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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

Science China Materials 2018年第11期61卷 1367-1386页

作者： Serge Mignani Joao Rodrigues Helena Tomas Anne-Marie Caminade Regis Laurent Xiangyang Shi Jean-Pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging

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Conformal manufacturing of soft deformable sensors on the curved surface

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International Journal of Extreme Manufacturing 2021年第4期3卷 1-21页

作者： Wanqing Zhang Ling Zhang Yabin Liao Huanyu Cheng Department of Engineering Science and Mechanics The Pennsylvania State UniversityPennsylvaniaPA 16802United States of America James Watt School of Engineering University of GlasgowG128QQ GlasgowUnited Kingdom State Key Laboratory of Advanced Welding&Joining Flexible Printed Electronics Technology CenterHarbin Institute of TechnologyShenzhen 518055People’s Republic of China Department of Mechanical Engineering Technology Pennsylvania State University-ErieThe Behrend CollegeEriePA 16563United States of America Department of Materials Science and Engineering The Pennsylvania State UniversityPennsylvaniaPA 16802United States of America Department of Mechanical Engineering The Pennsylvania State UniversityPennsylvaniaPA 16802United States of America Department of Biomedical Engineering The Pennsylvania State UniversityPennsylvaniaPA 16802United States of America

Health monitoring of structures and people requires the integration of sensors and devices on various 3D curvilinear,hierarchically structured,and even dynamically changing ***,it is highly desirable to explore conformal manufacturing techniques to fabricate and integrate soft deformable devices on complex 3D curvilinear *** planar fabrication methods are not directly suitable to manufacture conformal devices on 3D curvilinear surfaces,they can be combined with stretchable structures and the use of transfer printing or assembly methods to enable the device integration on 3D *** with functional nanomaterials,various direct printing and writing methods have also been developed to fabricate conformal electronics on curved surfaces with intimate contact even over a large *** a brief summary of the recent advancement of the recent conformal manufacturing techniques,we also discuss the challenges and potential opportunities for future development in this burgeoning field of conformal electronics on complex 3D surfaces.

关键词： conformal manufacturing soft deformable sensors curved surfaces transfer printing direct printing and writing methods

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Antimicrobial Activity against Escherichia coli of Cu-Ni Nanoalloy and Combination of Ag Nanoparticles,Obtained by Different Method

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Journal of Pharmacy and Pharmacology 2021年第12期9卷 420-427页

作者： Cecilia A.Fernandez Yamila AIllanez Gaston Fernandez Marcelo R.Esquivel María de los ACangiano Research Institute of Chemical Technology(INTEQUI) National University of San Luis(UNSL)-CONICET.Almirante Brown 1455San Luis 5700Argentina School of Engineering and Farming Sciences(FICA) National University of San Luis(UNSL)Ruta 55 Ext.NorteVilla MercedesSan Luis5730Argentina School of Chemistry Biochemistry and PharmacyUNSLSan LuisArgentina School of Medical Sciences of the Catholic University of Cuyo San LuisArgentina Atomic center of Bariloche(CNEA-CONICET) Avenida Bustillo km 95BarilocheRío Negro8400Argentina National University of Comahue(UNCo)-Bariloche Quintral 1250BarilocheRío Negro8400Argentina

Escherichia coli,is a pathogenic bacterium that causes serious infections,whose therapeutic treatment is threatened by the emergence of multiple resistance to conventional *** recent years,metal nanoparticles(NPs)have been studied for their antimicrobial capacity and their possible applications as an alternative to antibiotics against different *** also vary in synthesis techniques;either by chemical,physical and biological *** objective of this work was to study the possible antimicrobial capacity of Cu-Ni nanoalloys obtained by a method called *** antimicrobial capacity of the NPs mentioned above was evaluated in vitro by the agar diffusion *** of the NPs evaluated showed antibacterial activity against the strain of *** *** combining chemical and biological NP,synergistic effects are observed with an increase in antibacterial activity in some *** can conclude that NPs derived from chemical and biological synthesis could be used as antimicrobials against *** and when these are combined,antibacterial effects *** the future,these applications of nanomaterials could be used as an alternative to the use of antibiotics against infections that have limited treatments.

关键词： Nanoalloys Cu-Ni antibacterial activity human pathogens nanotechnology

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外加物理场调控二维材料的HER和OER性能

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物理化学学报 2024年第9期40卷 28-34页

作者：秦春玲陈爽 Hassanien Gomaa Mohamed A.Shenashen Sherif A.El-Safty 刘倩安翠华刘熙俊邓齐波胡宁无河北工业大学机械工程学院材料科学与工程学院天津300401 广西大学资源环境与材料学院省部共建特色金属材料与组合结构全寿命安全国家重点实验室广西有色金属及特色材料加工重点实验室南宁530004 Research center for Macromolecules and Biomaterials National Institute for Materials Science(NIMS)1-2-1 SengenTsukubashiIbaraki-ken 305-0047Japan Department of Chemistry Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt 河北工业大学电工装备可靠性与智能化国家重点实验室天津300130 河北工业大学高端装备与结构技术研究院天津300401

长期以来,氢燃料一直被认为是一种有前途和可行的传统化石燃料的替代品,可以支撑我们未来的能源格局。电催化水分解是一种可用于大规模高效生产高纯度氢气的可持续和环保的技术。该技术的工业化需要我们不断地提高两个电极上的析氢反应(... 详细信息

长期以来,氢燃料一直被认为是一种有前途和可行的传统化石燃料的替代品,可以支撑我们未来的能源格局。电催化水分解是一种可用于大规模高效生产高纯度氢气的可持续和环保的技术。该技术的工业化需要我们不断地提高两个电极上的析氢反应(HER)和析氧反应(OER)的反应动力学。此外,催化剂催化活性和结构稳定性的持续优化对于该技术的实际实施同样关键。因此,合适的催化剂的选取是影响电催化水分解的关键因素之一。二维(2D)纳米材料由于其独特的物理化学性质和丰富的活性位点成为了电解水领域的热点。此外,2D材料独特的物理化学特性能与外加物理场之间高度契合,可以产生一些独特的效果来增强电催化性能。因此,近些年,外加物理场在辅助改善HER和OER方面的作用和机制越来越受到关注。外加物理场,如电场,磁场,应变,光,温度和超声波,可以应用于催化剂合成和电催化过程。本文首先总结了物理场辅助电解水催化剂合成的研究。随后,根据外场在电催化过程中作用机制的不同,对外场辅助HER和OER的研究进行了分类。最后,本文指出了本领域快速发展所面临的主要挑战和前景。

关键词：外加物理场析氢反应析氧反应合成二维材料

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Theranostics:纳米热疗法或可软化肿瘤,提高癌症靶向疗法的治疗效率

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现代生物医学进展 2017年第3期17卷 I0003-I0003页

作者： Iris Marangon Amanda A. K. Silva Thomas Guilbert Jelena Kolosnjaj-Tabi Carmen Marchiol Sharuja Natkhunarajah Foucault Chamming’s Cécilia Ménard-Moyon Alberto Bianco Jean-Luc Gennisson Gilles Renault Florence Gazeau Laboratoire Matière et Systèmes Complexes (MSC) CNRS-UMR 7057 Université Paris Diderot Sorbonne Paris Cité 10 rue Alice Domon et Léonie Duquet F-75205 Paris Cedex 13 France Plateforme Imagerie Institut Cochin Inserm U1016-CNRS UMR8104-Université Paris Descartes Sorbonne Paris Cité Paris 22 rue Méchain 75014 Paris France PARCC Inserm U970 Paris Cardiovascular Research Center-PARCC / Université Paris-Descartes Sorbonne Paris Cité 56 rue Leblanc 75015 Paris France University of Strasbourg CNRS Immunopathology and Therapeutic Chemistry UPR 3572 67000 Strasbourg France Institut Langevin CNRS-UMR 7587 1 place Jussieu 75205 Paris France.✉ Corresponding author: Florence GAZEAU rf.toredid-sirap-vinu@uaezag.ecnerolf. Tel: +33 (0)1 57 27 62 03 Fax: +33 (0)1 57 27 62 11.Competing Interests: The authors have declared that no competing interest exists.

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于... 详细信息

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于国际杂志Theranostics上。

关键词：恶性肿瘤热疗法软化纳米癌症疗效附带损伤机械阻力

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