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Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1, MAPK, NF-κB signaling

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chinese Journal of Natural Medicines 2025年第1期23卷 90-101页

作者： Yongxian Li Jinbo Yuan Wei Deng Haishan Li Yuewei Lin Jiamin Yang Kai Chen Heng Qiu Ziyi Wang Vincent Kuek Dongping Wang Zhen Zhang Bin Mai Yang Shao Pan Kang Qiuli Qin Jinglan Li Huizhi Guo Yanhuai Ma Danqing Guo Guoye Mo Yijing Fang Renxiang Tan Chenguang Zhan Teng Liu Guoning Gu Kai Yuan Yongchao Tang De Liang Liangliang Xu Jiake Xu Shuncong Zhang The First Clinical Academy Guangzhou University of Chinese Medicine The First Affiliated Hospital of Guangzhou University of chinese Medicine Lingnan Medical Research Center of Guangzhou University of chinese Medicine School of Biomedical Sciences University of Western Australia Curtin Medical School Curtin University Foshan Hospital of Traditional chinese Medicine School of Public Health and Management Guangzhou University of Chinese Medicine The State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecules Nanjing University

Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength, leading to increased fragility. Buqi-Tongluo(BQTL) decoction, a traditional chinese medicine(TCM) prescription, has yet to be fully evaluated for its potential in treating bone diseases such as osteoporosis. To investigate the mechanism by which BQTL decoction inhibits osteoclast differentiation in vitro and validate these findings through in vivo *** employed MTS assays to assess the potential proliferative or toxic effects of BQTL on bone marrow macrophages(BMMs) at various concentrations. TRAc P experiments were conducted to examine BQTL's impact on osteoclast differentiation. RT-PCR and Western blot analyses were utilized to evaluate the relative expression levels of osteoclast-specific genes and proteins under BQTL stimulation. Finally, in vivo experiments were performed using an osteoporosis model to further validate the in vitro findings. This study revealed that BQTL suppressed receptor activator of NF-κB ligand(RANKL)-induced osteoclastogenesis and osteoclast resorption activity in vitro in a dose-dependent manner without observable *** inhibitory effects of BQTL on osteoclast formation and function were attributed to the downregulation of NFATc1 and c-fos activity, primarily through attenuation of the MAPK, NF-κB, and Calcineurin signaling pathways. BQTL's inhibitory capacity was further examined in vivo using an ovariectomized(OVX) rat model, demonstrating a strong protective effect against bone loss. BQTL may serve as an effective therapeutic TCM for the treatment of postmenopausal osteoporosis and the alleviation of bone loss induced by estrogen deficiency and related conditions.

关键词： Buqi-Tongluo Estrogen deficiency MAPK NF-κB NFATc1 Osteoclast Osteoporosis

Water Quality,Influential Factors,and Management Strategies from 2016 to 2020 in the Yangtze River Economic Belt,China

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chinese Geographical Science 2025年第1期35卷 175-186页

作者： LIN Lanyu GUO Congrong CHEN Yanan HE Lihuan YAN Luyu FANG Dekun MA Guangwen ZHANG Fengying LI Mingsheng China National Environmental Monitoring Centre Beijing 100012China Department of Health Ethics&SocietyCare and Public Health Research InstituteFaculty of HealthMedicine and Life SciencesMaastricht UniversityMaastricht 6200the Netherlands

The Yangtze River economic belt(YREB),China is important to the chinese economy and for supporting sustainable *** the relationship between water quality indices and socioeconomic indicators could help improve aquatic environment management in the YREB and our understanding of the causes and effects of water quality variations in other large river *** this study,river water quality,factors affecting water quality,and management strategies,and correlations between water quality indices and socioeconomic indicators in the YREB during the 13th Five-Year Plan period(2016-2020)were *** single-factor evaluation method,constant price for GDP,and correlation analyses were *** results showed that:1)water quality in the YREB improved during the 13th Five-Year Plan *** number of aquatic environment sections meeting GradeⅠ-Ⅲwater quality standards increased by 13.1%and the number below Grade V decreased by 2.9%.2)The values of 12 indicators in the YREB exceeded relevant *** indicators with highest concentreation were the total phosphorus,chemical oxygen demand,ammonia nitrogen,and permanganate index,which were relatively high in downstream regions in Anhui Province,Jiangsu Province,and Shanghai Municipality.3)Ammonia nitrogen,chemical oxygen demand,and total phosphorus emissions per unit area and water extraction per unit area are relatively high in the three downstream regions mentioned above.4)Increased domestic sewage discharges have increased total wastewater discharges in the YREB.5)River water quality in the YREB strongly correlated with population,economic,and water resource indices and less strongly correlated with government investment,agriculture,meteorology,energy,and forestry *** confirmed the need to decrease wastewater discharges and non-point-source pollutant *** aquatic environment could be improved by taking reasonable measures to control population growth,adjusting the industrial str

关键词： water quality factors coping strategies Yangtze River economic belt(YREB),China

Global rare earth resources and scenarios of future rare earth industry

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Journal of Rare Earths 2011年第1期29卷 1-6页

作者：陈占恒 Academic Department The Chinese Society of Rare Earths

It is known to all that China is abundant in rare earth resources. But rare earth deposits are really not that rare in the earth crest. In the five continents, i.e. Asia, Europe, Australia, North and South America, and Africa, there are about thirty four countries found to have rare earth deposits; Brazil might surpass China and rank the first in rare earth deposits. At present, investment in rare earth production was surged, there have been about 200 projects, and the total production for 25 of them would be more than 170 thousand tons after 2015, a multi-supply system on rare earths is being established worldwide. Cautions on the investment of rare earth production are involved.

关键词： rare earth elements deposit resources reserves rare earth industry

Three-dimensional fracture of UO_(2)ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 165-176页

作者： Wei Xiong Xuan Ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Fracture is the primary failure type for the UO_(2)ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional(3D)UO_(2)ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Scientific statement of the chinese society of Cardiology(CSC) on using of renin angiotensin system blockers in patients with cardiovascular disease and COVID-19

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Journal of Geriatric Cardiology 2020年第5期17卷 241-242页

作者： Ya-Ling HAN Yu-Ming LI Chang-Sheng MA the Editorial Board of chinese Journal of Cardiology 无不详 the chinese society of Cardiology

The coronavirus disease 2019(COVID-19), which is caused by SARS-CoV-2, has become a worldwide public health crisis. Published clinical data from China and other countries have shown a much higher risk of developing COVID-19 and dying from the disease among the elderly, especially among those who had preexisting hypertension, cardiovascular diseases(CVD) and diabetes mellitus[1].

关键词： Angiotensin converting enzyme Cardiovascular disease COVID-19 Scientific statement

Effects of nitrogen enrichment on soil enzyme activities in grassland ecosystems in China: A multilevel meta-analysis

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Pedosphere 2025年第1期35卷 84-96页

作者： SHI, Jibo RAHMAN, Muhammad KHASHI U MA, Ruonan LI, Qiang HUANG, Yingxin LI, Guangdi Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun 130102 China Jilin Provincial Key Laboratory of Grassland Farming Changchun 130102 China Key Laboratory of Mollisols Agroecology Chinese Academy of Sciences Changchun 130102 China Microbiology and Genetics Department & Institute for Agribiotechnology Research (CIALE) University of Salamanca Salamanca 37007 Spain University of chinese Academy of Sciences Beijing 100049 China New South Wales Department of Primary Industries Wagga Wagga Agricultural Institute Wagga Wagga 2650 Australia

Nitrogen (N) enrichment has resulted in widespread alteration of grassland ecosystem processes and functions mainly through disturbance in soil enzyme activities. However, we lack a comprehensive understanding of how N deposition affects specific key soil enzymes that mediate plant-soil feedback of grassland. Here, with a meta-analysis on 1 446 cases from field observations in China, we show that N deposition differently affects soil enzymes associated with soil biochemical processes. Specifically, N-promoted C, N, and P-acquiring hydrolase activities significantly increased by 8.73%, 7.67%, and 8.69%, respectively, related to an increase in microbial-specific enzyme secretion. The increased relative N availability and soil acidification were two potential mechanisms accounting for the changes in soil enzyme activities with N enrichment. The mixed N addition in combination of NH4NO3 and urea showed greater stimulation effect on soil enzyme activities. However, the high rate and long-term N addition tended to weaken the positive responses of soil C-, N- and P-acquiring hydrolase activities to N enrichment. Spatially increased mean annual precipitation and temperature primarily promoted the positive effects of N enrichment on N- and P-acquiring hydrolase activities, and the stimulation of C- and N-acquiring hydrolase activities by N enrichment was intensified with the increase in soil depth. Finally, multimodal inference showed that grassland type was the most important regulator of responses of microbial C, N, and P-acquiring hydrolase activities to N enrichment. This meta-analysis provides a comprehensive insight into understanding the key role of N enrichment in shaping soil enzyme activities of grassland ecosystems. © 2025 Soil Science society of China

关键词： C, N, and P-acquiring hydrolases grassland type model selection N addition oxidase soil acidification

Sintering Behaviour and Dielectric Properties of MnCO_(3)-doped MgO-based ceramics

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无机材料学报 2025年第1期40卷 97-103页

作者： WANG Zhixiang CHEN Ying PANG Qingyang LI Xin WANG Genshui School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Inorganic Functional Materials and Devices Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China The State Key Laboratory of High Performance ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

ceramic dielectric materials with high dielectric strength and mechanisms of their internal factors affecting dielectric strength are significantly valuable for industrial application,especially for selection of suitable dielectric materials for high-power microwave transmission devices and reliable power *** magnesium oxide(MgO),a kind of ceramic dielectric material,possesses great application potential in high-power microwave transmission devices due to its high theoretical dielectric strength,low dielectric constant,and low dielectric loss properties,but its application is limited by high sintering temperature during *** work presented the preparation of a new type of multiphase ceramics based on MgO,which was MgO-1%ZrO_(2)-1%CaCO_(3-x)%MnCO_(3)(MZCM_(x),x=0,0.25,0.50,1.00,1.50,in molar),and their phase structures,morphological features,and dielectric properties were *** was found that inclusion of ZrO_(2) and CaCO_(3) effectively inhibited excessive growth of MgO grains by formation of second phase,while addition of MnCO_(3) promoted the grain boundary diffusion process during the sintering process and reduced activation energy for the grain growth,resulting in a lower ceramic sintering *** performance,including high dielectric strength(Eb=92.3 kV/mm)and quality factor(Q×f=216642 GHz),simultaneously accompanying low dielectric loss(ceramics under a relatively low sintering temperature of 1350℃.This work offers an effective solution for selecting dielectric materials for high-power microwave transmission devices.

关键词： MgO ceramic dielectric strength sintering temperature growth activation energy

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Temperature Fluctuation Synthesis/Simultaneous Densification and Microstructure Control of Titanium Silicon Carbide (Ti_3SiC_2) ceramics

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Journal of Materials Science & Technology 2000年第5期16卷 461-465页

作者： Zhimei SUN and Yanchun ZHOU (ceramic and Composite Department, Institute of Metal Research, chinese Academy of Sciences, Shenyang 110015, China) ceramic and Composite Department Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

A novel temperature fluctuation synthesis/simultaneous densification process was developed for the preparation of Ti3SiC2 bulk ceramics. In this process. Si is used as an in-situ liquid forming phase and it is favorable for both the solid-liquid synthesis and the densification of Ti3SiC2 rainies. The present work demonstrated that the temperature fluctuation synthesis/simultaneous densification process is one of the most effective and simple methods for the preparation of Ti3SiC2 bulk materials providing relatively low synthesis temperature. short reaction time; and simultaneous synthesis and densification. This work also showed the capability to control the microstructure, e.g., the preferred orientation, of the bulk Ti3SiC2 materials simply by applying the hot pressing pressure at different Stages of the temperature fluctuation process. And textured Ti3SiC2 bulk materials with {002} faces of laminated Ti3SiC2 grains normal to the hot pressing axis were prepared.

关键词： ceramics Temperature Fluctuation Synthesis/Simultaneous Densification and Microstructure Control of Titanium Silicon Carbide Ti3SiC2 SiC

Carbon and oxygen isotope variation and its implication for marine sequence: A case study of Ordovician in Tarim Basin

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Petroleum Research 2017年第3期2卷 281-290页

作者： Zongju Zhao Jianguo Wang Peixi Wang chinese Petroleum society Beijing 100724China

Carbon and oxygen isotopes of marine carbonate rocks or fossil shells could indicate global sea-level relative ***,heavier carbon isotopes or lighter oxygen isotopes reflected rise of global sea-level relative changes,and vice *** carbonate rocks deposited before Tertiary,carbon isotope was more stable than oxygen isotope,and thus it was more suitable to indicate global sea-level relative *** time limit of the 3rd-order sequence(1-10Ma),large scale migration of carbonate platforms would not occur and carbonate productivity would not change greatly,therefore,a research method of marine tectonic sequence(i.e,a contrastive analysis method of carbon and oxygen isotopessedimentary cycles)was ***,the marine 3rd-order sequences were divided the global sealevel sequence which was controlled by global sea-level change and the tectonic sequence which was controlled by regional tectonic subsidence and *** global sea-level fluctuation indicated by carbon and oxygen isotopes were consistent with variation of sedimentary cycles and water depth of the global sea-level sequence,but were not consistent with variation of sedimentary cycles and water depth of the tectonic *** a case study of Ordovician in Tarim Basin,two 3rd-order global sea-level sequences were identified in the Lower Ordovician,while six 3rd-order tectonic sequences controlled by collision and compression between Arkin island arc,Kudi active continental margin uplift and Tarim Plate were identified in the Middle and Upper ***,OSQ6 in the Upper Ordovician(Lianglitage Formation)was a typical tectonic sequence.

关键词： The global sea-level sequence The tectonic sequence The 3rd-order sequence Carbon and oxygen isotope Lianglitage Formation Ordovician Tarim Basin