactions with epigenetic and other environmental factors,including the *** the wealth of knowledge gained from molecular and genome-wide investigations in patients with NAFLD,the precise mechanisms that explain the variability of the histological phenotypes are not fully *** studies of the gut microbiota in patients with NAFLD and nonalcoholic steatohepatitis(NASH)provided clues on the role of the fecal microbiome in the disease ***,the composition of the gut microbiota does not fully explain tissue-specific mechanisms associated with the degree of disease severity,including liver inflammation,ballooning of hepatocytes,and *** liver acts as a key filtration system of the whole body by receiving blood from the hepatic artery and the portal ***,not only microbes would become entrapped in the complex liver anatomy but,more importantly,bacterial derived products that are likely to be potentially powerful stimuli for initiating the inflammatory ***,the study of liver tissue microbiota offers the opportunity of changing the paradigm of host-NAFLD-microbial interactions from a“gut-centric”to a“liver-centric”***,we highlight the evidence on the role of liver tissue bacterial DNA in the biology of NAFLD and ***,we provide evidence of metagenomic findings that can serve as the seed of further hypothesis-raising studies as well as can be leveraged to discover novel therapeutic targets.

关键词： Nonalcoholic fatty liver disease(NAFLD) nonalcoholic steatohepatitis(NASH) HSD17B13 microbiota microbiome proteobacteria lipopolysaccharide(LPS) drug prediction

Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal structure of the ARL2-GTP-BART complex reveals a nov...

第二届全国“跨学科蛋白质研究”学术讨论会

作者：丁建平 State Key Laboratory of molecular biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

ARL2 is a member of the ARF family of small GTPases but has unique biochemical and structural features and appears to have distinct function(s)different from the ARF proteins,BART is an effector of ARL2 which has been shown to be essential for nuclear retention of STAT3 through interaction with *** present here the crystal structure of human ARL2-GTP- BART *** ARL2-GTP assumes a typical small GTPase fold with the N-terminalo-helix in a conformation different

关键词：

Adenosine A2A,but not A1,receptors are important in sleep-wake regulation

在线全文

cnki会议

学校读者我要写书评

暂无评论

Adenosine A2A,but not A1,receptors are important in sleep-wa...

2006年中国睡眠研究会第四届学术年会

作者： Yoshihiro Urade Naomi Eguchi Osamu Hayaishi Department of molecular Behavioral biology Osaka Bioscience InstituteOsaka 565-0874Japan Department of molecular Behavioral biology Osaka Bioscience InstituteOsaka 565-0874Japan Waseda-Olympus Bioscience InstituteHelios #05-01／0211 Biopolis WaySingapore 138667 Department of molecular Behavioral biology Osaka Bioscience InstituteOsaka 565-0874Japan

＜正＞Adenosine is recognized as a major humoral sleep-inducing factor accumulated in the brain during the prolongation of wakefulness. It is converted to AMP by adenosine kinase in the brain parenchyma and to inosine by adenosine deaminase dominantly expressed in the leptomeninges （1）. Because adenosine metabolized rapidly in vivo, stable adenosine analogues were used to identify the adenosine receptor subtype involved in sleep regulation. In wild-type （WT） mice, i.c.v. infusion of cyclopentyl adenosine, an agonist of A1 receptor （A1R）, did not change the sleep-wake cycle, whereas CGS21680, an agonist of A2A receptor （A2AR）, induced potent non-REM sleep （2, 3）. The infusion of A2AR-agonist increased the expression of c-fos protein in ventrolateral preoptic area （VLPO）, one of the sleep centers, in a non-REM sleep-dependent manner. Consequently, the activation of VLPO neurons was associated with a decrease in the c-fos expression in histaminergic tuberomammillary nucleus （TMN）, one of the arousal centers. On the other hand, the GABAergic inhibition of TMN was found to be involved in non-REM sleep induction by adenosine CGS21680 （3）. Hence, the neural network between VLPO and TMN plays a key role in the regulation of vigilance states. We then examined the sleep-wake cycles of WT, A1R-gene knockout （KO）, and A2AR-KO mice. Compared with the WT mice, A1R-KO mice did not show any changes in non-REM and REM sleep regulation under basal conditions and exhibited the same amount of rebound sleep after 6-hr sleep deprivation during the light period. On the other hand, A2ARHKO mice showed a slight increase in non-REM and REM sleep during the dark period under the basal conditions and exhibited almost no rebound of non-REM sleep after the 6-h sleep deprivation （4）. Moreover, caffeine binds to A1R and A2AR with similar affinities as a receptor antagonist and inhibited non-REM and REM sleep in WT and A1R-KO mice, but not at all in A2AR-KO mice （5）. These results, taken together, ind

关键词：

Development of aggregated state chemistry accelerated by aggregation-induced emission

在线全文

cnki会议

学校读者我要写书评

暂无评论

National Science Review 2021年第6期8卷 20-22页

作者： Yujun Xie Zhen Li institute of molecular Aggregation Science Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Department of Chemistry Wuhan University

Light is an essential ingredient of human civilization, and has been tightly associated with society and everyone’s daily life. Light can be emitted from various kinds of luminophores, and the concept of aggregation-induced emission(AIE)was a breakthrough in the field of organic light-emitting materials, which experienced stages of pursuing truth, discarding prejudices and creating new knowledge.

关键词：

Scattering Resonance States and Partial Potential Energy Surface of Reaction I+HI(v=0)→IH(v′=0) +I

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2005年第5期21卷 569-572页

作者： SUN Xiao-min WANG Hua-yang CAI Zheng-ting FENG Da-cheng BIAN Wen-sheng institute of Theoretical Chemistry Shandong University Jinan 250100 P. R. China State Key Laboratory of molecular Dynamics Institute of ChemistryChinese Academy of Scienees Beijing 100080 P. R. China

The partial potential energy surface of the I ＋ HI →IH ＋ I reaction involving the translational and vibrational motions has been constructed at the QCISD（ T ）//MP4SDQ level with the pseudo potential method that is helpful to interpreting the scattering resonance states. The lifetimes of the scattering resonance states in the title reaction obtained from the partial potential energy surface are about 90-120 fs, which agrees with the result of high-resolved threshold photodetachment spectroscopy of anion IHI^- measured by Neumark.

关键词： Partial potential energy surface Reaction pathway Dynamic Eyring Lake Scattering resonance state,Lifetime of resonance