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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Sharp Bounds for Upper and Bottom Spectrum of Hermitizable Tridiagonal Matrices

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Journal of Mathematical Research with Applications 2025年第1期 125-132页

作者： Yueshuang LI Lingdi WANG School of Statistics Capital University of Economics and Business School of Mathematics and Statistics Henan University

We display sharp bounds for upper and lower spectrum of a Hermitizable tridiagonal matrix. The representations are brought to light by exploiting the characteristic for eigenpairs(eigenvalue and its corresponding eigenvector) of tridiagonal matrices, isospectral transforms and sharp bounds for speed stability of birth-death processes.

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The Changing of Common Priors in Sequential Auctions

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Journal of Systems Science & Complexity 2016年第5期29卷 1342-1357页

作者： QIAO Heng MA Jun School of economics Central University of Finance and Economics business School University of International Business and Economics

In sequential auctions the phenomenon of declining prices is often observed, which in theory can be represented by a supermartingale. This paper employs the perspective that bidders' values may change over stages and the common priors are sequentially adjusted by the remaining bidders. It is shown that the declining price sequence can be explained by the adjustment of common priors between auctions. The adjustment of common priors is characterized by stochastic orders. Sufficient and necessary conditions for a supermartingale price sequence are derived.

关键词： First-price sealed-bid auction private-value paradigm sequential auctions.

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Scanner color management model based on improved back-propagation neural network

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Chinese Optics Letters 2008年第3期6卷 231-234页

作者：黎新伍 Electronic business department of Jiangxi University of Finance and economics

Scanner color management is one of the key techniques for color reproduction in information optics. A new scanner color management model is presented based on analyzing rendering principle of scanning objects. In this model, a standard color target is taken as experimental sample. Color blocks in color shade area are used to substitute complete color space to solve the difficulties in selecting experimental color blocks. Immune genetic algorithm is used to correct back-propagation neural network （BPNN） to speed up the convergence of the model. Experimental results show that the model can improve the accuracy of scanner color management.

关键词： Backpropagation algorithms Genetic algorithms Neural networks Scanning

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Impact of climate-smart agricultural technology on multidimensional poverty in rural Ethiopia

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Journal of Integrative Agriculture 2021年第4期20卷 1021-1041页

作者： Tsegaye Mulugeta HABTEWOLD department of economics College of Business and EconomicsArsi UniversityAssela 2120Ethiopia

A large body of empirical literature showed that the adoption of agricultural technologies reduces poverty. However, dominants of those studies so far used one-dimensional income or expenditure-based measures of poverty which may not reflect other types of deprivations. Therefore, the major objective of this study is to examine the impact of adopting climate-smart agricultural technology, which refers to a joint application of row planting methods and the use of chemical fertilizers, on the multidimensional poverty status of rural households in Ethiopia. To estimate the impact of the stated technologies, this study employs propensity score matching and endogenous switching regression methods. To measure the multidimensional poverty index, the study also uses the Alkire and Foster counting approach. Using the Ethiopian Socioeconomic Survey(ESS), collected in 2015-Wave 3, the results of the study show that the adoption of these technologies reduces deprivation score and one of its component, the standard of living part. Regionally, a high reduction in deprivation is observed in Amhara and Oromiya regions. The results also show that the impact is significantly higher in severely deprived households. It is also observed that the reduction in multidimensional poverty due to the technology is through an increase in income/consumption via improvement in production gain. The impact channels more through the non-food expenditure pathway. Finally, this study also sheds light on the effects that technology adoption has on multidimensional poverty reduction.

关键词： multidimensional poverty rural poverty technology adoption poverty reduction poverty pathways Ethiopia

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A Markov-switching dynamic regression analysis of the asymmetries related to the determinants of US crude oil production between 1982 and 2019

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Petroleum Science 2021年第2期18卷 679-686页

作者： Serge Djoudji Temkeng Achille Dargaud Fofack department of economics University of BueaBueaCameroon department of business and economics Rauf DenktaşUniversityLefkoşaTurkey

The structural changes brought about by shale oil revolution have inspired this paper of which the aim is to analyze the potential asymmetries related to the determinants of crude oil production in the ***,using a Markov-switching dynamic regression model in which parameters change when oil production moves from one regime to the other,it is found that for both oil production and oil relative importance,the regime that was dominant during the 1980s and the early 1990s when oil production in the USA was substantially high is the same regime that has once again become dominant in the decade corresponding to the shale oil ***,the study reveals the existence of asymmetries in the relationship between US crude oil production and both manufacturing production and the consumer price *** are also found in the relationship between the relative importance US crude oil and manufacturing ***,it is found that the intercept and the variance parameter also vary from one regime to the other,thus justifying the use of regime-dependent models.

关键词： Crude oil production Energy markets Regime switching

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A Two-folded Impact Analysis of Schema Changes on Database Applications

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International Journal of Automation and computing 2009年第2期6卷 109-123页

作者： Spyridon K. Gardikiotis Nicos Malevris department of Informatics Athens University of Economics and Business

Database applications are becoming increasingly popular, mainly due to the advanced data management facilities that the underlying database management system offers compared against traditional legacy software applications. The interaction, however, of such applications with the database system introduces a number of issues, among which, this paper addresses the impact analysis of the changes performed at the database schema level. Our motivation is to provide the software engineers of database applications with automated methods that facilitate major maintenance tasks, such as source code corrections and regression testing, which should be triggered by the occurrence of such changes. The presented impact analysis is thus two-folded： the impact is analysed in terms of both the affected source code statements and the affected test suites concerning the testing of these applications. To achieve the former objective, a program slicing technique is employed, which is based on an extended version of the program dependency graph. The latter objective requires the analysis of test suites generated for database applications, which is accomplished by employing testing techniques tailored for this type of applications. Utilising both the slicing and the testing techniques enhances program comprehension of database applications, while also supporting the development of a number of practical metrics regarding their maintainability against schema changes. To evaluate the feasibility and effectiveness of the presented techniques and metrics, a software tool, called DATA, has been implemented. The experimental results from its usage on the TPC-C case study are reported and analysed.

关键词： Software engineering database applications impact analysis program slicing coupling metrics.

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Properties of Phase Transition of Traffic Flow on Urban Expressway Systems with Ramps and Accessory Roads

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Communications in Theoretical Physics 2011年第11期56卷 945-951页

作者：梅超群刘业进 School of Statistics Capital University of Economics and Business School of Urban economics and Public Affair Capital University of Economics and Business

In this paper, we develop a cellular automaton model to describe the phase transition of traffic flow on urban expressway systems with on-off-ramps and accessory roads. The lane changing rules are given in detailed, the numerical results show that the main road and the accessory road both produce phase transitions. These phase transitions will omen be influenced by the number of lanes, lane changing, the ramp flow, the input flow rate, and the geometry structure.

关键词： traffic flow ramp phase transition

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COLLABORATIVE DESIGN OF RFID SYSTEMS FOR MULTI-PURPOSE SUPPLY CHAIN APPLICATIONS

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Journal of Systems Science and Systems Engineering 2013年第2期22卷 152-170页

作者： Hongyan DAI Jing XU School of business Central University of Finance and Economics department of Industrial Engineering Tsinghua University

One of the key challenges for implementing RFID systems in supply chain management is the difficulty in economic justification. Such difficulty is further amplified by its public participation nature as multiple self-interest beneficiaries may receive diverse paybacks, and their incentives to join the system are difficult to align. This paper aims to address these problems by a collaborative design from two aspects. First, we propose to introduce a centralized planning mechanism in the chain to facilitate the participation, so that the cost of the overall system can be minimized. Second, we propose to analyze the multi-facet economic return from multi-purpose applications to achieve the full potential of RFID systems. To illustrate our approach, its application for inventory inaccuracy and product recall in RFID system is presented.

关键词： RFID collaborative design economic justification centralized planning

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The Convergence of Set-Valued Scenario Approach for Downside Risk Minimization

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Journal of Systems Science & Complexity 2016年第3期29卷 722-735页

作者： JI Xiaodong ZHU Shushang department of economics College of BusinessHebei Normal University department of Finance and Investment Sun Yat-Sen Business SchoolSun Yat-Sen University

Scenario approach is a widely used tool in portfolio risk management,however,it often runs into dilemma when determining the distribution of asset returns with insufficient information,which will be used to simulate the *** the quality of generated scenarios are not guaranteed even when the distribution of asset returns is known exactly.A set-valued scenario approach was proposed by Zhu,et al.(2015)as a possible *** a necessary supplement of the results proposed by Zhu,et al.(2015),this paper theoretically investigates the convergent property of the numerical solution based on the set-valued scenario approach under the condition that the underlying distribution is known.

关键词： Convergence downside risk portfolio risk management set-valued scenarios.

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