检索结果-南通市图书馆

Cerebral Palsy and Stroke—Early and Late Brain Lesion Present Differences in Systemic Biomarkers and Gene Expression Related to Muscle Contractures

引用

World Journal of Neuroscience 2021年第1期11卷 34-47页

作者： Jessica Pingel Camille Potts Theis Wolter Petersen Jens Bo Nielsen Department of Neuroscience University of Copenhagen Copenhagen Denmark the elsass foundation Research Unit Charlottenlund Denmark

Background: CNS lesions that are acquired early in life e.g. cerebral palsy (CP) disturb muscle development and growth, while CNS injuries acquired later in life e.g. stroke, affect fully matured muscles and cause paresis and atrophy. These differences may result in different contracture phenotypes. Aim: The purpose of this study was to compare systemic biomarkers and gene expression levels in muscle of individuals with CNS lesions acquired early and later in life. Methods: Blood samples and muscle biopsies were analyzed using Enzyme-linked immunosorbent assay and Real-time PCR from n = 24 control participants, n = 14 individuals with cerebral palsy, and n = 12 stroke survivors. Results: Systemic markers: Myostatin was significantly decreased in both the cerebral palsy (p = 0.0051), and the stroke group (p = 0.036). Creatine Kinase-MB and C-Reactive Protein were significantly elevated in stroke patients only (p 0.034 respectively). Gene expressions: The expression of myostatin (MSTN) was significantly lower in both the ST and the CP group when compared to Ctrl (p = 0.02). In addition, collagen type 4A1 (COL4A1) was significantly lower in the CP group compared to the other groups (p = 0.015). Finally, the troponin 1 slow skeletal muscle type was significantly increased in the ST group when compared to both CP and Ctrl (p = 0.03). Conclusion: The downregulation of myostatin in individuals with both early and late CNS injury is likely a compensatory reaction to muscle weakness, reduced muscle mass and/or muscle atrophy. Changes in gene expression may reflect a specific alteration depending on when in life the CNS lesions were acquired.

关键词： Cerebral Palsy Stroke Biomarkers Creatin Kinase Myostatin C-Reactive Protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Singing Therapy Improving Peak Flow, Speech and Eating Abilities in Adults with Cerebral Palsy

引用

Open Journal of Therapy and Rehabilitation 2022年第4期10卷 158-178页

作者： Jessica Pingel Christina T. Andersen Peter Raffalt Camilla Kowalczyk Department of Neuroscience University of Copenhagen Copenhagen Denmark the elsass foundation Charlottenlund Denmark Department of Biology University of Southern Denmark Odense Denmark

Introduction: Individuals with cerebral palsy (CP) often suffer from speech impairments and dysphagia due to impaired motor control of the tongue and lips. Aim: To investigate the effect of singing on peak flow, speech- and swallowing abilities in individuals with CP. Method: Ten adults with CP received one-to-one singing lessons by a professional singing teacher for one hour twice a week for 6 months. Methods: The peak flow, swallowing-, speech-, and eating abilities were investigated pre, and after 3 months and 6 months of singing. Results: The meal analysis revealed that an average of eleven factors was improved after 6 months of singing. Nine out of ten participants improved their pronunciation of the letter “N” and seven participants improved their pronunciation of the letter “G”. The singing lessons increased the peak flow significantly (p = 0.02;Pre = 246 ± 36, 3 months = 287 ± 34, and 6 months = 336 ± 48). Self-reported difficulties on a 1 - 10 scale reduced significantly for both swallowing (p = 0.039) and speaking (p = 0.049). Conclusion: 6 months of singing lessons improve the peak flow, speech-, swallowing- and eating abilities in adults with CP. The present study indicates that singing is a very promising intervention for the treatment of speech and eating impairments in individuals with CP.

关键词： Singing Cerebral Palsy Pronunciation Eating Swallowing Mealtime

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：