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Neurobehavioral Biomarkers of Aging: Influence of Genotype and Dietary Restriction

Biomedical and Environmental Sciences 1991年第1期4卷 144-165页

作者： MICHAEL J.FORSTER HARBANS LAL Department of Pharmacology Texas College of Osteopathic Medicine 3500 Camp Bowie Boulevard Fort Worth Texas 76107Department of Pharmacology Texas College of Osteopathic Medicine 3500 Camp Bowie Boulevard Fort Worth Texas 76107 University of North Texas Denton Texas 76203University of North Texas Denton Texas 76203

Because of the importance of central nervous system (CNS) functions to productive capacity and quality of life, biomarkers of these functions will play a key role in evaluating the success of interventions targeting aging processes. The CNS biomarkers may also be useful for predicting aging in other systems and in the organism as a whole. Age-related behavioral changes, the products of CNS aging, have content and predictive validity with respect to human functional capacities and may, therefore, represent important 'neurobehavioral' markers of functional aging. This article presents a discussion of some behavioral paradigms which are currently being considered as neurobehavioral biomarkers of aging in mice and the experimental approaches being employed in the assessment of their validity. Studies conducted in the authors' laboratory using dietary restriction and genetic comparisons to evaluate the validity of neurobehavioral biomarkers have revealed several methodological concerns, and hypothetical and empirical examples of these pitfalls are described and discussed. In spite of those concerns, it is concluded that approaches to validity using genetic comparisons and dietary restriction can be successfully implemented and should ultimately lead to identification of valid and useful neurobehavioral biomarkers of aging.

关键词： Neurobehavioral Biomarkers of Aging

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Neurobehavioral Biomarkers of Aging: Influence of Genotype and Dietary Restriction

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Biomedical and Environmental Sciences 1991年第Z1期 144-165页

作者： MICHAEL J.FORSTER,HARBANS LAL Department of Pharmacology texas college of osteopathic medicine 3500 camp bowie boulevard Fort Worth texas 76107 Department of Pharmacology texas college of osteopathic medicine 3500 camp bowie boulevard Fort Worth texas 76107 University of North texas Denton texas 76203 University of North texas Denton texas 76203

Because of the importance of central nervous system (CNS) functions to productive capacity and quality of life, biomarkers of these functions will play a key role in evaluating the success of interventions targeting aging processes. The CNS biomarkers may also be useful for predicting aging in other systems and in the organism as a whole. Age-related behavioral changes, the products of CNS aging, have content and predictive validity with respect to human functional capacities and may, therefore, represent important "neurobehavioral" markers of functional aging. This article presents a discussion of some behavioral paradigms which are currently being considered as neurobehavioral biomarkers of aging in mice and the experimental approaches being employed in the assessment of their validity. Studies conducted in the authors' laboratory using dietary restriction and genetic comparisons to evaluate the validity of neurobehavioral biomarkers have revealed several methodological concerns, and hypothetical and

关键词： Neurobehavioral Biomarkers of Aging

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