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Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation

World Journal of Gastroenterology 2020年第33期26卷 4889-4899页

作者： Ronald Neil Kostoff Michael Brandon Briggs Darla Roye Shores School of Public Policy Georgia Institute of TechnologyGainesvilleVA 20155United States Independent Consultant RoscommonMI 48653United States the hopkins resource for intestinal vitality and enhancement the Johns Hopkins University School of MedicineBaltimoreMD 21287United States

Inflammatory bowel disease(IBD)incidence has been increasing steadily,most dramatically in the Western developed *** often includes lifelong immunosuppressive therapy and *** is a critical need to reduce the burden of IBD and to discover medical therapies with better efficacy and fewer potential *** of treatments originally studied in other diseases with similar pathogenesis is less costly and time intensive than de novo drug *** study used a treatment repurposing methodology,the literature-related discovery and innovation(LRDI)text mining system,to identify potential treatments(developed for non-IBD diseases)with sufficient promise for extrapolation to treatment of *** searching for desirable patterns of twenty key biomarkers relevant to IBD(e.g.,inflammation,reactive oxygen species,autophagy,barrier function),the LRDI-based query retrieved approximately 9500 records from *** most recent 350 records were further analyzed for *** 18%(64/350)met the criteria for discovery(not previously studied in IBD human or animal models)and relevance for application to IBD *** of the treatments were compounds derived from herbal remedies,and the majority of treatments were being studied in cancer,diabetes,and central nervous system disease,such as depression and *** further validation of the search strategy,the query identified ten treatments that have just recently begun testing in IBD models in the last three ***-related discovery and innovation text mining contains a unique search strategy with tremendous potential to identify treatments for repurposing.A more comprehensive query with additional key biomarkers would have retrieved many thousands more records,further increasing the yield of IBD treatment repurposing discovery.

关键词： Treatment repurposing Treatment repositioning Inflammatory bowel disease Literature-based discovery Text mining Crohn’s disease Ulcerative colitis Novel treatments

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Effects of Seed vitality and Regeneration on Genetic Integrity in Soybean by SSR Markers

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Agricultural Biotechnology 2019年第1期8卷 21-27,72页

作者： Dong WANG Xiaodong ZHANG Runfang LI Lingyun LU Xiaomu WANG Xiaohong GU Xia XIN Guangkun YIN Xinxiong LU Hanfeng DING Crop Germplasm resource Center of Shandong Province/Shandong Research Station of Crop Gene resource & Germplasm enhancement Ministry of Agriculture Institute of Crop Sciences Chinese Academy of Agricultural Sciences

The seeds of Zhonghuang 18 were selected as a test material,and subjected to artificial aging treatment(0,112,154 and 196 d),obtaining four 4 populations,i.e.,G_0-1,G_0-2,G_0-3 and G_0-4,the germination rates of which were 98.0%,95.0%,81.0%and 79.0%,*** four populations were reproduced twice in field,giving four populations of the first reproduced generation G_1-1,G_1-2,G_1-3 and G_1-4 and four populations of the second reproduced generation G_2-1,G_2-2,G_2-3 and G_*** results showed that the number of alleles(Ae)per locus and genetic identity of all the treatment populations did not change significantly compared with the control population G_0-1,and population G_0-4 still shared 0.996 2 genetic identity with the control population,indicating that the genetic identity between the population with a germination rate of 79.0%and the control population was still *** results of t test showed that populations G_0-2,G_1-1 and G_2-1 showed number of alleles per locus(A),genetic diversity index(H)and Shannon index without significantly differences from the control population G_0-1;populations G_1-2 and G_2-2 had the number of alleles per locus(A)significantly decreased;and the above genetic diversity parameters of populations G_0-3,G_0-4,G_1-3,G_1-4,G_2-3 and G_2-4 decreased significantly or very *** results ofχ~2test showed that there were almost no differences in the allelic frequency distribution between populations G_0-2,G_1-1 and G_2-1 and the control populaiton G_0-1;and populations G_0-3,G_0-4,G_1-2,G_1-3,G_1-4,G_2-2,G_2-3and G_2-4 differed in allele frequency distribution,and the lower the vitality level,the greater the *** with the control population G_0-1,populations G_0-2,G_1-1 and G_2-1 had no significant changes in number of rare alleles,while populations G_0-3,G_0-4,G_1-2,G_2-2,G_1-3,G_1-4,G_2-3 and G_2-4 decreased significantly in number of rare *** above results showed that compared with the control

关键词： Soybean vitality Regeneration SSR Genetic integrity Germplasm preservation

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