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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen beijing international Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第1期68卷 10-11页

作者： Zhoumei Tan Kun Xu Chengchu Zeng beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by international Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

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international Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin Liu Run Hou Chenghao Wu Ruishan Xie Shujun Chen college of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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international Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu Wei Sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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Efficacy and safety of Tuomin Zhiti decoction(脱敏止嚏汤) on patients with seasonal allergic rhinitis: A randomized， double-blind， placebo-controlled trial

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Journal of Traditional Chinese Medicine 2025年

作者： ZHAO Weibo WANG Yaqi KONG Lingyao WANG Tianyi ZHAO Haihong ZHANG Ying LUO Bin WANG Ji WANG Qi National Institute of TCM Constitution and Preventive Medicine， beijing University of Chinese Medicine college of Basic Medical Sciences， Zhejiang Chinese Medical University Centre for Evidence-Based Chinese Medicine， beijing University of Chinese Medicine beijing University of Chinese Medicine international School

Objective: To evaluate the clinical efficacy and safety of Tuomin Zhiti decoction (TZD) in the short-term treatment of seasonal allergic rhinitis (SAR). Methods: This study is a randomized， double-blind placebo-controlled， and single-center clinical trial. In April 2021， during the spring pollen season in beijing， 94 SAR patients aged 19-60 years were randomized (1:1 ratio) to receive two weeks of TZD or placebo. The primary outcome was the change of Total Nasal Symptom Score (TNSS) and Total Ocular Symptom Score (TOSS) from baseline to the end of treatment. Secondary outcomes were the changed score of the mini Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)， Rescue Medication Score (RMS)， and Patient Global Impression of Change (PGIC). All adverse events were recorded and evaluated by two senior physicians. Results: TZD significantly reduced both the total nasal symptom scores and total ocular symptom scores compared to scores at baseline， while the placebo group showed an increasing trajectory in both symptom scores. Compared to the placebo group， the TZD group also showed a greater improvement in the quality of life， scores of RMS， nasal and eye symptoms scores after TZD treatment (P < 0.001). Most notably， at the end of treatment， the proportion of remission measured by PGIC was significantly higher in the TZD group (82.97%) compared with the placebo group (47.72%， P < 0.001). Conclusion: This study suggested that two weeks of TZD is an effective and safe treatment for SAR patients and spring pollen allergy， TZD could significantly improve the nasal and eye symptoms and improve the quality of life of patients.

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Overview of in-situ oxygen production technologies for lunar resources

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international Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang Liangwei Cong Guoyu Qian Dong Wang Laishi Li Yusheng Wu Zhi Wang college of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

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UP-TreeRec: Building Dynamic User Profiles Tree for News Recommendation

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China Communications 2019年第4期16卷 219-233页

作者： Ming He Xiaofei Wu Jiuling Zhang Ruihai Dong beijing University of Technology University college dublin

Online news recommendation systems aim to address the information explosion of news and make personalized recommendations for users. The key problem of personalized news recommendation is to model users' interests and track their changes. A common way to deal with the user modeling problem is to build user profiles from observed behavior. However, the majority of existing methods make static representations of user profiles and little research has focused on effective user modeling that could dynamically capture user interests in news topics. To address this problem, in this paper, we propose UP-TreeRec, a news recommendation framework based on a user profile tree(UP-Tree), which is a novel framework combining content-based and collaborative filtering techniques. First, by exploiting a novel topic model namely UILDA, we obtain the representation vectors for news content in a topic space as the fundamental bridge to associate user interests with news topics. Next, we design a decision tree with a dynamically changeable structure to construct a user interest profile from the user's feedback. Furthermore, we present a clustering-based multidimensional similarity computation method to select the nearest neighbor of the UP-Tree efficiently. We also provide a Map-Reduce framework-based implemen-tation that enables scaling our solution to real-world news recommendation problems. We conducted several experiments compared to the state-of-the-art approaches on real-world datasets and the experimental results demonstrate that our approach significantly improves accuracy and effectiveness in news recommendation.

关键词： News recommendation user profiling content-based recommendation collaborative filtering

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HYDRAULIC CHARACTERIZATIONS OF TORTUOUS FLOW IN PATH DRIP IRRIGATION EMITTER

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Journal of Hydrodynamics 2006年第4期18卷 449-457页

作者： LI Yun-kai YANG Pei-ling REN Shu-mei XU Ting-wu college of Hydraulic and Civil Engineering China Agricultural University Beijing 100083 China international college at beijing China Agricultural University Beijing 100083 China

At present, the tortuous emitter has the most advanced performances in drip irrigation. But the theories and methods for designing its flow path have been strictly confidential and the researches on the function of practical guidance have seldom been published. Seven types of most representative tortuous emitting-pipes currently used in agricultural irrigation regions of China were chosen for investigating the geometric parameters of the flow path by means of combining high-precision microscope and AutoCAD technology. By the measurement platform developed by the authors for hydraulic performances of emitters, the free discharge rates from the 7 types of emitters were measured at 9 pressure levels of 1.5 m, 3.0 m, 5.0 m, 7.0 m, 9.0 m, 10.0 m, 11.0 m, 13.0 m and 15.0 m. Then the discharge-pressure relationship, manufacturing variation coefficient, average velocity on the cross-section of flow path and the critical Reynolds number for the flow regime transformation within the paths were analyzed in detail. The results show that both pressure-ascending work pattern and pressure-descending work pattern have some impacts on the discharge rates of tortuous emitters, but the impact level is not significant. The target pressure could be approached by repetitive applications of the two work patterns during pressure regulation. The operation under low pressures has some impacts on the hydraulic performances of emitters, but the impact level is also not significant. The classical model of the discharge-pressure relationship is suitable for the pressure range of 1.5 m -15.0 m. The Reynolds number for fluids within the 7 types of tortuous emitters ranges from Re=105 to Re =930. The critical Reynolds number for the flow regime transformation is smaller than that for the routine dimension flow path. The variation coefficient of emitter discharge rates is slightly fluctuating around a certain value within the whole pressure range.

关键词： drip irrigation emitters tortuous flow pathhydraulic performances flow characteristics

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MWCNTs/SiO2 Composite System:Carrier Transmission,Twin-Percolation and Dielectric Properties

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Chinese Physics Letters 2011年第10期28卷 232-235页

作者： CAO Wen-Qiang LU Ming-Ming WEN Bo CHEN Yuan-Lu LI Hong-Bo YUAN Jie CAO Mao-Sheng School of Material Science and Engineering Beijing Institute of TechnologyBeijing 100081 School of EMPS University College DublinDublin 4Ireland School of Information Engineering Minzu University of ChinaBeijing 100081

We synthesize composite systems of multi-wall carbon nanotubes(MWCNTs)/SiO_(2) by using the sol−gel *** dielectric properties of the systems with different-concentration MWCNTs are *** our MWCNTs/SiO_(2) inorganic systems,the twin−percolation phenomenon exists when the concentrations of MWCNTs are 5–10%and 15–20%.The permittivity and conductivity have jumping *** twin−percolation phenomenon is attributed to the special transfer mechanism of MWCNTs in the system,determined by hopping and migrating *** of dielectric properties and conductance of the MWCNTs/SiO_(2) systems are conformed to the percolation *** special percolation phenomenon and electric properties of MWCNTs/SiO_(2) can help us comprehend the conductivity mechanism of the MWCNTs/SiO2 systems effectively,and promote the development of a high performance function composite system.

关键词： composite percolation conductivity

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