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Multifunction-oriented high-mobility polymer semiconductors

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National Science Review 2024年第3期11卷 16-19页

作者： Mingliang Zhu Yunlong Guo Yunqi Liu Beijing National Laboratory for Molecular sciences Organic Solids Laboratory Institute of Chemistry Chinese Academy of Sciences school of Chemical sciences University of Chinese Academy of Sciences

The discovery of conductive polyacetylene has initiated interdisciplinary research into condensed matter physics and synthetic chemistry in organic electronics. Unlike their inorganic and small-molecule counterparts, polymer semiconductors possess the inherent advantages of facile solution processing,large-area manufacturing, excellent mechanical strength and intrinsic flexibility.

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Cloning and Characterization of β-Carotene Ketolase Gene Promoter in Haematococcus pluvialis

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Acta Biochimica et Biophysica Sinica 2005年第4期37卷 270-275页

作者： Chun-Xiao MENG~(1,2) Chang-Ying TENG~1 Peng JIANG~1 Song QIN~1 Cheng-Kui TSENG~1 ~1Institute of Oceanology,chinese academy of sciences.Qingdao 266071,China ~2graduate school of the chinese academy of sciences,Beijing 100039.China Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China graduate school of the chinese academy of sciences Beijing 100039 China

The unicellular green alga Haematococcus pluvialis accumulates a highly valuable ketocarotenoid,astaxanthin,under various environmental stresses.β-carotene ketolase (BKT) plays a key role in astaxanthinbiosynthesis in H.pluvialis.In this paper,an approximate 700 bp 5'-flanking region of the bkt gene contain-ing a putative promoter was cloned through walking upstream.The results of the sequence analysis showedthat this bkt 5'-flanking region might have cis-acting elements such as sterol regulatory element(SRE-1)-likemotifs,the C-repeat/dehydration responsive element (DRE) and al-3 proximal element (APE)-like motifs.except for typical TATA and CCAAT boxes.The results of the β-galactosidase assay and the transientexpression of lacZ driven by a series of sequential deletions revealed that a minimal promoter-like regionmight exist from-630 to-408 bp,and the highest promoter activity was observed to span the positionsfrom-630 to-308 bp.The results of the site-directed mutagenesis of a C-repeat/DRE and two APE-likemotifs in a promoter-like region(-630 to -308 bp)suggested that two APE-like motifs might be essential fortranscriptional control of the bkt gene.

关键词： Haematococcus pluvialis astaxanthin β-carotene ketolase gene (bkt) cis-acting element promoter

Cloning and Analyzing of Xenopus Mespo Promoter in Retinoic Acid Regulated Mespo Expression

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Acta Biochimica et Biophysica Sinica 2006年第11期38卷 759-764页

作者： Jin-Hu WANG Xiao-Yan DING* Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological sciences,chinese academy of sciences,graduate school of the chinese academy of sciences,Shanghai 200031,China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China

During vertebrate embryogenesis,presomitic mesoderm cells enter a segmental program togenerate somite,a process termed somitogenesis.Mespo,a member of the bHLH transcription factor family,plays important roles in this process.However,how Mespo expression is regulated remains unclear.Toaddress this question,we isolated a genomic DNA sequence containing 4317 bp of Mespo 5’ flanking regionin Xenopus.Luciferase assays show that this upstream sequence has transcription activity.Transgenic assayshows that this genomic contig is sufficient to recapitulate the dynamic stage-and tissue-specific expressionpattern of endogenous Mespo from the gastrula to the tailbud stage.We further mapped a 326 bp DNAsequence responding to retinoic acid signaling.These results shed light on how Mespo expression is regulated,and suggest that retinoic acid signaling pathways play roles in somitogenesis through regulating Mespo.

关键词： bHLH paraxial presomitic segmental tailbud Xenopus laevis

The cDNA and Genomic DNA Organization of a Novel Toxin SHT-I from Spider Ornithoctonus huwena

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Acta Biochimica et Biophysica Sinica 2004年第10期36卷 656-660页

作者： Peng QIAO, Xiao-Pan ZUO, Zhi-Fang CHAI, and Yong-Hua JI* Institute of Physiology, Shanghai Institutes for Biological sciences, chinese academy of sciences, graduate school of the chinese academy of sciences, Shanghai 200031, China Institute of Physiology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China

In present study the full-length cDNA of a novel toxin from the venom gland of spider Ornithoctonus huwena, named as SHT-I, has been cloned using the strategy of rapid amplification of cDNA ends, and then the whole genomic sequence of SHT-I (Selenocosmia huwena toxin-I) was determined using sequence-specific primers synthesized based on the acquired 3’ and 5’ ends of SHT-I cDNA sequence. It is unexpectedly found that intron was lacking in the genomic sequence of SHT-I. The result might evoke an interesting question whether the gene code of inhibitor cystine-knot peptides from spider venom is distinct from that of those known toxic peptides of scorpion and cone snail.

关键词： Ornithoctonus huwena spider cDNA genomic DNA peptide toxin ICK motif

Diversity and ecological assembly process of aerobic anoxygenic phototrophic bacteria in a low irradiation area,Three Gorges Reservoir

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Journal of Environmental sciences 2024年第9期143卷 116-125页

作者： Lixin Huo Anran Ma Hong Liu Xingzu Wang Cheng Song Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Chongqing school University of Chinese Academy of SciencesCollege of Resources and EnvironmentChongqing 400714China Key Laboratory of Reservoir Aquatic Environment Chinese Academy of SciencesChongqing 400714China University of chinese academy of sciences Beijing 100049China

Aerobic anoxygenic phototrophic bacteria(AAPB)are significant bacterial groups in aquatic ecosystems,known for their rapid growth and photoheterotrophic characteristics.However,the distribution and ecological assembly process of AAPB in low irradiation freshwater basins remain unclear,warranting further investigation.In this study,we present the diversity,abundance,spatial variations,ecological process,and community interaction of AAPB in sediment of Three Gorges Reservoir(TGR)under low irradiation.Our findings demonstrate the dominant genera of AAPB community that exist in the TGR area also are appeared in different waters,with some regional preference.Moreover,the concentration of pufM gene,an indicator for AAPB,maintains a consistently high numerical level ranging from(2.21±0.44)×10^(4)to(9.98±0.30)×10^(7)gene copies/g.Although solar irradiation is suggested as the major factor affecting AAPB,it remains unclear whether and how AAPB differ between regions due to varying solar irradiation levels.Our results show spatial differences between total bacteria and AAPB communities,with significant differences observed only in AAPB.Geographical and environmental factor contributed less than 10%to the spatial difference of community,with sediment type and environmental factors being the key factors influencing microbial community structure.The stochastic process plays a dominant role in the aggregation and replacement of AAPB communities,among which the most contribution is dispersal limitation.For AAPB network,Yoonia and Gemmobacter are the hubs for modules.Those results valuable insights into the AAPB communities in TGR with low irradiation.

关键词： Three Gorges Reservoir(TGR) Aerobic anoxygenic phototrophic bacteria(AAPB) Bacterial community Null model Community assembly

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In Vitro Reassembly of Tobacco Ribulose-1,5-bisphosphate Carboxylase/Oxygenase from Fully Denatured Subunits

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Acta Biochimica et Biophysica Sinica 2006年第10期38卷 737-745页

作者： Zhen-Hua YONG Gen-Yun CHEN* Jiao-Nai SHI Da-Quan XU Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological sciences,chinese academy of sciences,and graduate school of the chinese academy of sciences,Shanghai 200032,China Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences and Graduate School of the Chinese Academy of SciencesShanghai 200032 China

It has been generally proved impossible to reassemble ribulose-1,5-bisphosphate carboxylase/oxygenase （Rubisco） from fully denatured subunits in vitro in higher plant,because large subunit of fullydenatured Rubisco is liable to precipitate when the denaturant is removed by common methods of directdilution and one-step dialysis.In our experiment,the problem of precipitation was resolved by an improvedgradual dialysis method,which gradually decreased the concentration of denaturant.However,fully denaturedRubisco subunits still could not be reassembled into holoenzyme using gradual dialysis unless chaperonin 60was added.The restored activity of reassembled Rubisco was approximately 8% of natural enzyme.Thequantity of reassembled Rubisco increased greatly when heat shock protein 70 was present in the reassemblyprocess.ATP and Mg2+ were unnecessary for in vitro reassembly of Rubisco,and Mg2+ inhibited the reassemblyprocess.The reassembly was weakened when ATP,Mg2+ and K+ existed together in the reassembly process.

关键词： Rubisco reassembly gradual dialysis chaperonin 60 Hsp70

chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis

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chinese Journal of Integrative Medicine 2024年第7期30卷 643-652页

作者： LI Rui ZHANG Tong YAN Shao-hua YAN Yun-zi DING Ya-cong WANG Yan-song YANG Yu-fei Department of Oncology China Academy of Chinese Medical Sciences Xiyuan Hospital Department of Oncology Dongfang Hospital Beijing University of Chinese Medicine graduate school Beijing University of Chinese Medicine

Objective: To assess the effectiveness of chinese herbal medicine(CHM) combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(CRC) patients using network meta-analysis(NMA). Methods: Literature searches in both international(PubMed, Embase, Web of Science, and Cochrane Library) and chinese(China Science and Technology Journal Database, Wanfang Data, China National Knowledge Infrastructure) databases for relevant randomized controlled trials(RCTs) were conducted from inception until October 10, 2022. We included RCTs of patients who received CHM combined with chemotherapy, including FOLFOX, XELOX, FOLFIRI, and other relevant regimens in the CHM treatment group. The outcomes included the incidence of myelosuppression, leukopenia, hemoglobin reduction, and thrombocytopenia. Two reviewers independently screened the databases, extracted the data, and assessed the risk of bias and credibility of evidence. RevMan 5.4.1 software and STATA 14.0 were used to perform the NMA. Results: A total of 31 RCTs were included, published from 2008 to 2021 in chinese. Among these, 2,314 participants comparing the following 9 CHMs were identified: Shengbai Recipe(SBR), Bazhen Decoction(BZD), Jianpi Jiedu Recipe(JJR), Jianpi Recipe(JR), Compound Cantharis Capsule(CCC), Zaofan Pill(ZFP), Guilu Erxian Gel(GL), Buzhong Tiaogan Decoction(BZ), and Qiamagu Capsule(QM). The results of NMA found an indirect comparison. Based on the surface under the cumulative ranking curve(SUCRA), the ZFP+ chemotherapy group had the lowest incidence of myelosuppression, with an odds ratio(OR) of 0.08 [95% confidence interval(CI): 0.01, 0.76], whereas the GL+ chemotherapy group had the lowest incidence of leukopenia, hemoglobin reduction, and thrombocytopenia, with an OR of 5.25(95% CI: 2.41, 11.43), 4.66(95% CI: 2.23, 9.72), and 0.27(95% CI: 0.13, 0.54), respectively. Moreover, BZD + chemotherapy could alleviate leukopenia, hemoglobin reduction, and thrombocytopenia(P<0.01). Pairwise comparison showed that there was no difference in the

关键词： chinese herbal medicine colorectal cancer network meta-analysis systematic review myelosuppression chemotherapy

Schottky infrared detectors with optically tunable barriers beyond the internal photoemission limit

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The Innovation 2024年第3期5卷 69-76页

作者： Jintao Fu Zhongmin Guo Changbin Nie Feiying Sun Genglin Li Shuanglong Feng Xingzhan Wei Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China University of chinese academy of sciences Beijing 100049China Chongqing school University of Chinese Academy of SciencesChongqing 400714China

Internal photoemission is a prominent branch of the photoelectric effect and has emerged as a viable method for detecting photons with energies below the semiconductor bandgap.This breakthrough has played a significant role in accelerating the development of infrared imaging in one chip with state-of-the-art silicon techniques.However,the performance of these Schottky infrared detectors is currently hindered by the limit of internal photoemission;specifically,a low Schottky barrier height is inevitable for the detection of low-energy infrared photons.Herein,a distinct paradigm of Schottky infrared detectors is proposed to overcome the internal photoemission limit by introducing an optically tunable barrier.This device uses an infrared absorbing material-sensitized Schottky diode,assisted by the highly adjustable Fermi level of graphene,which subtly decouples the photon energy from the Schottky barrier height.Correspondingly,a broadband photoresponse spanning from ultraviolet to mid-wave infrared is achieved,with a high specific detectivity of 9.83×1010 cm Hz1/2 W−1 at 2,700 nm and an excellent specific detectivity of 7.2×109 cm Hz1/2 W−1 at room temperature under blackbody radiation.These results address a key challenge in internal photoemission and hold great promise for the development of the Schottky infrared detector with high sensitivity and room temperature operation.

关键词： Schottky tunable beyond

Preliminary studies on differential defense responses induced during plant communication

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Cell Research 2005年第3期15卷 187-192页

作者： Jin Ying PENG1,3,Zhong Hai LI2,Hui XIANG1,3,Jian Hua HUANG1,3,Shi Hai JIA1,3,Xue Xia MIAO1,Yong Ping HUANG1* 1Institute of Plant Physiology and Ecology,Shanghai Institute for Biological sciences,graduate school of the chinese academy of sciences,chinese academy of sciences,300 Fenglin Road,Shanghai 200032,China 2chinese National Human Genome Center at Shanghai,250 Bibo Road,Shanghai 201203,China 3graduate school of the chinese academy of sciences,Beijing 100039,China Institute of Plant Physiology and Ecology Shanghai Institute for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China graduate school of the chinese academy of sciences Beijing China chinese National Human Genome Center at Shanghai Shanghai China

We compared the expression patterns of three representative genes in undamaged tomato and tobacco plants in response to exposure to either tomato or tobacco fed on by Helicoverpa armigera (cotton bollworm). When tomato and tobacco, two species of one family, were incubated in the chambers with the tomato plants damaged by the cotton bollworm, the expression of the PR1, BGL2, and PAL genes was up-regulated in leaves of both plants. However, the levels of gene expression were significantly higher in the tomato than that in the tobacco. In addition, the activities of enzymes, peroxidase, polyphenol oxidase, and lipoxygenase were found to be higher in the tomato than those in the tobacco. Similar results were obtained when the damaged plants were replaced by the tobacco.

关键词： plant-plant communication tomato (Lycopersicon esculentum) tobacco (Nicotiana tabacum) cotton boll- worm (Helicoverpa armigera) inducible defenses.