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小胶质细胞再激活可缓解脑损伤后炎症反应并促进脑功能恢复

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神经损伤与功能重建 2017年第3期12卷 F0003-F0003页

作者： Rice RA Pham J Lee RJ Najafi AR West BL Green KN 唐颖馨(编译) Department of Neurobiology and Behavior Institute for Memory Impairments and Neurological DisordersUniversity of CaliforniaIrvineCalifornia92697 Plexxikon inc BerkeleyCalifornia94710 不详

中枢神经系统疾病或损伤后,小胶质细胞介导的慢性神经炎症反应会损伤局部脑组织,加重病情,不利于神经功能的恢复。小胶质细胞的激活通过集落刺激因子1受体(CSF1R)信号通路,CSF1R抑制剂可阻断小胶质细胞的激活。抑制慢性神经炎症反应是... 详细信息

中枢神经系统疾病或损伤后,小胶质细胞介导的慢性神经炎症反应会损伤局部脑组织,加重病情,不利于神经功能的恢复。小胶质细胞的激活通过集落刺激因子1受体(CSF1R)信号通路,CSF1R抑制剂可阻断小胶质细胞的激活。抑制慢性神经炎症反应是治疗中枢神经系统疾病的有效方法,但长时间抑制小胶质细胞在临床实践中无法实现。值得注意的是,去掉CSF1R抑制剂可刺激中枢神经系统内新的小胶质细胞的彻底重激活。本课题组建立小鼠广泛性神经元丢失模型,在该模型中探讨急性小胶质细胞的消除及再激活的作用。神经元的丢失导致了较长时间的神经炎性反应,表现为小胶质细胞肿胀,并表达CD68和CD45;同时,细胞因子、趋化因子、补体及其他炎症信号的表达增加。小胶质细胞的再激活可以缓解上述炎症反应,还可以促进小鼠神经功能的恢复,即使该小鼠的海马神经元丢失80%,其在水迷宫测试中的得分与正常小鼠的得分相差无几。对突触的分析结果显示,小胶质细胞的再激活可增加PSD95和突触泡蛋白点状突触体的表达,提示小胶质细胞有助于重塑和调节突触的形态和功能。综上所述,本研究结果显示,小胶质细胞的短时间消除及再激活可能是一种新颖有效的方法用于减少神经炎性反应并促进脑功能恢复。

关键词：集落刺激因子1受体树突棘胶质细胞神经炎症反应神经元丢失

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2332-2342页

作者： Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMI 48201USA School of Life Sciences Jilin University130021 ChangchunChina Division of Pediatric Hematology and Oncology Children’s Hospital of MichiganDetroitMIUSA48201 Department of Pediatrics Wayne State University School of MedicineDetroitMI 48201USA Department of Oncology Wayne State University School of MedicineDetroitMI 48201USA Molecular Therapeutics Program Karmanos Cancer InstituteWayne State University School of MedicineDetroitMI 48201USA Department of Hematology and Oncology The First Hospital of Jilin University130021 ChangchunChina

Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a *** this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient ***9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and ***,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of ***,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of *** preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML.

关键词： venetoclax clinical CDK9

BENEFICIAL EFFECT OF A CONTROLLED HERBAL REMEDY, K-17.22, IN CCL4-INDUCED LIVER TOXICITY

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BENEFICIAL EFFECT OF A CONTROLLED HERBAL REMEDY, K-17.22, IN...

TREM2依赖性小胶质细胞功能对于髓鞘再生及其神经保护至关重要

The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects

作者： F.Marotta A.Rouge H.Anzulovic M.Harada G.M.IdéoGI Dept., S. G. Hosp. K.Kajikawa N.Yanaihara G.Princess G.Idéo. GI Dept. S. G. Hosp. α-Ω Tech α-Ω Tech MCH Hosp. MCK Hosp. Yanaihara institute. α-Ω Tech GI Dept. S. G. Hosp.

Recently, it has been devised an herbal formula (Yojyo-Henshiko: K-17.22, Kyotsu inc., Tokyo, Japan), obtained from selective control of the processing preparation and which has been shown in preliminary clinical tests to significantly decrease transaminases level in HCV-positive chronic liver disease patients. The aim of this study was to test K-17.22 in

关键词： CCL BENEFICIAL EFFECT OF A CONTROLLED HERBAL REMEDY IN CCL4-INDUCED LIVER TOXICITY K-17.22

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神经损伤与功能重建 2023年第7期18卷 F0003-F0003页

作者： YuanyuanWang Roxanne V Kyauk Yun-An A Shen Luke Xie Mike Reichelt Han Lin Zhiyu Jiang Hai Ngu Kimberle Shen Jacob J Greene Morgan Sheng Tracy J Yuen 杜一星(编译) Department of Neuroscience Genentech Inc.South San FranciscoCaliforniaUSA Department of Biomedical Imaging Genentech Inc.South San FranciscoCaliforniaUSA Department of Pathology Genentech Inc.South San FranciscoCaliforniaUSA Stanley Center for Psychiatric Research Broad Institute of MIT and HarvardCambridgeMassachusettsUSA. 不详

多发性硬化症(MS)的残疾在一定程度上是由髓鞘再生失败和进行性神经变性引起的。小胶质细胞和髓系细胞触发受体2(TREM2)(一种在小胶质细胞中高度表达的因子)已被证明在髓鞘再生中发挥重要作用。本研究使用大脑局灶性脱髓鞘模型,证明脱... 详细信息

多发性硬化症(MS)的残疾在一定程度上是由髓鞘再生失败和进行性神经变性引起的。小胶质细胞和髓系细胞触发受体2(TREM2)(一种在小胶质细胞中高度表达的因子)已被证明在髓鞘再生中发挥重要作用。本研究使用大脑局灶性脱髓鞘模型,证明脱髓鞘在TREM2敲除小鼠中持续存在;脱髓鞘在注射溶血卵磷脂后持续超过6周,并导致严重的神经变性。我们还发现TREM2敲除小鼠在脱髓鞘后表现出神经胶质反应的改变。TREM2敲除小胶质细胞表现出迁移和吞噬髓磷脂碎片的缺陷。此外,来自携带人类疾病中普遍存在的TREM2突变的受试者的人类单核细胞衍生的巨噬细胞也显示出髓磷脂碎片吞噬作用的缺陷。综上所述,我们强调了TREM2信号在髓鞘再生和神经保护中的核心作用。这些发现揭示了慢性脱髓鞘如何导致轴突损伤,并有助于确定多发性硬化症的新型神经保护治疗靶点。

关键词：髓系细胞触发受体2 轴突变性脱髓鞘小胶质细胞多发性硬化症少突胶质细胞髓鞘再生

Low-Cost Sustainable Technologies for the Production of Clean Drinking Water—A Review

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Journal of Environmental Protection 2014年第1期5卷 42-53页

作者： Sharmin Zaman Sabina Yeasmin Yasuhiro Inatsu Chiraporn Ananchaipattana Mohammad Latiful Bari Department of Biology Faculty of Science and Technology Rajamangala University of Technology Thanyaburi Thailand Department of Genetic Engineering and Biotechnology University of Dhaka Dhaka Bangladesh Food Analysis and Research Laboratory Center for Advanced Research in Sciences University of Dhaka Dhaka Bangladesh National Food Research institute National Agriculture and Food Research Organization Tsukuba-shi Japan

Water has always been an important and life-sustaining drink to humans and is essential to the survival of all known organisms. Over large parts of the world, humans have inadequate access to drinking water and use water contaminated with disease vectors, pathogens or unacceptable levels of toxins or suspended solids. Drinking such water or using it in food preparation leads to widespread, acute and chronic illnesses and is a major cause of death and misery in many countries. The UN estimates that over 2.0 billion people have limited access to safe water and nearly 800 million people lack even the most basic supply of clean water. The main issue is the affordability of water purifying systems. Many people rely on boiling water or bottled water, which can be expensive. Therefore, technologies that are cost effective, sustainable, ease of operation/maintenance and the treatment processes with locally available materials are required. In this article, some unique low-cost sustainable technologies available/or in-use, i.e. natural filtration, riverbank filtration, biosand filtration, membrane filtration, solar water disinfection technique, biologically degradable materials such as moringa powder, scallop powder treatment, and biosand pitcher treatments have been discussed.

关键词： Sustainable Technology Clean Drinking Water Low Cost Bio-Sand Filtration Natural Filtration Solar Disinfection

Quality improvement in pediatric inflammatory bowel disease: Moving forward to improve outcomes

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World Journal of Gastroenterology 2013年第38期19卷 6367-6374页

作者： Pauline Quach Geoffrey C Nguyen Eric I Benchimol CHEO IBD Centre Division of GastroenterologyHepatology and NutritionChildren’s Hospital of Eastern OntarioOttawa K1H 8L1Canada institute for Clinical Evaluative Sciences Ottawa K1Y 4E9Canada Zane Cohen Center for Digestive Research Division of GastroenterologyMount Sinai HospitalToronto M5T 3L9Canada Department of Medicine University of TorontoToronto M5S 2J7Canada Departments of Pediatrics Epidemiology and Community MedicineUniversity of OttawaOttawa K1H 8M5Canada

In recent years,pediatric health care has embraced the concept of quality improvement to improve patient *** quality improvement efforts are implemented,network collaboration(where multiple centers and practices implement standardized programs)is a popular *** a collaborative network,improvement in the conduct of structural,process and outcome quality measures can lead to improvements in overall health,and benchmarks can be used to assess and compare *** this review article,we provided an overview of the quality improvement movement and the role of quality indicators in this *** reviewed current quality improvement efforts in pediatric inflammatory bowel disease (IBD),as well as other pediatric chronic *** discussed the need to standardize the development of quality indicators used in quality improvement networks to assess medical care,and the validation techniques which can be used to ensure that process indicators result in improved outcomes of clinical *** aimed to assess current quality improvement efforts in pediatric IBD and other diseases,such as childhood asthma,childhood arthritis,and neonatal *** doing so,we hope to learn from their successes and failures and to move the field forward for future improvements in the care provided to children with IBD.

关键词： Inflammatory bowel disease Colitis Ulcerative Crohn’s disease Child Adolescent Quality of health care Review

Validation of the 8-Item Morisky Medication Adherence Scale in chronically Ill Ambulatory Patients in Rural Greece

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Open Journal of Nursing 2016年第3期6卷 158-169页

作者： Sotirios Plakas Dimos Mastrogiannis Marianna Mantzorou Theodoula Adamakidou Georgia Fouka Angeliki Bouziou Chrysoula Tsiou Donald E. Morisky Department of Nursing Technological Educational Institution (TEI) of Athens Athens Greece Research Unit for Nursing Rehabilitation of the chronically Ill Technological Educational Institution (TEI) of Athens Athens Greece Department of Nursing Technological Educational Institute of Central Greece Lamia Greece General Hospital of Aitoloakarnania Agrinion Greece Department of Community Health Sciences UCLA Fielding School of Public Health Los Angeles CA USA

Objective: To validate a Greek version of the structured self-reported 8-item Morisky Medication Adherence Scale (MMAS-8) and determine its psychometric properties in patients with chronic illnesses. Methods: A cross-sectional survey was conducted in a small public hospital and a public health care centre, in a rural town in western Greece. The sample consisted of 100 patients with various chronic illnesses. Data were collected between January-May 2011, on the Greek version of the MMAS-8 and Beliefs about Medicines Questionnaire (BMQ). Results: Scale’s reliability analysis revealed an overall Cronbach’s alpha of 0.753 and the corrected item to total correlations, were greater than 0.30 for each of the 8 items comprising the medication adherence scale, showing good internal consistency. Convergent validity was supported by a significant correlation between the present scale’s total score and the BMQ-Specific Necessity score (Spearman’s rho = 0.492, p chronic illnesses. The validated Greek version of the MMAS-8 can help towards understanding adherence barriers in Greece so as to develop effective strategies to increase adherence and reduce the costs.

关键词： Adherence Validation chronic illnesses Morisky MMAS-8 Scale

Wearable ultrasound bioelectronics for healthcare monitoring

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The Innovation 2023年第4期4卷 7-8页

作者： Shan Jiang Tianqi Zhang Yingying Zhou Puxiang Lai Yuan Huang Hangzhou institute of Technology Xidian UniversityHangzhou 311200China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPediatric Cardiac Surgery CenterFuwai HospitalChinese Academy of Medical Sciencesand Peking Union Medical CollegeBeijing 100037China

Customized and personalized healthcare,being self-administered by patients,is highly sought after in light of the increasing burdens of chronic illnesses and aging *** clinics that empower individuals to have a more prominent role in managing their health are becoming a trend due to many *** example,they can reduce hospital visits and infection risk during a pandemic like COVID-19.

关键词： becoming managing illness

Skype Support for Preschool Children with Long-Term Illness One Year Follow-Up

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Psychology Research 2016年第2期6卷 69-78页

作者： Margaretha Jenholt Nolbris Agneta Simeonsdotter Svensson Anna-Lena Hellstrom The Centre for Person-Centered Care (GPCC) The institute of Health and Care Sciences Sahlgrenska Academy University of Gothenburg The Centre for Children's Right to Health Queen Silvia Children's Hospital Gothenburg Sweden The Centre for Person-Centered Care (GPCC) Department of Education Communication andLearning University of Gothenburg Gothenburg Sweden The Centre for Person-Centered Care (GPCC) The institute of Health and Care Sciences Sahlgrenska Academy institute of Women and Children's Health University of Gothenburg Section of Pediatric Urology Queen Silvia Children's Hospital Gothenburg Sweden