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Neural Regeneration Research 2025年第10期20卷 2921-2922页

作者： Ori Bar Avi Eran Perlson Department of Physiology and Pharmacology Faculty of Medical&Health ScienceTel-Aviv UniversityTel-AvivIsrael Sagol School of Neuroscience Tel-Aviv UniversityTel-AvivIsrael

Neurons are highly polarized cells with axons reaching over a meter long in adult *** survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and metabolic events,which need to be carried out at the right place,time,and *** mechanisms include axonal transport,local synthesis,and liquid-liquid phase *** and malfunctions in these processes are correlated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS).

关键词： synthesis local aggregation

Effective extraction of polyribosomes from astrocytes enables future discoveries on translation regulation

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Neural Regeneration Research 2025年第4期20卷 1083-1084页

作者： Orna Elroy-Stein Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael Shmunis School of Biomedicine and Cancer Research George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain *** of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological *** advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease ***,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain ***,it is widely accepted that regulation at the translation level is a vital layer of gene *** of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020).

关键词： translation enable landscape

Temporal scatterplots

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Computational Visual Media 2020年第4期6卷 385-400页

作者： Or Patashnik Min Lu Amit H.Bermano Daniel Cohen-Or tel-aviv university Tel-AvivIsrael Shenzhen university ShenzhenChina

Visualizing high-dimensional data on a 2D canvas is generally *** becomes significantly more difficult when multiple time-steps are to be presented,as the visual clutter quickly ***,the challenge to perceive the significant temporal evolution is even *** this paper,we present a method to plot temporal high-dimensional data in a static scatterplot;it uses the established PCA technique to project data from multiple *** key idea is to extend each individual displacement prior to applying PCA,so as to skew the projection process,and to set a projection plane that balances the directions of temporal change and spatial *** present numerous examples and various visual cues to highlight the data trajectories,and demonstrate the effectiveness of the method for visualizing temporal data.

关键词： scatterplot temporal data visual clutter principle component analysis(PCA)

Peptide self‐assembly as a strategy for facile immobilization of redox enzymes on carbon electrodes

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Carbon Energy 2023年第11期5卷 15-30页

作者： Itzhak Grinberg Oren Ben‐Zvi Lihi Adler‐Abramovich Iftach Yacoby Department of Oral Biology The Goldschleger School of Dental MedicineFaculty of MedicineTel Aviv UniversityTel AvivIsrael The Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel AvivIsrael The Center for the Physics and Chemistry of Living Systems Tel Aviv UniversityTel AvivIsrael School of Plant Sciences and Food Security The George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Redox-enzyme‐mediated electrochemical processes such as hydrogen production,nitrogen fixation,and CO_(2) reduction are at the forefront of the green chemistry *** scale up,the inefficient two‐dimensional(2D)immobilization of redox enzymes on working electrodes must be replaced by an efficient dense 3D *** of 3D electrodes was demonstrated by embedding enzymes in polymer ***,several requirements,such as simple immobilization,prolonged stability,and resistance to enzyme leakage,still need to be *** study presented here aims to overcome these gaps by immobilizing enzymes in a supramolecular hydrogel formed by the self‐assembly of the peptide hydrogelator *** the self‐assembly process avoids the need for tedious and potentially harmful chemistry,allowing the rapid loading of enzymes on a 3D electrode under mild *** the[FeFe]hydrogenase enzyme,high enzyme loads,prolonged resistance against electrophoresis,and highly efficient hydrogen production are ***,this enzyme retention is shown to arise from its interaction with the peptide ***,this method is successfully used to retain other redox enzymes,paving the way for a variety of enzyme‐mediated electrochemical applications.

关键词： 3D electrode enzymes encapsulation H2 production hydrogenase peptide hydrogel

Dance to the beat： Synchronizing motion to audio

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Computational Visual Media 2018年第3期4卷 197-208页

作者： Rachele Bellini Yanir Kleimani Daniel Cohen-Or tel aviv university Tel Aviv 6997801 Israel.

In this paper we introduce a video post-processing method that enhances the rhythm of a dancing performance,in the sense that the dancing movements are more in time to the beat of the *** dancing performance as observed in a video is analyzed and segmented into motion intervals delimited by motion *** present an image-space method to extract the motion beats of a video by detecting frames at which there is a significant change in direction or motion *** motion beats are then synchronized with the music beats such that as many beats as possible are matched with as little as possible time-warping distortion to the *** show two applications for this cross-media synchronization:one where a given dance performance is enhanced to be better synchronized with its original music,and one where a given dance video is automatically adapted to be synchronized with different music.

关键词： video processing synchronization motionsegmentation video analysis

Postnatal therapeutic approaches in genetic neurodevelopmental disorders

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Neural Regeneration Research 2021年第3期16卷 414-422页

作者： Gilad Levy Boaz Barak The Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael The School of Psychological Sciences Faculty of Social SciencesTel Aviv UniversityTel AvivIsrael

Genetic neurodevelopmental disorders are characterized by abnormal neurophysiological and behavioral phenotypes,affecting individuals *** the subject has been heavily researched,current treatment options relate mostly to alleviating symptoms,rather than targeting the altered genome *** this review,we address the neurogenetic basis of neurodevelopmental disorders,genetic tools that are enabling precision research of these disorders in animal models,and postnatal gene-therapy approaches for neurodevelopmental disorders derived from preclinical studies in the laboratory.

关键词： adeno-associated virus CRISPR-Cas9 developmental window genetic therapy mouse models neurodevelopmental disorders non-human primates preclinical studies

Pioneering the direct large-scale laser printing of flexible“graphenic silicon”self-standing thin films as ultrahigh-performance lithium-ion battery anodes

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Carbon Energy 2024年第7期6卷 26-40页

作者： Avinash Kothuru Adam Cohen Gil Daffan Yonatan Juhl Fernando Patolsky School of Chemistry Faculty of Exact SciencesTel Aviv UniversityTel AvivIsrael Department of Materials Science and Engineering The Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael

Recent technological advancements,such as portable electronics and electric vehicles,have created a pressing need for more efficient energy storage ***-ion batteries(LIBs)have been the preferred choice for these applications,with graphite being the standard anode material due to its ***,graphite falls short of meeting the growing demand for higher energy density,possessing a theoretical capacity that lags *** address this,researchers are actively seeking alternative materials to replace graphite in commercial *** promising avenue involves lithiumalloying materials like silicon and phosphorus,which offer high theoretical ***-silicon composites have emerged as a viable option,showing improved capacity and performance over traditional graphite or pure silicon ***,the existing methods for synthesizing these composites remain complex,energy-intensive,and costly,preventing widespread adoption.A groundbreaking approach is presented here:the use of a laser writing strategy to rapidly transform common organic carbon precursors and silicon blends into efficient“graphenic silicon”composite thin *** films exhibit exceptional structural and energy storage *** resulting three-dimensional porous composite anodes showcase impressive attributes,including ultrahigh silicon content,remarkable cyclic stability(over 4500 cycles with∼40%retention),rapid charging rates(up to 10 A g^(-1)),substantial areal capacity(>5.1 mAh cm^(-2)),and excellent gravimetric capacity(>2400 mAh g^(-1) at 0.2 A g^(-1)).This strategy marks a significant step toward the scalable production of high-performance LIB *** widely available,cost-effective precursors,the laser-printed“graphenic silicon”composites demonstrate unparalleled performance,potentially streamlining anode production while maintaining exceptional *** innovation not only paves the way for advanced LIBs but also sets a precedent for

关键词： 4D printing energy storage fast-charging laser-induced graphene lithium-ion silicon carbon composite anodes

Unsupervised natural image patch learning

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Computational Visual Media 2019年第3期5卷 229-237页

作者： Dov Danon Hadar Averbuch-Elor Ohad Fried Daniel Cohen-Or tel-aviv university Tel Aviv 6997801Israel Stanford university StanfordCA 94305USA

A metric for natural image patches is an important tool for analyzing images. An efficient means of learning one is to train a deep network to map an image patch to a vector space, in which the Euclidean distance reflects patch similarity. Previous attempts learned such an embedding in a supervised manner,requiring the availability of many annotated images. In this paper, we present an unsupervised embedding of natural image patches, avoiding the need for annotated images. The key idea is that the similarity of two patches can be learned from the prevalence of their spatial proximity in natural images. Clearly, relying on this simple principle, many spatially nearby pairs are outliers. However, as we show, these outliers do not harm the convergence of the metric learning. We show that our unsupervised embedding approach is more effective than a supervised one or one that uses deep patch representations. Moreover, we show that it naturally lends itself to an efficient self-supervised domain adaptation technique onto a target domain that contains a common foreground object.

关键词： unsupervised learning metric learning

Image resizing by reconstruction from deep features

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Computational Visual Media 2021年第4期7卷 453-466页

作者： Dov Danon Moab Arar Daniel Cohen-Or Ariel Shamir tel aviv university Tel Aviv69978Israel The Interdisciplinary Center Herzliya Herzliya4610101

Traditional image resizing methods usually work in pixel space and use various saliency *** challenge is to adjust the image shape while trying to preserve important *** this paper we perform image resizing in feature space using the deep layers of a neural network containing rich important semantic *** directly adjust the image feature maps,extracted from a pre-trained classification network,and reconstruct the resized image using neuralnetwork based *** novel approach leverages the hierarchical encoding of the network,and in particular,the high-level discriminative power of its deeper layers,that can recognize semantic regions and objects,thereby allowing maintenance of their aspect *** use of reconstruction from deep features results in less noticeable artifacts than use of imagespace resizing *** evaluate our method on benchmarks,compare it to alternative approaches,and demonstrate its strengths on challenging images.

关键词： image retargeting reconstruction deep seam carving image resizing

‘Jelly to Joule’:Direct laser writing of sustainable jellyfish-based ‘graphenic silicon’ anodes for environmentally remediating high-performance lithium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 553-565,I0012页

作者： Gil Daffan Adam Cohen Yuval Sharaby Roman Nudelman Shachar Richter Fernando Patolsky Department of Materials Science and Engineering the Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel Aviv 69978Israel school of Chemistry Faculty of Exact SciencesTel Aviv UniversityTel Aviv 69978Israel

The ramifications of global climate change and resource scarcities have made it imperative to re-examine the definition of sustainable energy-storage *** is crucial to recognize that not all renewable resources are inherently sustainable,and their full impact on the environment must be *** the proliferation of invasive jellyfish species wreaking havoc on marine ecosystems and economies worldwide,utilizing overabundant jellyfish as a carbon source presents an opportunity to create energy-storage systems that are both financially beneficial and environmentally ***,a comprehensive approach to sustainability also requires eco-friendly solutions throughout the entire lifecycle,from material sourcing to battery production,without compromising highperformance ***,most electrode syntheses for lithium-ion batteries(LIBs) employed are energy-intensive,multiple-steps,complex,and *** response,this work pioneers the straightforward use of low-energy laser irradiation of a jellyfish biomass/silicon nanoparticle blend to encapsulate the silicon nanoparticles in-situ within the as-forming conductive carbonized matrix,creating sustainable and additive-free composite *** self-standing anode is directly synthesized under ambient conditions and requires no ***,a laser-synthesized conductive threedimensional porous carbon/silicon composite anode from raw jellyfish biomass for LIBs is presented,displaying outstanding cyclic stability(>1000 cycles),excellent capacity retention(>50% retention after1000 cycles),exceptional coulombic efficiency(>99%),superb reversible gravimetric capacity(>2000 mAh/g),and high rate performance capability(>1.6 A/g),paving a new path to future sustainable energy production.

关键词： Laser Silicon Carbon Jellyfish Sustainable Lithium Biomass