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Journal of Traditional Chinese Medicine 2024年第3期44卷 545-553页

作者： JIN Xiao WU Bingxin LIN Miaoyang ZHONG Biying LIN Luoqi XU Danping Department of Traditional Chinese Medicine the First Affiliated Hospital of Jinan UniversityJinan University Department of Cardiology Second Clinical College of Guangzhou University of Chinese Medicine Department of Traditional Chinese Medicine the Eighth Affiliated HospitalSun Yat-Sen University

OBJECTIVE: To evaluate the clinical efficacy and safety of Shenzhu Guanxin recipe granules(参术冠心颗粒, SGR) in treating patients with intermediate coronary lesions(ICL), and to investigate the potential mechanism though a transcriptome sequencing approach. METHODS: ICL patients with Qi deficiency and phlegm stasis were adopted and randomly assigned to a case group or a control by random number generator in a 1∶1 randomization ratio to evaluate the clinical efficacy. RESULTS: There was no significant difference between the two groups in coronary computed tomography angiography related indexes in the two groups before and after intervention. Through the gene chip expression analysis, it is finally concluded that there are 355 differential mRNAs(190 up-regulated genes and 165 down regulated genes) when compared the SGR group and placebo group. Through protein-protein interaction network analysis of differentially expressed genes, 10 hub genes were finally obtained: CACNA2D2, CACNA2D3, DNAJC6, FGF12, SGSM2, CACNA1G, LRP6, KIF25, OXTR, UPB1. CONCLUSIONS: SGR combined with Western Medicine can be safely used to treat ICL patients with Qi deficiency and phlegm stasis. The possible mechanism of action and relevant gene loci and pathway were proposed.

关键词： Shenzhu Guanxin recipe granules deficiency and phlegm stasis gene expression profiling intermediate coronary lesions

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Causal relationship between hypertension and epilepsy:a mendelian randomization study

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Acta Epileptologica 2024年第1期7卷 53-59页

作者： Zhen Sun Tong Jiang Mengwen Zhang Yulong Li Jing Zhang Yanping Sun Xiaofeng Yu Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdao266000China Department of Endocrinology and Metabolism The Affiliated Hospital of Qingdao UniversityQingdao266000China Department of Neurology Qingdao Eighth People’s HospitalQingdao266000China

Background Recent studies suggest that hypertension may increase the risk of epilepsy onset,revealing intricate interactions between cardiovascular health and neurological disorders,thus emphasizing the significance of conducting further investigations into their *** study aimed to investigate the potential causality between hypertension,either in systolic or diastolic blood pressure,and epilepsy,using a Mendelian randomization *** A two-sample Mendelian randomization design was used in this *** extracted data from the UK Biobank,FinnGen,and the International Consortium of Blood Pressure,utilizing blood pressure-related single nucleotide polymorphisms as instrumental variables to evaluate the influence of hypertension on the risk of *** variance weighted,weighted median,and MR-Egger approaches were used for *** There was a potential association between hypertension,primarily in systolic blood pressure,and an elevated epilepsy risk,while the relationship between hypertension in diastolic blood pressure and epilepsy risk remained *** analyses suggest an absence of substantial heterogeneity and confounding effects,suggesting the reliability of our *** Our study lays the groundwork for further investigations into the mechanisms of this causal relationship,which may potentially involve vascular change,neuroinflammatory pathways,and alterations in cerebral blood flow,which are crucial for understanding the complex hypertension-epilepsy nexus.

关键词： Mendelian randomization Epilepsy Hypertension Systolic blood pressure

Effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients

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Pharmacology & Pharmacy 2024年第2期15卷 15-26页

作者： Jiaxin Lin Hui Yang Shaofen Chen Jiao Xu Department of Anesthesiology The Eighth Affiliated Hospital Sun Yat-sen University Shenzhen China

Objective: To determine the effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients. Methods: In this double-blind randomized controlled study, patients aged 65 to 80 who were undergoing spinal fusion surgery for disc herniation were administered flurbiprofen 100 mg (P group, flurbiprofen group), prednisolone 0.6 mg/kg (D group, prednisolone group), prednisolone 0.6 mg/kg plus flurbiprofen 100 mg (P + D group, flurbiprofen + prednisolone group) or normal saline (S group, saline group) 15 minutes before the induction of anesthesia. Plasma samples were collected before surgery (T0) and on day 1 (T1), day 2 (T2) and day 3 (T3) following surgery. At the same time, systemic inflammatory response syndrome (SIRS) was assessed by SIRS criteria. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) for collected samples were measured. Results: Other groups had significantly lower levels of IL-6, CRP and occurrence of SIRS than S group (p 0.05). Conclusion: Compared to prednisolone or flurbiprofen, combining flurbiprofen with prednisolone in elderly surgery patients led to an increased suppression of IL-6.

关键词： SIRS Systemic Inflammatory Response Syndrome IL-6 Interleukin-6 CRP C-Reactive Protein

Application of artificial intelligence in diagnosis of pulmonary tuberculosis

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Chinese Medical Journal 2024年第5期137卷 559-561页

作者： Jingli Du Yue Su Juan Qiao Shang Gao Enjun Dong Ruilan Wang Yanhui Nie Jing Ji Zhendong Wang Jianqin Liang Wenping Gong Tuberculosis Control Team Senior Department of TuberculosisThe Eighth Medical Center of PLA General HospitalBeijing 100091China Department of Computer Science and Technology College of Management Science and EngineeringCapital University of Economics and BusinessBeijing 100071China The Second Ward of Tuberculosis Department Senior Department of TuberculosisThe Eighth Medical Center of PLA General HospitalBeijing 100091China Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Senior Department of TuberculosisThe Eighth Medical Center of PLA General HospitalBeijing 100091China

Tuberculosis(TB)is an infectious disease caused by Mycobacterium *** the diagnostic technology of pulmonary tuberculosis(PTB)has advanced,accurate and differential diagnoses of PTB are still *** recent years,the rapid development of artificial intelligence(AI)and its wide application in the medical field have provided new opportunities for diagnosing and treating TB and *** machine learning model of AI has not only helped physicians improve diagnostic accuracy,but also enabled them to make early preventive diagnoses for individuals at increased risk of ***,AI can guide physicians to formulate targeted treatment strategies for PTB patients with different conditions.

关键词： tuberculosis diagnosis artificial

Clinicopathological analysis of EWSR1/FUS::NFATC2 rearranged sarcoma in the left forearm:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2887-2893页

作者： Qiao-Ling Hu Chao Zeng Department of Pathology The Eighth Affiliated Hospital of Sun Yatsen UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND We present a case of an EWSR1/FUS::NFATC2 rearranged sarcoma in the left forearm and analyze its clinicopathological and molecular *** SUMMARY The patient is a 23-year-old ***,the tumor cells were medium-sized round cells arranged in small *** cytoplasm was clear,nuclei were relatively uniform,chromatin was dense,nucleoli were visible,and mitotic figures were ***,the tumor cells were positive for Vimentin,INI-1,CD99,NKX2.2,CyclinD1,friend leukaemia virus integration 1,and ***-generation sequencing revealed the presence of the EWSR1-NFATC2 fusion ***1/FUS::NFATC2 rearranged sarcomas are rare and can easily be *** Clinical imaging,immunohistochemistry,and molecular pathology should be considered to confirm the diagnosis.

关键词： EWSR1 NFATC2 Sarcoma Forearm Case report

Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： Yuncong Shi Zhengzhipeng Zhang Binyan Wang Yu Wang Xiangyi Kong Yong Sun Aimin Li Yimin Cui Yan Zhang Jianping Li Yong Huo Hui Huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(Q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(Q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1871-1882页

作者： Long Li Dong-Yuan Liu Jing Leng Xue-Mei Tao Hui-Qin Wu Yan-Peng Zhu Department of General Surgery The 971^(st)Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Surgery Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Hyperbaric Oxygen Department The Eighth Peoples Hospital of QingdaoQingdao 266121Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND The development of laparoscopic technology has provided a new choice for surgery of gastric cancer(GC),but the advantages and disadvantages of laparoscopic total gastrectomy(LTG)and laparoscopic-assisted total gastrectomy(LATG)in treatment effect and safety are still *** purpose of this study is to compare the efficacy and safety of the two methods in the treatment of GC,and to provide a basis for clinical *** To compare the efficacy of totally LTG(TLTG)and LATG in the context of radical gastrectomy for ***,we investigated the safety and feasibility of the total laparoscopic esophagojejunostomy *** Literature on comparative studies of the above two surgical methods for GC(TLTG group and LATG group)published before September 2022 were searched in the PubMed,Web of Science,Wanfang Database,CNKI,and other Chinese and English *** addition,the following search keywords were used:Gastric cancer,total gastrectomy,total laparoscopy,laparoscopy-assisted,esophagojejunal anastomosis,gastric/stomach cancer,total gastrectomy,totally/completely laparoscopic,laparoscopic assisted/laparoscopy assisted/laparoscopically assisted,and esophagojejunostomy/esophagojejunal *** Manager 5.3 software was used for the meta-analysis after two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included *** After layer-by-layer screening,258 pieces of literature were recovered,and 11 of those pieces were eventually *** resulted in a sample size of 2421 instances,with 1115 cases falling into the TLTG group and 1306 cases into the LATG *** or sex differences between the two groups were not statistically significant,according to the meta-analysis,however the average body mass index of the TLTG group was considerably higher than that of the LATG group(P=0.01).Compared with those in the LATG group,the incision length in the TLTG

关键词： Total laparoscopic gastrectomy Laparoscopically assisted total gastrectomy Gastric cancer Meta-analysis

Prevalence of bacteria, fungi, and virus coinfections with SARS-CoV-2 Omicron variant among patients with severe COVID-19 in Guangzhou, China, winter 2022

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Biosafety and Health 2024年第2期6卷 92-97页

作者： Qinghong Fan Mengling Jiang Jun Zhang Guofang Tang Ming Gao Yingfen Wen Xizi Deng Jun Dai Honghao Lai Peng Qian Yaqing Lin Ruiying He Liya Li Yueping Li Zhengtu Li Xuesong Liu Yimin Li Na Yu Yun Lan Fengyu Hu Feng Li Institute of Infectious Diseases Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhou 510440China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of GuangzhouMedicalUniversityGuangzhou510120China Guangzhou Laboratory Guangzhou 510700China

The status of coinfection during the national outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron BA.5.2 or BF.7 in China in the winter of 2022,which is suspected to contribute substantially to the overloaded severe cases,needs to be *** analyzed the coinfection status of 385 severe patients infected with the Omicron variant in Guangzhou using metagenomic *** found that 317(82.3%)patients were coinfected with at least one additional pathogen(s),including bacteria(58.7%),fungi(27.1%)and viruses(73.5%).Pseudomonas aeruginosa(***)(24.2%),Staphylococcus aureus(***)(14.0%),andKlebsiella pneumoniae(***)(13.4%)ranked as the top three coinfected *** fumigatus(***)(39.5%),Pneumocystis jirovecii(***)(24.4%)andCanidia albicans(***)(22.1%)were the top three coinfected ***-Barr virus(EBV)(63.1%),Human herpesvirus 7(HHV-7)(34.8%),and Herpes simplex virus 1(HSV-1)(32.6%)were the top three coinfected *** note,the detection of multiple coinfections of potential pathogenic bacteria,fungi,and viruses,despite lacking consistent patterns,highlighted a complicated synergistic contribution to disease *** study presents the most comprehensive spectrum of bacterial,fungal,and viral coinfections in Omicron-associated severe coronavirus disease 2019(COVID-19),implying that the coinfection of conditional pathogens might synergistically deteriorate the Omicron infection outcomes.

关键词： SARS-CoV-2 Omicron BA.5.2 Omicron BF.7 Coinfection Severeinfection

Hierarchical learning of gastric cancer molecular subtypes by integrating multi-modal DNA-level omics data and clinical stratification

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Quantitative Biology 2024年第2期12卷 182-196页

作者： Binyu Yang Siying Liu Jiemin Xie Xi Tang Pan Guan Yifan Zhu Xuemei Liu Yunhui Xiong Zuli Yang Weiyao Li Yonghua Wang Wen Chen Qingjiao Li Li C.Xia Department of Statistics and Financial Mathematics School of MathematicsSouth China University of TechnologyGuangzhouChina School of Physics and Optoelectronics South China University of TechnologyGuangzhouChina Department of Pathology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina Department of Laboratory Medicine the Eighth Affiliated HospitalSun Yat-sen UniversityShenzhenChina

Molecular subtyping of gastric cancer(GC)aims to comprehend its genetic ***,the efficacy of current subtyping methods is hampered by their mixed use of molecular features,a lack of strategy optimization,and the limited availability of public GC *** is a pressing need for a precise and easily adoptable subtyping approach for early DNA-based screening and *** on TCGA subtypes,we developed a novel DNA-based hierarchical classifier for gastric cancer molecular subtyping(HCG),which employs gene mutations,copy number aberrations,and methylation patterns as *** incorporating the closely related esophageal adenocarcinomas dataset,we expanded the TCGA GC dataset for the training and testing of HCG(n=453).The optimization of HCG was achieved through three hierarchical strategies using Lasso-Logistic regression,evaluated by their overall the area under receiver operating characteristic curve(auROC),accuracy,F1 score,the area under precision-recall curve(auPRC)and their capability for clinical stratification using multivariate survival ***-specific DNA alteration biomarkers were discerned through difference tests based on HCG defined *** HCG classifier demonstrated superior performance in terms of overall auROC(0.95),accuracy(0.88),F1 score(0.87)and auPRC(0.86),significantly improving the clinical stratification of patients(overall p-value=0.032).Difference tests identified 25 subtype-specific DNA alterations,including a high mutation rate in the SYNE1,ITGB4,and COL22A1 genes for the MSI subtype,and hypermethylation of ALS2CL,KIAA0406,and RPRD1B genes for the EBV *** is an accurate and robust classifier for DNA-based GC molecular subtyping with highly predictive clinical stratification *** training and test datasets,along with the analysis programs of HCG,are accessible on the GitHub website(***/LabxSCUT).

关键词： DNA alterations gastric cancer hierarchical classification molecular subtyping multi-omics

Long-term kidney transplant outcomes in Chinese patients with primary glomerulonephritis:A multicenter study in China

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Chinese Medical Journal 2024年第12期137卷 1492-1494页

作者： Kenan Xie Jinsong Chen Longshan Liu Rending Wang Baoshan Gao Xiaopeng Hu Xiaotian Tang Zheng Jin Ming Zhang Yong Han Turen Song Jiqiu Wen Jiong Zhang Department of Nephrology National Clinical Research Center of Kidney DiseasesJinling HospitalNanjing University School of MedicineNanjingJiangsu 210002China Department of Organ Transplantation The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Kidney Disease The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department II of Urology First Hospital of Jilin UniversityChangchunJilin 130021China Department of Urology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Urology The Secend Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Renal Transplantation Hospital of NephrologyThe First Affiliated Hospital of Medical CollegeXi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Liver Surgery Shanghai Jiaotong University School of Medicine Affiliated Renji HospitalShanghai 200127China Department of Respiratory and Critical Care Medicine The Eighth Medical Center of PLA General HospitalBeijing Key Laboratory of OTIRBeijing 100091China Department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China

To the Editor:The primary cause of end-stage kidney disease(ESKD)in China is chronic glomerulonephritis(GN),which accounts for 45%of ESKD patients.[1]There is currently no nationwide large-scale study on the longterm prognosis of kidney transplantation in patients with chronic GN in *** the past decade,however,few landmark studies from populations in Europe[2,3]and the United States[4]have provided important reference data for this ***,we propose to conduct a nationwide multicenter retrospective study,which was launched by the National Clinical Research Center of Kidney Diseases,Jinling hospital,Nanjing University School of Medicine,from 2017 to 2020.

关键词： nationwide patients glomerulonephritis