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Cellular model of neuronal atrophy induced by DYNC111 deficiency reveals protective roles of ras-RAF-MEK signaling

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Protein & Cell 2016年第9期7卷 638-650页

作者： Zhi-Dong Liu Su Zhang Jian-Jin Hao Tao-Rong Xie Jian-Sheng Kang Key La.o.a.o.y of Nutrition and Meta.o.ism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200231 China University of Chinese Academy of Sciences Beijing 100049 China

Neuronal atrophy is a common pathological feature occurred in aging and neurodegenerative diseases. A variety of abnormalities including motor protein mal- function and mitochondrial dysfunction contribute to the loss of neuronal architecture; however, less is known a.o.t the intracallular signaling pathways that can pro- tect against or delay this pathogenic process. Here, we show that the DYNClll deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. With this cellular model, we are able to find that activation of *** signaling protects against neuronal atrophy induced by DYNClll deficiency, which relies on MEK-dependent autophagy in neuron. Moreover, we further reveal that BRAF also protects against neuronal atrophy induced by mitochondrial impairment. These findings demon- strate protective roles of the ras-RAF-MEK axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention.

关键词： ras-RAF-MEK pathway atrophy dyneinintermediate chain mitochondria hippocampal neuron,autophagy

Characteristics of the active-layer under the China-Russia Crude oil pipeline

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Journal of Mountain Science 2021年第2期18卷 323-337页

作者： SERBAN Mihaela LI Guo-yu SERBAN Raul-David WANG Fei FEDoRoV Alexander VERA Samsonova CAo Ya-peng CHEN Peng-chao WANG Wei State Key La.o.a.o.y of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Da Xing’anling observation and research Station of Frozen-Ground Engineering and Environment Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesJiagedaqi 165000China University of Chinese Academy of Sciences Beijing 100049China Melnikov Permafrost institute SB RASYakutsk 677010Russia PetroChina Pipeline Company Langfang 065000China Jiagedaqi oil and Gas Transmission Sub-company PetroChina Pipeline CompanyJiagedaqi 165000China

Active layer is a key component for permafrost environment studies as many subsurface biological,biogeochemical,ecological,and pedogenic activities prevail in this *** study focuses on active layer temperature monitoring in an area with sporadic permafrost at two adjacent sites a.o.g China-Russia Crude oil Pipeline(CRCoP),NorthEast *** T1 is located in disturbed ground on the right-of-way(on-RoW)2 m away from the center of the oil pipeline.T2 is located in a natural and undisturbed site,a.o.nd 16.6 m *** objective was to study sea.o.al variability of the active layer depth and thermal regime from october 2017 to September *** monitoring sites consist of soil temperature probes arranged in a vertical array at different depths at both *** following parameters were computed:number of isothermal days(ID),freezing days(FD),thawing days(TD),freezing degree days(FDD),thawing degree days(TDD),number of freeze-thaw days(FTD).The mean air temperature in the monitoring period reached-3.2℃.The temperature profile indicates that the maximum active layer thickness observed during the study period was 10 m at T1 and 2 m at *** ma.o.ity of the soil temperatures were a.o.e or close to 0℃,resulting in great values of TDD,especially in the first 4 m *** for T1 were predominant and ranged between 600-1160℃·days(0-4 m depth)reflecting the influence of oil temperature from the *** T2 borehole FDD were predominant for all the soil layer depths resulting in less permafrost *** comparison emphasizes the significant influence of vegetation removal and the dispersed heat from the pipeline on the active layer thickness.

关键词： Soil thermal regime Permafrost China Russia Crude oil Pipeline Active layer

The history and future of the biological resources of the Caspian and the Aral Seas

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Journal of ocea.o.ogy and Limnology 2018年第6期36卷 2061-2084页

作者： N.V.ALADIN T.CHIDA Yu.S.CHUIKoV Z.K.ERMAKHa.o. Y.KAWABATA J.KUBoTA P.MICKLIN I.S.PLoTNIKoV a.o.SMURoV V.F.ZAITZEV Zoological institute ras St.-Petersburg 199034Russia Na.o.a University of Foreign Studies Nisshin 470-0197Japan Astrakhan State University Astrakhan 414056Russia Aral Branch of Kazakh research institute of Fishery Aralsk 120100Kazakhstan Tokyo University of Agriculture and Technology Fuchu Tokyo 183-8509Japan National institutes for the Humanities Tokyo 105-0001Japan Western Michigan University Kalamazoo 49008USA Astrakhan State Technical University Astrakhan 414056Russia

The term ‘biological resources' here means a set of organisms that can be used by man directly or indirectly for consumption. They are involved in economic activities and represent an important part of a country's raw material potential. Many other organisms are also subject to rational use and protection. They can be associated with true resource species through interspecific relationships. The Caspian and Aral Seas are continental water bodies, giant saline lakes. Both categories of species are represented in the benthic and pelagic communities of the Caspian and Aral Seas and are involved in human economic activities. The most important biological resource of the Caspian Sea and the Aral Sea is their ichthyofauna, represented by both a.o.iginal species and species introduced by man in the 20 th century. a.o.g invertebrates, the main biological resource of these saline lakes is the brine shrimp A rtemia. The physical state of the Caspian as a water body is relatively stable but its biological resources are very seriously af fected by irrational use. The Aral Sea since the second half of the 20 t h century has experienced catastrophic anthropogenic regression, which has led to the almost complete loss of its biological resources due to salinization. However, thanks to efficacious engineering measures, it has now become possible to preserve its northern part(Small Aral) and rehabilitate it, lowering the salinity to its former state. The result has been the restoration of its fish biological resources. In the southern part of Aral(Large Aral), which turned into a group of separated hypersaline reservoirs, the only resource species currently available is the brine shrimp A rtemia. The main environmental threats for biological resources of the future Caspian and Aral as well as potential solutions are considered.

关键词： Caspian Sea Aral Sea biological resources fauna fish invertebrates

Fungal diversity notes 1611-1716: ta.o.omic and phylogenetic contributions on fungal genera and species emphasis in south China

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Fungal Diversity 2023年第5期122卷 161-403页

作者： Indunil C.Senanayake Walter Rossi Marco Leonardi Alex Weir Mark McHugh Kunhiraman C.Rajeshkumar Rajnish K.Verma Samantha C.Karunarathna Saowaluck Tibpromma Nikhil Ashtekar Sreejith K.Ashta.o.rthy Sanjay Raveendran Gurmeet Kour Aishwarya Singh Saúl De la Peña-Lastra Antonio Mateos Miroslav Kolařík Vladimír Antonín HanaŠevčíková Fernando Esteve-Raventós Ellen Larsson Fermín Pancorbo Gabriel Moreno Alberto Altés Yolanda Turéga.o.Tian-Ye Du Li Lu Qi-Rui Li Ji-Chuan Kang Sugantha Gunaseelan Kezhocuyi Kezo Malarvizhi Kaliyaperumal Jizhen Fu Milan C.Samara.o.n Yusufjon Gafforov Shakhnoza Tesha.o.va Pradeep C.Kunjan Arya Chamaparambath Adam Flakus Javier Eta.o.Pamela Rodriguez-Flakus Mikhail P.Zhurbenko Nimali Ide Silva Danushka S.Tenna.o.n KPDeepna Latha Patinjareveettil Manimohan KNAnil Raj Mark S.Cala.o. Abdollah Ahmadpour Zeinab Heidarian Zahra Alavi Fatemeh Alavi Youbert Ghosta Razmig Azizi Mei Luo Min-Ping Zhao Nuwan D.Kularathnage Li Hua Yun-Hui Yang Chun-Fang Liao Hai-Jun Zhao Anis S.Lestari Subashini C.Jayasiri Feng-Ming Yu Lei Lei Jian-Wei Liu omid Karimi Song-Ming Tang Ya-Ru Sun Yong Wang Ming Zeng Zin H.Htet Benedetto T.Linaldeddu Artur Alves Alan J.L.Phillips Carlo Bregant Lucio Montecchio AndréDe Kesel Vincent P.Hustad Andrew N.Miller Anna G.Fedosova Viktor Kučera Mubashar Raza Muzammil Hussain Yan-Peng Chen Vinodhini Thiyagaraja Deecksha Gomdola Achala R.Rathnayaka Asha J.Dissanayake Nakarin Suwannarach Sinang Hongsanan Sajeewa S.N.Maharachchikumbura Lakmali S.Dissanayake Nalin N.Wijayawardene Rungtiwa Phookamsak Saisa.o.n Lumyong E.B.Gareth Jones Neelamanie Yapa Dhanushka N.Wanasinghe Ning Xie Mingkwan Doilom Ishara S.Manawasinghe Jian-Kui(Jack)Liu Qi Zhao Biao Xu Kevin D.Hyde Jiage Song Innovative institute for Plant Health/Key La.o.a.o.y of Green Prevention and Control on Fruits and Vegetables in South China Ministry of Agriculture and Rural AffairsZhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225GuangdongChina Center of Excellence in Fungal research Mae Fah Luang UniversityChiang Rai 57100Thailand Guangdong Provincial Key La.o.a.o.y for Plant Epigenetics College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518055GuangdongChina Sect.Environmental Sciences Department MeSVAUniversity of L’AquilaVia Vetoio67100 CoppitoAQItaly Department of Environmental Biology SUNY-ESF241 Illick Hall1 Forestry DriveSyracuseNY 13210USA National Fungal Culture Collection of India MACS Agharkar Research InstitutePuneMaharashtra 411004India Department of Plant Pathology Punjab Agricultural UniversityLudhianaPunjab 141004India Center for Yunnan Plateau biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanChina Department of Forest Ecology Kerala Forest Research InstitutePeechiThrissurKerala 680653India Department of Botany The American CollegeTallakkulamMaduraiTamil Nadu 625002India Department of Zoology Savitribai Phule Pune UniversityGaneshkhind RdGaneshkhindPuneMaharashtra 411007India University of Santia.o.de Compostela 15782 Santiago de CompostelaSpain Sociedad Micológica Extremeña C/Sagitario 1410001 CáceresSpain institute of Microbiology of the Czech Academy of Sciences Vídeňská108314220 Prague 4Czech Republic Department of Botany Moravian MuseumZelnýtrh 665937 BrnoCzech Republic Department of Life Sciences(Botany Unit) University of Alcalá28805 Alcaláde HenaresMadridSpain biological and Enviromental Sciences University of Gothemburgand Gothemburg Global Biodiversity CentreBox 46140530 GöteborgSweden Madrid Mycological Society Real Jardín BotánicoC/Claudio Moyano 128014 MadridSpain State Ke

This article is the 15th contribution in the Fungal Diversity Notes series,wherein 115 taxa from three phyla,nine classes,28 orders,48 families,and 64 genera are *** taxa described and illustrated in the present study include a new family,five new genera,61 new species,five new combinations,one synonym,one new variety and 31 records on new hosts or new geographical *** *** introduced and accommodated in *** new genera introduced in this study are Ageratinicola,Kevinia,Pseudomultiseptospora(Parabambusicolaceae),Marasmiellomycena,and Vizzinia(Porotheleaceae).Newly described species are Abrothallus altoandinus,Ageratinicola kunmingensis,Allocryptovalsa aceris,Allophoma yuccae,Apiospora cannae,***,***,Boeremia wisteriae,Calycina papaeana,Clypeo-coccum lichenostigmoides,Coniochaeta riskali-shoyakubovii,Cryphonectria kunmingensis,Dia.o.the angustiapiculata,***,***,Diatrypella guangdongense,Dothiorella franceschinii,Endocalyx phoenicis,Epicoc-cum terminosporum,Fulvifomes karaiensis,***,Ga.o.erma ghatensis,Hysterobrevium baoshanense,Inocybe avellaneorosea,***,Jahnula.o.longa,Kevinia lignicola,Kirschsteiniothelia guangdongensis,La.o.lbenia caprina,***,***,***,***,***,***,***,***,Laccaria rubriporus,Lasiodiplodia morindae,Lyophyllum agnijum,Marasmiellomycena pseudoomphaliiformis,Melomastia beihaiensis,Nemania guangdongensis,Nigrograna thailandica,Nigrospora ficuum,oxydothis chinensis,***,Petriella thailandica,Pha.o.cremonium chinensis,Phia.o.ephala chinensis,Phytophthora debattistii,Polyplosphaeria nigrospora,Pronectria loweniae,Seriascoma acutispora,Setoseptoria bambusae,Stictis a.o.ianthi,Tarzetta tibetensis,Tarzetta urceolata,Tetraploa.o.pyriformis,Trichoglossum beninense,and Tricoderma *** provide an emendation for Urnula ailaoshanensis Agaricus duplocingula.o.des *** i

关键词： Agaricomycetes Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Fungal diversity Geoglossomycetes Geographical distribution Host records Incertae sedis La.o.lbeniomycetes Leca.o.omycetes Leotiomycetes Novel taxa New combination oomycota Peronosporea Pezizomycetes Phylogeny Sordariomycetes South Chinese fungi Ta.o.omy

Express Screening of biological objects Using Multisensor Stripping Voltamperometry with Pattern Recognition

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American Journal of Analytical Chemistry 2016年第7期7卷 588-596页

作者： I. I. Kolesnichenko L. M. Balachova E. P. Kantarzhi A. N. Frumkin institute of Physical Chemistry and Electrochemistry ras (IPCE) Moscow Russia Pirogov Russian National research Medical University Moscow Russia

Express diagnostics of biological objects is necessary for operational preliminary assessment of the condition of the patient. A method of recognition of differences between the norm and pathology is based on analysis of multidimensional patterns of the voltamperogram electrochemical test systems in Electronic formats “language”, “electronic nose”. The basis of such systems is the use of a set (matrix) sensor with completely different characteristics. A. N. Frumkin institute of Physical Chemistry and Electrochemistry ras (IPCE) developed a method for multidimensional stripping voltammetry, which allowed you to provide information on biological matter being investigated not as a number, as a response to a single dimension, and in the form of N-dimensional image. Formats are implemented in the process of electrochemical studies of liquid or gaseous phase. Evaluating the closeness of the resulting image object under test with known samples is collected in a database. Examples of express diagnostics of glaucoma are with accordance of the results of the electrochemical research of blood serum.

关键词： Express Screening biological objects Multisensor Stripping Voltamperometry Glaucoma

Evaluation of activated sludge properties’changes in industrial-wastewater pre-treatment:role of residual aluminum hydrolyzed species with different polymerization degree

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Frontiers of Environmental Science & Engineering 2023年第6期17卷 141-151页

作者： Ziqi Zhao Meng Li Wansong Huang Nuowei Guo Qian Zhang School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan 430070China Hubei Jianke International Construction Ltd.Co Wuhan 430070China Wuhan Hanyang Municipal Construction Group Co.Ltd. Wuhan 430000China Shenzhen research institute of Wuhan University of Technology Shenzhen 518000China

With the widespread introduction of pre-coagulation prior to the biological unit in various industrial wastewater treatments,it is noteworthy that long-term accumulation of residual coagulants has certains effect on both micro and macro characteristics of activated sludge(AS).In this study,the morphology distributions of residual aluminum salts(ras)and their effects on the removal efficiency of AS were investigated under different PAC *** results showed that the dominance of medium polymeric ras,formed under an appropriate PAC dose of 20 mg/L enhanced the hydrophobicity,flocculation,and sedimentation performances of AS,as well as the enzymatic activity in cells in the sludge system,improving the main pollutants removal efficiency of the treatment *** the species composition with monomer and dimer/high polymer ras as the overwhelming parts under an over-dosed PAC concentration of 55 mg/L resulted in excessive secretion of EPS with loose flocs structure and conspicuous inhibition of cellular activity,leading to the deterioration of physico-chemical and biological properties of *** on these findings,this study can shed light on the role of the ras hydrolyzed species distributions,closely relevant to Al dosage,in affecting the comprehensive properties of AS and provide a theoretical reference for coagulants dosage precise control in the pretreatment of industrial wastewater.

关键词： Coagulation/flocculation Hydroxyl-aluminum Hydrolysis reaction Reactor performance Activated sludge property Surface properties

Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

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Neural Regeneration research 2022年第12期17卷 2623-2631页

作者： Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma research Center of Neurobiology The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi ProvinceChina Department of Neurology Datong Fifth People’s HospitalDatongShanxi ProvinceChina institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

ras homolog(Rho)-associated kinases(RoCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,a.o. guidance,and regeneration of *** are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple *** studies by us and others confirmed that RoCKs inhibitors attenuated the symptoms and progression of experimental models of the a.o.ementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin ***,the first RoCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative *** increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell *** review will systematically describe,for the first time,the effects of abnormal activation of RoCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of RoCKs *** review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based *** from this review add support for further investigation of RoCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases.

关键词： Alzheimer’s disease cell-based therapy central nervous system cells fasudil immunocytes multiple sclerosis Parkinson’s disease pericytes Rho kinase inhibitor Rho-associated kinases

Image Analysis in Microbiology: A Review

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Journal of Computer and Communications 2016年第15期4卷 8-32页

作者： Evgeny Puchkov All-Russian Collection of Microorganisms Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS Pushchino Russia

This review is focused on using computer image analysis as a means of objective and quantitative characterizing optical images of the macroscopic (e.g. microbial colonies) and the microscopic (e.g. single cell) objects in the microbiological research. This is the way of making many visual inspection assays more objective and less time and la.o. consuming. Also, it can provide new visually inaccessible information on relation between some optical parameters and various biological features of the microbial cul-tures. of special interest is application of image analysis in fluorescence microscopy as it opens new ways of using fluorescence based methodology for single microbial cell studies. Examples of using image analysis in the studies of both the macroscopic and the microscopic microbiological objects obtained by various imaging techniques are presented and discussed.

关键词： Computer Image Analysis Microorganisms Viability Yeast Bacteria Fungi Colony Counter Microbial Identification Multispectral Imaging Hyperspectral Imaging Diffraction Pattern Imaging Scatter Pattern Imaging Multifractal Analysis Support Vector Machines Principal Component Analysis Linear Discriminant Analysi ImageJ Matlab Fluorescence Microscopy Microfluorimetry Green Fluorescent Protein (GFP)

Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration

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National Science Review 2021年第2期8卷 60-73页

作者： Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Ana.o.y Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Ja.o. Zscheischler Bertrand Guenet Daniel S.Goll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu State Key La.o.a.o.y of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F University CSIRo oceans and Atmosphere 15. institute for Geology CEN—Center for Earth System Research and SustainabilityUniversity of Hamburg 16. Department of Earth System ScienceStanford University 17. Department of Earth System ScienceStanford UniversityStanford 18. School of Geographical SciencesNanjing University of Information Science and Technology 19. Department of Ecological SciencesVrije Universiteit Amsterdam 20. Research Institute for Global ChangeJAMSTEC La.o.a.o.re des Sciences du Climat et de l'Environnement CEA-CNRS-UVSQ-UPSACLAY Center for Environmental Remote Sensing Chiba University institute of Soil Science and Agrochemistry Siberian Branch of the Russian Academy of Sciences (SB RAS) Tuva State University Republic of Tuva Max Planck institute for Meteorology NASA Goddard Space Flight Center Biospheric Sciences Lab. 26. Department for Innovation in BiologicalAgro-food and Forest systems (DIBAF)University of Tuscia RUDN University Department of Environmental Science and Engineering Shanghai Key Laboratory of Atmospheric Particle Pollution and PreventionInstitute of Atmospheric SciencesFudan University 29. Division of Geological and Planetary SciencesCalifornia Institute of Technology 30. Climate and Environmental Physics and Oeschger Centre for Climate Change ResearchUniversity of Bern 31. Department of Ecosystem and Conservation Sci

Resolving regional carbon budgets is critical for informing land-based mitigation policy. For nine regions covering nearly the whole globe, we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing. The net land–atmospheric carbon exchange(NEE) was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade, and riverine-carbon export to the ocean. Summing up NEE from all regions, we obtained a global ‘bottom-up’ NEE for net land anthropogenic Co2uptake of –2.2 ± 0.6 Pg C yr-1consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009. This estimate is so far the most comprehensive global bottom-up carbon budget accounting, which set up an important milestone for global carbon-cycle studies. By decomposing NEE into component fluxes, we found that global soil heterotrophic respiration a.o.nts to a source of Co2of 39 Pg C yr-1with an interquartile of 33–46 Pg C yr-1—a much smaller portion of net primary productivity than previously reported.

关键词： carbon budget human appropriation of ecosystems soil carbon