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Medicine in Novel Technology and Devices 2021年第3期11卷 94-99页

作者： Parichad Plangtaisong Wei Shen Patrick C.Wheeler Daniel T.P.Fong National centre for Sport and Exercise Medicine School of SportExercise and Health SciencesLoughborough UniversityLoughboroughUK Department of Sport and Exercise Medicine University Hospitals of Leicester NHS TrustLeicesterUK

The purpose of this study was to determine whether interventions could improve peroneal reaction time in both healthy and those with injured ankle participants based on a systematic review and *** electronic search of the following database was carried out:MEDLINE,ScienceDirect and SPORTDiscus(1965–2020).Studies utilising sudden ankle inversion to measure peroneal reaction times were selected.28 studies were included for the systematic review,and 18 studies for the *** peroneal reaction time for pre-and post-intervention were compared into two groups,Group 1 was therapeutic exercise intervention,and Group 2 was prophylactic *** results showed a statistically significant difference in reduced peroneal reaction time in favour of participants in the exercise group(SMD=0.74,95%CI[1.09,0.39],pintervention *** effect size measured was 0.81 and 0.31 in Group 1 and Group 2,*** peroneal muscle onset reaction time post-intervention,which was found following therapeutic exercise,should be considered for rehabilitation and preventing of ankle sprain injury.

关键词： Peroneal reaction time Exercise intervention Prophylactic devices Ankle instability

Towards a Pan-Anti-Allergy Vaccine

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Journal of Immune Based Therapies, Vaccines and Antimicrobials 2013年第2期2卷 15-27页

作者： Sari S. Sabban Hongtu Ye Athanassios Vratimos Arthur J. G. Moir Alan W. Wheeler Birgit A. Helm Allergy therapeutics Ltd. Worthing UK Dr. Soliman Fakeeh College of Nursing and Medical Sciences Jeddah KSA Molecular Diagnostics Laboratory National Centre for Scientific Research “Demokritos” Athens Greece The Krebs Institute for Biomolecular Research Department of Molecular Biology and Biotechnology The University of Sheffield Sheffield UK

Allergic manifestations affect 20% - 30% of the population in industrialized countries. The global market for asthma and allergy medications has been estimated to exceed USD 6 billion, since 40% of the human population has some form of IgE sensitization to diverse proteins. Most therapeutic intervention strategies cope with the symptoms of allergy without eliminating the underlying cause and many are associated with undesirable and often long-term debilitating side effects. We designed a peptide immunogen encompassing sequences of the human Cε2-3 linker region to prime rat (Rattus norvegicus) immune systems, we then designed a chimeric human-dog-human IgE antibody and used it to boost the immune system and produce high-affinity antibodies that targets native IgE. The investigation showed that this peptide immunogen elicit the formation of antibodies recognizing the native IgE of human, canine and equine origin. The current investigation describes novel approaches aimed at the development of safe anti-allergy vaccines based on active immunization with IgE-derived peptides that are involved in the complementary interaction with the high affinity receptor. The immunization strategy was successful but did not fully work as predicted, thus we propose that peptides described in the current study may lead to the development of a pananti-allergy vaccine with applications for the treatment of all IgE-mediated allergic response independent of the nature of the offending allergen.

关键词： Anti-Allergy Vaccine Hypersensitivity Responses IgE Immunotherapy Original Antigenic Sin

Bone marrow mesenchymal stem cells intervention inhibits the progression of epithelial-mesenchymal transition by attenuating Wnt/β-catenin signaling pathway to alleviate silica-induced pulmonary fibrosis

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Bone marrow mesenchymal stem cells intervention inhibits the...

Developmental programming of the metabolic syndrome critical windows for intervention

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Enguo Zhang Ye Yang Juan Zhang Shangya Chen Cheng Peng Martin F Lavin Abrey J Yeo Zhongjun Du Hua Shao Department of Toxicology Shandong Academy of Occupational Health and Occupational MedicineShandong Academy of Medical Sciences School of Medicine and Life Sciences University of Jinan-Shandong Academy of Medical Sciences Queensland Alliance for Environmental Health Sciences (QAEHS) the University of Queensland University of Queensland centre for Clinical Research (UQCCR) the University of Queensland

Objectives Pulmonary fibrosis induced by silica dust is an irreversible,chronic,progressive and fibroproliferative lung disease with no effective treatment at *** studies have shown that early intervention with bone marrow mesenchymal stem cells(BMSCs) has positive effect on anti-pulmonary fibrosis caused by silica ***,early intervention using BMSCs is not practical,and the therapeutic effects of BMSCs advanced intervention on pulmonary fibrosis have rarely been *** this study,we investigated the effects of advanced transplantation of BMSCs(on the 28 th day after exposure to silica suspension) on an established rat model of pulmonary fibrosis by non-exposed tracheal perfusion of silica *** Specific pathogen Free(SPF) grade healthy adult male Sprague Dawley(SD) rats were randomly divided into 4 groups including(1) Control group(n=6)which were normally fed;(2) Silica model group(n=6) which were exposed to silica suspension;(3) BMSCs transplantation group(n=6) which received 2×10 BMSCs by tail vein injection on the 28 day after exposed to silica;(4) BMSC-CM(Conditioned medium) transplantation group(n=6) which received CM from the same cell number by tail vein injection on the 28 day after exposed to *** rat model of silicosis was induced with 1 mL of One-off infusing silica suspension using the non-exposed intratracheal *** were isolated and cultured by whole bone marrow adherence *** and concentration of BMSC-CM was used ultracentrifugation by Millipore Amicon Ultra-15 ultrafiltration centrifuge *** tomography(CT) was used to scan the range of the neck to diaphragm of the rats on the 56 day after exposed to *** lung tissues were stained with hematoxylin and eosin(H&E) for histopathological evaluation,and stained with Masson’s trichrome stain for fibrotic examination.E-cadherin(E-cad),cytokeratin19(CK19),Vimentin(Vim),a-Smooth actin(α-SMA),Gsk3β,P-Gsk3β and β-catenin prote

关键词： Silicosis Bone marrow mesenchymal stem cells(BMSCs) Animal model Transplantation Cell therapy

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World Journal of Diabetes 2011年第9期2卷 137-148页

作者： Mark H Vickers Liggins Institute and the National Research centre for Growth and Development University of AucklandAuckland 1023New Zealand

Metabolic disease results from a complex interaction of many factors,including genetic,physiological,behavioral and environmental *** recent rate at which these diseases have increased suggests that environmental and behavioral influences,rather than genetic causes,are fuelling the present *** this context,the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual,fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic *** the mechanisms are yet to be fully elucidated,this programming was generally considered an irreversible change in developmental *** work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental *** review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.

关键词： Developmental programming Metabolic syndrome Obesity Type 2 diabetes Leptin Animal models Predictive adaptive responses

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卒中介入治疗培训指南：国际多学会共识文件

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian interventional Neuro Group (CING) Edmonton AB Canada World Federation of interventional and therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic Therapy (ESMINT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

Acquired aortocameral fistula occurring late after infective endocarditis: An emblematic case and review of 38 reported cases

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World Journal of Cardiology 2016年第8期8卷 488-495页

作者： Salah AM Said Massimo A Mariani Department of Cardiology Hospital Group Twente Thorax centre Department of Cardiac Surgery University Medical Center Groningen

AIM To delineate the features and current therapeutic option of congenital and acquired aortocameral fistulas(ACF) secondary to iatrogenic or infectious *** From a Pub Med search using the term "aortocameral fistula", 30 suitable papers for the current review were retrieved. Reviews, case series and case reports published in English were considered. Abstracts and reports from scientific meetings were not included. A total of 38 reviewed subjects were collected and analyzed. In addition, another case- an adult male who presented with ACF between commissures of the right and noncoronary sinuses and right atrium as a late complication of Staphylococcus aureus infective endocarditis of the AV- is added, the world literature is briefly *** A total of thirty-eight subjects producing 39 fistulas were reviewed, analyzed and stratified into either congenital(47%) or acquired(53%) according to their etiology. Of all subjects, 11% were asymptomatic and 89% were symptomatic with dyspnea(21 ×) as the most common presentation. Diagnosis was established by a multidiagnostic approach in 23(60%), single method in 14(37%)(echocardiography in 12 and catheterization in 2), and at autopsy in 2(3%) of the subjects. Treatment options included percutaneous transcatheter closure in 12(30%) with the deployment of the Amplatzer duct or septal occluder and Gianturco coil and surgical correction in 24(63%). CONCLUSION Acquired ACF is an infrequent entity which may occur late after an episode of endocarditis of the native AV. The management of ACF is generally by surgical correction but non-surgical device intervention has recently been introduced as a safe alternative.

关键词： Aortic-atrial shunt Aortic-atrial fistulas Infective endocarditis Late complication Surgical correction

Comments by opponents on the British Medical Association’s guidance on non-therapeutic male circumcision of children seem one-sided and may undermine public health

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World Journal of Clinical Pediatrics 2023年第5期12卷 244-262页

作者： Stephen Moreton Guy Cox Mark Sheldon Stefan A Bailis Jeffrey D Klausner Brian J Morris CircFacts Warrington WA51HYCheshireUnited Kingdom Australian centre for Microscopy&Microanalysis and School of Aeronautical Mechanical and Mechatronic EngineeringUniversity of SydneySydney 2006New South WalesAustralia Medical Humanities and Bioethics Program Feinberg School of MedicineNorthwestern UniversityChicagoIL 60661United States Cornerstone Therapy&Recovery Center St.PaulMN 55101United States Department of Medicine Population and Public Health SciencesKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States School of Medical Sciences University of SydneySydney 2006New South WalesAustralia

The British Medical Association(BMA)guidance on non-therapeutic circumcision(NTMC)of male children is limited to ethical,legal and religious *** we evaluate criticisms of the BMA’s guidance by Lempert et *** their arguments promoting autonomy and consent might be superficially appealing,their claim of high procedural risks and negligible benefits seem one-sided and contrast with high quality evidence of low risk and lifelong *** literature reviews by the American Academy of Pediatrics and the United States Centers for Disease Control and Prevention in developing evidence-based policies,as well as risk-benefit analyses,have found that the medical benefits of infant NTMC greatly exceed the risks,and there is no reduction in sexual function and *** BMA’s failure to consider the medical benefits of early childhood NTMC may partly explain why this prophylactic intervention is discouraged in the United *** consequence is higher prevalence of preventable infections,adverse medical conditions,suffering and net costs to the UK’s National Health Service for treatment of *** of the issues and contradictions in the BMA guidance identified by Lempert et al stem from the BMA’s guidance not being sufficiently ***,that document called for a review by others of the medical issues surrounding *** societal factors apply,ultimately,NTMC can only be justified rationally on scientific,evidence-based *** are entitled to an accurate presentation of the medical evidence so that they can make an informed *** decision either for or against NTMC should then be respected.

关键词： Circumcision,Male Child Infections Risk Policy Public health

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of interventional Radiology Nantong First People’s HospitalNantong 226001China Department of interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Role of Toll-like receptors in Helicobacter pylori infection and immunity

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 133-146页

作者： Sinéad M Smith Department of Clinical Medicine Trinity Centre Adelaide and Meath Hospital School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin

The gram-negative bacterium Helicobacter pylori(H. pylori) infects the stomachs of approximately half of the world's population. Although infection induces an immune response that contributes to chronic gastric inflammation, the response is not sufficient to eliminate the bacterium. H. pylori infection causes peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. Disease outcome is linked to the severity of the host inflammatory response. Gastric epithelial cells represent the first line of innate immune defence against H. pylori, and respond to infection by initiating numerous cell signalling cascades, resulting in cytokine induction and the subsequent recruitment of inflamma-tory cells to the gastric mucosa. Pathogen recognition receptors of the toll-like receptor(TLR) family mediate many of these cell signalling events. This review dis-cusses recent findings on the role of various TLRs in the recognition of H. pylori in distinct cell types, describes the TLRs responsible for the recognition of individual H. pylori components and outlines the influence of innate immune activation on the subsequent development of the adaptive immune response. The mechanistic iden-tification of host mediators of H. pylori-induced patho-genesis has the potential to reveal drug targets and opportunities for therapeutic intervention or prevention of H. pylori-associated disease by means of vaccines or immunomodulatory therapy.

关键词： Helicobacter pylori Toll-like receptor Gastric epithelium Monocyte Macrophage Dendritic cell Cytokine Lipopolysaccharide

Effects of therapeutic horseback riding on post-traumatic stress disorder in military veterans

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Military Medical Research 2018年第1期5卷 19-32页

作者： Rebecca A.Johnson David L.Albright James R.Marzolf Jessica L.Bibbo Hayley D.Yaglom Sandra M.Crowder Gretchen K.Carlisle Amy Willard Cynthia L.Russell Karen Grindler Steven Osterlind Marita Wassman Nathan Harms Research Center for Human Animal interaction College of Veterinary Medicine University of Missouri Columbia MO 65211 USA. ResearchService Harry S. Truman Memorial Veterans' Hospital ColumbiaMO 65211 USA. School of Social Work University of AlabamaTuscaloosa AL 35487 USA. Occupational Health Services Harry S. Truman Memorial Veterans' Hospital Columbia MO 65211 USA. Center for the Human-Animal Bond College of Veterinary MedicinePurdue University West Lafayette IN 47907 USA. School of Health Professions University of Missouri Columbia MO 65211 USA. TREE House of Greater St. Louis Wentzville MO 63385 USA. School of Nursing and Health Studies University of Missouri-Kansas CityKansas City MO 64108 USA. Cedar Creek therapeutic Riding Center Columbia MO 65201 USA. College of Education School and Counseling Psychology University of Missouri Columbia MO 65211USA. Ride-On St. Louis Kimmswick MO 63053 USA.

Background:Large numbers of post-deployment *** are diagnosed with post-traumatic stress disorder(PTSD)and/or traumatic brain injury(TBI),leading to an urgent need for effective interventions to reduce symptoms and increase veterans’*** includes anxiety,flashbacks,and emotional *** symptoms increase health care costs for stress-related illnesses and can make veterans’civilian life ***:We used a randomized wait-list controlled design with repeated measures of *** veterans to address our specific aim to test the efficacy of a 6-week therapeutic horseback riding(THR)program for decreasing PTSD symptoms and increasing coping self-efficacy,emotion regulation,social and emotional *** participants were recruited and 29 enrolled in the randomized *** were randomly assigned to either the horse riding group(n=15)or a wait-list control group(n=14).The wait-list control group experienced a 6-week waiting period,while the horse riding group began *** wait-list control group began riding after 6 weeks of participating in the control *** and health history information was obtained from all the *** symptoms were measured using the standardized PTSD Checklist-Military Version(PCL-M).The PCL-M as well as other instruments including,The Coping Self Efficacy Scale(CSES),The Difficulties in Emotion Regulation Scale(DERS)and The Social and Emotional Loneliness Scale for Adults-short version(SELSA)were used to access different aspects of individual well-being and the PTSD ***:Participants had a statistically significant decrease in PTSD scores after 3 weeks of THR(P≤0.01)as well as a statistically and clinically significant decrease after 6 weeks of THR(P≤0.01).Logistic regression showed that participants had a 66.7%likelihood of having lower PTSD scores at 3 weeks and 87.5%likelihood at 6 *** the generalized linear model(GLM),our ANOVA findings for the coping self

关键词： Animal-assisted intervention Coping self-efficacy Emotion regulation Military veterans Post-traumatic stress disorder Social engagement therapeutic horseback riding Traumatic brain injury