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非编码RNA及其在组织工程中的潜在应用

Engineering 2017年第1期3卷 12-38页

作者：李石营钱天梅王星辉刘杰顾晓松 Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co-Innovation Center of Neuroregeneration Nantong University

组织工程是医学科学中一个相对较新但发展迅速的领域。非编码RNA(nc RNA)是不编码蛋白质的功能性RNA分子,它们可以调节细胞的行为、改变组织的生物学环境。虽然以对ncRNA作为治疗靶点尚未进入临床实践,但ncRNA在组织工程中的应用已经吸... 详细信息

组织工程是医学科学中一个相对较新但发展迅速的领域。非编码RNA(nc RNA)是不编码蛋白质的功能性RNA分子,它们可以调节细胞的行为、改变组织的生物学环境。虽然以对ncRNA作为治疗靶点尚未进入临床实践,但ncRNA在组织工程中的应用已经吸引了越来越多的关注,而且对ncRNA的调节作用和释放方法的深入探讨可以促进其在组织工程中的应用。本文简要介绍了ncRNA在神经、皮肤、肝脏、血管和肌肉的调控作用和可能的释放方法及其潜在的治疗应用价值。

关键词：组织工程非编码RNA(ncRNA) microRNA(miRNA) 神经皮肤肝脏血管系统肌肉

Nanoparticles modified by polydopamine: Working as “drug” carriers

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Bioactive Materials 2020年第3期5卷 522-541页

作者： Anting Jin Yitong Wang Kaili Lin Lingyong Jiang Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011PR China

Inspired by the mechanism of mussel adhesion,polydopamine(PDA),a versatile polymer for surface modification has been *** to its unique properties like extraordinary adhesiveness,excellent biocompatibility,mild synthesis requirements,as well as distinctive drug loading approach,strong photothermal conversion capacity and reactive oxygen species(ROS)scavenging facility,various PDA-modified nanoparticles have been desired as drug *** nanoparticles with diverse nanostructures are exploited in multifunctions,consisting of targeting,imaging,chemical treatment(CT),photodynamic therapy(PDT),photothermal therapy(PTT),tissue regeneration ability,therefore have attracted great attentions in plenty biomedical ***,recent progress of PDA-modified nanoparticle drug carriers in cancer therapy,antibiosis,prevention of inflammation,theranostics,vaccine delivery and adjuvant,tissue repair and implant materials are reviewed,including preparation of PDA-modified nanoparticle drug carriers with various nanostructures and their drug loading strategies,basic roles of PDA surface modification,*** advantages of PDA modification in overcoming the existing limitations of cancer therapy,antibiosis,tissue repair and the developing trends in the future of PDA-modified nanoparticle drug carriers are also discussed.

关键词： Surface modification Polydopamine Nanoparticles Drug carriers

Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?

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Neural regeneration Research 2015年第1期10卷 7-9页

作者： Suk Yu Yau Ang Li Aimin Xu Kwok-fai So State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong Division of Medical Sciences University of Victoria BCCanada Department of Anatomy The University of Hong Kong Department of medicine The University of Hong Kong Department of Pharmacology and Pharmacy The University of Hong Kong Research Centre of Heart BrainHormone and Healthy AgeingThe University of Hong Kong State Key Laboratory of Pharmaceutical Biotechnology Li Ka Shing Faculty of MedicineThe University of Hong Kong Department of Ophthalmology The University of Hong Kong Guangdong-Hong Kong-Macao Institute of CNS regeneration Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University

Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.

关键词： hippocampus adult neurogenesis physical exercise voluntary wheel running depression neural progenitor cell adipocyte adiponectin adiponectin receptor AMP-activated protein kinase

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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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Dysfunctional stem and progenitor cells impair fracture healing with age

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World Journal of Stem Cells 2019年第6期11卷 281-296页

作者： Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li Department of Mechanical and Energy Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202United States Department of Medicinal Chemistry and Molecular Pharmacology Purdue UniversityWest LafayetteIN 47907United States Department of Physical Therapy Indiana University- Purdue University IndianapolisIndianapolisIN 46202United States Division of Biomedical Science Marian University College of Osteopathic MedicineIndianapolisIN 46222United States Department of Chemistry Purdue UniversityWest LafayetteIN 47907 United States Richard L. Roudebush VA Medical center IndianapolisIN 46202United States Department of medicine Indiana University School of MedicineIndianapolisIN 46202United States Department of Biology Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.

关键词： Fracture healing Aging Bone Angiogenesis Mesenchymal stem cells Endothelial progenitor cells

Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin regeneration via Improved Angiogenesis and Immunomodulation

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Advanced Fiber Materials 2023年第1期5卷 327-348页

作者： Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji UniversityShanghai 200092China Shanghai Engineering Research center of Lung Transplantation Shanghai 200433China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China center for Life Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Medical Neurobiology and MOE Frontiers center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200433China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore 54000Pakistan Department of Cardiothoracic Surgery Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315000China

tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell ***,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue ***,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue *** endothelial growth factor(VEGF)plays a significant role in wound healing by promoting *** overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual ***-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based *** sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound ***,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the *** dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment ***,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen ***,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a p

关键词： Skin regeneration Angiogenesis Immunomodulation Peptide Wound bandage Electrospun nanofiber

Role and prospects of regenerative biomaterials in the repair of spinal cord injury

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Neural regeneration Research 2019年第8期14卷 1352-1363页

作者： Shuo Liu Yuan-Yuan Xie Bin Wang Clinical Stem Cell center The Affiliated Drum Tower Hospital of Nanjing University Medical School

Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some regenerative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.

关键词： nerve regeneration spinal cord injury regenerative biomaterials scaffolds tissue engineering regeneration transplantation combination functional recovery repair strategy microenvironment neural regeneration

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Therapeutic nucleic acids in regenerative medicine and tissue repair

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Nano Research 2024年第10期17卷 8942-8976页

作者： Qimanguli Saiding Duotian Qin Soohwan An Dylan Neal Patel Muhammad Muzamil Khan Na Kong Wei Tao center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA

In the vanguard of biomedical innovation,regenerative medicine emerges as a transformative paradigm,concentrating its efforts on rectifying tissue deficits and functional aberrations in patients through the strategic augmentation of endogenous cellular *** to this approach is nucleic acid therapy,which offers a novel pathway for tissue regeneration by modulating key signaling *** one of the most effective ways to regulate cell function,nucleic acids are crucial for various tissue regeneration;however,their in vivo therapeutic applications face substantial challenges,including nuclease degradation,cell membrane impermeability,and targeted intracellular ***-based gene delivery systems offer a solution for stable and localized drug delivery by enabling the controlled overexpression of therapeutic nucleic acids,producing functional regulatory *** review presents examples of nucleic acid applications in regenerative medicine,highlighting the synergy between nucleic acids and biomaterial *** underlines the importance of nucleic acid delivery techniques,the choice of therapeutic nucleic acids,and biomaterials for advancing tissue *** latest developments in designing nucleic acid biomaterial-based delivery vehicles are explored,the mechanism of nucleic acids in tissue regeneration is elucidated,and their limitations are discussed while considering future directions for the clinical translation of nucleic acid-based therapeutics.

关键词： tissue repair nucleic acids biomaterials delivery systems regenerative medicine

Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts

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Bioactive Materials 2021年第6期6卷 1791-1809页

作者： Yu Zhuang Chenglong Zhang Mengjia Cheng Jinyang Huang Qingcheng Liu Guangyin Yuan Kaili Lin Hongbo Yu Department of Oral and Cranio-maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China National Clinical Research center for Oral Diseases Shanghai200011China Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology Shanghai200011China National Engineering Research center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong University800 Dongchuan RoadShanghai200240China

Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,which even result in dysfunction and *** regeneration or artificial vascular graft,as the conventional treatment modality,has received keen ***,small-diameter(diameter<4 mm)vascular grafts have a high risk of thrombosis and intimal hyperplasia(IH),which makes long-term lumen patency *** cells(ECs)form the inner endothelium layer,and are crucial for anti-coagulation and ***,promoting in situ endothelialization in vascular graft remodeling takes top priority,which requires recruitment of endothelia progenitor cells(EPCs),migration,adhesion,proliferation and activation of EPCs and *** aimed at ligands on EPC surface can be utilized for EPC homing,while nanofibrous structure,biocompatible surface and cell-capturing molecules on graft surface can be applied for cell ***,cell orientation can be regulated by topography of scaffold,and cell bioactivity can be modulated by growth factors and therapeutic ***,surface modification can also reduce thrombogenesis,and some drug release can inhibit *** the influence of macrophages on ECs and smooth muscle cells(SMCs),scaffolds loaded with drugs that can promote M2 polarization are alternative *** conclusion,the advanced strategies for enhanced long-term lumen patency of vascular grafts are summarized in this *** for recruitment of EPCs,adhesion,proliferation and activation of EPCs and ECs,anti-thrombogenesis,anti-IH,and immunomodulation are *** vascular grafts with appropriate surface modification,loading and fabrication strategies are required in further studies.

关键词： Vascular graft In situ endothelialization Thrombogenesis Intimal hyperplasia Immunomodulation