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An Enhanced Lung Cancer Detection Approach Using Dual-Model Deep Learning Technique

Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Sumaia Mohamed Elhassan Saad Mohamed Darwish Saleh Mesbah Elkaffas Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing and Information Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic *** detection of lung tumors significantly increases the chances of successful treatment and ***,current diagnostic methods often fail to detect tumors at an early stage or to accurately pinpoint their location within the lung ***-model deep learning technologies for lung cancer detection,while beneficial,cannot capture the full range of features present in medical imaging data,leading to incomplete or inaccurate ***,it may not be robust enough to handle the wide variability in medical images due to different imaging conditions,patient anatomy,and tumor *** overcome these disadvantages,dual-model or multi-model approaches can be *** research focuses on enhancing the detection of lung cancer by utilizing a combination of two learning models:a Convolutional Neural Network(CNN)for categorization and the You Only Look Once(YOLOv8)architecture for real-time identification and pinpointing of *** automatically learn to extract hierarchical features from raw image data,capturing patterns such as edges,textures,and complex structures that are crucial for identifying lung ***8 incorporates multiscale feature extraction,enabling the detection of tumors of varying sizes and scales within a single *** is particularly beneficial for identifying small or irregularly shaped tumors that may be challenging to ***,through the utilization of cutting-edge data augmentation methods,such as Deep Convolutional Generative Adversarial Networks(DCGAN),the suggested approach can handle the issue of limited data and boost the models’ability to learn from diverse and comprehensive *** combined method not only improved accuracy and localization but also ensured efficient real-time processing,which is crucial for practical clinical applicati

关键词： Lung cancer detection dual-model deep learning technique data augmentation CNN YOLOv8

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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

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Neural Regeneration Research 2025年第1期20卷 184-185页

作者： Teruyuki Ishikura Tatsusada Okuno Department of Molecular Neuroscience Graduate School of MedicineOsaka UniversityOsakaJapan Department of Neurology Osaka University Graduate School of MedicineOsaka UniversityOsakaJapan

In this article, we present our previous research, which highlighted adenosine triphosphate(ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD). In NMOSD pathology, damageassociated molecular patterns(DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD.

关键词： pain acute pathology

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Therapeutic potential of stem cells in subarachnoid hemorrhage

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Neural Regeneration Research 2025年第4期20卷 936-945页

作者： Hideki Kanamaru Hidenori Suzuki Department of Neurosurgery Mie University Graduate School of MedicineTsuJapan

Aneurysm rupture can result in subarachnoid hemorrhage,a condition with potentially severe consequences,such as disability and *** the acute stage,early brain injury manifests as intracranial pressure elevation,global cerebral ischemia,acute hydrocephalus,and direct blood–brain contact due to aneurysm *** may subsequently cause delayed cerebral infarction,often with cerebral vasospasm,significantly affecting patient *** complications such as brain volume loss and chronic hydrocephalus can further impact *** the mechanisms of subarachnoid hemorrhage-induced brain injury is paramount for identifying effective *** cell therapy,with its multipotent differentiation capacity and anti-inflammatory effects,has emerged as a promising approach for treating previously deemed incurable *** review focuses on the potential application of stem cells in subarachnoid hemorrhage pathology and explores their role in neurogenesis and as a therapeutic intervention in preclinical and clinical subarachnoid hemorrhage studies.

关键词： delayed cerebral ischemia early brain injury matricellular protein neurogenesis stem cell therapy subarachnoid hemorrhage

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In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

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Neural Regeneration Research 2025年第8期20卷 2309-2310页

作者： Takashi Irie Taito Matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Neurology Neurological InstituteGraduate School of Medical SciencesKyushu UniversityFukuokaJapan

Stroke causes neuronal loss,which ultimately results in persistent neurological ***,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and ischemic heart *** that year,there were 12.2 million incident strokes,101 million prevalent strokes,and 143 million disability-adjusted life-years due to stroke.

关键词： neonatal death therapeutic

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Study on Radial Position of Impurity Ions in Core and Edge Plasma of LHD Using Space-Resolved EUV Spectrometer

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Plasma Science and Technology 2011年第2期13卷 140-144页

作者：董春风 Shigeru MORITA Motoshi GOTO Masahiro KOBAYASH graduate university for advanced studies National Institute for Fusion Science

Radial profiles of impurity ions of carbon, neon and iron were measured for high- temperature plasmas in large helical device （LHD） using a space-resolved extreme ultraviolet （EUV） spectrometer in the wavelength range of 60A to 400 A. The radial positions of the impurity ions obtained are compared with the local ionization energies, El of these impurity ions and the electron temperatures T,z there. The impurity ions with 0.3 keV 〈_ Ei ≤ 1.0 keV are always located in outer region of plasma, i.e., 0.7 ≤ p ≤ 1.0, and those with Ei ≤ 0.3 keV are located in the ergodic layer, i.e., 1.0 ≤ p≤ 1.1, with a sharp peak edge, where p is the normalized radial position. It is newly found that Tez is approximately equal to Ei for the impurity ions with Ei ≤ 0.3 keV, whereas roughly half the value of El for the impurity ions with 0.3 keV≤ Ei ≤ 1.0 keV. It is known that Tez is considerably lower than Ei in the plasma edge and approaches to Ei in the plasma core. Therefore, this result seems to originate from the difference in the transverse transport between the plasma edge at p 〈1.0 and the ergodic layer at p ≥ 1.0. The transverse transport is studied with an impurity transport simulation code. The result revealed that the difference appearing in the impurity radial positions can be qualitatively explained by the different values of diffusion coefficient, e.g., D=0.2 m2/s and 1.0 m2/s, which can be taken as a typical index of the transverse transport.

关键词： impurity radial profile EUV spectrometer diffusion coefficient

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan university of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Observation of Magnetic Dipole Forbidden Transitions in LHD and Its Application to Burning Plasma Diagnostics

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Plasma Science and Technology 2010年第3期12卷 341-347页

作者： Shigeru MORITA Motoshi GOTO Ryuji KATAI Chunfeng DONG Hiroyuki SAKAUE Hangyu ZHOU National Institute for Fusion Science Institute of Laser Engineering Osaka University graduate university for advanced studies

Magnetic dipole forbidden （M1） transition was studied in large helical device （LHD） and F-, Si- and Ti-like M1 transitions are successfully observed for highly ionized Ar, Kr, Mo and Xe ions. The wavelengths measured in visible range for the heavy elements, which are carefully determined with extremely small uncertainties of 0.02 - 0.05 A as a standard wavelength of usual electric dipole （El） plasma emissions, are compared with theoretical predictions. The result shows a good agreement with recent Hatree-Fock calculation including semi-empirical adjustment. The M1 intensity for the F-like ions is examined by analyzing the intensity ratio of M1 to El. Density dependence of the ratio is experimentally verified by comparing with collisional- radiative model calculation on level population. The M1/E1 line ratio for the F-like ions is applied to the α （He^2＋） particle diagnostics in ITER, in which a steady-state operation of burning plasmas based on D-T fusion reaction is expected with α particle heating. Unfortunately, the present estimation suggests a negative result for the α particle measurement because the ratio is largely enhanced by the collisional excitation with bulk ions due to high ion temperature of ITER of 10 keV as assumed and the resultant effect of the collisional excitation with α particles becomes less. Meanwhile, the M1 transition, in particular, Ti-like WLIII （W^52＋） transition （3627 A） emitted in visible range, is very useful for diagnostics of the impurity behavior and the core plasma parameters in ITER.

关键词： magnetic dipole transition, α particle ITER

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Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun Hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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Is resilience socially emerging or embedded?A review of“resilience”under climate change in Sri Lanka

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Journal of Safety Science and Resilience 2021年第4期2卷 258-266页

作者： Ryo Tsuchida Shutaro Takeda graduate School of advanced Integrated studies in Human Survivability Kyoto UniversityKyotoJapan

Since the advent of a new academic regime that examines the nexus of humans and water,resilience studies of the coevolution of human-water systems have advanced rapidly because of the climate ***,the concept of resilience poses a new social *** study analyzes the gap in resilience studies through a Sri Lankan water-related disaster research ***,the authors discuss the potential and challenges for resilience evolution under climate change in Sri *** the nuance of resilience,the review showed that resilience is complementarily emerging and embedded in culture and society,such as traditional knowledge and local history,and from scientific research-oriented translation and wide international policy view in *** is the accumulation of stable states and supporting mechanisms found in the interaction between normal phases and emergencies in elements unique to the *** study suggests that it is critical to support the resilience and mechanisms of the whole and each layer,leveraging the diverse and sustainable livelihoods in the Sri Lankan context against climate change.

关键词： Resilience Climate change Water-related disasters Adaptation Sri Lanka

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