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Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell lines in vitro

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Chinese Medical Journal 2012年第24期125卷 4338-4343页

作者： SHAO Cui-jie WU Ming-wei CHEN Fu-rong LI Cong XIAYun-fei CHEN Zhong-ping state Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen University Guangzhou Guangdong 510060 China Department of Neurosurgery/Neuro-oncology Cancer Center of Sun Yat-sen University Guangzhou Guangdong 510060 China Department of Radiation Oncology Cancer Center of Sun Yat-sen University Guangzhou Guangdong 510060 China

Background Treatment for malignant glioma generally consists of cytoreductive surgery followed by radiotherapy and chemotherapy. In this study, we intended to investigate the effects of 2-propylpentanoic acid （VPA）, a histone deacetylase inhibitor, on chemosensitivity and radiosensitivity in human glioma cell lines. Methods Human glioma cell lines, T98-G, and SF295, were treated with temozolomide （TMZ） or irradiation （IR）, with or without VPA （1.0 mmol/L）. Then, cytotoxicity and clonogenic survival assay was performed. Cell cycle stage, apoptosis, and autophagy were also detected using flow cytometry and dansyl monocadaverin （MDC） incorporation assay. One-way analysis of variance （ANOVA） and t-test were used to analyze the differences among variant groups. Results Mild cytotoxicity of VPA was revealed in both cell lines, T98-G and SF295, with the 50% inhibiting concentration （IC50） value of （3.85±0.58） mmol/L and （2.15±0.38） mmol/L, respectively; while the IC50 value of TMZ was （0.20±0.09） mmol/L for T98-G and （0.08＋0.02） mmol/L for SF295. Moreover, if combined with VPA （1.0 mmol/L） for 96 hours, the sensitivity of glioma cells to TMZ was significant increased （P 〈0.05）. The surviving fractions at 2 Gy （SF2） of T98-G and SF295 cells exposed to IR alone were 0.52 and 0.58. However, when VPA was combined with IR, the SF2 of T98-G and SF295 dropped to 0.39 （P=0.047） and 0.49 （P=0.049）, respectively. Treatment with VPA plus TMZ or IR also resulted in a significant decrease in the proportion of cells in the G2 phase and increased apoptotic rates as well as autophagy in T98-G and SF295 cell lines （P 〈0.01）. Conclusion VPA may enhance the activities of TMZ and IR on glioma cells possibly through cell cycle block and promote autophagy, and thus could be a potential sensitizer of glioma treatment.

关键词： 2-propylpentanoic acid radiosensitivity glioma cell line

Optical frequency divider with division uncertainty at the 10-21 level

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National Science Review 2016年第4期3卷 463-469页

作者： Yuan Yao Yanyi Jiang Hongfu Yu Zhiyi Bi Longsheng Ma state Key Laboratory of Precision Spectroscopy East China Normal University Collaborative Innovation center of Extreme Optics Shanxi University

Optical clocks with unprecedented accuracy of 10promise innovations in many research *** applications rely to a large extent on the ability of precisely converting the frequency from one optical clock to another,or particularly to the frequencies in the iber telecom band for long-distance *** report demonstrates a low-noise,high-precision optical frequency divider,which realizes accurate optical frequency conversion and enables precise measurement of optical frequency *** measuring against the frequency ratio between the fundamental and the second harmonic of a 1064-nm laser instead of a second copy of the same system,we demonstrate that the optical frequency divider has a fractional frequency division instability of 6×10at 1 s and a fractional frequency division uncertainty of 1.4×*** remarkable numbers can support frequency division of the best optical clocks in the world without frequency-conversion-caused degradation of their performance.

关键词： optical frequency comb optical atomic clock precision measurement frequency metrology

Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer

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Bioactive Materials 2021年第11期6卷 3678-3691页

作者： Wen Nie Ting Yu Xiaoxiao Liu Bilan Wang Tingting Li Yin Wu Xikun Zhou Lu Ma Yunfeng Lin Zhiyong Qian Xiang Gao Department of Neurosurgery1nd Institute of Neurosurgery State Key Laboratory of Biotherapy1nd Cancer CenterWest China HospitalWest China Medical SchoolSichuan University1nd Collaborative Innovation Center for BiotherapyChengdu610041PR China Department of Medical Oncology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Pathology1nd Laboratory of Pathology State Key Laboratory of BiotherapyWest China HospitalWest China School of MedicineSichuan UniversityChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration1nd Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical UniversityXuzhou221000China Department of Pharmacy West China Second University Hospital of Sichuan UniversityChengdu610041China state Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China College of Biomedical Engineering Sichuan UniversityChengdu610041China

The immunosuppressive tumor microenvironment(TME)of cancer strongly hinders the anti-tumor immune responses,thereby resulting in disappointing responses to *** and promotive traits of chemokines exerted on leukocytes have garnered interest in improving the efficiency of immunotherapy by increasing the infiltration of immune cells in the *** this study,a folic acid(FA)-modified gene delivery system based on the self-assembly of DOTAP,MPEG-PCL-MPEG,and FA-PEG-PCL-PEG-FA,namely F-PPPD,was developed to deliver plasmids encoding the immunostimulating chemokine *** delivery of plasmid CKb11(pCKb11)by F-PPPD nanoparticles resulted in the high secretion of CKb11 from tumor cells,which successfully activated T cells,suppressed the M2 polarization of macrophages,promoted the maturation of dendritic cells(DCs),facilitated the infiltration of natural killer(NK)cells and inhibited the infiltration of immunosuppressive cells in tumor *** of F-PPPD/pCKb11 also significantly suppressed the cancer *** study demonstrated a nanotechnology-enabled delivery of pCKb11,that remodeled the immunosuppressive TME,for cancer treatment.

关键词： cancer Immunogene therapy CKb11 Nanocomposites Macrophages polarization

In silico designing of power conversion efficient organic lead dyes for solar cells using todays innovative approaches to assure renewable energy for future

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npj Computational Materials 2017年第1期3卷 263-274页

作者： Supratik Kar Juganta K.Roy Jerzy Leszczynski Interdisciplinary center for Nanotoxicity Department of Chemistry and BiochemistryJackson State UniversityJacksonMS 39217USA

Advances in solar cell technology require designing of new organic dye sensitizers for dye-sensitized solar cells with high power conversion efficiency to circumvent the disadvantages of silicon-based solar *** silico studies including quantitative structureproperty relationship analysis combined with quantum chemical analysis were employed to understand the primary electron transfer mechanism and photo-physical properties of 273 arylamine organic dyes from 11 diverse chemical families explicit to iodine *** direct quantitative structure-property relationship models enable identification of the essential electronic and structural attributes necessary for quantifying the molecular prerequisites of 11 classes of arylamine organic dyes,responsible for high power conversion efficiency of dye-sensitized solar ***,N,N′-dialkylaniline and indoline have been least explored classes under arylamine organic dyes for dye-sensitized solar ***,the identified properties from the corresponding quantitative structure-property relationship models of the mentioned classes were employed in designing of“lead dyes”.Followed by,a series of electrochemical and photo-physical parameters were computed for designed dyes to check the required variables for electron flow of dye-sensitized solar *** combined computational techniques yielded seven promising lead dyes each for all three chemical classes ***(130,183,and 46%)increment in predicted %power conversion efficiency was observed comparing with the existing dye with highest experimental %power conversion efficiency value for tetrahydroquinoline,N,N′-dialkylaniline and indoline,respectively maintaining required electrochemical parameters.

关键词： designing dye aniline

Two Alkali Metal Germanophosphates Na_(3)[Ge(OH)(PO_(4))_(2)]·2H_(2)O and Li_(2)Na[GeO(HPO_(4))(PO_(4))]:Crystal Structures and Thermal Stability

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Chinese Journal of Structural Chemistry 2021年第1期40卷 114-124,5页

作者： YANG Dong ZHUANG Rong-Chuan MI Jin-Xiao HUANG Ya-Xi Fujian Key Laboratory of Advanced Materials(Xiamen university) Department of Materials Science and EngineeringCollege of MaterialsXiamen UniversityXiamen 361005China state Key Laboratory of comprehensive Utilization of Low-grade Refractory Gold Ores Shanghang 364200China

Two new alkali metal germanophosphates,namely,Na_(3)[Ge(OH)(PO_(4))_(2)]·2 H2 O and Li_(2)Na[GeO(HPO_(4))(PO_(4))],have been prepared by solvothermal method,and their crystal structures were determined by single-crystal X-ray *** title two compounds crystalize in the same orthorhombic space group Pbcm(No.57)and feature similar chain-like structure which is built from zig-zag GeO_(6) octahedral thread loop branched by PO_(4) *** Na_(3)[Ge(OH)(PO_(4))_(2)]·2 H_(2)O,a=10.1650(9),b=13.1975(12),c=6.9751(7)Å,V=935.73(15)Å^(3),Z=4,R=0.0356 and wR=0.1109;and for Li_(2)Na[GeO(HPO_(4))(PO_(4))],a=6.9855(5),b=14.5809(18),c=6.6620(5)Å,V=678.56(11)Å^(3),Z=4,R=0.0286,and w R=*** partial substitution of Na ions by Li ions not only significantly influences the total structural features and the water molecule contents,but also impacts on their thermal ***_(2)Na[GeO(HPO_(4))(PO_(4))]is thermally stable up to 400℃,whereas only 150℃ for Na_(3)[Ge(OH)(PO_(4))_(2)]·2 H2 O.

关键词： alkali metal chain-like structure germanophosphates thermal stability

Stiffness heterogeneity-induced double-edged sword behaviors of carcinoma-associated fibroblasts in antitumor therapy

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Science China Materials 2019年第6期62卷 873-884页

作者： Jiantao Fen Shivani Sharma Elizabeth Rao Xiang Li Qiang Zhang Fulong Liao Jie He Dong Han Jianyu Rao cancer Hospital Chinese Academy of Medical Sciences Department of Pathology and Laboratory Medicine University of CaliforniaLos Angeles California NanoSystems Institute University of CaliforniaLos Angeles Jonhson comprehensive cancer Institute University of CaliforniaLos Angeles National center for Nanoscience and Technology Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Carcinoma-associated fibroblasts(CAFs) function as a double-edged sword in tumor progression. However,factors affecting the transition between tumor promotion and inhibition remain to be investigated. Here, we found that the transition was determined by stiffness heterogeneity of the tumor stroma in which tumor cells and CAFs were *** tumor cells were grown on a rigid plastic substrate,supernatants from CAFs inhibited the cytotoxic effects of 5-fluorouracil. In contrast, when tumor cells were grown on a soft substrate(5.3 kPa), supernatants from CAFs grown on a soft substrate increased the cytotoxicity of 5-fluorouracil. The diverse effects of CAFs were mediated by mechanotransduction factors, including stroma stiffness-induced cytokine expression in CAFs and signal transduction associated with stress fiber formation of CAFs. Moreover, we found that the cytokine expression in CAFs was regulated by nuclear Yesassociated protein, which changed according to cell stiffness,as characterized by atomic force microscopy. Overall, these findings suggested that modulating the mechanotransduction of the stroma together with CAFs might be important for increasing the efficacy of chemotherapy.

关键词： stiffness carcinoma-associated fibroblast tumor microenvironment chemotherapy atomic force microscopy

Acidic Magnetic Biocarbon-Enabled Upgrading of Biomass-Based Hexanedione into Pyrroles

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Journal of Renewable Materials 2023年第11期11卷 3847-3865页

作者： Zhimei Li Kuan Tian Keping Wang Zhengyi Li Haoli Qin Hu Li School of Chemistry and Materials Science Guizhou Normal UniversityGuiyang550001China National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang550025China

Sustainable acquisition of bioactive compounds from biomass-based platform molecules is a green alternative for existing CO_(2)-emitting fossil-fuel ***,a core–shell magnetic biocarbon catalyst functionalized with sulfonic acid(Fe3O4@SiO_(2)@chitosan-SO_(3)H,MBC-SO_(3)H)was prepared to be efficient for the synthesis of various N-substituted pyrroles(up to 99% yield)from bio-based hexanedione and amines under mild *** abundance of Bronsted acid sites in the MBC-SO_(3)H ensured smooth condensation of 2,5-hexanedione with a variety of amines to produce N-substituted *** reaction was illustrated to follow the conventional Pall-Knorr coupling pathway,which includes three cascade reaction steps:amination,loop closure and *** prepared MBC-SO_(3)H catalyst could effectively activate 2,5-hexanedione,thus weakening the dependence of the overall conversion process on the amine *** influence of different factors(e.g.,reaction temperature,time,amount of catalyst,molar ratio of substrates,and solvent type)on the reaction activity and selectivity were investigated ***,the MBC-SO_(3)H possessed excellent thermochemical stability,reusability,and easy separation due to the presence of magnetic core-shell ***,there was no activity attenuation after 5 consecutive catalytic *** work demonstrates a wide range of potential applications of developing functionalized core-shell magnetic materials to construct bioactive backbones from biomass-based platform molecules.

关键词： Magnetic materials biomass conversion heterogeneous catalysis sustainable chemistry

Small interfering RNA-based molecular therapy of cancers

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Chinese Journal of cancer 2013年第9期32卷 488-493页

作者： Wei Guo Wangbing Chen Wendan Yu Wenlin Huang Wuguo Deng state Key Laboratory of Oncology in South China Research Department Sun Yat-sen University Cancer Center Institute of cancer Stem Cell Dalian Medical University Cancer Center Key Laboratory of Targeted Drug for Tumors of Guangdong Province Guangzhou Double Bioproduct Inc.

RNA interference(RNAi)has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other *** minireview focuses on the potential of small interfering RNAs(siRNAs)in anticancer treatment,including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer *** article also describes the current delivery approaches of siRNAs using lipids,polymers,and,in particular,gold nanoparticles to induce significant gene silencing and tumor growth regression.

关键词：小干扰RNA 癌症治疗 siRNAs 分子 RNA干扰金纳米粒子科学研究基因功能

Efficacy of an esfenvalerate plus methoprene aerosol for the control of eggs and fifth instars of Plodia interpunctella （Lepidoptera： Pyralidae）

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Insect Science 2010年第1期17卷 21-28页

作者： Emily A. Jenson Frank H. Arthur James R. Nechols Kansas state university USDA-ARS Grain Marketing and Production Research center Manhattan KS USA

Aerosol insecticides may provide an alternative to fumigants for control of the Indianmeal moth, Plodia interpunctella （Hübner）, the Indianmeal moth, a major insect pest of stored processed food. In this study, eggs and larvae （5th instars） ofP. interpunctella were exposed to aerosol applications of the pyrethroid esfenvalerate and insect growth regulator methoprene, alone and in combination, in open and obstructed positions inside small sheds. When larvae were exposed to methoprene alone, adult emergence from those exposed larvae was 7.1% ± 1.5%. In contrast, adult emergence was 92.5% ± 3.5% when larvae were exposed to esfenvalerate alone. When eggs were exposed to methoprene, adult emergence of those exposed eggs was approximately 75%; however, when eggs were exposed to esfenvalerate, adult emergence was approximately 35%. In the combination treatment of methoprene plus esfenvalerate at their respective label rates, adult emergence following larval exposure was 0.91% ±0.61% compared to 16.3% ± 9.6% when eggs were exposed. Based on our results, methoprene alone is highly effective in reducing adult emergence after larval exposure. However, it is not as effective on eggs as esfenvalerate. A combination treatment of esfenvalerate plus methoprene could be used to control eggs and the wandering-phase larval stages ofP. interpunctella. An economic risk analysis also supports a strategy of combining methoprene and esfenvalerate.

关键词： control Indianmeal moth Plodia interpunctella