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Being a Father of a Premature Newborn: The Parental Experience and the Father/Premature Newborn Relationship: A Study Carried out in the department of Neonatology Intensive Care Unit of Mohammed VI University Hospital

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Open Journal of pediatrics 2024年第2期14卷 412-419页

作者： Hasnae Elhaddadi Sahar Messaoudi Anass Ayyad Rim Amrani department of Neonatology Intensive Care Unit Mohammed VI University Hospital Faculty of Medicine and Pharmacy of Oujda Mohammed First University Oujda Morocco

Introduction: Despite advances in obstetrics and pediatrics over the past 20 years, premature birth remains an unpredictable event that can have a devastating impact on parenthood. This study aimed to analyze the psycho-affective experiences of fathers of premature newborns. Methods: This was a descriptive cross-sectional study, carried out in the department of neonatology and neonatal intensive care unit of the CHU Mohamed VI in OUJDA, over 6 months from March 2022 to August 2022. It focused on 30 fathers of premature newborns hospitalized in our department. Results: The majority of fathers described a state of fear and stress, and attributed their negative experience to the unexpected nature of the premature birth. At the first meeting, half the fathers had a positive image of their newborn’s physical appearance, while 22% of fathers reported feeling uncomfortable about their newborn’s low weight. Most fathers reported that they appreciated the welcome they received, the skill with which they cared for their newborn, and the availability of the pediatrician to provide information on their child’s state of health. Two fathers enjoyed skin-to-skin contact with their newborns. None of the fathers met a psychologist. When they returned home, half the fathers had a positive outlook, marked by happiness at being able to fully invest in their role as fathers, the other half reported being torn between the desire to see their child integrated into the family cocoon and the fear of not being able to manage delicate situations properly without a medical team. Conclusion: Bringing a premature baby into the world can be a difficult experience, leading to the development of even minor psychological distress in some fathers, and hence the need for specific psychological care.

关键词： Prematurity Psychiatrist Emotional Disorder Depression

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Immune phenotype in children with therapy-nave remitted and relapsed Crohn’s disease

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World Journal of Gastroenterology 2010年第47期16卷 6001-6009页

作者： Aron Cseh Barna Vasarhelyi Kriszta Molnar Balazs Szalay Peter Svec Andras Treszl Antal Dezsofi Peter Laszlo Lakatos Andras Arato Tivadar Tulassay Gabor Veres Research Group for pediatrics and Nephrology Semmelweis University Hungarian Academy of Sciences department of Laboratory Medicine Semmelweis University first department of pediatrics Semmelweis University first department of Medicine Semmelweis University

AIM: To characterize the prevalence of subpopulations of CD4+ cells along with that of major inhibitor or stimulator cell types in therapy-nave childhood Crohn's disease (CD) and to test whether abnormalities of immune phenotype are normalized with the improvement of clinical signs and symptoms of disease. METHODS: We enrolled 26 pediatric patients with CD. 14 therapy-nave CD children; of those, 10 children remitted on conventional therapy and formed the remission group. We also tested another group of 12 chil-dren who relapsed with conventional therapy and were given infliximab; and 15 healthy children who served as controls. The prevalence of Th1 and Th2, nave and memory, activated and regulatory T cells, along with the members of innate immunity such as natural killer (NK), NK-T, myeloid and plasmocytoid dendritic cells (DCs), monocytes and Toll-like receptor (TLR)-2 and TLR-4 expression were determined in peripheral blood samples. RESULTS: Children with therapy-nave CD and those in relapse showed a decrease in Th1 cell prevalence. Simultaneously, an increased prevalence of memory and activated lymphocytes along with that of DCs and monocytes was observed. In addition, the ratio of myeloid /plasmocytoid DCs and the prevalence of TLR-2 or TLR-4 positive DCs and monocytes were also higher in therapy-nave CD than in controls. The majority of alterations diminished in remitted CD irrespective of whether remission was obtained by conventional or biological therapy. CONCLUSION: The finding that immune phenotype is normalized in remission suggests a link between immune phenotype and disease activity in childhood CD. Our observations support the involvement of members of the adaptive and innate immune systems in childhood CD.

关键词： Crohn’s disease Dendritic cell Infliximab Lymphocyte Monocyte Regulatory T cell Relapse Remission Therapy-nave Toll-like receptor

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Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis

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Chinese Journal of Natural Medicines 2024年第9期22卷 808-821页

作者： XU Xinyue ZHU Wenping MIAO Mengqiu BAI Mi FAN Jiaojiao NIU Yujia LI Yuting ZHANG Aihua JIA Zhanjun WU Mengqiu School of Medicine Southeast UniversityNanjing 210009China department of Nephrology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Nanjing Key Laboratory of pediatrics Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Jiangsu Key Laboratory of Early Development and Chronic Diseases Prevention in Children Nanjing Medical UniversityNanjing 210029China

Pharmaceutical formulations derived from Aristolochiaceae herbs, which contain aristolochic acids(AAs), are widely used for medicinal purposes. However, exposure to these plants and isolated AAs is linked to renal toxicity, known as AA nephropathy(AAN). Currently, the mechanisms underlying AAN are not fully understood, leading to unsatisfactory treatment strategies. In this study, we explored the protective role of 84-B10(5-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl) phenyl] amino]-5-oxo-3-phenylpentanoic acid) against AAN. RNA-seq analysis revealed that the mitochondrion and peroxisome were the most affected cellular components following 84-B10 treatment in AAN mice. Consistently, 84-B10 treatment preserved mitochondrial ultrastructure, restored mitochondrial respiration, enhanced the expression of key transporters(carnitine palmitoyltransferase 2) and enzymes(acylCoenzyme A dehydrogenase, medium chain) involved in mitochondrial fatty acid β-oxidation, and reduced mitochondrial ROS generation in both aristolochic acid I(AAI)-challenged mice kidneys and cultured proximal tubular epithelial cells. Additionally, 84-B10 treatment increased the expression of key transporters(ATP binding cassette subfamily D) and rate-limiting enzymes(acyl-CoA oxidase 1) involved in peroxisomal fatty acid β-oxidation and restored peroxisomal redox balance. Knocking down LONP1 expression diminished the protective effects of 84-B10 against AAN, suggesting LONP1-dependent protection. In conclusion, our study provides evidence that AAN is associated with significant disturbances in both mitochondrial and peroxisomal functions. The LONP1 activator 84-B10 demonstrates therapeutic potential against AAN, likely by maintaining homeostasis in both mitochondria and peroxisomes.

关键词： Aristolochic acid nephropathy 84-B10 LONP1 Mitochondrion Peroxisome

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Successful treatment of acute liver failure due to Wilson’s disease: Serendipity or fortuity?

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World Journal of Hepatology 2024年第8期16卷 1111-1119页

作者： Valeria Delle Cave Fabiola Di Dato Pier Luigi Calvo Maria Immacolata Spagnuolo Raffaele Iorio department of Translational Medical Science Section of PediatricsUniversity of Naples Federico IINaples 80131Italy Pediatric Gastroenterology Unit Regina Margherita Children's HospitalAzienda Ospedaliera-Universitaria Cittàdella Salute e della ScienzaTurin 10126Italy

BACKGROUND Acute liver failure(ALF)may be the first and most dramatic presentation of Wilson’s disease(WD).ALF due to WD(WD-ALF)is difficult to distinguish from other causes of liver disease and is a clear indication for liver *** is no firm recommendation on specific and supportive medical treatment for this *** To critically evaluate the diagnostic and therapeutic management of WD-ALF patients in order to improve their survival with native *** A retrospective analysis of patients with WD-ALF was conducted in two pediatric liver units from 2018 to *** During the study period,16 children(9 males)received a diagnosis of WD and 2 of them presented with *** first was successfully treated with an unconventional combination of low doses of D-penicillamine and zinc plus steroids,and survived without liver *** second,exclusively treated with supportive therapy,needed a hepatotransplant to overcome *** Successful treatment of 1 WD-ALF patient with low-dose D-penicillamine and zinc plus steroids may provide new perspectives for management of this condition,which is currently only treated with liver transplantation.

关键词： Fulminant liver failure Copper Chelator Zinc Steroids Liver transplantation Autoimmune hepatitis Prognostic score 24 hour-urinary copper excretion Native liver

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Extra Dural Hematoma of the Dorso-Lumbar Region in a Hemophiliac: A Rare Entity

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Open Journal of pediatrics 2024年第1期14卷 84-88页

作者： Hanane Hajaj Hanae Bahari Ayyad Ghanam Aziza El Ouali Abdeladim Babakhouya Maria Rkain department of pediatrics Mohammed VI University Hospital Oujda Morocco Faculty of Medicine and Pharmacy Mohammed Ist University Oujda Morocco

Introduction and objective: Hemophilia is a genetic bleeding disorder inherited as a recessive train linked to the male gender. Bleeding into the central nervous system in patients with hemophilia is an extremely dangerous condition that can be directly life-threatening, if left untreated. Extradural hematoma of the dorso-lumbar region is rare but potentially deadly disease in children. This condition can result in severe neurological deficits. We aim to discuss the clinical, radiological and progressive clinical aspects of this illness. Case report: We report the case of a 5-year-old child with severe hemophilia A treated for extradural hematoma of the dorso-lumbar region resulting from trauma. A spinal magnetic resonance imaging revealed an extradural hematoma. The patient was successfully treated with intensive replacement therapy and did not require surgical intervention. Conclusion: Extradural hematoma is a rare complication of hemophilia, that needs to be looked for in children who have bleeding disorders. For the best neurological outcome, early diagnosis is crucial.

关键词： Extradural Hematoma Children Hemophilia

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Trends in Respiratory Infectious Pathogens in Children Under the Age of 14—Xiamen City,Fujian Province,China,2017-2023

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China CDC weekly 2024年第8期6卷 143-147页

作者： Jiali Cao Jie Pan Xiaoqing Yang Jumei Liu Min Zhu Zeyu Zhao Ling Chen Tianmu Chen Huiming Ye department of Laboratory Medicine Fujian Key Clinical Specialty of Laboratory MedicineWomen and Children’s HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina department of pediatrics Women and Children's HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina

Summary What is already known about this topic?Respiratory infections pose a significant burden on public *** recent outbreaks occurring in various locations,there is limited information available on the prevalence tr... 详细信息

关键词： Xiamen spite Fujian

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Pathophysiology and Individualized Management of Vasovagal Syncope and Postural Tachycardia Syndrome in Children and Adolescents:An Update

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Neuroscience Bulletin 2020年第6期36卷 667-681页

作者： Ying Liao Junbao Du department of pediatrics Peking University First HospitalBeijing 100034China

Vasovagal syncope(VVS) and postural tachycardia syndrome(POTS) are the main forms of orthostatic intolerance in pediatrics and both are underlying causes of neurally-mediated *** recent years,increasing attention has been paid to the management of VVS and POTS in children and adolescents.A number of potential mechanisms are involved in their pathophysiology,but the leading cause of symptoms varies among patients.A few studies thus have focused on the individualized treatment of VVS or POTS based on selected hemodynamic parameters or biomarkers that can predict the therapeutic effect of certain therapies and improve their *** review summarizes the latest developments in individualized treatment of VVS and POTS in children and indicates directions for further research in this field.

关键词： Vasovagal syncope Postural tachycardia syndrome Individualized management Pathophysiology Children Adolescents

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Wilson disease associated with immune thrombocytopenia: A case report and review of the literature

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World Journal of Clinical Cases 2019年第17期7卷 2630-2636页

作者： Tian-Jiao Ma Gui-Lian Sun Fang Yao Zhi-Liang Yang department of pediatrics The First Hospital of China Medical University

BACKGROUND Wilson disease (WD) is a genetic disorder of hepatic copper excretion,leading to copper accumulation in various *** manifestations are quite variable,and hemolytic anemia is the most common hematological *** associated with thrombocytopenia is very *** SUMMARY We report the case of an 11-year-old Chinese girl with WD that was associated with immune thrombocytopenia (ITP).Thrombocytopenia was the initial chief complaint for her to visit a hematologist,and ITP was diagnosed based on the results of a bone marrow biopsy and positive antiplatelet *** two weeks before the thrombocytopenia was found,the patient developed *** developed in her right hand about one week after being diagnosed with ITP,after which she was admitted to our *** evaluations were *** was decreased,with an increased level of copper in her 24-h urine *** Fleischer's ring (K-F ring) was *** ultrasound showed liver cirrhosis,and brain magnetic resonance imaging showed that the lenticular nucleus,caudate nucleus,and brainstem presented a low signal intensity in T1-weighted images and high signal intensity in T2-weighted *** was diagnosed and a genetic analysis was performed.A compound heterozygous mutation in ATP7B was detected;c.2333G>T (***778Leu) in exon 8 and c.3809A>G (***1270Ser) in exon *** former was inherited from her father and the latter from her ***,her parents showed normal liver function and negative K-F *** a compound mutation in a case of WD associated with ITP in children has not been published *** WD can associate with thrombocytopenia but the mechanism is still *** recommend that antiplatelet autoantibodies should be tested in WD patients with thrombocytopenia in future to verify the association.

关键词： Wilson disease Immune thrombocytopenia ATP7B Case report

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Actors of Psychoactive Drug Initiation among Adolescents in Yaoundé-Cameroon

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Open Journal of pediatrics 2024年第2期14卷 246-254页

作者： Claude-Audrey Meguieze Atabe Ngwene Neri Ngole Georges Eric Nseme Etouckey Paul Olivier Koki Ndombo department of pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon department of Morphologic Sciences Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Introduction: Actors of psychoactive drug initiation refer to those who introduce others to psychoactive drug use (initiators) and those who are introduced to psychoactive drugs (users). By identifying their features, better prevention and intervention programs can be developed to reduce psychoactive drug use among adolescents. This article describes the role of actors of psychoactive drug initiation among teenagers in secondary schools in Yaoundé (Cameroon). Methodology: A cross sectional study was carried out in twelve secondary schools in Yaoundé from October 2022 to May 2023. Adolescents from Form four to upper sixth, who assented to participate in the study and received parental consent were included. Data were collected in a structured self-reported questionnaire and analyzed using SPSS 23. Quantitative variables were expressed using means, standard deviations, median and interquartile ranges depending on the distribution of data. Qualitative variables were expressed in the form of frequency and percentages. Results: Drug use was more prevalent among male adolescents (55.3%) from nuclear families (91.4%) who received relatively high pocket money. The main sources of drug exposure were non-family members (49.7%), especially friends outside school. The most frequent place of initiation was snack bars (33.1%). Conclusion: The study revealed the importance of the family, friends and leisure places in the initiation process of drug use in teenagers. Based on these results, parents and school authorities should work together to create a safe and supportive environment that fosters communication, education to prevent drug abuse among adolescents in Yaoundé.

关键词： Initiators Drug Users Adolescents Cameroon

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Value of improved nursing measures and enhanced nursing management to reduce the occurrence of adverse events in pediatric infusion

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World Journal of Clinical Cases 2024年第20期12卷 4130-4136页

作者： Yan-Song Lv Jv Xue Zhu Meng Qing Zhang Xiao-Hong Liu department of pediatrics Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China department of Obstertrics and Gynecology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Intravenous infusion is a common method of drug administration in clinical *** in any aspect of the infusion process,from the verification of medical orders,preparation of the drug solution,to infusion by nursing staff,may cause adverse infusion *** To analyzed the value of improving nursing measures and enhancing nursing management to reduce the occurrence of adverse events in pediatric *** The clinical data of 130 children who received an infusion in the pediatric department of our hospital from May 2020 to May 2021 were analyzed and divided into two groups according to the differences in nursing measures and nursing management:65 patients in the control group received conventional nursing and nursing management interventions,while 65 patients in the observation group received improved nursing measure interventions and enhanced nursing *** occurrence of adverse events,compliance of children,satisfaction of children’s families,and complaints regarding the transfusion treatment were recorded in both *** The incidence of fluid extravasation and infusion set dislodgement in the observation group were 3.08%and 1.54%,respectively,which were significantly lower than 12.31%and 13.85%in the control group(P0.05).The compliance rate of children in the observation group was 98.46%(64/65),which was significantly higher than 87.69%(57/65)in the control group,and the satisfaction rate of children’s families was 96.92%(63/65),which was significantly higher than 86.15%(56/65)in the control group(P<0.05).The observation group did not receive any complaints from the child’s family,whereas the control group received four complaints,two of which were due to the crying of the child caused by repeated punct

关键词： Improved nursing measures Improved nursing management Pediatric infusion Adverse events Compliance Family complaints

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