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Manganese silicate nanospheres-incorporated hydrogels:starvation therapy and tissue regeneration

Bioactive Materials 2021年第12期6卷 4558-4567页

作者： Hongshi Ma Qingqing Yu Yu Qu Yufang Zhu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai200050China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesNo19(A)Yuquan RoadBeijing100049China

To prevent postoperative skin tumor recurrence and repair skin wound,a glucose oxidase(GOx)-loaded manganese silicate hollow nanospheres(MS HNSs)-incorporated alginate hydrogel(G/MS-SA)was constructed for starvation-photothermal therapy and skin tissue *** MS HNSs showed a photothermal conversion efficiency of 38.5%,and endowed composite hydrogels with satisfactory photothermal *** advantage of the catalytic activity of Mn ions,the composite hydrogels could decompose hydrogen peroxide(H2O2)into oxygen(O2),which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor ***,hyperthermia triggered by near infrared(NIR)irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx,but also ablate tumor *** anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups,and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation ***,the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS *** is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.

关键词： Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy tissue regeneration

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Zizhu ointment promote shealing of diabetic foot ulcers by inhibiting inflammatory reaction

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Journal of Hainan Medical University 2020年第21期26卷 15-21页

作者： Qiang Han Guo-Bin Liu Shi-Meng Yan Ren-Yan Huang Feng Xu Xiao-Ming Hu Chen-Yan Shi Xiao Yang Li-Xiang Wang Shao-Qing Yan Shuguang hospital affiliated to Shanghai university of traditional Chinese medicine Shanghai university of traditional Chinese medicine

Objective:This study aims to explore the mechanism of Chinese medicine Zizhu substance in the ranging of diabetic foot ulcer model from the perspective of inflammatory ***:High-fat feed and streptozotocin(STZ)were 2 to establish diabetes,And an experimental model of diabetic foot ulcer was established with constant temperature and constant *** The intervention control of The experimental model that included physiologicalEnzyme-linked immunosorbent assay(ELISA)was used to detect serum nitric oxide NO,C-reactive protein(CRP)and interleukin-6(il-6),Western blot(WB)detection of nuclear factor-bp65(NF-B P65),c-jun n-terminal kinase(JNK),Phosphorylated phosatidylinositol 3-kinase(p-pi3k),Immunohistochemistry(IHC)detection of vascular endothelial growth factor(VEGF)and leukemic cell leuk-34(CD34)of wound tissues,A cold atomic absorption method to detect blood mercury(Hg)content,study purple The effect of Zhu substance on The inflammation of diabetic foot ulcers and The safety of ***:The expression of inflammatory factors in diabetic foot ulcer rats was who that in ordinary ulcers,Zizhu substance could reduce The expression of inflammatory factors(NO,CRP and IL-6)in diabetic foot ulcer *** the diabetic foot ulcer model,the activation of the nf-kappa B,JNK,PI3K pathway,Zizhu substance can significantly inhibit the phosphorylation of JNK and nf-kappa B P65,PI3K,reduce the inflammation of the wound,happens the expression of VEGF,CD34 and promote the wound Angiogenesis and the detection of blood mercury content in rats treated with Zizhu lought indicate that the drug has good ***:Zizhu substance can promote diabetic foot ulcer tissue repair and improve wound ranging by inhibiting inflammation-related pathways,Showing that Zizhu substance is a safe and effective drug for the treatment of diabetic foot ulcers.

关键词： Zizhu ointment Diabetic foot ulcer Inflammation Mercury Nf-KB

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Bioactive hydrogels for bone regeneration

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Bioactive Materials 2018年第4期3卷 401-417页

作者： Xin Bai Mingzhu Gao Sahla Syed Jerry Zhuang Xiaoyang Xu Xue-Qing Zhang Engineering Research center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong University800 Dongchuan RoadShanghai200240P.R.China Department of Chemical and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

Bone self-healing is limited and generally requires external intervention to augment bone repair and *** traditional methods for repairing bone defects such as autografts,allografts,and xenografts have been widely used,they all have corresponding disadvantages,thus limiting their clinical *** the development of a variety of biomaterials,including metal implants,calcium phosphate cements(CPC),hydroxyapatite,etc.,the desired therapeutic effect is not fully ***,polymeric scaffolds,particularly hydrogels,are of interest and their unique configurations and tunable physicochemical properties have been extensively *** review will focus on the applications of various cutting-edge bioactive hydrogels systems in bone regeneration,as well as their advantages and *** will examine the composition and defects of the bone,discuss the current biomaterials for bone regeneration,and classify recently developed polymeric materials for hydrogel *** will also elaborate on the properties of desirable hydrogels as well as the fabrication techniques and different delivery ***,the existing challenges,considerations,and the future prospective of hydrogels in bone regeneration will be outlined.

关键词： Bone regeneration Hydrogel Biomaterials tissue engineering

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The innovation of biomaterials:From bioactive to bioelectroactive

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Science China Materials 2022年第7期65卷 1723-1726页

作者： Peng Yu Guoxin Tan Xuliang Deng Zhengao Wang Chengyun Ning Liming Ding School of Materials Science and Engineering Metallic Materials Surface Functionalization Engineering Research Center of Guangdong ProvinceSouth ChinaUniversity of TechnologyGuangzhou 510641China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Department of Geriatric Dentistry NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical MaterialsPeking University School and Hospital of StomatologyBeijing 100081China center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human ***,researchers have sought to develop bioactive materials with unique physical and chemical properties,such as stiffness,functional groups,nanotopographies and stimulus-responsive properties,to promote tissue regeneration at the biointerface.

关键词：生物活性材料功能仿生理性设计电活性拓扑结构材料革新电信号

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A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury

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Neural regeneration Research 2021年第11期16卷 2284-2292页

作者： Shuo Liu Yuan-Yuan Xie Liu-Di Wang Chen-Xu Tai Dong Chen Dan Mu Yan-Yan Cui Bin Wang Clinical Stem Cell center Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Department of Radiology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Department of Cell Biology and Genetics Chongqing Medical UniversityChongqingChina

Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation,the passage of nutrients and oxygen,and the discharge of *** this study,a porous collagen scaffold with axially-aligned luminal conduits was *** vitro biocompatibility analysis of the collagen scaffold revealed that it enhances the activity of neural stem cells and promotes cell extension,without affecting cell *** collagen scaffold loaded with neural stem cells improved the hindlimb motor function in the rat model of T8 complete transection and promoted nerve *** collagen scaffold was completely degraded in vivo within 5 weeks of implantation,exhibiting good *** temperature,C-reactive protein expression and CD68 staining demonstrated that rats with spinal cord injury that underwent implantation of the collagen scaffold had no notable inflammatory *** findings suggest that this novel collagen scaffold is a good carrier for neural stem cell transplantation,thereby enhancing spinal cord repair following *** study was approved by the Animal Ethics Committee of Nanjing Drum Tower Hospital(the Affiliated Hospital of Nanjing University Medical School),China(approval No.2019AE02005)on June 15,2019.

关键词： axially-aligned luminal conduits biomaterial cell transplantation collagen complete transection inflammation neural stem cell regeneration scaffold spinal cord injury tissue engineering

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Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially

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The innovation 2021年第3期2卷 126-134页

作者： Lingxia Xie Guomin Wang Yuzheng Wu Qing Liao Shi Mo Xiaoxue Ren Liping Tong Wei Zhang Min Guan Haobo Pan Paul KChu Huaiyu Wang center for Human tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China

The immune responses are involved in every stage after implantation but the reported immune-regulated materials only work at the beginning without fully considering the different phases of bone ***,poly(aryl-ether-ether-ketone)(PEEK)is coated with a programmed surface,which rapidly releases interleukin-10(IL-10)in the first week and slowly delivers dexamethasone(DEX)up to 4 *** to the synergistic effects of IL-10 and DEX,an aptly weak inflammation is triggered within the first week,followed by significant M2 polarization of macrophages and upregulation of the autophagy-related *** suitable immunomodulatory activities pave the way for osteogenesis and the steady release of DEX facilitates bone regeneration *** sequential immune-mediated process is also validated by an 8-week implementation on a rat *** is the first attempt to construct implants by taking advantage of both immune-mediated modulation and sequential regulation spanning all bone regeneration phases,which provides insights into the fabrication of advanced biomaterials for tissue engineering and immunological therapeutics.

关键词： poly(aryl-ether-ether-ketone) surface modifications sequential release immune-mediated osteogenesis bone regeneration

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Advanced application of collagen-based biomaterials in tissue repair and restoration

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Journal of Leather Science and Engineering 2022年第1期4卷 409-427页

作者： Jiayi Zhu Zhulian Li Yaping Zou Gonggong Lu Alfredo Ronca Ugo D’Amora Jie Liang Yujiang Fan Xingdong Zhang Yong Sun National Engineering Research center for Biomaterials Sichuan University29#Wangjiang RoadChengdu 610064People’s Republic of China Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly College of Biomedical Engineering Sichuan University29#Wangjiang RoadChengdu 610064People’s Republic of China Department of Neurosurgery West China HospitalSichuan University37#Guoxue LaneChengdu 610041SichuanPeople’s Republic of China Sichuan Testing center for Biomaterials and Medical Devices Sichuan University29 Wangjiang RoadChengdu 610064People’s Republic of China.

In tissue engineering,bioactive materials play an important role,providing structural support,cell regulation and establishing a suitable microenvironment to promote tissue *** the main component of extracellular matrix,collagen is an important natural bioactive material and it has been widely used in scientific research and clinical *** is available from a wide range of animal origin,it can be produced by synthesis or through recombinant protein production *** use of pure collagen has inherent disadvantages in terms of physico-chemical *** this reason,a processed collagen in different ways can better match the specific requirements as biomaterial for tissue ***,collagen may be used in bone/cartilage regeneration,skin regeneration,cardiovascular repair and other fields,by following different processing methods,including cross-linked collagen,complex,structured collagen,mineralized collagen,carrier and other forms,promoting the development of tissue *** review summarizes a wide range of applications of collagen-based biomaterials and their recent progress in several tissue regeneration ***,the application prospect of bioactive materials based on collagen was outlooked,aiming at inspiring more new progress and advancements in tissue engineering research.

关键词： Collagen Bioactive material tissue engineering regeneration repair

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Articular cartilage and osteochondral tissue engineering techniques:Recent advances and challenges

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Bioactive Materials 2021年第12期6卷 4830-4855页

作者： Wenying Wei Honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan430070China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan528200China

In spite of the considerable achievements in the field of regenerative medicine in the past several decades,osteochondral defect regeneration remains a challenging issue among diseases in the musculoskeletal system because of the spatial complexity of osteochondral units in composition,structure and *** order to repair the hierarchical tissue involving different layers of articular cartilage,cartilage-bone interface and subchondral bone,traditional clinical treatments including palliative and reparative methods have showed certain improvement in pain relief and defect *** is the development of tissue engineering that has provided more promising results in regenerating neo-tissues with comparable compositional,structural and functional characteristics to the native osteochondral *** in this review,some basic knowledge of the osteochondral units including the anatomical structure and composition,the defect classification and clinical treatments will be first *** we will highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design,cell encapsulation and signaling factor incorporation including bioreactor *** products for osteochondral defect repair will be analyzed and summarized ***,we will discuss the current obstacles and future directions to regenerate the damaged osteochondral tissues.

关键词： Osteochondral tissue engineering Cartilage tissue engineering Gradient scaffold Bioreactors

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BMSCs-assisted injectable Col I hydrogel-regenerated cartilage defect by reconstructing superficial and calcified cartilage

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Regenerative Biomaterials 2020年第1期7卷 35-45页

作者： Hanxu Cai PeileiWang Yang Xu Ya Yao Jia Liu Tao Li Yong Sun Jie Liang Yujiang Fan Xingdong Zhang National Engineering Research center for Biomaterials Sichuan University29 Wangjiang RoadChengdu 610064P.R.China Department of Gynecology and Obstetrics Development and Related Disease of Women and Children Key Laboratory of Sichuan ProvinceKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second HospitalSichuan University20 Renmin South RoadChengdu 610041P.R.China

The self-healing capacity of cartilage was limited due to absence of vascular,nervous and lymphatic *** many clinical treatments have been used in cartilage defect repair and shown a promising repair result in short term,however,regeneration of complete zonal structure with physiological function,reconstruction cartilage homeostasis and maintaining long-term repair was still an unbridgeable *** has complex zonal structure and multiple physiological functions,especially,superficial and calcified cartilage played an important role in keeping *** address this hurdle of regenerating superficial and calcified cartilage,injectable tissue-induced type I collagen(Col I)hydrogel-encapsulated BMSCs was chosen to repair cartilage *** 1 month implantation,the results demonstrated that Col I gel was able to induce BMSCs differentiation into chondrocytes,and formed hyaline-like cartilage and the superficial layer with lubrication *** 3 months post-surgery,chondrocytes at the bottom of the cartilage layer would undergo hypertrophy and promote the regeneration of calcified *** months later,a continuous anatomical tidemark and complete calcified interface were *** regeneration of neo-hyaline cartilage was similar with adjacent normal tissue on the thickness of the cartilage,matrix secretion,collagen type and *** multilayer zonal structure with physiological function remodeling indicated that BMSCs-assisted injectable Col I hydrogel could reconstruct cartilage homeostasis and maintain long-term therapeutic effect.

关键词： BMSCs injectable Col I hydrogel superficial cartilage,calcified cartilage

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Engineered extracellular vesicles:Regulating the crosstalk between the skeleton and immune system

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Engineered regeneration 2022年第3期3卷 270-282页

作者： Wei-Wei Yu Qian-Qian Wan Yu Wei Yu-Tao Li Qi-Hong Li Tao Ye Ke-Hui Xu Jing-Han Song Chen Lei Mei-Chen Wan Kai Jiao Franklin R Tay Li-Na Niu State Key Laboratory of Military Stomatology&National Clinical Research center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of Stomatologythe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Stomatology the Fifth Medical CentreChinese PLA General HospitalDongda StreetBeijing 100071China The Dental College of Georgia Augusta UniversityAugustaGeorgiaUnited States

Osteoimmunology has gained momentum in recent years,focusing on the crosstalk between the skeleton and the immune *** vesicles(EVs)are nanoscale vesicles that are potential candidates for cell-free tissue regeneration *** may be used for repairing damaged tissues and regulating the body’s immune system and bone-related metabolic *** of the ability of EVs to deliver bioactive signals and mediate intercellular communication,they can decipher the complex mechanisms of interaction within the“osteoimmune system”at the molecular *** address the lack of targeting ability caused by vesicle heterogeneity in the clinical applications of EVs,these nanoscopical entities may be modified by bioengineering techniques to optimize the interaction between bone repair and immunomodulation for improving treatment efficacy,specificity and *** the present review,the endogenous properties that make EVs natural delivery agents are *** that may be improved by bioengineering are *** therapeutic applications of EVs in the rehabilitation of bone defects are *** opportunities and challenges that need to be addressed for translating this field of research into clinical practice are brought into perspectives.

关键词： Bone defect Crosstalk Engineered extracellular vesicles Immune regulation Osteoimmunology

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