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Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis

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Traditional Medicine Research 2025年第2期10卷 30-36页

作者： Abdur Rauf Zuneera Akram Naveed Muhammad Najla AlMasoud Taghrid Saad Alomar Saima Naz Abdul Wadood Chandni Hayat Marcello Iriti Department of Chemistry University of SwabiAmbar 23561Pakistan Department of Pharmacology Faculty of Pharmaceutical SciencesBaqai Medical UniversityKarachi 74600Pakistan Department of Pharmacy Abdul Wali Khan University MardanMardan 23200Pakistan Department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Biotechnology BKUC-Bacha Khan University CharsaddaCharsadda 24620Pakistan Department of Biochemistry Abdul Wali Khan University MardanMardan 23200Pakistan Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20129Italy National Interuniversity Consortium of Materials Science and Technology(INSTM) Firenze 50121Italy

Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and *** study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia ***:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were *** docking studies were conducted using a molecular operating ***:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µ*** antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%*** docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/***:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.

关键词： Pistacia chinensis Bunge antioxidant DPPH assay antilipoxygenase docking analysis

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Numerical investigation of transitions in flow states and variation in aerodynamic forces for flow around square cylinders arranged inline

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Chinese Journal of Aeronautics 2018年第11期31卷 2111-2123页

作者： Waqas SARWAR ABBASI Shams UL ISLAM Lubna FAIZ Hamid RAHMAN Mathematics Department Air UniversityIslamabad Mathematics Department COMSATS Institute of Information Technology Mathematics and Statistics Department Bacha Khan University

This study focuses on the transitions in flow states around two-, three-and four-inline square cylinders under the effect of Reynolds numbers at two different gap spacing values using the lattice Boltzmann method. For this purpose, Reynolds number is varied in the range 1–130 while two different values of spacing taken into account are gap spacing =2 and 5. Before going to actual problem, the code is tested for flow around a single square cylinder by comparing the results with experimental and numerical results of other researchers, and good agreement is *** current numerical computations yield that for both spacing values and all combinations of cylinders there exist three different sates of flow depending on Reynolds numbers: steady state, transitional state and unsteady state. It is found that the range of Reynolds numbers for these flow states is different for both spacing values. At gap spacing =2 the range of Reynolds numbers for each flow state decreases by increasing the number of cylinders while at gap spacing =5 opposite trend is observed. The results also show that at gap spacing =2 the reduction in drag force is greater than the corresponding reduction at gap spacing =5. The maximum reduction in drag force is observed at Reynolds numbers =1 at both spacing values. Similarly, at both spacing values and all Reynolds numbers, the maximum reduction in drag force is observed for the case of four-inline square cylinders.

关键词： Drag reduction Flow states Gap spacing Inline cylinders Reynolds number

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Estimation of the Shale Oil/Gas Potential of a Paleocene–Eocene Succession: A Case Study from the Meyal Area, Potwar Basin, Pakistan

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Acta Geologica Sinica(English Edition) 2017年第6期91卷 2180-2199页

作者： Ali AAMIR Ullah MATEE Hussain MATLOOB Asher Samuel BHATTI Rehman KHAISTA Department of Earth Sciences Quaid-i-Azam University bacha khan university National Centre of Excellence in Geology University of Peshawar

The successful exploration and production of shale-gas resources in the United States and Canada sets a new possible solution towards the energy crisis presently affecting most countries of Asia. This study focuses on the use of well log and 2D seismic data for the characterization of the shale oil/gas potential of a Paleocene-Eocene succession -- the Meyal area in the Potwar Basin of Pakistan. Two shaly plays are identified in Paleocene-Eocene strata in well logs using ALogR and modified ALogR cross-plot techniques. The results indicate that Paleocene shale （the Patala Formation） and the lower shaly part of Eocene limestone （Sakesar Formation） can be potentially mature source rocks. However, the thermal maturity modelling proves that only the Paleocene shale is mature. Our results also suggest that the maturity responses on ALogR models for the lower shaly part of the Eocene limestone are due to trapped hydrocarbons in the intra-formational fractures. Petroelastic/petrophysical analysis of the Patala Formation reveals two potential shale oil/gas zones on the basis of Young＇s modulus, Poisson＇s ratio, Brittleness index and Total Organic Content at an exploitation depth of 3980-3988 m. This work can provide valuable insight for estimating shale oil/gas potential in highly deformed basins not only in Asia but in other parts of the world.

关键词： petroleum geology ALogR pseudo-sonic curve total organic carbon (TOC) burial history,thermal maturity

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The Influence of Saturated and Bilinear Incidence Functions on the Dynamical Behavior of HIV Model Using Galerkin Scheme Having a Polynomial of Order Two

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1661-1685页

作者： Attaullah Kamil Zeb Abdullah Mohamed Department of Mathematics&Statistics Bacha Khan UniversityCharsadda24461Pakistan Research Centre Future University in EgyptNew Cairo11835Egypt

Mathematical modelling has been extensively used to measure intervention strategies for the control of contagious *** between different models is pivotal for furnishing strong substantiation for policymakers because the differences in model features can impact their *** modelling has been widely used in order to better understand the transmission,treatment,and prevention of infectious ***,we study the dynamics of a human immunodeficiency virus(HIV)infection model with four variables:S(t),I(t),C(t),and A(t)the susceptible individuals;HIV infected individuals(with no clinical symptoms of AIDS);HIV infected individuals(under ART with a viral load remaining low),and HIV infected individuals with two different incidence functions(bilinear and saturated incidence functions).A novel numerical scheme called the continuous Galerkin-Petrov method is implemented for the solution of *** influence of different clinical parameters on the dynamical behavior of S(t),I(t),C(t)and A(t)is described and *** the results are depicted *** the other hand,we explore the time-dependent movement of nanofluid in porous media on an extending sheet under the influence of thermal radiation,heat flux,hall impact,variable heat source,and *** flow is considered to be 2D,boundary layer,viscous,incompressible,laminar,and *** transformations turn governing connected PDEs intoODEs,which are solved using the proposed *** justify the envisaged problem,a comparison of the current work with previous literature is presented.

关键词： HIV/AIDS Galerkin technique bilinear and saturated incidence functions

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Ag-Co3O4：Synthesis,characterization and evaluation of its photo-catalytic activity towards degradation of rhodamine B dye in aqueous medium

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1264-1269页

作者： Muhammad Saeed Majid Muneer Nida Mumtaz Mohsin Siddique Nadia Akram Muhammad Hamayun Department of Chemisny Government College University Faisalabad Pakistan Department of Chemistry Bacha Khan University Charsadda Pakistan Department of Chemistry University of Gujrat Hafiz Hayat Campus Gujrat Pakistan

Synthesis,characterization of Co_3O_4 and Ag-Co_3O_4 composites and evaluation of their photo-catalytic activities towards photo-degradation of aqueous solution of rhodamine B dye under irradiation of visible light have been described in this ***_3O_4 was prepared by solid phase mechano chemical process using Co(NO_3)_2·6H_2O and NH_4 HCO_3 as precursor *** was deposited on Co_3O_4 from AgNO_3 using Calotropis gigantea extract as reducing ***,SEM and FTIR were used for characterization of prepared ***-catalytic efficiencies of as-prepared Co_3O_4 and Ag-Co_3O_4 were evaluated for aqueous phase photo-degradation of rhodamine *** was found that deposition of Ag on Co_3O_4 highly enhanced the photo-catalytic activity of Co_3O_***-catalytic degradation followed the Eley–Rideal *** 100% and 91% photo-degradation of 40 ml dye solution achieved at 313 K in 90 and 120 min over 0.05 g of Ag-Co_3O_4 as photo-catalyst using 100 and 200 mg·L^(-1) as initial concentration of dye respectively.

关键词： Co3O4 Ag-Co3O4 Photo-catalysis Photo-degradation Calotropis gigantea Rhodamine B Elay–Rideal mechanism

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Timing of metamorphism and deformation in the Swat valley, northern Pakistan:Insight into garnet-monazite HREE partitioning

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Geoscience Frontiers 2019年第3期10卷 849-861页

作者： Kyle P.Larson Asghar Ali Sudip Shrestha Mathieu Soret John M.Cottle Rafique Ahmad university of British Columbia Okanagan Earth Environmental and Geographic Sciences university of Peshawar Department of Geology university of Califomia Santa Barbara Department of Earth Sciences the bacha khan university Department of Geology

New metamorphic petrology and geochronology from the Loe Sar dome in the Swat region of northern Pakistan place refined constraints on the pressure, temperature and timing of metamorphism and deformation in that part of the Himalayan orogen. Thermodynamic modelling and monazite petrochronology indicate that metamorphism in the area followed a prograde evolution from ～525 ± 25 ℃and 6 士 0.5 kbar to ～610 ± 25 ℃ and 9 士 0.5 kbar, between ca. 39 Ma and 28 Ma. Partitioning of heavy rare earth elements between garnet rims and 30-28 Ma monazite are interpreted to indicate coeval crystallization at peak conditions. Microtextural relationships indicate that garnet rim growth post-dated the development of the main foliation in the area. The regional foliation is folded about large-scale N-S trending fold axes and overprinting E-W trending folds to form km-scale domal culminations. The textural relationships observed indicate that final dome development must be younger than the 30-28 Ma monazite that grew with garnet rims post-regional foliation development, but pre-doming-related deformation. This new timing constraint helps resolve discrepancy between previous interpretations,which have alternately suggested that N-S trending regional folds must be either pre-or post-early Oligocene. Finally, when combined with existing hornblende and white mica cooling ages, these new data indicate that the study area was exhumed rapidly following peak metamorphism.

关键词： Pakistan Himalaya Monazite petrochronology Metamorphism Phase equilibria modelling Deformation

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PAIgG and PAIgM levels in secondary dengue virus infections lead to thrombocytopenia in patients from KP, Pakistan

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Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 801-805页

作者： Ibrar Alam Said Hassan Iftikhar Alam Rahmat Gul Farhad AliIjaz Ali Sana Ullah Imtiaz Ali khan Aasif Awan Department of Biotechnology Bacha Khan University Charsadda Institute of Biotechnology and Genetic Engineering(IBGE) The University of Agriculture Center of Biotechnology and Microbiology University of Peshawar Department of Human Nutrition and Dietetics Bacha Khan University Charsadda Department of Zoology University of Peshawar Department of Entomology The University of Agriculture

Objective: To understand the impact of platelet associated immunoglobulin G(PAIg G)/platelet associated immunoglobulin M(PAIg M) on severity of dengue virus infection leading to ***: In this study we examined a total of 52 patients who were having secondary infection of dengue in acute phase by using competitive ***: A decrease in the platelet count was observed at the acute phase of infection while all along the recovery stage the count of platelet was significantly increased. A significant decrease was observed in PAIg G and PAIg M in these subjects. Inverse correlation was found between platelets count and PAIg G/PAIg M among the subjects studied. In the platelets elution from ten subjects, anti-dengue virus immunoglobulin G and immunoglobulin M were observed. PAIg G and PAIg M with inclined levels were higher in dengue hemorrhagic fever than the classical dengue fever. In the development of dengue hemorrhagic fever PAIg M inclined level was independently associated with high specificity, showing a possible indication of dengue hemorrhagic ***: This study suggests that in secondary dengue virus infection, the PAIg G and PAIg M levels, and the activity of anti-dengue virus play key roles, both in the development and severity of the disease.

关键词： dengue Pakistan immunoglobulin hemorrhagic severit

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Exploring Placer Gold Deposits through Integrated Geophysical and Geochemical Techniques at the Confluence of the Indus and Kabul Rivers,NW Pakistan

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Acta Geologica Sinica(English Edition) 2020年第5期94卷 1440-1450页

作者： Asghar ALI Khaista REHMAN Owais TAYYAB Tahir ZAMAN Mahad JAMEEL Azeem khan Rafique AHMAD Muhammad IRFAN Department of Geology University of PeshawarKhyber Pakhtunkhwa 25120Pakistan National Centre of Excellence in Geology University of PeshawarKhyber Pakhtunkhwa 25120Pakistan Department of Geology The Bacha Khan UniversityCharsadda24420Pakistan

Analysis of the anomalous magnetic mineral intensities and geochemistry for placer gold deposits are presented for those of the Attock area at the confluence of the Indus and Kabul rivers in northwestern *** grids covering an area of 10 x18 m2 and 8 x10 m2 were analyzed using a G-858 Cesium Vapor *** anomalous zones obtained were plotted on contour maps,2 D and 3 D magnetic intensity *** on the magnetic anomalies,grid-1 of the study area was sampled at three different anomalous zones for geochemical *** zones contain gold concentrations,ranging from 2.11 ppm to 6.109 ppm with an average of 4.01 *** in gold concentration in the subsurface within the anomalous zones indicates that magnetometer survey followed by a geochemical analysis can potentially narrow down the gold-bearing anomalous zones.

关键词： geochemistry geophysics placer gold deposits magnetometer survey anomalous zones Pakistan

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Emergency Decision-Making Based on q-Rung Orthopair Fuzzy Rough Aggregation Information

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Computers, Materials & Continua 2021年第12期69卷 4077-4094页

作者： Ahmed B.Khoshaim Saleem Abdullah Shahzaib Ashraf Muhammad Naeem Department of Mechanical Engineering King Abdulaziz UniversityJeddahSaudi Arabia Department of Mathematics Abdul Wali Khan University MardanMardan23200Pakistan Department of Mathematics and Statistics Bacha Khan UniversityCharsadda24420Pakistan Deanship of Combined First Year Umm Al-Qura UniversityMakkahSaudi Arabia

With the frequent occurrences of emergency events,emergency decision making(EDM)plays an increasingly significant role in coping with such situations and has become an important and challenging research area in recent *** is essential for decision makers to make reliable and reasonable emergency decisions within a short span of time,since inappropriate decisions may result in enormous economic losses and social *** handle emergency effectively and quickly,this paper proposes a new EDM method based on the novel concept of q-rung orthopair fuzzy rough(q-ROPR)set.A novel list of q-ROFR aggregation information,detailed description of the fundamental characteristics of the developed aggregation operators and the q-ROFR entropy measure that determine the unknown weight information of decision makers as well as the criteria weights are *** an algorithm is given to tackle the uncertain scenario in emergency to give reliable and reasonable emergency *** using proposed list of q-ROFR aggregation information all emergency alternatives are ranked to get the optimal *** this,the q-ROFR entropy measure method is used to determine criteria and experts’weights objectively in the EDM ***,through an illustrative example of COVID-19 analysis is compared with existing EDM *** results verify the effectiveness and practicability of the proposed methodology.

关键词： q-rung orthopair fuzzy rough set q-ROFR entropy measure aggregation information emergency decision making

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Effect of regional factor productivity on manufacturing sector: The case of Sino-Pak economic ties

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Financial Innovation 2020年第1期6卷 95-108页

作者： Muhammad Imran An HuSen Muhammad Kaleem Arshad khan Bangash Nizam Ud Din Sobia Department of Economics Bacha Khan UniversityCharsaddaPakistan School of Economics Nankai UniversitTianjinChina Department of Sociology and Gender Studies Bacha Khan UniversityCharsaddaPakistan Department of Business Administration Karakoram International UniversityGilgitPakistan Government Postgraduate Jahanzeb College SwatPakistan

Introduction:Economic ties and trade blocs increase the flow of trade between participating countries and lead to different levels of economic and structural *** description:This paper focuses on the structure of industrial value-added between China and Pakistan,as the two countries recently launched the CPEC(China-Pakistan Economic Corridor)*** and evaluation:This study utilizes panel data from 1995 to 2015 to test certain factor effects on regional value-added through econometric *** results show that each country has its own economic growth rate and market size that respond differently to industrial value-added ***:Aggregate factor productivity at China is higher than in Pakistan but growth in factor productivity in the latter is higher than the former;similarly,the share of bilateral trade is higher in the case of *** each country responds differently to the new economic ties,the macroeconomic results support bilateral economic ties between them.

关键词： New economic geography China-Pakistan economic-ties Factor productivities

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