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Nuclear domain 10 of the viral aspect

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World Journal of Virology 2013年第3期2卷 110-122页

作者： Yisel A Rivera-Molina Francisco Puerta Martínez Qiyi Tang department of Microbiology/RCMI Program Ponce School of Medicine and Health Sciences Ponce PR 00732-7004 United States

Nuclear domain 10(ND10) are spherical bodies distributed throughout the nucleoplasm and measuring around 0.2-1.0 μm. First observed under an electron microscope, they were originally described as dense bodies found in the nucleus. They are known by a number of other names, including Promyelocytic Leukemia bodies(PML bodies), Kremer bodies, and PML oncogenic domains. ND10 are frequently associated with Cajal bodies and cleavage bodies. It has been suggested that they play a role in regulating gene transcription. ND10 were originally characterized using human autoantisera, which recognizes Speckled Protein of 100 kD a, from patients with primary biliary cirrhosis. At the immunohistochemical level, ND10 appear as nuclear punctate structures, with 10 indicating the approximate number of dots per nucleus observed. ND10 do not colocalize with kinetochores, centromeres, sites of mR NA processing, or chromosomes. Resistance of ND10 antigens to nuclease digestion and salt extraction suggest that ND10 are associated with the nuclear *** are often identified by immunofluorescent assay using specific antibodies against PML, Death domainassociated protein, nuclear dot protein(NDP55), and so on. The role of ND10 has long been the subject of investigation, with the specific connection of ND10 and viral infection having been a particular focus for almost 20 years. This review summarizes the relationship of ND10 and viral infection. Some future study directions are also discussed.

关键词： Nuclear domain 10 Promyelocytic Leukemia Speckled protein of 100 kDa Death domainassociated protein Virus Viral replication

Clinicopathological features and impact of adjuvant chemotherapy on the long-term survival of patients with multiple gastric cancers:a propensity score matching analysis

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Cancer Communications 2019年第1期39卷 28-38页

作者： Jian-Xian Lin Zu-Kai Wang Jian-Wei Xie Jia-Bin Wang Jun Lu Qi-Yue Chen Long-Long Cao Mi Lin Ru-Hong Tu Ze-Ning Huang Ju-Li Lin Chao-Hui Zheng Chang-Ming Huang Ping Li department of Gastric Surgery Fujian Medical University Union HospitalNo.29 Xinquan RoadFuzhou 350001FujianP.R.China department of General Surgery Fujian Medical University Union HospitalFuzhou 350001FujianP.R.China Key Laboratory of Ministry of Education of Gastrointestinal Cancer Fujian Medical UniversityFuzhou 350001FujianP.R.China

Background:Little is known about the correlation between the clinicopathological features,postoperative treatment,and prognosis of multiple gastric cancers(MGCs).In this study,we aimed to investigate the correlation between these features and the impact of postoperative adjuvant chemotherapy on the long-term survival of patients with ***:The clinical and pathological data of patients diagnosed with gastric adenocarcinoma who had radical gastrectomy from January 2007 to December 2016 were *** propensity score matching,the prognostic differences,and the impact of postoperative adjuvant chemotherapy between those with MGC and solitary gastric cancers(SGC)were ***:Among the 4107 patients investigated,the incidence of MGC was 3.2%(133/4107).Before matching,patients with MGC and SGC had disparities in the type of gastrectomy,pathological tumor stage(pT),pathological node stage(pN),and pathological tumor-node-metastasis stage(pTNM).After a 1:4 ratio matching,the clinical data of 133 cases of MGC and 532 cases of SGC were found to be *** 5-year overall survival(OS)rate was 56.6%in the entire matched cohort,48.1%in the MGC group,and 58.7%in the SGC group(P=0.013).Multivariate analysis revealed that MGC,age,pT stage,pN stage,and adjuvant chemotherapy were independent predictors of OS(all P<0.05).Stratified analyses demonstrated that for the cohort of advanced gastric cancer(AGC)patients who did not had adjuvant chemotherapy,the 5-year OS rate of advanced cases of MGC was inferior than that of SGC patients(34.0%vs.46.1%,respectively;P=0.025)but there were no significant difference in the 5-year OS rate between advanced MGC and SGC patients who had adjuvant chemotherapy(48.0%vs.53.3%,respectively;P=0.292).Further,we found that the 5-year OS rate of advanced MGC who had adjuvant chemotherapy was significantly higher than those who did not had adjuvant chemotherapy(48.0%vs.34.0%,P=0.026).Conclusions:Patients with advanced MGC was identif

关键词： Multiple gastric cancer Solitary gastric cancer Propensity score matching Adjuvant Chemotherapy Prognosis Eighth edition American Joint Committee on Cancer

Total Trihalomethane Levels in Major Watersheds across the United States

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Journal of Geoscience and Environment Protection 2020年第6期8卷 1-14页

作者： Kaleh Karim Sujata Guha Ryan Beni department of Chemistry Tennessee State University Nashville TN USA department of Biological Sciences Tennessee State University Nashville TN USA

Trihalomethanes, such as chloroform, bromoform, dibromo(chloro)methane, and bromo(dichloro)methane, are present in the major watersheds across the United States. These chemicals play an important role in the development of cancer, have adverse reproductive outcomes, and were found to be present above the threshold established by the Environmental Protection Agency. To understand the impact of socioeconomic background on the quality of water and possible disparities, we have analyzed the levels of total trihalomethanes in the metropolitan areas in the major watersheds across the United States, in 2018, as they correlated to average household incomes. Our study found that Arkansas, Nevada, and Rhode Island demonstrated higher than federally mandated levels of total trihalomethanes in their watersheds. The median annual household and per capita incomes of the three states (Arkansas, Nevada, and Rhode Island) were lower than the national average. In addition, Delaware, New Hampshire, and Wisconsin, which had higher median income levels, demonstrated the lowest total trihalomethane levels across the United States.

关键词： Total Trihalomethanes Contaminants Watersheds Household Income Income per Capita Environmental Justice Chlorination

Modeling Ocean Chlorophyll Distributions by Penalizing the Blending Technique

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Open Journal of Marine Science 2014年第1期4卷 25-30页

作者： Mathias A. Onabid Simon Wood department of Mathematical Sciences University of Bath Bath UK department of Maths-Computer Science Faculty of Sciences University of Dschang Dschang Cameroon

disparities between the in situ and satellite values at the positions where in situ values are obtained have been the main handicap to the smooth modeling of the distribution of ocean chlorophyll. The blending technique and the thin plate regression spline have so far been the main methods used in an attempt to calibrate ocean chlorophyll at positions where the in situ field could not provide value. In this paper, a combination of the two techniques has been used in order to provide improved and reliable estimates from the satellite field. The thin plate regression spline is applied to the blending technique by imposing a penalty on the differences between the satellite and in situ fields at positions where they both have observations. The objective of maximizing the use of the satellite field for prediction was outstanding in a validation study where the penalized blending method showed a remarkable improvement in its estimation potentials. It is hoped that most analysis on primary productivity and management in the ocean environment will be greatly affected by this result, since chlorophyll is one of the most important components in the formation of the ocean life cycle.

关键词： In Situ Satellite Ship and Buoy Penalized Regression Spline Penalty Penalized Blending

Radioactive Contaminants in U.S. Drinking Water and Water Quality disparities

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Journal of Geoscience and Environment Protection 2020年第11期8卷 238-251页

作者： Kaleh Karim Sujata Guha Ryan Beni department of Chemistry Tennessee State University Nashville TN USA department of Biological Sciences Tennessee State University Nashville TN USA

Radioactive contaminants, such as radium, radon, and uranium isotopes are naturally present in drinking water, and gas and oil extraction like hydraulic fracturing can exasperate radionuclide leakage into groundwater. The concentration of radionuclide in drinking water is dependent upon the water source and the underlying lithology within the aquifers. In United States, the Environmental Protection Agency regulates the level of radioactivity in drinking water via the gross alpha test, which is conducted to measure the emitted alpha particles as a result of the radioactive elements’ natural decay. Radionuclides, such as radium and uranium, are known to cause bone cancer and other forms of cancer. Communities with crippling water purification infrastructure may be at a higher risk of being exposed to radionuclides, and this is a significant environmental justice concern. The radionuclide concentrations for the metropolitan or most populated city in each state in the United States and its territories (Puerto Rico, US Virgin Islands and Guam) were analyzed and correlated to the annual household income, to determine any disparities that maybe present. Lower income communities had elevated levels of radionuclides when compared to higher income communities which had lower frequency in elevated radionuclide contaminants.

关键词： Radioactive Contaminants Household Income Income Per Capita Environmental Justice Water Quality Radionuclides Radium Uranium Radon Cancer

Effects of Exposure to Electromagnetic Field on of Some Hematological Parameters in Mice

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Open Journal of Medicinal Chemistry 2012年第2期2卷 30-42页

作者： Mariam S. Alghamdi Nawal A. El-Ghazaly department of Science Alexandria University Alexandria Egypt Sciences Faculty for Girl Department of Zoology King Abdulaziz University Jeddah Kingdom of Saudi-Arabia

Objective: To investigate the effects of electromagnetic fields on some hematological parameters of Male white mice. Methods: In this study two experiments were used as short-term and long-term experiments. Short-term experiments were carried out in 80 male white Balb/c mice exposed to two types of mobile phone for a period time up to 60 min a day for 2 weeks. Long-term experiments was carried out in 30 male white Balb/c mice exposed to two types of mobile phone for a period time up to 90 min a day for a day for a month, two months, three months. Result: The present result found that a decline in hemoglobin, hematocrit, red blood cells count, in addition to the platelets count after short and long exposure to both types of mobile phone (Alcatel, Nokia,). It was observed that the average number of white cells and lymphocytes increased significantly, indicating the increase to the body’s immune response to radiation. Also, when exposed to both devices (Alcatel, Nokia) for 15 minutes, the red blood cells began to take roles formation due to an increase in the viscosity of the blood and the ability of the cells adhesion. Increased duration of exposure to 30-minute to both devices revealed disparities in the sizes of red blood cells with the appearance of a large proportion of cells with pale colors due to lack of hemoglobin. In the group exposed for 45 minutes showed clearly the influence of mobile phones on examining blood smears which observed a proportion variation in the cell sizes with the emergence of forms of abnormal forms, including pellets cleft with many areas empty of red blood cells, With increasing in of exposure duration to 60 minutes, red blood cells appeared completely different from the natural form and took the forms resembling the eye and tear that appear in the case of anemia. After three months of exposure to both types of mobile phone showed pathological changes in red blood cells where gripped the outer membrane of the red corpuscle changes and b

关键词： Component White Blood Cells (WBC) Male White Balb/C Mice Strain Complete Blood Count Platelets (PLT) Count

Census and Segmentation-Based Disparity Estimation Algorithm Using Region Merging

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Journal of Signal and Information Processing 2015年第3期6卷 191-202页

作者： Viral H. Borisagar Mukesh A. Zaveri Computer Engineering department Government Engineering College Gandhinagar India Computer Engineering department Sardar Vallabhbhai National Institute of Technology Surat India

Disparity estimation is an ill-posed problem in computer vision. It is explored comprehensively due to its usefulness in many areas like 3D scene reconstruction, robot navigation, parts inspection, virtual reality and image-based rendering. In this paper, we propose a hybrid disparity generation algorithm which uses census based and segmentation based approaches. Census transform does not give good results in textureless areas, but is suitable for highly textured regions. While segment based stereo matching techniques gives good result in textureless regions. Coarse disparities obtained from census transform are combined with the region information extracted by mean shift segmentation method, so that a region matching can be applied by using affine transformation. Affine transformation is used to remove noise from each segment. Mean shift segmentation technique creates more than one segment of same object resulting into non-smoothness disparity. Region merging is applied to obtain refined smooth disparity map. Finally, multilateral filtering is applied on the disparity map estimated to preserve the information and to smooth the disparity map. The proposed algorithm generates good results compared to the classic census transform. Our proposed algorithm solves standard problems like occlusions, repetitive patterns, textureless regions, perspective distortion, specular reflection and noise. Experiments are performed on middlebury stereo test bed and the results demonstrate that the proposed algorithm achieves high accuracy, efficiency and robustness.

关键词： Stereo Vision Census Transform Mean Shift Segmentation Affine Transform Region Merging

Cardiogenic shock in the setting of acute myocardial infarction:Another area of sex disparity?

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World Journal of Cardiology 2021年第6期13卷 170-176页

作者： Syed Bukhari Shumail Fatima Islam Y Elgendy Cardiovascular Medicine University of PittsburghPittsburghPA 15261United States department of Medicine Weill Cornell Medicine-QatarDoha 24144Qatar

Cardiogenic shock in the setting of acute myocardial infarction(AMI)carries significant morbidity and mortality,despite advances in pharmacological,mechanical and reperfusion *** suggest that there is evidence of sex disparities in the risk profile,management,and outcomes of cardiogenic shock complicating *** with men,women tend to have more comorbidities,greater variability in symptom presentation and are less likely to receive timely revascularization and mechanical circulatory *** factors might explain why women tend to have worse *** this review,we highlight sex-based differences in the prevalence,management,and outcomes of cardiogenic shock due to AMI,and discuss potential ways to mitigate them.

关键词： Cardiogenic shock Myocardial infarction Sex Morbidity

Impact of geography on organ allocation:Beyond the distance to the transplantation center

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World Journal of Hepatology 2015年第13期7卷 1782-1787页

作者： Rony Ghaoui Jane Garb Fredric Gordon Elizabeth Pomfret Division of Gastroenterology Baystate Medical CenterTufts University School of Medicine Epidemiology/Biostatistics research Core Baystate Medical CenterTufts University School of Medicine department of Trans- plantation and Hepatobiliary Diseases Lahey Medical CenterTufts University School of Medicine

AIM:To illustrate the application and utility of Geographic Information System(GIS) in exploring patterns of liver ***,we aim to describe the geographic distribution of transplant registrations and identify disparities in access to liver transplantation across United Network of Organ Sharing(UNOS) region ***:Based on UNOS data,the number of listed transplant candidates by ZIP code from 2003 to 2012 for Region 1 was ***(color-coded) maps were used to visualize the geographic distribution of transplant registrations across the *** interaction analysis was used to analyze the geographicpattern of total transplant registrations by ZIP *** tested included ZIP code log population and log distance from each ZIP code to the nearest transplant center;ZIP code population density;distance from the nearest city over 50000;and dummy variables for state residence and location in the southern portion of the ***:Visualization of transplant registrations revealed geographic disparities in organ allocation across Region *** total number of registrations was highest in the southern portion of the *** interaction analysis,after adjusting for the size of the underlying population,revealed statistically significant clustering of high and low rates in several geographic areas could not be predicted based solely on distance to the transplant center or density of ***:GIS represents a new method to evaluate the access to liver transplantation within one region and can be used to identify the presence of disparities and reasons for their existence in order to alleviate them.

关键词： health geographic's healthcare disparities Outcome research