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Identification of common genetic variants in KCNQ family genes associated with gastric cancer survival in a Chinese population

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Journal of Biomedical Research 2025年第1期39卷 76-86页

作者： Yuetong Chen Chen Li Yi Shi Jiali Dai Yixuan Meng Shuwei Li Cuiju Tang Dongying Gu Jinfei Chen Department of Radiation Oncology the Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215008China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Oncology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325015China Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

The KCNQ family of genes(KCNQ1–KCNQ5),encoding voltage-gated K+(Kv)channels,have been demonstrated to play potential pathophysiological roles in ***,the associations between genetic variants located in KCNQ family genes and gastric cancer survival remain *** this study,a large-scale cohort comprising 1135 Chinese gastric cancer patients was enrolled to identify genetic variants in KCNQ family genes associated with overall survival(OS).Based on the survival evaluation of all five KCNQ family genes,KCNQ1 was selected for subsequent genetic *** both Cox regression model and stepwise Cox regression model used to evaluate survival-related genetic variants,we found that KCNQ1 rs10832417G>T was associated with an increased OS in gastric cancer patients(adjusted hazards ratio[HR]=0.84,95%confidence interval[CI]:0.72–0.98,P=0.023).Subsequently,a nomogram was constructed to enhance the prognostic capacity and clinical translation of rs10832417 *** rs10832417 T allele was predicted to increase the minimum free energy of the secondary ***,we observed that gastric cancer patients with downregulated KCNQ1expression had a poorer survival across multiple public *** findings of the present study indicate that KCNQ1 rs10832417 may serve as an independent prognostic predictor of gastric cancer,providing novel insights into the progression and survival of the disease.

关键词： gastric cancer survival genetic variants ionic channels

Electronic Circular Dichroism Spectra Calculation Based on Generalized Energy-Based Fragmentation Approach

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Chinese Journal of Chemical Physics 2025年第1期38卷 102-112,I0040-I0049,I0056,I0057页

作者： Zhongye Wang Ziyi Lv Shuhua Li Wei Li School of Chemistry and Chemical Engineering Key Laboratory of Mesoscopic Chemistry of Ministry of EducationInstitute of Theoretical and Computational ChemistryNanjing UniversityNanjing 210023China

Electronic circular dichroism(ECD)spectrum is an important tool for as-sessing molecular ***-al methods,like linear response time-dependent density functional theory(LR-TDDFT),predict ECD spectra well for small or medium-sized molecules,but struggle with large sys-tems due to high computational costs,making it a significant challenge to ac-curately and efficiently predict the ECD properties of complex *** the framework of the generalized energy-based fragmentation(GEBF)method for localized excited states(ESs)calculation,we propose a combination algorithm for calculating rotatory strengths of ESs in condensed phase *** algorithm estimates the rotatory strength of the total system by calculating and combin-ing the transition electric and magnetic dipole moments of *** have used the GEBF method to calculate the ECD properties of chiral drug molecule derivatives,green fluo-rescent protein,and cyclodextrin derivatives,and compared their results with traditional methods or experimental *** results show that this method can efficiently and accu-rately predict the ECD spectra of these ***,the GEBF method for ECD spectra demonstrates great potential in the chiral analysis of complex systems and chiral material design,promising to become a powerful theoretical tool in chiral chemistry.

关键词： Generalized energy-based fragmentation approach Electronic circular dichro-ism Rotatory strength Chirality Localized excited state

Effects of water level variations on the water quality of Huayang Lakes,China

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Journal of Geographical Sciences 2025年第1期35卷 173-188页

作者： AN Lesheng LIU Chun FAN Zhongya LIAO Kaihua WANG Wencai WANG Nan School of Resources and Environment Anqing Normal UniversityAnqingAnhui246133China South China institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou510655China The Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyCASNanjing210008China

To explore water level variations and their dynamic influence on the water quality of Huayang Lakes,the water level from 1967 to 2023 and water quality from 2015 to 2023 were analyzed using the Mann–Kendall trend test,box plots,and violin *** results show a notable hydrological rhythm of water level alternation between dry and flood seasons in Huayang Lakes,with an average water level of 12.82 m and a monthly range of 11.21–*** 2017,the water level of Huayang Rivers has shown a decreasing trend of–0.02 m/*** phosphorus(TP)has become the primary *** TP concentrations in Longgan Lake(the largest lake)during the dry,rising,flood,and retreating seasons from 2015 to 2023were 0.083,0.061,0.050,and 0.059 mg/L,*** effect of water level on TP was mainly observed during the low-water *** the water level in the dry season rose to 12.25 and 13.00 m,the percentage of TP exceeding 0.1 mg/L in Longgan Lake decreased to 55.8%and 33.3%,*** the dry season,wind and wave disturbances caused the release of endogenous phosphorus in Huayang *** led to drastic fluctuations in TP concentration,reducing the correlation between water level and *** external control is limited,the water level during the dry season should be maintained between 12.25 and 13.0 ***,it is necessary to accelerate the restoration of submerged macrophyte species(such as Hydrilla verticillata and Vallisneria natans)in the Huayang Rivers.

关键词： shallow lake water level water quality total phosphorus Huayang Lakes

Improving the Seasonal Forecast of Summer Precipitation in Southeastern China Using a CycleGAN-based Deep Learning Bias Correction Method

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Advances in Atmospheric Sciences 2025年第1期42卷 26-35页

作者： Song YANG Fenghua LING Jing-Jia LUO Lei BAI institute of Climate Application Research(ICAR)/School of Future Technology/CIC-FEMD/KLME/ILCEC Nanjing University of Information Science and TechnologyNanjing 210044China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Accurate seasonal precipitation forecasts,especially for extreme events,are crucial to preventing meteorological hazards and their potential impacts on national development,social activity,and ***,the intensity of summer precipitation is often largely underestimated in many current dynamic *** study uses a deep learning method called Cycle-Consistent Generative Adversarial Networks(CycleGAN)to improve the seasonal forecasts for June-JulyAugust precipitation in southeastern China by the nanjing university of Information Science and Technology Climate Forecast System(NUIST-CFS 1.0).The results suggest that the CycleGAN-based model significantly improves the accuracy in predicting the spatiotemporal distribution of summer precipitation compared to the traditional quantile mapping(QM)*** the unpaired bias-correction model,we can also obtain advanced forecasts of the frequency,intensity,and duration of extreme precipitation events over the dynamic model *** study expands the potential applications of deep learning models toward improving seasonal precipitation forecasts.

关键词： bias correction CycleGAN QM NUIST-CFS 1.0 extreme precipitation

Spatially confined synthesis of TiNb_(2)O_(7)quantum dots onto mesoporous carbon and Ti_(3)C_(2)T_(X)MXene for boosting lithium storage

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Green Energy & Environment 2025年第2期10卷 358-366页

作者： Daoguang Sun Cheng Tang Haitao Li Xinlin Zhang Guanjia Zhu Zhen-Dong Huang Aijun Du Haijiao Zhang institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai200444China School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbaneQLD4001Australia State Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing210023China

TiNb_(2)O_(7)has been emerged as one of the most promising electrode materials for high-energy lithium-ion ***,limited by the slow electron/ion transport kinetics,and insufficient active sites in the bulk structure,the TiNb_(2)O_(7)electrode still suffers from unsatisfactory lithium storage ***,we demonstrate a spatially confined strategy toward a novel TiNb_(2)O_(7)-NMC/MXene composite through a triblock copolymer-directed one-pot solvothermal route,where TiNb_(2)O_(7)quantum dots with a particle size of 2-3 nm are evenly embedded into N-doped mesoporous carbon(NMC)and Ti_(3)C_(2)T_(X)***,the as-prepared TiNb_(2)O_(7)-NMC/MXene anode exhibits a high reversible capacity(486.2 mAh g^(-1)at 0.1 A g^(-1)after 100 cycles)and long cycle lifespan(363.4 mAh g^(-1)at ss1 A g^(-1)after 500 cycles).Both experimental and theorical results further demonstrate that such a superior lithium storage performance is mainly ascribed to the synergistic effect among 0D TiNb_(2)O_(7)quantum dots,2D Ti_(3)C_(2)T_(X)MXene nanosheets,and N-doped mesoporous *** strategy presented also opens up new horizon for space-confined preparation of high-performance electrode materials.

关键词： TiNb_(2)O_(7)quantum dots Ti_(3)C_(2)T_(X)MXene Mesoporous carbon Confined synthesis Lithium-ion batteries

PtCu dendroframe octahedrons:Enhancing peroxidase-like activity and antibacterial efficiency through structural evolution

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Nano Research 2025年第1期18卷 100-106页

作者： Ri Feng Jiuyi Hu Liangjun Wang Jiayu Xu Jiajia Li Zeeshan Ahmad Shaohui Zheng Muhammad Farhan Farid Wenjing Liu Faisal Saleem Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)and School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816China

Nanozymes,which possess enzyme-like catalytic activity,are attractive alternatives to natural *** activity is largely dependent on the structure of the ***,challenges remain in optimizing the structure-activity *** work explores the synthesis and utilization of PtCu nanostructures(NSs),focusing on their peroxidase(POD)-like properties and their potential as antibacterial *** developed PtCu dendrites that transform into unique dendroframe octahedrons(DFOs)and subsequently stabilize into solid octahedrons with unusual growth *** intermediate DFO,showed higher POD-like activity in comparison to other shapes of PtCu *** DFOs also have the better ability to consume glutathione,thus enhancing their sterilization ***,we demonstrate the effectiveness of these PtCu DFOs as powerful antibacterial *** work provides valuable information on shape dependent activities of PtCu NSs in the field of biomedicine.

关键词： nanozymes antibacterials peroxidase PtCu dendroframe octahedrons dendrites

Passive Integrated Sensing and Communication Scheme Based on RF Fingerprint Information Extraction for Cell-Free RAN

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China Communications 2025年第1期22卷 171-181页

作者： Yu Jingxuan Zeng Fan Li Jiamin Liu Feiyang Zhu Pengcheng Wang Dongming You Xiaohu National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 210096China Purple Mountain Laboratories Nanjing 211111China 54th Research institute of Electronics Technology Group Corporation Shijiazhuang 050081China

This paper investigates how to achieve integrated sensing and communication(ISAC)based on a cell-free radio access network(CF-RAN)architecture with a minimum footprint of communication *** propose a new passive sensing *** scheme is based on the radio frequency(RF)fingerprint learning of the RF radio unit(RRU)to build an RF fingerprint library of *** source RRU is identified by comparing the RF fingerprints carried by the signal at the receiver *** receiver extracts the channel parameters from the signal and estimates the channel environment,thus locating the reflectors in the *** proposed scheme can effectively solve the problem of interference between signals in the same time-frequency domain but in different spatial domains when multiple RRUs jointly serve users in CF-RAN *** results show that the proposed passive ISAC scheme can effectively detect reflector location information in the environment without degrading the communication performance.

关键词： CF-RAN ISAC passive sensing RF fingerprinting

Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei NI Yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO Yi-Xiang CHEN Yunguo LI Wan-Cai LI Xuan GUO Yang-Yang WANG Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of ChinaHefei230026China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China Guangzhou institute of Geochemistry Chinese Academy of SciencesGuangzhou510640China School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China State Key Lab of Superhard Materials Jilin UniversityChangchun130012China

In this work,we provide a comprehensive review on the formation,evolution,properties,and effects of supercritical *** Earth's interior,enhanced miscibility between H_(2)O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H_(2)O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems,typified by pegmatite system,is governed by meltfluid critical *** formation of supercritical geofluid in metamorphic systems,typified by subducted slab,is governed by the second critical end *** results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths,but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth.A major presence of both H_(2)O and depolymerized structural units(monomers,dimers,etc.)endows supercritical geofluid with unique physical properties including low density,low elastic moduli,low viscosity,high diffusivity,and high electrical *** geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth *** chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts,and this could give an explanation of the oxidation of arc *** separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt *** fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical *** geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab,and can be linked with intermediate-focus *** geofluid may have played a crucial role in the formation of pegmatites and associ

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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Comparative transcriptome analysis identifies key regulators of nitrogen use efficiency in chrysanthemum

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Journal of Integrative Agriculture 2025年第1期24卷 176-195页

作者： Lijiao Ge Weihao Miao Kuolin Duan Tong Sun Xinyan Fang Zhiyong Guan Jiafu Jiang Sumei Chen Weimin Fang Fadi Chen Shuang Zhao College of Horticulture Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Landscaping Ministry of Agriculture and Rural AffairsNanjing 210095China Jiangsu Yanjiang institute of Agricultural Sciences Nantong 226012China

Nitrogen(N)is a limiting factor that determines the yield and quality of *** variation in N use efficiency(NUE)has been reported among chrysanthemum *** performed a transcriptome analysis of two chrysanthemum genotypes,'Nannonglihuang'(LH,N-efficient genotype)and'Nannongxuefeng"(XF,N-inefficient genotype),under low N(0.4 mmol L^(-1)N)and normal N(8 mmol L^(-1)N)treatments for 15 d and an N recovery treatment for 12 h(low N treatment for 15 d and then normal N treatment for 12 h)to understand the genetic factors impacting NUE in *** two genotypes exhibited contrasting responses to the different N *** N-efficient genotype LH had significant superiority in agronomic traits,N accumulation and glutamine synthase activity under both normal N and low N *** N treatment promoted root growth in LH,but inhibited root growth in *** analysis revealed that the low N treatment increased the expression of some N metabolism genes,genes related to auxin and abscisic acid signal transduction in the roots of both genotypes,as well as genes related to gibberellin signal transduction in roots of *** N recovery treatment just increased the expression of genes related to cytokinin signal transduction in roots of *** expression levels of the NRT2.1,AMT1.1,and Gln1 genes related to gibberellin and cytokinin signal transduction were higher in roots of LH than in XF under different N treatments,suggesting that the genes related to N metabolism and hormone(auxin,abscisic acid,gibberellin,and cytokinin)signal transduction in roots of LH are more sensitive to different N treatments than those of ***-expression network analysis(WGCNA)also identified hub genes like bZIP43,bHLH93,NPF6.3,IBR10,MYB62,PP2C,PP2C06 and NLP7,which may be the key regulators of N-mediated responses in chrysanthemum and play crucial roles in enhancing NUE and resistance to low N stress in the N-efficient chrysanthemum *** results r

关键词： chrysanthemum genotype NUE gene expression transcriptome analysis