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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 94-95页

作者：徐佰达 Dept Cardiol 904th HospJoint Logistic Support ForcePLAWuxi 214000

Objective To investigate the correlation between serum growth differentiation factor 11(GDF11)level and coronary artery lesions in patients with ST-segment elevation myocardial infarction(STEMI),and the predictive efficacy of nomogram risk prediction model based on GDF11 combined with traditional risk factors on the occurrence of *** this study was a retrospective cross-sectional *** hospitalized in the department of Cardiology of the 904th Hospital of Joint Logistic Support Force of People's Liberation Army of China from 2016 to 2018 were selected and divided into control group and STEMI *** demographic data,blood lipid level,laboratory indicators of blood and GDF11 level were *** regression analysis screened out independent correlated factors for the occurrence of *** correlation analysis clarified the correlation of each indicator with the SYNTAX or Gensini scores.A nomogram risk prediction model for the risk of STEMI occurrence and the receiver operating characteristic curve was used to compare the prediction efficiency of each *** A total of 367 patients were enrolled.

关键词： patients coronary infarction

Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1626-1646页

作者： Kai-Lin Jiang Xiang-Xiang Wang Xue-Jiao Liu Li-Kun Guo Yong-Qi Chen Qing-Ling Jia Ke-Ming Yang Jiang-Hong Ling department of Gastroenterology Shuguang HospitalShanghai 200021China department of Pathology Shuguang HospitalShanghai 200021China

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally *** To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using *** PubMed,Web of Science,and EMBASE were searched for *** trained researchers selected the studies and extracted *** 17.0 software was used for meta-analysis of the incidence of each outcome *** adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included *** plots and Egger’s test were used to detect publication *** analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging *** Eight studies with a pooled success rate of 66.6%were *** derived from women and men had success rates of 67%and 46.7%,*** from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,*** of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,*** with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,*** generated with collagenase were more successful than those constructed with Liberase th and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM *** Y-27632,and using Liberase th,TrypLE,or collagenase yields greater success than EDTA.

关键词： Gastric cancer organoids Human-derived organoids Gastric cancer Cell lines In vitro research models

Doping engineering of iron oxide nanoparticles towards high performance and biocompatible T_(1)-weighted MRI contrast agents

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Rare Metals 2024年第1期43卷 298-308页

作者： Xue Xu Ping-Li Dong Yu-Yun Chai Run Yang Zhen-Hui Ma Chi-Chong Lu department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China department of Physics Beijing Technology and Business UniversityBeijing 100048China

Extremely small-sized iron oxide nanoparticles(IONPs) are of great interest in magnetic resonance imaging(MRI) due to their biosafety as an alternative to clinical gadolinium(Ⅲ) complexes-based contrast *** when the particle size is less than 10 nm,it has strong diffusion ability and deep penetration distance in tumor *** doping can significantly enhance the T_(1)contrast effect of nanoparticles by regulating the surface exposed ***,the nucleation and growth processes of multi-component synthesis systems are complex and difficult to be accurately controlled,leading to great challenges in the synthesis of ultra-small-sized nanoparticles with different components and ***,extremely smallsized superparamagnetic gadolinium-doped iron oxide nanoparticles(GdIONPs,Gd_(x)Fe_(3-x)O_(4) NPs) with adjustable doping amount and controllable size in the range of 3.5-7.5 nm were synthesized by thermal ***,as-synthesized GdIONPs were surface modified with a highly water-soluble and biocompatible carboxyl-polyethylene glycol-phosphoric acid ligand with high binding ***_(0.65)Fe_(2.35)O_(4) NPs exhibited very high r_(1) relaxivity of 10.6 mmol^(-1)·L·s^(-1) in terms of all metal concentrations and 49.0 mmol^(-1)·L·s^(-1) in terms of gadolinium alone,respectively,3 and 14 times higher than clinical T_(1) contrast agents(Gd-DTPA).GdIONPs can continuously obtain high resolution images of blood vessels,and can be used as an efficient and multifunctional contrast agent for MR T_(1)*** stable and efficient doping strategy provides an easy and effective method to individually optimize the magnetic properties of complex oxides and their relaxation effects for a variety of biomedical applications.

关键词： Iron oxide nanoparticles Small size Magnetic resonance imaging Substitutional doping Gd dopant

Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients

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Stroke & Vascular Neurology 2024年第1期9卷 18-29页

作者： Yongjie Ma Zihao Song Yinqing Wang Jiachen Wang Chuan He Guilin Li Peng Zhang Tao Hong Liyong Sun Peng Hu Ming Ye Hongqi Zhang department of Neurosurgery Xuanwu Hospital Capital Medical University

Background Craniocervical junction(CCJ)arteriovenous fistulas(AVFs)are *** current treatment strategies for AVFs with different angioarchitecture need to be *** present study aimed to analyse the correlation between angioarchitecture and clinical characteristics,share our experience in treating this disease and identify risk factors associated with subarachnoid haemorrhage(SAH)and poor *** A total of 198 consecutive patients with CCJ AVFs from our neurosurgical centre were retrospectively *** patients were grouped according to their clinical manifestations,and their baseline clinical characteristics,angioarchitecture,treatment strategies and outcomes were *** the patients’median age was 56 years(IQR 47–62 years).the majority of patients were men with 166(83.8%)*** most common clinical manifestation was SAH(52.0%),followed by venous hypertensive myelopathy(VHM)(45.5%).the most common CCJ AVFs type was dural AVF,with 132(63.5%)*** most frequent fistula location was C-1(68.7%)and dural branch of vertebral artery(70.2%)was the most involved arterial feeders for *** most common direction of venous drainage was descending intradural drainage(40.9%),followed by ascending intradural drainage(36.5%).Microsurgery was the most common treatment strategy applied for 151(76.3%)patients,15(7.6%)patients were treated with interventional embolisation only,and 27(13.6%)received both interventional embolisation and microsurgical *** learning curve for microsurgery only was analysed by cumulative summation method,and the turning point was the 70th case,and blood loss in post-group was lower than that in pre-group(p=0.034).At the last follow-up,there were 155(78.3%)patients with favourable outcomes(modified Rankin Scale(mRS)the clinical manifestation(OR 4.102,95%CI 2.108 to 7.982,p<0.001)and pretreatment mRS≥3(OR 3.127,95%CI 1.617 to 6.047,p<0

关键词： patients treatment hypertensive

Determining the surface fault-rupture hazard zone for the Pazarcık segment of the East Anatolian fault zone through comprehensive analysis of surface rupture from the February 6,2023,Earthquake(Mw 7.7)

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Journal of Mountain Science 2024年第8期21卷 2646-2663页

作者： Mustafa SOFTA Dokuz Eylul University department of Geological Engineering Izmir 35390Türkiye Kansas State University department of Geology Manhattan 66506KansasUSA

Following surface rupture observations in populated areas affected by the KahramanmaraşEarthquake(Mw 7.7)on February 6th,2023,along the Pazarcık segment of the East Anatolian Fault Zone(EAFZ),this study presents novel insights into physical criteria for delineating surface fault-rupture hazard zones(SRHZs)along ruptured strike-slip *** achieve this objective,three trench studies across the surface rupture were conducted on the Pazarcık segment of the EAFZ to collect field data,and earthquake recurrence intervals were interpreted using Bayesian statistics from previously conducted paleoseismological *** results of the proposed model indicate that the Pazarcık segment produced five significant surface-rupturing earthquakes in the last∼11 kyr:E1:11.13±1.74 kyr,E2:7.62±1.20 kyr,E3:5.34±1.05 kyr,E4:1.82±0.93 kyr,and E5:0.35±0.11 *** addition,the recurrence intervals of destructive earthquakes on the subject in question range from 0.6 kyr to 4.8 *** that the last significant earthquake occurred in 1513,the longest time since the most recent surface fault rupturing earthquake on this particular segment was 511 *** results indicate that,in terms of the theoretical recurrence interval of earthquakes that can create surface ruptures on the Pazarcık segment,the period in which the February 6,2023,earthquake occurred was within the end of the expected return *** a result,the potential for a devastating earthquake in the near future is not foreseen on the same ***,the SRHZ proposed for the Pazarcık section of Gölbaşıvillage was calculated as a 61-meter-wide offset on the fault lineament to reduce the negativities that may occur in the ruptured area in the *** is recommended to take into account this width in the settlement of this area and nearby areas.

关键词： Surface rupture Earthquake mitigation Recurrence interval Pazarcık segment East Anatolian Fault Zone(EAFZ)

Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2106-2118页

作者： Xiao Wang Zhao-Yi Lin You Zhou Qin Zhong Zong-Ren Li Xi-Xiang Lin Ming-Gen Hu Kun-Lun He Medical Big Data Research Center Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China department of Hepatobiliary Surgery Chinese PLA 970th HospitalYantai 264001Shandong ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Post-hepatectomy liver failure(PHLF)is a common consequence of radical partial hepatectomy in hepatocellular carcinoma(HCC).AIMS To investigate the relationship between preoperative antiviral therapy and PHLF,as well as assess the potential efficacy of hepatitis B virus(HBV)DNA level in predicting *** A retrospective study was performed involving 1301 HCC patients with HBV who underwent radical *** operating characteristic(ROC)analysis was used to assess the capacity of HBV DNA to predict PHLF and establish the optimal cutoff value for subsequent *** regression analyses were performed to assess the independent risk factors of *** increase in the area under the ROC curve,categorical net reclassification improvement(NRI),and integrated discrimination improvement(IDI)were used to quantify the efficacy of HBV DNA level for predicting *** Pthat preoperative antiviral therapy was independently associated with a reduced risk of PHLF(Pth an optimal cutoff value of 269 IU/mL(Pthe reference models by adding the variable of HBV DNA level had an improvement in area under the curve,categorical NRI,and IDI,particularly for the fibrosis-4 model,with values of 0.729(95%CI:0.705-0.754),1.382(95%CI:1.341-1.423),and 0.112(95%CI:0.110-0.114),*** the above findings were statistically *** In summary,preoperative antiviral treatment can reduce the incidence of PHLF,whereas an increased preoperative HBV DNA level has a correlative relationship with an increased susceptibility to PHLF.

关键词： Hepatocellular carcinoma Hepatitis B virus Preoperative antiviral treatment Liver resection Post-hepatectomy liver failure

the circadian clock in enamel development

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International Journal of Oral Science 2024年第3期16卷 371-380页

作者： Ke Wu Xiaochan Li Yunyang Bai Boon Chin Heng Xuehui Zhang Xuliang Deng department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingChina 4th Division Peking University School and Hospital of StomatologyBeijingChina department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina Oral Translational Medicine Research Center Joint Training base for Shanxi Provincial Key Laboratory in Oral and Maxillofacial Repair Reconstruction and Regeneration the First People’s Hospital of Jinzhong JinzhongChina

Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of physiological *** circadian clock mechanisms in brain and peripheral tissues can oscillate independently or be synchronized/disrupted by external *** enamel is a type of mineralized tissue that forms the exterior surface of the tooth *** Retzius lines are readily observable microstructures of mature tooth enamel that indicate the regulation of amelogenesis by circadian *** enamel is formed by enamel-forming cells known as ameloblasts,which are regulated and orchestrated by the circadian clock during *** review will first examine the key roles of the circadian clock in regulating ameloblasts and *** physiological processes are involved,including gene expression,cell morphology,metabolic changes,matrix deposition,ion transportation,and ***,the potential detrimental effects of circadian rhythm disruption on enamel formation are *** rhythm disruption can directly lead to Enamel Hypoplasia,which might also be a potential causative mechanism of amelogenesis ***,future research trajectory in this field is *** is hoped that this review will inspire more intensive research efforts and provide relevant cues in formulating novel therapeutic strategies for preventing tooth enamel developmental abnormalities.

关键词： enamel crown exterior

Sinonasal teratocarcinosarcoma involving the nasal cavity,unilateral paranasal sinuses,and intracranial invasion:A case report

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World Journal of Clinical Cases 2024年第25期12卷 5784-5790页

作者： Li-Yuan Fu Mi-Yang Yang Pei-Yun Ye Zhao-Chu Wang Chu-Jie Chen Hui Li Shang-Wen Xu department of Radiology 900th Hospital of Joint Logistics Support ForceFuzhou 350025Fujian ProvinceChina the First Clinical Medical College Fuzong Teaching HospitalFujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

BACKGROUND Sinonasal teratocarcinosarcoma(SNTCS)is a rare and highly invasive neoplasm originating from the nasal cavity and ***,it exhibits an invasive behavior towards adjacent structures;however,in exceptional instances,it may infiltrate the intracranial *** to the tumor's rarity and lack of distinctive features on computed tomography(CT)and magnetic resonance imaging(MRI)images,SNTCS is often *** SUMMARY In this study,we present a case of SNTCS in a 56-year-old patient who exhibited unexplained cognitive impairment before *** and MRI scans revealed the presence of a mass in the right nasal cavity,with lesions extending to the right ethmoid sinus and right frontal ***,the patient underwent pathological examination for confirmation and received surgical intervention to excise the *** future advancement in our understanding of this disease will significantly contribute to the precise diagnosis and treatment of *** SNTCS is an exceptionally rare malignant tumor that originates from the nasal cavity and paranasal sinuses,presenting a diagnostic challenge due to its nonspecific imaging *** accurately delineates the location,morphological characteristics,size,internal structure,extent of surrounding involvement,and metabolic information of the *** aspects play a pivotal role in the precise localization and qualitative assessment of ***,a definitive diagnosis still requires a pathological biopsy.

关键词： Paranasal sinus Malignant tumor Sinonasal teratocarcinosarcoma Brain invasion Case report

the Promoting Role of TCM Nursing in the Rehabilitation of Stroke Hemiplegia Patients

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Open Journal of Nursing 2024年第7期14卷 321-328页

作者： Nong Yan Lihua Qin Buqing Su Xiaoye Su Yanfang Wei department of Internal Medicine Pingguo Hospital of Traditional Chinese Medicine Baise China department of Neurology Peoples Hospital of Guangxi-ASEAN Economic and Technological Development Zone (10th Peoples Hospital of Nanning City) Nanning China the Clinical Nursing Program at Liaoning Medical Vocational College Shenyang China department of Internal Medicine Batou Township Central Health Center of Debao County Baise China department of Cardiothoracic Surgery Nanning Third Peoples Hospital Nanning China

Objective: To explore the promoting function of TCM nursing in the rehabilitation of hemiplegia patients with stroke. Methods: 78 stroke hemiplegic patients admitted from April 2022 to April 2024 were randomly divided into a control group of 38 cases who received routine care, and an experimental group of 40 cases who received routine nursing basis plus traditional Chinese medicine nursing;the nursing effects of the two groups of patients were compared. Results: After 12 days of nursing care, the experimental group showed better psychological status [SAS score (21.71 ± 3.21), SDS score (22.18 ± 2.31)], limb motor function, daily living ability, and neurological function [NIHSS score (12.23 ± 2.21)] than the control group, with significant differences in data (P Conclusion: Traditional Chinese medicine nursing for stroke hemiplegia patients is more conducive to promoting rehabilitation than routine nursing.

关键词： Traditional Chinese Medicine Nursing Routine Nursing Stroke Hemiplegia Rehabilitation Effect

Low-grade myofibrosarcoma of the maxillary sinus:Two case reports

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World Journal of Clinical Oncology 2024年第4期15卷 566-575页

作者： Anna Mydlak ŁukaszŚcibik Monika Durzynska Jakub Zwoliński Karolina Buchajska Olga Lenartowicz Jakub Kucharz department of Head and Neck Cancer Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland department of Otolaryngology and Head and Neck Oncological Surgery The 5th Military Clinical Hospital with PolyclinicKrakow 30-901Poland department of Pathology Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland department of Genitourinary Oncology Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland

BACKGROUND Low-grade myofibroblastic sarcoma(LGMS)is an extremely rare tumor characterized by the malignant proliferation of *** most commonly develops in adults,predominantly in males,in the head and neck region,oral cavity,especially on the tongue,mandible,and *** article presents 2 cases of LGMS localized to the maxillary sinus and provides an overview of the available *** SUMMARY Two patients with LGMS located in the maxillary sinus underwent surgery at the department of Head and Neck *** 1:A 46-year-old patient was admitted to the clinic with suspected LGMS recurrence in the right maxillary sinus(rT4aN0M0),with symptoms of pain in the suborbital area,watering of the right eye,thick discharge from the right nostril,and augmented facial *** open biopsy-confirmed LGMS,the patient underwent expanded maxillectomy of the right side with immediate palate reconstruction using a microvascular skin flap harvested surgically from the middle *** patient qualified for adjuvant radiotherapy for the postoperative bed,with an additional ***,the patient is under 1.5 years of observation with no evidence of *** 2:A 45-year-old man was admitted to our clinic with facial asymmetry,strabismus,exophthalmos,and visual impairment in the right *** months earlier,the patient had undergone partial jaw resection at another hospital for fibromatosis.A contrast-enhanced computed tomography scan revealed a tumor mass in the postoperative log after an earlier *** open biopsy confirmed lowgrade fibrosarcoma(rT4aN0M0).the patient qualified for an extended total right maxillectomy with orbital excision and right hemimandibulectomy with immediate microvascular reconstruction using an anterolateral thigh *** patient subsequently underwent adjuvant radiotherapy to the postoperative *** 9 months,recurrence occurred in the right mandibular arch below the irradiated *** lesion infiltrated t

关键词： Head and neck cancer Paranasal sinuses Maxillary sinus Sarcoma Low-grade myofibroblastic sarcoma Case report