检索结果-南通市图书馆

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison N.DeVore marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implications of regional identity for neural stem and progenitor cell transplantation in the injured or diseased nervous system

引用

Neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Amar Kumar Jennifer N.Dulin Department of Biology Texas A&M UniversityCollege Station texas a&m Institute for Neuroscience Texas A&M UniversityCollege Station

Neural stem and progenitor cell(NSPC)transpla ntation has emerged as a promising therapeutic strategy for replacing lost neuronal populations and repairing damaged neural circuits following nervous system injury and disease.A great deal of experimental work has investigated the biology of NSPC grafting in preclinical animal models;more recently.

关键词： neural system injured

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hierarchically porous metal–organic frameworks:synthetic strategies and applications

引用

National Science Review 2020年第11期7卷 1743-1758页

作者： Liang Feng Kun-Yu Wang Xiu-Liang Lv Tian-Hao Yan Hong-Cai Zhou Department of Chemistry Texas A&M UniversityCollege Station Department of materials Science and Engineering Texas A&M UniversityCollege Station

Despite numerous advantages, applications of conventional microporous metal–organic frameworks (mOFs) are hampered by their limited pore sizes, such as in heterogeneous catalysis and guest delivery,which usually involve large molecules. Construction of hierarchically porous mOFs (HP-mOFs) is vital to achieve the controllable augmentation of mOF pore size to mesopores or even macropores, which can enhance the diffusion kinetics of guests and improve the storage capacity. This review article focuses on recent advances in the methodology of HP-mOF synthesis, covering preparation of HP-mOFs with intrinsic hierarchical pores, and modulated, templated and template-free synthetic strategies for *** key factors which affect the formation of HP-mOF architectures are summarized and discussed,followed by a brief review of their applications in heterogeneous catalysis and guest encapsulation. Overall,this review presents a roadmap that will guide the future design and development of HP-mOF materials with molecular precision and mesoscopic complexity.

关键词： metal–organic frameworks hierarchical design synthesis application

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ULTRASHORT PULSE mULTISPECTRAL NON-LINEAR OPTICAL mICROSCOPY

引用

Journal of Innovative Optical Health Sciences 2009年第1期2卷 27-35页

作者： ADAm m.LARSON ANTHONY LEE PO-FENG LEE KAYLA J.BAYLESS ALVIN T.YEH Department of Biomedical Engineering texas a&m University college Station TexasUSA Department of molecular and Cellular medicine texas a&m Health Science Center college Station TexasUSA

Ultrashort pulse,multispectral non-linear optical microscopy(NLOm)is developed and used to image,simultaneously,a mixed population of cells expressing different fluorescent protein mutants in a 3D tissue model of ***,sub-10-fs pulses are used to excite multiple fluorescent proteins and generate second harmonic in collagen.A 16-channel multispectral detector is used to delineate the multiple non-linear optical signals,pixel by pixel,in *** ability to image multiple fluorescent protein mutants and collagen,enables serial measurements of cell-cell and cell-matrix interactions in our 3D tissue model and characterization of fundamental processes in angiogenic morphogenesis.

关键词： Two-photon excited fluorescence second harmonic generation multiple molecular imaging angiogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

引用

Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,mAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The influence of bacteria on multitrophic interactions among plants, psyllids, and pathogen

引用

Insect Science 2017年第6期24卷 961-974页

作者： Cecilia Tamborindeguy Ordom Brian Huot Freddy Ibanez Julien Levy Department of Entomology Texas A&M University College Station Texas USA Department of Horticultural Sciences Texas A&M University College Station Texas USA

The recent emergence ofseveralplant diseases caused by psyllid-borne bacterial pathogens worldwide （Candidatus Liberibaeter spp.） has created renewed interest on the interaction between psyllids and bacteria. In spite of these efforts to understand psyllid association with bacteria, many aspects of their interactions remain poorly understood. As more organisms are studied, subtleties on the molecular interactions as well as on the effects of the bacteria on the psyllid host are being uncovered. Additionally, psyllid-borne bacterial phytopathogens can also affect the host plant, which in turn can impact psyllid physiology and behavior. Here, we review the current literature on different aspects of the influence of bacteria on multitrophic interactions among plants, psyllids, and pathogens. We then highlight gaps that need to be addressed to advance this field, which can have significant implications for controlling these newly emergent and other plant diseases.

关键词： bacteria interaction Liberibacter microbiome phytoplasma psyllid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu mao-Ju Tang man Luo Xiao-Wu Zhong Qiang ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory medicine&Translational medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μm and 39.59μm,*** values decreased to 37.22μm and 22.71μm,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATm)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

modular next generation fast-neutron detector for portal monitoring

引用

Nuclear Science and Techniques 2022年第1期33卷 140-148页

作者： E.Aboud S.Ahn G.V.Rogachev V.E.Johnson J.Bishop G.Christian E.Koshchiy C.E.Parker D.P.Scriven Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA Department of Physics and Astronomy Texas A&M UniversityCollege StationTX 77843USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA

Nuclear nonproliferation is of critical importance for global *** fissile materials including highly enriched uranium and weapons-grade plutonium are especially important to *** interrogation techniques may result in much better sensitivity but are difficult with conventional portal monitors that rely on detecting thermal ***,most conventional portal monitoring systems rely on ^(3)He,which has a finite and continually decreasing *** designing a highly segmented array of organic scintillators,we posit that we can accurately and quickly identify fissile materials,including weapons-grade plutonium and highly enriched uranium,being *** propose a new design for a fast-neutron detector that overcomes the limitations of the current generation of portal ***6 simulations have been performed in conjunction with the UmPBT statistical model to determine the sensitivity limitations of the proposed *** suggest that the proposed detector may be 10 times more efficient than current-generation thermal neutron detectors and may be able to positively identify a 81 mg 235U source in as little as 192 seconds utilizing active interrogation techniques.

关键词： Fast-neutron detection Portal monitoring Nonproliferation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bayesian optimization with adaptive surrogate models for automated experimental design

引用

npj Computational materials 2021年第1期7卷 1800-1811页

作者： Bowen Lei Tanner Quinn Kirk Anirban Bhattacharya Debdeep Pati Xiaoning Qian Raymundo Arroyave Bani K.mallick Department of Statistics Texas A&M UniversityCollege StationTXUSA Department of mechanical Engineering Texas A&M UniversityCollege StationTXUSA Department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTXUSA Department of Computer Science&Engineering Texas A&M UniversityCollege StationTXUSA Department of materials Science&Engineering Texas A&M UniversityCollege StationTXUSA

Bayesian optimization(BO)is an indispensable tool to optimize objective functions that either do not have known functional forms or are expensive to ***,optimal experimental design is always conducted within the workflow of BO leading to more efficient exploration of the design space compared to traditional *** can have a significant impact on modern scientific discovery,in particular autonomous materials discovery,which can be viewed as an optimization problem aimed at looking for the maximum(or minimum)point for the desired materials *** performance of BO-based experimental design depends not only on the adopted acquisition function but also on the surrogate models that help to approximate underlying objective *** this paper,we propose a fully autonomous experimental design framework that uses more adaptive and flexible Bayesian surrogate models in a BO procedure,namely Bayesian multivariate adaptive regression splines and Bayesian additive regression *** can overcome the weaknesses of widely used Gaussian process-based methods when faced with relatively high-dimensional design space or non-smooth patterns of objective *** simulation studies and real-world materials science case studies demonstrate their enhanced search efficiency and robustness.

关键词： functions properties optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Review on Thermophysical Properties and Nusselt Number Behavior of Al2O3 Nanofluids in Heat Exchangers

引用

Journal of Thermal Science 2021年第2期30卷 418-431页

作者： ISSA Roy Jean college of Engineering West Texas A&M UniversityCanyonTexas 79016USA

During the last several years,the increase in cooling power requirements for heat exchangers have led to an escalation in heat transfer studies being performed on the use of nanofluids as heat transfer ***,limited effort has been attempted to relate and interpret these findings or the anomalies associated with *** paper compiles test data from several studies conducted on different types of heat *** this review,a concentrated effort is spent to clarify the ambiguities regarding the effect of nanoparticle size on the nanofluid thermal conductivity and Nusselt *** show that the nanofluid thermal conductivity is not influenced by the nanoparticle size,but by the clustering of the particles *** less compact the structure of the nanoparticle clustering is,the greater the enhancement in the nanofluid thermal conductivity *** were also compiled to interpret the relation between the nanofluid flow pattern,nanoparticles volume fraction in the base fluid,and the convective heat *** results from the majority of the heat exchanger studies show an increase in the heat transfer coefficient with the increase in nanoparticle volume ***,studies conducted on plate heat exchanges display some *** the majority of the heat exchanger studies with the exception of few,the decrease in the nanoparticle size is shown to result in an enhancement of the bulk fluid Nusselt *** test data also reveal that the effectiveness of the alumina nanoparticles is dependent on the flow *** increase in the nanoparticles concentration is shown to result in an increase in the nanofluid heat transfer enhancement as the fluid is transitioning from laminar to turbulent *** general,the smaller the nanoparticle size is,the greater the enhancement in the fluid Nusselt number is.

关键词： heat exchanger Nusselt number alumina nanofluid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：