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Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?

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World Journal of Gastroenterology 2014年第41期20卷 15158-15163页

作者： Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam Division of paediatric surgery and paediatric Urology Department of SurgeryThe Prince of Wales HospitalThe Chinese University of Hong Kong

Complications aroused from Meckel's diverticulum tend to developed in *** presented with abdominal pain,intestinal obstruction,intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel's *** the advancement of minimally invasive surgery(MIS) in children,the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel's diverticulum has gained ***,single incision laparoscopic surgery(SILS) has emerged as a new technique in minimally invasive *** review offers the overview in the development of MIS in the management of children suffered from Meckel's *** current evidence in different laparoscopic techniques,including conventional laparoscopy,SILS,the use of special laparoscopic instruments,intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel's diverticulum in children were revealed.

关键词： Laparoscopy Meckel’s diverticulum Children

Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?

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World Journal of Clinical Pediatrics 2017年第1期6卷 40-44页

作者： Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam Division of paediatric surgery and paediatric Urology Department of Surgerythe Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January *** including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was *** outcome including the type of operation performed,operative time,the need for reoperation and mortality were *** demographics and the outcome between the 2 groups were *** During the study period,53 neonates had JIA underwent operation in our *** neonates(32%) were associated with *** was no statistical difference on the demographics in the two *** with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two *** Primary intestinal anastomosis can be performed in94% of patients with JIA associated with *** patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA.

关键词： Meconium Peritonitis Atresia Jejunoileal

Abnormal gait and hypoglycorrhachia in a toddler with seizures

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Pediatric Investigation 2022年第1期6卷 47-49页

作者： Maria Angeli Eleni Vergadi Georgios Niotakis Maria Raissaki Emmanouil Galanakis department of paediatrics University General Hospital of HeraklionSchool of MedicineUniversity of CreteHeraklionGreece paediatric Neurology Clinic Venizeleion General HospitalHeraklionGreece department of Radiology University General Hospital of HeraklionSchool of MedicineUniversity of CreteHeraklionGreece

Introduction:Glucose transporter type 1(Glut1)deficiency syndrome is a treatable neurometabolic disorder characterized by seizures,developmental delay,and *** to the rareness and non-specific clinical manifestations,it is usually mis-or *** presentation:We report the case of a toddler who presented with afebrile epileptic seizures and abnormal *** imaging and electroencephalogram were *** investigation of the cerebrospinal fluid revealed hypoglycorrhachia that was the clue to the diagnosis of Glut1 deficiency syndrome and the initiation of treatment with ketogenic ***:Our case highlights the importance of lumbar puncture while investigating a child with epileptic seizures and abnormal gait or developmental delay,in order not to miss treatable neurometabolic conditions,such as Glut1 deficiency syndrome.

关键词： Epilepsy Glut1 deficiency Developmental delay Ataxia Hypoglycorrhachia

Demographic determinants of risk,colon distribution and density scores of diverticular disease

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World Journal of Gastroenterology 2011年第8期17卷 1009-1017页

作者： Mark Golder Irina Chis Ster Pratusha Babu Amita Sharma Muhammad Bayat Abdulkadir Farah Centre for Academic surgery Institute of Cell and Molecular Science Barts and the London School of Medi-cine and Dentistry Queen Mary University MRC centre for paediatric Epidemiology and Biostatistics University College department of Radiology University Hospital Lewisham

AIM:To investigate associations between ethnicity,age and sex and the risk,colon distribution and density scores of diverticular disease(DD).METHODS:Barium enemas were examined in 1000 patients:410 male,590 female;760 whites,62 Asians,44 black africans(BAs),and 134 other blacks(OBs).Risks and diverticula density of left-sided DD(LSDD) and rightsided-component DD(RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic ***:Four hundred and forty-seven patients had DD(322 LSDD and 125 RSCDD).Adjusted risks:(1) LSDD:each year increase in age increased the odds by 6%(95% CI:5-8,SE:0.8%,P < 0.001);Asians:odds ratio(OR):0.23(95% CI:0.10-0.53,SE:0.1,P ≤ 0.001) and OBs:OR:0.25(95% CI:0.14-0.43,SE:0.07,P ≤ 0.001) appeared protected vs Whites;(2) RSCDD:each year increase in age increased the odds by 4%(95% CI:2-6,SE:1%,P < 0.001);females were 0.60 times(95% CI:0.40-0.90,SE:0.12,P = 0.01) less likely than males to have RSCDD;BAs were 3.51 times(95% CI:1.70-7.24,SE:1.30,P < 0.001) more likely than Whites to have RSCDD;and(3) DD density scores:each year increase in age increased the odds of highdensity scores by 4%(95% CI:1-6,SE:1%,P < 0.001);RSCDD was 2.77 times(95% CI:1.39-3.32,SE:0.67,P < 0.001) more likely to be of high density than *** further signif icant differences were found in the adjusted ***:Right colonic DD might be more common and has higher diverticula density in the west than previously *** appear predisposed to DD,whereas other ethnic differences appear conserved following migration.

关键词：高密度风险分数结肠 logistic回归人口种族差异 BAS

Application of stent implantation in congenital heart disease

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Chinese Medical Journal 2014年第21期127卷 3814-3824页

作者： Chau Kai Tung Adolphus department of paediatric Cardiology Queen Mary Hospital University of Hong Kong Hong Kong SAR China

Vascular stenoses and hypoplasia in children are associated with congenital heart disease or occur as residual lesions or complications after surgical repair. These obstructions can occur in arteries or veins of both the pulmonary and systemic circulations. Untreated vascular stenoses cause significant mortality and morbidity and will severely affect surgical outcome.

关键词： children congenital heart disease stent implantation transcatheter intervention treatment

Acute infectious osteomyelitis in children: new treatment strategies for an old enemy

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World Journal of Pediatrics 2020年第5期16卷 446-455页

作者： Sabrina Congedi Chiara Minotti Carlo Giaquinto Liviana Da Dalt Daniele Don department of Women's and Children's Health University of PaduaPaduaItaly Division of paediatric Infectious Diseases Department of Women's and Children's HealthUniversity of PaduaPaduaItaly paediatric Emergency department Department of Women's and Children's HealthUniversity of PaduaPaduaItaly

Background Acute osteomyelitis still represents a significant clinical challenge,with an increasing incidence in paediatric population.A careful assessment and a rapid diagnosis with proper timing and choice of empirical antimicrobial therapy are necessary to avoid *** initial treatment should consist of empirical antibiotic therapy,to cover the major responsible pathogens in each age *** sources We made a literature search with PubMed and Cochrane database from 2000 to 2019 in English,French,and Spanish languages using the key words"osteomyelitis,children,clinical,diagnosis,and treatment".Results The child's clinical features,age,and the microbiological profile of the geographic area should be evaluated for diagnosis and in the choice of antibiotic *** data suggest the administration of intravenous antibiotics for a short period,with subsequent oral therapy,according to the improvement of clinical status and inflammatory *** children older than 3 months,the shift to oral medications is already possible after a short course of intravenous therapy,until *** timing for the shift from cefazolin to cephalexin or cefuroxime,intravenous clindamycin to oral clindamycin,and intravenous ceftriaxone+oxacillin to oral equivalents will be decided according to the improvement of clinical status and inflammatory *** also present the approach to osteomyelitis due to difficult pathogens,such as Methicillin-resistant Staphylococcus aureus(MRSA)and Panton-Valentine leukocidin(PVL)-positive *** *** In this review,we present the current approach to the clinical diagnosis and management of osteomyelitis in childhood,with an update on recent recommendations,as a useful instrument to understand the rationale of antibiotic therapy.

关键词： Acute osteomyelitis Children Diagnosis Treatment

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

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World Journal of Gastroenterology 2007年第37期13卷 4996-5002页

作者： Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling department of General Visceral Vascular and Paediatric Surgery University of the Saarland Homburg 66421 Germany Institute of Pathology University of the Saarland Homburg 66421 Germany Institute of Medical Biometrics Epidemiology and Medical Informatics University of the Saarland Homburg 66421 Germany

AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases.

关键词：白介素结直肠癌临床特征基因表达

Comparison of Dartos flap and spongioplasty in Snodgrass urethroplasty in distal penile hypospadias

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World Journal of Pediatric surgery 2021年第3期4卷 39-43页

作者： Anju Verma Shahid Murtaza Vijay Kumar Kundal Amita Sen Divya Gali department of paediatric surgery Dr Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical SciencesNew DelhiDelhiIndia

Background Hypospadias surgery has been continuously evolving,although there is no single technique which can be said to be perfect and suitable for all types of *** incised plate(TIP)urethroplasty(Snodgrass procedure)is presently the most common surgical procedure performed for distal penile hypospadias(DPH).The aim of this study was to compare the outcome of TIP urethroplasty using Dartos flap(DF)and spongioplasty as second layer in *** A total of 30 patients of DPH were repaired using TIP urethroplasty with DF or spongioplasty as second layer from January 2017 to June *** of 30 patients,TIP with DF was done in 15 patients(group A)and TIP with spongioplasty was done in the remaining 15 patients(group B).Preoperative mean age and weight were comparable in both *** complications,namely,postoperative edema,residual chordee,urethrocutaneous fistula(UCF),meatal stenosis and final cosmesis,were *** In both groups,complications included postoperative edema(Gp A-1Gp B-1),residual chordee(Gp A-1,Gp B-1),UCF(Gp A-3,Gp B-4),meatal stenosis(Gp A-1,Gp B-5)and poor cosmesis(Gp A-3,Gp B-4).Wound infection was managed with appropriate antibiotics,and meatal stenosis responded to calibration in five *** it seems that DF has a better outcome clinically,the difference between the two techniques was statistically not *** DF as an additional cover to TIP is associated with an acceptable complication and has good cosmesis compared with spongioplasty;however,the difference is not statistically significant.

关键词： edema Snodgrass distal

Fracture risk assessment in children with benign bone lesions of long bones

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World Journal of Clinical Cases 2021年第24期9卷 7053-7061页

作者： Hai-Bing Li Wen-Song Ye Qiang Shu department of paediatric Orthopaedics The Children’s HospitalZhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina department of Pediatric surgery The Children’s HospitalZhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina

BACKGROUND Fracture risk assessment in children with benign bone lesions of long bones remains poorly *** To investigate the risk factors for pathological fracture in children with benign bone lesions and to propose a modified scoring system for quantitative analysis of the pathologic fracture *** We retrospectively reviewed 96 pediatric patients with benign bone *** compared radiographic and clinical features between 40 patients who had fractures through a benign bone lesion and 56 who had no *** including histological diagnosis,anatomical site,radiographic appearance,severity of pain,and lesion size was recorded for the patients.A modified scoring system was proposed to predict the risk of *** The univariate comparisons showed a significant difference between the fracture and non-fracture groups in terms of lesion type,pain,lesion-to-bone width,and axial cortical involvement of the patients(P7 indicates a high risk of a pathologic fracture and is an indication for prophylactic internal fixation.

关键词： Benign bone lesion Pathological fracture Risk factor Children